Topics

PubMed Journals Articles About "Merck Aktie Gibt Ordentlich" RSS

23:21 EST 16th February 2020 | BioPortfolio

Merck Aktie Gibt Ordentlich PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Merck Aktie Gibt Ordentlich articles that have been published worldwide.

More Information about "Merck Aktie Gibt Ordentlich" on BioPortfolio

We have published hundreds of Merck Aktie Gibt Ordentlich news stories on BioPortfolio along with dozens of Merck Aktie Gibt Ordentlich Clinical Trials and PubMed Articles about Merck Aktie Gibt Ordentlich for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Merck Aktie Gibt Ordentlich Companies in our database. You can also find out about relevant Merck Aktie Gibt Ordentlich Drugs and Medications on this site too.

Showing "Merck Aktie gibt ordentlich" PubMed Articles, all 14

Prediction of active human dose: learnings from 20 years of Merck KGaA experience, illustrated by case studies.

High-quality dose predictions based on a good understanding of target engagement is one of the main translational goals in drug development. Here, we systematically evaluate active human dose predictions for 15 Merck KGaA/EMD Serono assets spanning several modalities and therapeutic areas. Using case studies, we illustrate the value of adhering to the translational best practices of having an exposure-response relationship in an appropriate animal model, having validated, translatable pharmacodynamic (PD) b...


Stereoselective Synthesis of Dysoxylactam A.

The first report on the stereoselective synthesis of dysoxylactam A is disclosed. The five stereogenic centers of the fatty acid chain are created by utilizing Merck-Carreira and Marshall's propargylation reaction, Evans' alkylation methodology, and Noyori's transfer hydrogenation protocol.

An In Vitro comparison of four different immunoassays for the monitoring of Infliximab biosimilars drug levels.

SB2 (Renflexis®, Merck) and CT-P13 (Inflectra®, Pfizer) are biosimilars of the reference Infliximab (Remicade®, Janssen) and are approved in Canada for use in indications for which Infliximab is approved, including inflammatory bowel disease. These biosimilars are structurally different but exhibit comparable physicochemical characteristics, pharmaceutical effectiveness and immunogenicity compared to Infliximab. Optimal Infliximab therapy currently relies on therapeutic drug monitoring offered by several...


Iron deficiency anaemia in school age children of District Tank Khyber Pakhtunkhwa Province, Pakistan.

In the current study the occurrence and severity of iron deficiency anemia (IDA) was recorded from September, 2014 to April, 2015 in children of school age in District Tank. Random sampling of blood and questionnaires were planned to record general information while blood was analyzed through automatic haematological analyzer model Sysmex Kx- 21 Stromatolyser- WH, Cell Pack (Merck). Total prevalence of anaemia in school age children was 37.1% with 63.8% in boys and 64.3% in girls.

Applying drug synergy metrics to oncology combination screening data: agreements, disagreements and pitfalls.

Synergistic drug combinations are commonly sought to overcome monotherapy resistance in cancer treatment. To identify such combinations, high-throughput cancer-cell-line combination screens are performed; and synergy is quantified using competing models based on fundamentally different assumptions. Here, we compare the behaviour of four synergy models, namely Loewe additivity, Bliss independence, highest single agent and zero interaction potency, using the Merck oncology combination screen. We evaluate agre...

Fine-Needle Aspiration for the Evaluation of Hepatic Pharmacokinetics of Vaniprevir: A Randomized Trial in Patients With Hepatitis C Virus Infection.

Fine-needle aspiration (FNA) for serial hepatic sampling may be an efficient and less invasive alternative to core needle biopsy (CNB), the current standard for liver tissue sampling. In this randomized, open-label trial in 31 participants with hepatitis C virus genotype 1 infection (NCT01678131/Merck protocol PN048), we evaluated the feasibility of using FNA to obtain human liver tissue samples appropriate for measuring hepatic pharmacokinetics (PK), using vaniprevir as a tool compound. The primary endpoin...

Metabolic engineering of Escherichia coli to produce a monophosphoryl lipid A adjuvant.

Monophosphoryl lipid A (MPLA) species, including MPL (a trade name of GlaxoSmithKline) and GLA (a trade name of Immune Design, a subsidiary of Merck), are widely used as an adjuvant in vaccines, allergy drugs, and immunotherapy to boost the immune response. Even though MPLA is a derivative of lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, bacterial strains producing MPLA have not been found in nature nor engineered. In fact, MPLA generation involves expensive and labo...

Antibacterial activity of griseofulvin analogs as example of drug repurposing.

Griseofulvin is a well-known antifungal drug launched in 1962 by Merck & Co. for treatment of dermatophyte infections. However, according to the predictions using Way2Drug computational drug repurposing platform, it may have antibacterial activity. Since no faultless confirmation of this prediction was found in the published literature, we estimated in silico antibacterial activity for 42 griseofulvin derivatives synthesized earlier. Antibacterial activity was predicted for 33 from 42 molecules, which lead ...

Recurrent herpes zoster in the Shingles Prevention Study: Are second episodes caused by the same varicella-zoster virus strain?

Herpes zoster (HZ) is caused by reactivation of varicella zoster virus (VZV) that established latency in sensory and autonomic neurons during primary infection. In the Shingles Prevention Study (SPS), a large efficacy trial of live attenuated Oka/Merck zoster vaccine (ZVL), PCR-confirmed second episodes of HZ occurred in two of 660 placebo and one of 321 ZVL recipients with documented HZ during a mean follow-up of 3.13 years. An additional two ZVL recipients experienced a second episode of HZ in the Long-...

The Effectiveness and Value of Treatments for Spinal Muscular Atrophy.

Funding for this summary was contributed by the Laura and John Arnold Foundation and California Health Care Foundation to the Institute for Clinical and Economic Review (ICER), an independent organization that evaluates the evidence on the value of health care interventions. ICER's annual policy summit is supported by dues from Aetna, AHIP, Anthem, Blue Shield of California, CVS Caremark, Express Scripts, Harvard Pilgrim Health Care, Cambia Health Solutions and MedSavvy, United Healthcare, Kaiser Permanente...

"In-House" Data on the Outside - A Mobile Health Approach.

Mobile health (mHealth) technologies have the potential to capture dense patient data on the background of real-life behavior. Merck & Co., Inc. (Kenilworth, NJ, USA), in collaboration with Koneksa Health, conducted a Phase I clinical trial to validate cardiovascular mHealth technologies for concordance with traditional approaches and to establish sensitivity to detect effects of pharmacological intervention. This two-part study enrolled 18 healthy male subjects. Part I, a 5-day study, compared mHealth meas...

Evaluation of arsenic field test kits for drinking water: Recommendations for improvement and implications for arsenic affected regions such as Bangladesh.

Arsenic field test kits are widely used to measure arsenic levels in drinking water sources, especially in countries like Bangladesh, where water supply is highly decentralized and water quality testing infrastructure is limited. From a public health perspective, the ability of a measurement technique to distinguish samples above and below relevant and actionable drinking water standards is paramount. In this study, the performance of eight commercially available field test kits was assessed by comparing ki...

Development of a highly efficient decontamination approach for ceftolozane in the pharmaceutical manufacturing environment.

The β-lactam core is a key structure responsible for inducing both IgE-mediated acute-onset hypersensitivity and T-cell-mediated delayed-onset hypersensitivity with penicillins in humans. There is essentially no clinically significant immunologic cross-reactivity noted between the β-lactam cores of penicillins and cephalosporins based on challenge studies in humans. The side-chains appear to be more important in inducing IgE-mediated acute-onset hypersensitivity and T-cell delayed-onset hypersensitivity w...

Use of 13-Valent Pneumococcal Conjugate Vaccine and 23-Valent Pneumococcal Polysaccharide Vaccine Among Adults Aged ≥65 Years: Updated Recommendations of the Advisory Committee on Immunization Practices.

Two pneumococcal vaccines are currently licensed for use in adults in the United States: a 13-valent pneumococcal conjugate vaccine (PCV13 [Prevnar 13, Pfizer, Inc.]) and a 23-valent pneumococcal polysaccharide vaccine (PPSV23 [Pneumovax 23, Merck and Co., Inc.]). In 2014, the Advisory Committee on Immunization Practices (ACIP)* recommended routine use of PCV13 in series with PPSV23 for all adults aged ≥65 years based on demonstrated PCV13 safety and efficacy against PCV13-type pneumonia among adults aged...


Quick Search