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Merkel Tries Bridge Climate Coalition Talks Heat PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Merkel Tries Bridge Climate Coalition Talks Heat articles that have been published worldwide.
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Excessive summer heat is a serious environmental health problem in several European cities. Heat-related mortality and morbidity is likely to increase under climate change scenarios without adequate prevention based on locally relevant evidence.
Tarsometatarsal osseous coalition is extremely rare. Herein, we present a case of osseous coalition between the base of the third metatarsal and the lateral cuneiform. The patient is a 38-year-old male who presented with an acute episode of foot pain following strenuous activity. Radiographs of the left foot demonstrated an osseous coalition between the third metatarsal base and the lateral cuneiform. Tarsal coalition is a congenital defect that results when adjacent tarsals fail to separate during embryoni...
Temporal variation of temperature-health associations depends on the combination of two pathways: pure adaptation to increasingly warmer temperatures due to climate change, and other attenuation mechanisms due to non-climate factors such as infrastructural changes and improved health care. Disentangling these pathways is critical for assessing climate change impacts and for planning public health and climate policies. We present evidence on this topic by assessing temporal trends in cold- and heat-attributa...
The classic visual representation of climate change is a dramatic video of distant melting glaciers and stranded polar bears. The public health reality is that the environment is a key determinant of human health, and climate change is now affecting the health and well-being of communities throughout the world. On the global level, the increasing concentrations of heat-entrapping greenhouse gases affect the climate drivers of increased temperatures, increased precipitation, and extreme weather events. Altho...
Consumption of fossil fuel resources leads to global warming and climate change. Apart from the negative impact of greenhouse gases on the climate, the increasing emission of anthropogenic heat from energy consumption also brings significant impacts on urban ecosystems and the surface energy balance. The objective of this work is to develop a new method of estimating the global anthropogenic heat budget and validate it on the global scale with a high precision and resolution dataset. A statistical algorithm...
Multiple methods are employed for modeling adaptation when projecting the impact of climate change on heat-related mortality. The sensitivity of impacts to each is unknown because they have never been systematically compared. In addition, little is known about the relative sensitivity of impacts to "adaptation uncertainty" (i.e., the inclusion/exclusion of adaptation modeling) relative to using multiple climate models and emissions scenarios.
There was no consistent definition for heat wave worldwide, while a limited number of studies have compared the mortality effect of heat wave as defined differently. This paper aimed to provide epidemiological evidence for policy makers to determine the most appropriate definition for local heat wave warning systems.
The Alabama Health Action Coalition is a state coalition whose purpose is to enable access to high-quality, safe, and patient-centered health care for all Alabamians by leading change in nursing and health care.
Merkel cell carcinoma (MCC) is a rare aggressive cutaneous tumor that commonly occurs in sun-exposed sites. It has a tendency for rapid growth, local recurrence, lymph node invasion, and distant metastases. Risk factors include immunosuppression, advanced age, exposure to UV radiation, and infection with the Merkel cell polyomavirus. We report a case of a 67-year-old woman with rapidly aggressive MCC 6 years after liver transplantation.
Construction workers are at an elevated risk of heat stress, due to the strenuous nature of the work, high temperature work condition, and a changing climate. An increasing number of workers are at risk, as the industry's growth has been fueled by high demand and vast numbers of immigrant workers entering into the U.S., the Middle East and Asia to meet the demand. The risk of heat-related illnesses is increased by the fact that little to no regulations are present and/or enforced to protect these workers. T...
Merkel cell polyomavirus (MCPyV) is a ubiquitous cutaneous virus that causes Merkel cell carcinoma (MCC), which develops preferentially in white European/North American populations. However, the genomic variations of MCPyV among ethnic groups have not been well delineated, and even less is known regarding alterations in the noncoding control region (NCCR) in the general population.
Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor frequently associated with the Merkel cell polyomavirus. Immune checkpoint therapy showed remarkable results, although not all patients are responsive to this therapy. Anti-tropomyosin receptor kinase A (TrkA)-targeted treatment has shown promising results in several tumor entities.
Global climate change is anticipated to raise overall temperatures and has the potential to increase future mortality attributable to heat. Urban areas are particularly vulnerable to heat because of high concentrations of susceptible people. As the world's largest developing country, China has experienced noticeable changes in climate, partially evidenced by frequent occurrence of extreme heat in urban areas, which could expose millions of residents to summer heat stress that may result in increased health ...
Climate change and its impacts jeopardize the health and well-being of people across the country. Communities most vulnerable to climate impacts tend to be the least prepared to manage and recover from the physical, economic, mental, and social devastation climate change can cause.(1) Children, the elderly, indigenous peoples, and those with preexisting health conditions are especially vulnerable to climate disruptions such as flooding, dangerous heat, drought, and poor air quality. This is particularly tru...
Merkel cell carcinoma is a rare neuroendocrine tumor of subspecialized dermal mechanoreceptors, associated with immunosuppression. The usual ophthalmic presentation is an eyelid lesion. The authors present a case of biopsy-proven orbital metastatic Merkel cell carcinoma in the absence of any eyelid lesion, in an immunosuppressed patient with a history of multiple cancers. There are to the authors' knowledge only 2 other case reports of presumed metastatic Merkel cell carcinoma to the orbit, though neither w...
Merkel cell carcinoma is a rare cutaneous tumor with an aggressive clinical course. In most cases it is associated with Merkel cell polyomavirus infection. Exceptionally, the tumor can present as a lymph node metastasis without a discernible cutaneous primary. In this report we present the case of a 42 year-old man with inguinal lymphadenopathy, histologically consistent with Merkel cell carcinoma. Tumor cells expressed immunohistochemically chromogranin-A, synaptophysin and displayed dot-like positivity fo...
With the increasing understanding that climate change is already affecting and will continue to affect human health,(1,2) health professionals, governments, businesses, and the general public must proactively address both climate change and its implications for public health. The observed and anticipated effects of climate change on human health are myriad and will affect both the vulnerable and the broader public. Examples of direct effects include overall elevated temperatures that generally exacerbate ch...
Merkel cell carcinoma (MCC) incidence rates are rising and strongly age-associated, relevant for an aging population.
The aim of this article was to provide worldwide, population-based incidence rates for Merkel cell carcinoma (MCC).
Neoplasms and reactivation of latent viruses have been observed in individuals taking fingolimod. Merkel cell carcinoma (MCC), a rare neuroendocrine skin cancer, is associated with immunosuppression and can be triggered by the oncogenic Merkel cell polyoma virus (MCPyV). We report a case of a 61-year-old man with multiple sclerosis who developed MCPyV-positive MCC 4 years after starting fingolimod. This is the second report of MCC associated with MCPyV in an individual on fingolimod.
To describe a clinical case of biopsy-proven Merkel cell carcinoma of the eyelid following golimumab therapy for rheumatoid arthritis (RA).
Investigators have examined how heat waves or incremental changes in temperature affect health outcomes, but few have examined both simultaneously. We utilized distributed lag nonlinear models (DLNM) to explore temperature associations and evaluate possible added heat wave effects on hospitalizations in 16 climate zones throughout California from May through October 1999-2009. We define heat waves as a period when daily mean temperatures were above the zone- and month-specific 95th percentile for at least t...
Avelumab is a promising new therapeutic agent for patients with metastatic Merkel cell carcinoma, a rare and aggressive type of neuroendocrine tumor of the skin. Until the recent approval of avelumab (Bavencio), no therapies were approved by the U.S. Food and Drug Administration for the treatment of metastatic Merkel cell carcinoma. In a recent trial, avelumab, an anti-programmed death ligand-1 antibody, demonstrated an objective response in 28 of 88 patients (31.8% [95.9% CI, 21.9-43.1]) with advanced, che...
During the summer of 2015, India was hit by a scorching heat wave that melted pavements in Delhi and caused thousands of deaths, mainly among the most marginalized populations. One such group facing growing heat risks from both occupational and meteorological causes are migrant brick kiln workers. This study evaluates both current heat risks and the potential future impacts of heat caused by climate change, for the people working at brick kilns in India. A case study of heat stress faced by people working a...