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PubMed Journals Articles About "Merck Named FTSE4Good Constituent Member" RSS

23:10 EST 18th January 2019 | BioPortfolio

Merck Named FTSE4Good Constituent Member PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Merck Named FTSE4Good Constituent Member articles that have been published worldwide.

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Showing "Merck Named FTSE4Good Constituent Member" PubMed Articles 1–25 of 2,300+

Merck vaccine heads Ebola countermeasures.


Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure.

It has been known for nearly 50 years that cannabis and the psychoactive constituent Δ9-tetrahydrocannabinol (THC) reduce intraocular pressure (IOP). Elevated IOP remains the chief hallmark and therapeutic target for glaucoma, a major cause of blindness. THC likely acts via one of the known cannabinoid-related receptors (CB1, CB2, GPR18, GPR119, GPR55) but this has never been determined explicitly. Cannabidiol (CBD) is a second major constituent of cannabis that has been found to be without effect on IOP i...

Characterization of a novel member of the family Caulimoviridae infecting Dioscorea nummularia in the Pacific, which may represent a new genus of dsDNA plant viruses.

We have characterized the complete genome of a novel circular double-stranded DNA virus, tentatively named Dioscorea nummularia-associated virus (DNUaV), infecting Dioscorea nummularia originating from Samoa. The genome of DNUaV comprised 8139 bp and contained four putative open reading frames (ORFs). ORFs 1 and 2 had no identifiable conserved domains, while ORF 3 had conserved motifs typical of viruses within the family Caulimoviridae including coat protein, movement protein, aspartic protease, reverse tra...


Enzalutamide after chemotherapy in advanced castration-resistant prostate cancer: the Italian Named Patient Program.

To collect efficacy and safety data of enzalutamide after docetaxel, we retrospectively evaluated the Italian Named Patient Program results.

Retrocausal Regulation for the Onset of a Reaction Cycle.

The emergence of a reaction cycle in a mixture of reacting molecules may require naturalized regulation of the constituent material elements. One source of naturalized regulation could be sought in updating the constituent elements through exchanging with those available from the outside under the conditions of unidirectional heat flow. One physical vehicle for implementing constant material exchange could be a durable reaction cycle serving as a necessary precursor to the phenomenon called life. Each const...

A lower blood pressure threshold to define hypertension: the effect on prevalence, control rate, and constituent ratio of systolic and/or diastolic hypertension.

To evaluate the impact of the new US hypertension criteria [systolic blood pressure/diastolic blood pressure (SBP/DBP ≥130/80 mmHg)] on hypertension prevalence and the constituent ratio of three hypertension phenotypes.

CCN family member 1 deregulates cholesterol metabolism and aggravates atherosclerosis.

CCN family member 1 (CCN1) is an extracellular matrix cytokine and appears in atherosclerotic lesions. However, we have no evidence to support the role of CCN1 in regulating of cholesterol metabolism and atherosclerosis.

Conditional random fields for clinical named entity recognition: A comparative study using Korean clinical texts.

This study demonstrates clinical named entity recognition (NER) methods on the clinical texts of rheumatism patients in South Korea. Despite the recent increase in the adoption rate of the electronic health record (EHR) system in global health institutions, health information technologies for handling and acquisition of information from numerous unstructured texts in the EHR system are still in their developing stages. The aim of this study is to verify the conventional named entity recognition (NER) method...

When team member familiarity affects transactive memory and skills: A simulation-based training among police teams.

The goal of this study was to evaluate the impact of team member familiarity on both technical and non-technical skills of police officers, and to examine the mediating role of transactive memory components (specialization, coordination and credibility). Student police officers (N = 150) carried out professional simulation sessions in groups of three, with either familiar (n = 22 teams) or unfamiliar (n = 28 teams) team members, followed by a skills evaluation exercise. Professional instructors ...

Red clover-associated luteovirus - a newly classifiable member of the genus Luteovirus with an enamo-like P5 protein.

This study reports the complete genomic sequence of a novel virus isolated from red clover. According to its genomic organization, its similarity to luteoviruses, and a greater than 10% difference in all genes, this virus isolate likely represents a new luteovirus species. As seen in nectarine stem pitting-associated virus (NSPaV) and NSPaV-South Korea (SK) luteoviruses, it differs from typical luteoviruses through the absence of ORF3a and ORF4 encoding movement proteins. Furthermore, its P5 protein (respon...

Australian musculoskeletal physiotherapist's perceptions, attitudes and opinions towards pre-manipulative screening of the cervical spine prior to manual therapy: Report from the focus groups.

The Australian Physiotherapy Association 2006 VBI Guidelines are used by many of the member organisations of IFOMPT. These Guidelines are due for revision incorporating recent research findings, international guides, and member's recommendations.

Analysis of distribution and drug resistance of pathogens from the wounds of 1 310 thermal burn patients.

To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens. E test was cond...

The role of semantic transparency in visual word recognition of compound words: A megastudy approach.

Previous studies on visual word recognition of compound words have provided evidence for the influence of lexical properties (e.g., length, frequency) and semantic transparency (the degree of relatedness in meaning between a compound word and its constituents) in morphological processing (e.g., to what extent is doorbell influenced by door and bell?). However, a number of questions in this domain, which are difficult to address with the available methodological resources, are still unresolved. We collected ...

Curcumin prevents cigarette smoke extract induced cognitive impairment.

Curcumin is a major phytochemical constituent in an herbaceous perennial plant of family, which exhibits anti-oxidant, anti-inflammatory and immunomodulatory properties. Here, we studied the therapeutic action of curcumin against CSE induced cognitive impairment in zebrafish. Montelukast (20 mg/kg), a cysteinyl-leukotriene receptor blocker was used as a reference drug. CSE exposure induced biochemical changes revealed that raise the brain acetylcholinesterase activity and lipid peroxidative products; and ...

Compounding matters: Event-related potential evidence for early semantic access to compound words.

Reading words in a native language triggers a largely obligatory cognitive process that we accept as leading to comprehension of the word - we cannot suppress our understanding of word meaning. In this study, we investigated the early stages of this comprehension process by means of event-related potentials (ERPs) to identify when this processing of meaning - that is, semantic processing - first occurs. We report that, when processing visually presented compound words, semantic access at some level occurs a...

PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells.

Multidrug resistance (MDR) induced by the ABC transporter subfamily B member 1 (ABCB1) and subfamilyG member 2 (ABCG2) limits successful cancer chemotherapy and no commercially available MDR modulator is used in the clinic. In the current study, we aimed to investigate the effects of PCI29732 on the enhancement of chemotherapeutic agents.

Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro.

Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins KN (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-indu...

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

Forkhead transcription factor, O subgroup, member 1 (FOXO1) is a regulatory protein that plays an essential role in cellular homeostasis. A biological function as a tumor suppressor has been proposed. Here, we examined FOXO1 expression in human pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions.

Total synthesis of γ-alkylidenebutenolides, potent melanogenesis inhibitors from Thai medicinal plant Melodorum fruticosum.

A hitherto unreported member of γ-alkylidenebutenolides in Merdorum fruticosum (Annonaceae), (4 E)-6-benzoyloxy-7-hydroxy-2,4-heptadiene-4-olide, named as isofruticosinol (4) was isolated from the methanol extract of flowers, along with the known related butenolides, namely, the (4 Z)-isomer (3) of 4, melodrinol (1) and its (4 E)-isomer (2). To unambiguously determine the absolute configuration at the C-6 position in these butenolides, the first total syntheses of both enantiomers of 2-4 were achieved over...

Compound Words Reflect Cross-Culturally Shared Bodily Metaphors.

Parts of the body are often embedded in the structure of compound words, such as heartbreak and brainchild. We explored the relationships between the semantics of compounds and their constituent body parts, asking whether these relationships are largely arbitrary or instead reflect deeper metaphorical mappings shared across languages and cultures. In three studies, we found that U.S. English speakers associated the English translation equivalents of Chinese compounds with their constituent body parts at rat...

Named lectures at ESC Congress 2018.

Family behind OxyContin named in lawsuit for the first time.

Comparing fertility preservation resources and policies between NCCN member and non-member institutions.

The National Comprehensive Cancer Network (NCCN) created guidelines to facilitate implementation of fertility preservation (FP) discussions and referrals for adolescent and young adult patients. We assessed if availability of workplace FP resources and referral policies differed among learners in the Educating Nurses about Reproductive Health in Cancer Healthcare (ENRICH) training program based on NCCN membership.

Investigations into the mechanism of action of sublancin.

Antimicrobial resistance is a global threat that poses a rising concern. One underlying challenge is the limited number of targets in bacteria affected by the current pool of antibiotics. To potentially help find new targets, we studied a member of the class of anti-microbial natural products named glycocins. We examined the mode of action of sublancin, which contains an unusual and essential glucosylated Cys residue, by monitoring macromolecular synthesis. Sublancin negatively affected DNA replication, tra...

Croton golden mosaic virus: a new bipartite begomovirus isolated from Croton hirtus in Colombia.

A new begomovirus infecting Croton hirtus (Euphorbiaceae) from Colombia has been characterized. The complete DNA-A and DNA-B components were determined to be 2613 and 2551 nt in length, respectively, showing the typical genome organization of bipartite New World begomoviruses. DNA-A showed the highest nucleotide sequence identity (81.2%) to sida yellow mottle virus (JN411687), a begomovirus isolated from Sida rhombifolia in Cuba. Based on the current ICTV species demarcation criterion for the genus Begomov...


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