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14:40 EST 20th January 2019 | BioPortfolio

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Showing "MDNA Life Sciences Medical Equipment Deals Alliances Profile" PubMed Articles 1–25 of 24,000+

Life sciences licensing deals in the second quarter of 2018: updates and trends.

During the second quarter of 2018, Cortellis Competitive Intelligence registered 985 new deals (excluding mergers and acquisitions) with a total disclosed deal value of USD 19.5 billion as part of its ongoing coverage of licensing activity in the life sciences sector compared to 964 and USD 35.6 billion in the first quarter and 1,104 and USD 13.6 billion in the second quarter of 2017. Total deal value in the second quarter did not quite reach the peak of 2014 (paced by Novartis' USD 16 billion purchase of G...

Hospital purchasing alliances: Ten years after.

Most hospitals outsource supply procurement to purchasing alliances, or group purchasing organizations (GPOs). Despite their early 20th century origin, we lack both national and trend data on alliance utilization, services, and performance. The topic is important as alliances help hospitals control costs, enjoy tailwinds from affiliated regional/local alliances, and face headwinds from hospital self-contracting and criticism of certain business practices.

Challenging the six-hour recommendation for reprocessing sterilizable medical equipment.

At present, reprocessing of sterilizable medical equipment is recommended to be initiated within 6 h after completion of surgery, to ensure that the quality of the instruments does not deteriorate. A literature search showed a lack of evidence for consequences that may occur if medical personnel deviate from the standard 6 h sterilization protocol.

Profile of Dr. Fuwen Wei.

Trust, Money, and Power: Life Cycle Dynamics in Alliances Between Management Partners and Accountable Care Organizations.

Policy Points Accountable care organizations (ACOs) form alliances with management partners to access financial, technical, and managerial support. Alliances between ACOs and management partners are subject to destabilizing tension around decision-making authority, distribution of shared savings, and conflicting goals and values. Management partners may serve either as trainers, ultimately breaking off from the ACO, or as central drivers of the ACO. Management partner participation in ACOs is currently unre...

The impact of reactogenicity after the first dose of recombinant zoster vaccine upon the physical functioning and quality of life of older adults: an open phase III trial.

Herpes zoster (HZ) and its related complications are associated with significant medical burden, which negatively impacts patients' quality-of-life (QoL) and daily functioning. The recently licensed recombinant zoster vaccine (RZV) offers high efficacy, but is associated with local and systemic reactions. This study assessed the impact of RZV upon the QoL and daily functioning of participants and implications for caregivers.

Dataset of leisure time among students at Kermanshah University of Medical Sciences and its relationship with health-related quality of life (HRQOL).

The present data article aimed to investigate the leisure time among students at Kermanshah University of Medical Sciences and its relationship with health-related quality of life. In this descriptive and correlational data article, the statistical population consisted of 420 students at faculties of Health, Paramedics, Nursing and Midwifery in Kermanshah University of Medical Sciences who were selected through multi-stage cluster sampling. For data collection, the demographic questions, 36-item short form ...

It is not an issue that basic science courses are vanishing from the medical curriculum.

There is some controversy regarding the role of and time devoted to so-called basic sciences in the medical curriculum. In this article, the author argues that nowadays basic sciences are a far less important element of the medical curriculum than in the past, and that in time they will likely be phased out completely. Arguments put forward are the changing role of the medical doctor, evidence that general clinical reasoning skills do not exist, and that the contrary assumption has led to havoc. He conclude...

Pharmacological profile of TAN-452, a novel peripherally acting opioid receptor antagonist for the treatment of opioid-induced bowel syndromes.

Opioid-induced bowel syndromes deteriorate patients' quality of life and may lead to nonadherence to opioid schedule and under-treatment of pain. The objective was to characterize the pharmacological profile of 17-cyclopropylmethyl-6,7-didehydro-4,5α-epoxy-6'-ethoxycarbonyl-3,14-dihydroxyindolo [2',3'-6,7]morphinan (TAN-452), a novel peripherally acting opioid receptor antagonist.

Living longer, with or without disability? A Global and Longitudinal Perspective.

Significant gains in life expectancy have been achieved, but living longer does not necessarily mean the years gained are productive and healthy. Different theories predict different patterns of time trends in old-age disability prevalence.

Co-administration with simvastatin or lovastatin alters the pharmacokinetic profile of sinomenine in rats through cytochrome P450-mediated pathways.

Sinomenine, an anti-rheumatoid arthritis drug used in China for decades, is usually co-administered with cardiovascular (CV) drugs to reduce arthritis-related risk of cardiovascular diseases. This study was to investigate whether and how CV drugs affect the pharmacokinetic profile of sinomenine.

Single center experience with medical cannabis in Gilles de la Tourette syndrome.

Patients with Gilles de la Tourette syndrome (GTS) experience reduced function and impaired quality of life. The current medical treatments for this syndrome can cause significant side effects and offer partial symptomatic relief. In a few small trials medical cannabis (MC) has been suggested to offer symptomatic relief with a relatively benign side effect profile. We conducted a real-life assessment of clinical benefit and adverse effects of chronic MC treatment among patients with GTS.

Medical education dilemma: how best to accommodate basic sciences in a curriculum for the 21st century medical students?

Over the years the medical curriculum has been changed to accommodate a variety of evolving disciplines and an exploding scientific knowledge of the basic sciences to prepare "a competent physician" of the 21st century. Therefore, we must be innovative in our approach of curricular development if we wish to continue to incorporate new basic sciences knowledge in the face of decreasing contact hours to satisfy the buzz word, "integration". Certainly, the challenges are phenomenal. The question how best to in...

Health promoting behaviors of staff in a university of medical sciences in southeast of Iran.

Background Health promoting behaviors are appropriate indicators to determine individuals' health status. The staff of a health care system plays an important role in enhancing health promoting behaviors in society; therefore, the present study is aimed to evaluate health promoting behaviors of the staff in a university of medical sciences. Methods A descriptive study was conducted on 140 staff of the Kerman University of Medical Sciences in the southeast of Iran. Data were collected using the Persian versi...

The prevalence of orthostatic hypotension: a systematic review and meta-analysis.

Orthostatic hypotension (OH) is associated with increased risk of falls, cognitive impairment and death as well as a reduced quality of life. Although it is presumed to be common in older people, estimates of its prevalence vary widely. This study aims to address this by pooling the results of epidemiological studies.

Quality of life of post-graduate medical students working in private and public hospitals in Punjab as measured by WHOQOL-BREF questionnaire.

To determine the impact of the type of specialty and hospital on the quality of life of medical consultants and residents..

Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults.

Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized the nutritional and metabolic profile of sarcopenia through an extensive exploration of a wide array of blood biomarkers related to muscle protein metabolism and transcriptomic signatures in community-dwelling elderly.

Effect of percutaneous coronary intervention and 
medical therapy on quality of life and cognitive function in patients with coronary heart disease.

To explore the effect and difference of percutaneous coronary intervention (PCI) and medical therapy on quality of life and cognitive function in patients with coronary heart disease (CHD), and to investigate the relationship between quality of life and cognitive function.
 Methods: A total of 320 patients with CHD, who underwent coronary angiography and PCI (PCI group, n=160), or underwent coronary angiography and medical therapy (drug therapy group, n=160), were selected. The quality of life was assesse...

Fatty acids profile in patients after heart or renal transplantation who developed metabolic complications.

Diabetes mellitus and hyperlipidemia are frequently observed after organ transplantation. It is known that in these disorders the fatty acid metabolism is impaired. The aim of this study was to compare the fatty acid profile in the heart and renal transplant recipients who developed metabolic disorders since there is no such research available.

On the necessity of philosophy in medical education.

Today, the study and practice of medicine are treated with a natural scientific approach. However, medical action has its foundations not only in the natural sciences and technology, but also in ethics, humanity and philosophy. The Wuerzburg Philosophicum teaches, apart from medical ethics, a systematic analysis of a theory of medicine in the context of other sciences, the theory of knowledge, anthropology and hermeneutics.

Translating the Lifestyle Interventions and Independence for Elders Clinical Trial to Older Adults in a Real-World Community-Based Setting.

The Lifestyle Interventions and Independence for Elders (LIFE) clinical trial demonstrated that a structured program of physical activity (PA) reduced mobility-disability in older adults by up to 28%. It remains unknown whether the benefits of LIFE PA can be translated to older adults at risk for mobility-disability in real-world community-based settings. To address this knowledge gap, we conducted the ENGAGE pilot study and examined the safety, feasibility and preliminary effectiveness of translating LIFE ...

The Model of Self Care Behaviour and the Relationship with Quality Of Life, Metabolic Control and Lipid Control of Type 2 Diabetes Mellitus Patients in Binjai City, Indonesia.

Diabetes is a type of chronic disease with exceptional medical care for a patient's lifetime, which ultimately requires lifestyle and behavioural adjustments to prevent complications to death. Patients with good self-care behaviour will cause diabetes to be controlled to avoid complications to death and make patients have a better quality of life.

A combination of mRNA expression profile and miRNA expression profile identifies detection biomarkers in different tumor stages of laryngeal squamous cell carcinoma.

This study was conducted to investigate microRNA (miRNA) target regulations during the disease progression in laryngeal squamous cell carcinoma (LSCC) and identify biomarkers in different tumor stages.

Plasma Vitamin B12, Supplementation and Mortality.

Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice.

Sclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects.

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