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PubMed Journals Articles About "Merck Named FTSE4Good Constituent Member" RSS

11:03 EDT 20th October 2018 | BioPortfolio

Merck Named FTSE4Good Constituent Member PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Merck Named FTSE4Good Constituent Member articles that have been published worldwide.

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Showing "Merck Named FTSE4Good Constituent Member" PubMed Articles 1–25 of 2,200+

Winners of the Emanuel Merck Lectureship and the Heinrich Emanuel Merck Award.


Treating MS without continuous immunosuppression: an interview with Luciano Rossetti.

Luciano Rossetti, MD, Executive Vice President, Global Head of R&D at Merck KGaA, Darmstadt, Germany speaks to Laura Dormer, Commissioning Editor Luciano Rossetti, MD, is Executive Vice President, Global Head of R&D at Merck KGaA, Darmstadt, Germany, and a member of the Healthcare Executive Committee. As Global Head of R&D, Rossetti leads the strategy for Merck KGaA, Darmstadt, Germany's discovery and development efforts in healthcare. He joined Merck KGaA in July 2014, and has since led the acceleration of...

Merck vaccine heads Ebola countermeasures.


WASP (Write a Scientific Paper): The right to privacy.

The data protection directive of the EU was set up to allow the freedom of movement of people between member states. This has the consequence of allowing the freedom of transfer of data between member states in research. The paper discusses three cases discussed during the project to see whether RECs can refuse research based on concern for data protection in some member states. Since the directive is not, as commonly thought, intended to protect the rights and freedoms of individuals - something which is t...

Japan Prize / Merck-Banyu Lectureship for Naoya Kumagai / DECHEMA Prize for Timothy Noël.

Member Input: The Challenge of Staffing in Ambulatory Infusion Settings.

The Oncology Nursing Society (ONS) has conducted several member surveys that included questions about staffing but has not established nurse-patient ratios, given the number and complexity of variables that must be considered. The 2016 ONS member survey showed that staffing was the most frequently cited challenge in the practice setting. With the implementation of ONS Communities in 2017, members have the opportunity to network and connect about issues. Staffing in chemotherapy infusion centers has been a f...

Characterization of a novel member of the family Caulimoviridae infecting Dioscorea nummularia in the Pacific, which may represent a new genus of dsDNA plant viruses.

We have characterized the complete genome of a novel circular double-stranded DNA virus, tentatively named Dioscorea nummularia-associated virus (DNUaV), infecting Dioscorea nummularia originating from Samoa. The genome of DNUaV comprised 8139 bp and contained four putative open reading frames (ORFs). ORFs 1 and 2 had no identifiable conserved domains, while ORF 3 had conserved motifs typical of viruses within the family Caulimoviridae including coat protein, movement protein, aspartic protease, reverse tra...

Enzalutamide after chemotherapy in advanced castration-resistant prostate cancer: the Italian Named Patient Program.

To collect efficacy and safety data of enzalutamide after docetaxel, we retrospectively evaluated the Italian Named Patient Program results.

Genome sequence of a novel partitivirus identified from the oomycete Pythium nunn.

The mycoparasitic oomycete Pythium nunn isolate UZ415 contains two double-stranded RNAs (dsRNAs) of different sizes. The 1707-nt dsRNA1 and the 1475-nt dsRNA2 potentially encode an RNA-dependent RNA polymerase (RdRp) and a coat protein (CP), respectively, with sequence similarity to the RdRp and CP of gammapartitiviruses (< 57% and < 36%). Phylogenetic analysis of the deduced RdRp amino acid sequences indicated that the virus identified from P. nunn is classifiable as a distinct member of the genus Ganmmapa...

Conditional random fields for clinical named entity recognition: A comparative study using Korean clinical texts.

This study demonstrates clinical named entity recognition (NER) methods on the clinical texts of rheumatism patients in South Korea. Despite the recent increase in the adoption rate of the electronic health record (EHR) system in global health institutions, health information technologies for handling and acquisition of information from numerous unstructured texts in the EHR system are still in their developing stages. The aim of this study is to verify the conventional named entity recognition (NER) method...

Red clover-associated luteovirus - a newly classifiable member of the genus Luteovirus with an enamo-like P5 protein.

This study reports the complete genomic sequence of a novel virus isolated from red clover. According to its genomic organization, its similarity to luteoviruses, and a greater than 10% difference in all genes, this virus isolate likely represents a new luteovirus species. As seen in nectarine stem pitting-associated virus (NSPaV) and NSPaV-South Korea (SK) luteoviruses, it differs from typical luteoviruses through the absence of ORF3a and ORF4 encoding movement proteins. Furthermore, its P5 protein (respon...

When team member familiarity affects transactive memory and skills: A simulation-based training among police teams.

The goal of this study was to evaluate the impact of team member familiarity on both technical and non-technical skills of police officers, and to examine the mediating role of transactive memory components (specialization, coordination and credibility). Student police officers (N = 150) carried out professional simulation sessions in groups of three, with either familiar (n = 22 teams) or unfamiliar (n = 28 teams) team members, followed by a skills evaluation exercise. Professional instructors ...

Honor among thieves: The interaction of team and member deviance on trust in the team.

In this article, we examine member trust in deviant teams. We contend that a member's trust in his or her deviant team depends on the member's own deviant actions; although all members will judge the actions of their deviant teams as rational evidence that they should not be trusted, deviant members, but not honest members, can hold on to trust in their teams because of a sense of connection to the team. We tested our predictions in a field study of 562 members across 111 teams and 24 organizations as well ...

The role of semantic transparency in visual word recognition of compound words: A megastudy approach.

Previous studies on visual word recognition of compound words have provided evidence for the influence of lexical properties (e.g., length, frequency) and semantic transparency (the degree of relatedness in meaning between a compound word and its constituents) in morphological processing (e.g., to what extent is doorbell influenced by door and bell?). However, a number of questions in this domain, which are difficult to address with the available methodological resources, are still unresolved. We collected ...

Knowledge and Attitude of Family Member of Mentally Ill Patient Regarding Restraint, 2016.

People who have observed or are aware that a consumer has been restrained may experience distress, confusion, concern, anger or fear and perceive as punishment. However, studies that examine the perspective of patient's family are limited. This study has explored the knowledge and attitude of family member of mentally ill patient.

In vitro and in silico antimicrobial activity of sterol and flavonoid isolated from Trianthema decandra L.

Phytochemical study on the leaves of Trianthema decandra leads to the isolation and characterization of two compounds from chloroform extract. The compounds were characterized using HPLC, UV, FT-IR, NMR, LCMS and CHNS. The structure of compounds were elucidated from spectral data and named according to rules laid down in IUPAC nomenclature. A novel sterol was named as 17-(5-ethyl-6-methylheptan-2-yl) -4, 4, 10, 13-tetramethyl-hexadecahydro-1H-cyclopenta (α) phenanthren-3-ol and the flavonoid was named as 2...

Inhibition of UVB-induced pro-inflammatory cytokines and MMP expression by Zanthoxylum rhetsa bark extract and its active constituent hesperidin.

The antiphoto aging property of Zanthoxylum rhetsa obtained from Pangkor Island, Malaysia, was evaluated. Solvent fractions of different polarity obtained from the methanolic extract of the bark material were initially tested for anticollagenase and antielastase activities. The ethyl acetate fraction showed bioactivity against the protease enzymes. Hence, it was subjected to further purification via column chromatography, to yield a major constituent, hesperidin. Subsequently, the ethyl acetate fraction and...

The Recipe for Corporate Longevity: From the Perspective of "Managing Innovation".

The elephant is in the room-a metaphorical idiom for an obvious problem or risk that nobody wants to discuss. This abstract is not intended to be a summary, to reveal major findings, or unveil conclusions. On the contrary, it is aimed to provoke curiosity as to the question of corporate survival. Is there any recipe to be followed for companies to achieve this? The answer comes neither from the modest and traditional study rooms of philosophers nor the recent fact-based studies from the offices (and well-pa...

In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient.

We read with interest the recent paper by Turan et al. (published online April 18, 2018) on eight patients with hypoaldosteronism resulting from biosynthetic defects of aldosterone secretion (3 cases) or aldosterone insensitivity syndromes named as pseudohypoaldosteronism type 1 (PHA) (5 cases). In 1991, we described for the first time that PHA type I may appear in two forms with distinct clinical, genetic, and endocrine characteristics. These two forms were named as the renal form, and the systemic (multi...

Identification of Hub Genes and Pathways in Zika Virus Infection Using RNA-Seq Data: A Network-Based Computational Approach.

Zika virus (ZIKV), a single-strand RNA flavivirus, is transmitted primarily through Aedes aegypti. The recent outbreaks in America and unexpected association between ZIKV infection and birth defects have triggered the global attention. This vouches to understand the molecular mechanisms of ZIKV infection to develop effective drug therapy. A systems-level understanding of biological process affected by ZIKV infection in fetal brain sample led us to identify the candidate genes for pharmaceutical intervention...

Mycenaflavin A, B, C, and D: Pyrroloquinoline Alkaloids from the Fruiting Bodies of the Mushroom Mycena haematopus.

Four so far unknown pyrroloquinoline alkaloids, the yellow mycenaflavins A, B, and C, and the purple mycenaflavin D, have been isolated from the fruiting bodies of Mycena haematopus. The structures of these new alkaloids were elucidated by NMR spectroscopy and HR-(+)-ESIMS. The mycenaflavins are structurally related to the mycenarubins and haematopodins, which have been previously identified in M. haematopus. However, compared to other known fungal pyrroloquinoline alkaloids, the mycenaflavins contain an ad...

Neo-clerodane diterpenes and phytoecdysteroids from Ajuga decumbens Thunb. and evaluation of their effects on cytotoxic, superoxide anion generation and elastase release in vitro.

Five novel compounds, including four neoclerodane diterpenoids, named ajugacumbins KN (1-4) along with a phytoecdysterone, named ajugacetalsterone E (5), were isolated from the whole herbs of Ajuga decumbens (Labiatae). Their structures were elucidated on the basis of detailed spectroscopic analysis including IR, HRESIMS, CD, 1D and 2D NMR spectroscopic experiments. Compounds 1-5 were evaluated for their cytotoxic activities and the effects on superoxide anion generation and elastase release in FMLP/CB-indu...

Extracellular α-synuclein disrupts membrane nanostructure and promotes S-nitrosylation induced neuronal cell death.

α-Synuclein, a major constituent of proteinaceous inclusions named Lewy body, has been shown to be released and taken up by cells, which may facilitate its progressive pathological spreading and neuronal cell death in Parkinson's disease. However, the pathophysiological effect and signalling cascade initiated by extracellular α-synuclein in cellular milieu are not well understood. Herein we have investigated the perturbations induced by low molecular weight α-synuclein and different types of α-synuclei...

PCI29732, a Bruton's Tyrosine Kinase Inhibitor, Enhanced the Efficacy of Conventional Chemotherapeutic Agents in ABCG2-Overexpressing Cancer Cells.

Multidrug resistance (MDR) induced by the ABC transporter subfamily B member 1 (ABCB1) and subfamilyG member 2 (ABCG2) limits successful cancer chemotherapy and no commercially available MDR modulator is used in the clinic. In the current study, we aimed to investigate the effects of PCI29732 on the enhancement of chemotherapeutic agents.

Early Loss of Forkhead Transcription Factor, O Subgroup, Member 1 Protein in the Development of Pancreatic Ductal Adenocarcinoma.

Forkhead transcription factor, O subgroup, member 1 (FOXO1) is a regulatory protein that plays an essential role in cellular homeostasis. A biological function as a tumor suppressor has been proposed. Here, we examined FOXO1 expression in human pancreatic ductal adenocarcinoma (PDAC) and its precursor lesions.


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