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PubMed Journals Articles About "Missing Link Fighting Antibiotic Resistance" RSS

11:53 EST 17th January 2020 | BioPortfolio

Missing Link Fighting Antibiotic Resistance PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Missing Link Fighting Antibiotic Resistance articles that have been published worldwide.

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Showing "Missing Link Fighting Antibiotic Resistance" PubMed Articles 1–25 of 9,500+

Black phosphorus nanosheets counteract bacteria without causing antibiotic resistance.

Antibiotic resistance poses severe health threats throughout the world. Exploring new antibiotics is widely recognized as an effective strategy to counter antibiotic resistance, but this approach will eventually lead to additional antibiotic resistance when new drugs are misused or overused. An alternative tactic may be antibacterial regulation on demand. In this paper, we show experimentally and theoretically that unstable black phosphorus nanosheets (BPNs) can function as antibacterial agents without caus...


Selection and co-selection of antibiotic resistances among Escherichia coli by antibiotic use in primary care: An ecological analysis.

The majority of studies that link antibiotic usage and resistance focus on simple associations between the resistance against a specific antibiotic and the use of that specific antibiotic. However, the relationship between antibiotic use and resistance is more complex. Here we evaluate selection and co-selection by assessing which antibiotics, including those mainly prescribed for respiratory tract infections, are associated with increased resistance to various antibiotics among Escherichia coli isolated fr...

Crossroads of Antibiotic Resistance and Biosynthesis.

The biosynthesis of antibiotics and self-protection mechanisms employed by antibiotic producers are an integral part of the growing antibiotic resistance threat. The origins of clinically relevant antibiotic resistance genes found in human pathogens have been traced to ancient microbial producers of antibiotics in natural environments. Widespread and frequent antibiotic use amplifies environmental pools of antibiotic resistance genes and increases the likelihood for the selection of a resistance event in hu...


Proteomics approach to understand bacterial antibiotic resistance strategies.

: The understanding of novel antibiotic resistance mechanisms is essential to develop strategies against antibiotic-resistant pathogens, which has become an urgent task due to the worldwide emergence of antibiotic resistance. : In this review, the authors summarize the recent progress on antibiotic resistance caused by lab-evolved bacteria and clinical multidrug-resistant bacterial pathogens from the proteomics perspective. : Proteomics provides a new platform for a comprehensive understanding of change in ...

Antimicrobial Stewardship Interventions to Combat Antibiotic Resistance: an Update on Targeted Strategies.

Overutilization of antimicrobials is a known contributor to the development of antimicrobial resistance, which is a threat to global health. The goal of antimicrobial stewardship programs (ASPs) is to implement targeted interventions to reduce inappropriate antimicrobial prescribing and prevent development of antimicrobial resistance. We aim to review recently published literature focused on five categories of ASP interventions that have demonstrated success in optimizing appropriate antimicrobial use, impr...

What Antibiotic Exposures Are Required to Suppress the Emergence of Resistance for Gram-Negative Bacteria? A Systematic Review.

The rates of antibiotic resistance in Gram-negative bacteria are increasing. One method to minimize resistance emergence may be optimization of antibiotic dosing regimens to achieve drug exposure that suppress the emergence of resistance.

The effect of spatiotemporal antibiotic inhomogeneities on the evolution of resistance.

Combating the evolution of widespread antibiotic resistance is one of the most pressing challenges facing modern medicine. Recent research has demonstrated that the evolution of pathogens with high levels of resistance can be accelerated by spatial and temporal inhomogeneities in antibiotic concentration, which frequently arise in patients and the environment. Strategies to predict and counteract the effects of such inhomogeneities will be critical in the fight against resistance. In this paper we develop a...

Antibiotic Resistance of Escherichia coli from Humans and Black Rhinoceroses in Kenya.

Upsurge of antibiotic resistance in wildlife poses unprecedented threat to wildlife conservation. Surveillance of antibiotic resistance at the human-wildlife interface is therefore needed. We evaluated differences in antibiotic resistance of Escherichia coli isolates from human and the endangered black rhinoceros in Lambwe Valley, Kenya. We used standard microbiological techniques to carry out susceptibility assays using eight antibiotics of clinical and veterinary importance. Standard PCR method was used t...

Antibiotic microbial resistance (AMR) removal efficiencies by conventional and advanced wastewater treatment processes: A review.

The World Health Organization (WHO) has identified the spread of antibiotic resistance as one of the major risks to global public health. An important transfer route into the aquatic environment is the urban water cycle. In this paper the occurrence and transport of antibiotic microbial resistance in the urban water cycle are critically reviewed. The presence of antibiotic resistance in low impacted surface water is being discussed to determine background antibiotic resistance levels, which might serve as a...

Overcoming Antibiotic Resistance.

We invited eleven experts in their fields to share their insights on the growing threats of antibiotic resistance, and how we, as a community, can address them.

Global prevalence of colistin resistance in clinical isolates of Acinetobacter baumannii: A systematic review and meta-analysis.

Acinetobacter baumannii antimicrobial resistance is a public health concern in developing and developed countries, especially in the hospital setting. Understanding the antibiotic resistance profile can help to provide better guidelines for the prescription of appropriate antibiotics, reduction of antibiotic resistance, and introducing new and effective treatment options.

Environmental and clinical antibiotic resistomes, same only different.

The history of antibiotic use in the clinic is one of initial efficacy followed inevitably by the emergence of resistance. Often this resistance is the result of the capture and mobilization of genes that have their origins in environmental reservoirs. Both antibiotic production and resistance are ancient and widely distributed among microbes in the environment. This deep reservoir of resistance offers the opportunity for gene flow into susceptible disease-causing bacteria. Not all resistance genes are equa...

Impact of antibiotic consumption on the carriage of antibiotic-resistant bacteria by school children.

Antibiotic consumption in the paediatric population is one of the key drivers of the emergence and spread of antimicrobial resistance, which is a serious global threat to public health and clinical medicine. The aims of this study were to investigate systemic antibiotic consumption in school children and to assess the associations among antibiotic consumption, carriage rate and resistance of respiratory pathogens residing in the upper respiratory tract mucosa.

Identification and Antibiotic Resistance Assessment of Ensifer adhaerens YX1, a Vitamin B -Producing Strain Used as a Food and Feed Additive.

This study provides phenotypic and molecular analyses of the antibiotic resistance of Ensifer adhaerens strain YX1 (CICC 11008s), a strain that was identified using a polyphasic taxonomy approach. The antibiotic resistance profile of E. adhaerens YX1 was assessed using the Clinical & Laboratory Standards Inst. (CLSI) method. The strain was susceptible to ciprofloxacin, levofloxacin, norfloxacin, ofloxacin, gentamicin, tobramycin, chloramphenicol, tetracycline, imipenem, and ceftazidime, and resistant to kan...

Antibiotic Resistance in the Neonatal Intensive Care Unit.

Antibiotic-resistant bacteria are an increasing problem in the NICU. Ineffective empiric antibiotic therapy is associated with increased risk for morbidity and mortality. Organisms that are resistant to multiple antimicrobial agents (multidrug-resistant organisms) are particularly problematic. These organisms may be transmitted to infants if infection control practices are not adhered to, or they may be created by antibiotic exposure. Therefore, meticulous infection prevention-including hand hygiene, survei...

Genomic and phenotypic comparison of environmental and patient-derived isolates of suggest that antimicrobial resistance is rare within the environment.

Patient-derived isolates of the opportunistic pathogen are frequently resistant to antibiotics due to the presence of sequence variants in resistance-associated genes. However, the frequency of antibiotic resistance and of resistance-associated sequence variants in environmental isolates of has not been well studied. Antimicrobial susceptibility testing (ciprofloxacin, ceftazidime, meropenem, tobramycin) of environmental (=50) and cystic fibrosis (=42) isolates was carried out. Following whole genome seq...

Antibiotic drug-resistance as a complex system driven by socio-economic growth and antibiotic misuse.

Overwhelming antibiotic use poses a serious challenge today to the public-health policymakers worldwide. Many empirical studies pointed out this ever-increasing antibiotic consumption as primary driver of the community-acquired antibiotic drug-resistance, especially in the middle- and lower-income countries. The association is well documented across spatio-temporal gradients in many parts of the world, but there is rarely any study that emphasizes the mechanism of the association, which is important for co...

The growing resistance of bacterial strains to antibiotics.

Understanding the mechanisms of bacterial resistance to antibiotics made it possible to divide this phenomenon into natural and acquired resistance. The natural resistance of the bacteria is related to the lack of antibiotic ability to penetrate into the interior of the bacteria and limit the ability of penetration through the cell wall, as well as the poor affinity of the drug for the receptor or the lack of such a receptor. The acquired bacterial resistance is related to the changes occurring within the r...

Integration of two pKPX-2 derived antibiotic resistance islands in the genome of an ESBL-producing Klebsiella pneumonia ST3483 from Lebanon.

Sewage contamination of fresh water with clinically important Gram-negative bacteria in Lebanon is being investigated in depth especially with the evidence of its dissemination into clinical settings. The aim of this study is to report the draft genome sequence of a Klebsiella pneumoniae strain with an integrated plasmid segment harboring two antibiotic resistance islands (ARI). To our knowledge this is the first report of plasmid antibiotic resistance islands integration in the genome of Klebsiella pneumon...

Global economic impact of antibiotic resistance: A review.

The pandemic of antibiotic resistance has become a serious threat to the therapeutic efficacy of the available antibiotics and their prescribed regimen. The problem is multifaceted as it encompasses medical, social, economic and anthropogenic spheres. The present review reports the global economic impact of antibiotic resistance among humans on the basis of published researches and reports of national and international organizations. The impacts are catastrophic because it includes patients, healthcare prov...

Occurrence of antibiotics and their associations with antibiotic resistance genes and bacterial communities in Guangdong coastal areas.

The concentration of 8 antibiotics and 21 antibiotic resistance genes were investigated in the coastal areas of Guangdong, China. Total concentrations of antibiotics ranged from 0.43 ng/L to 1040.31 ng/L. The concentrations of tetracyclines were much higher than that of sulfonamides in most sampling sites. The abundance of target antibiotic resistance genes ranged from 1.82 × 10 to 5.9 × 10 copies/mL and tetM accounted for the highest percentages of detected antibiotic resistance genes in most...

Antibiotic Use in Food Animals in the World with Focus on Africa: Pluses and Minuses.

Antibiotics are sometimes used in food animal production in developing countries to promote the well-being and growth of the animals. This practice provides some economic benefits to producers and consumers at large. Nevertheless, this practice is associated with a number of concerns. A major concern has been that repeatedly exposing these animals to small doses of antibiotics contributes significantly to antibiotic resistance, since a good fraction of the antibiotics used are the same or surrogates of anti...

A meta-analysis of the prevalence of class 1 integron and correlation with antibiotic resistance in Pseudomonas aeruginosa recovered from Iranian burn patients.

The role of integrons has been highlighted in antibiotic resistance among Pseudomonas aeruginosa isolates. Therefore, we here reviewed the prevalence of class 1 integrons and their correlations with antibiotic resistance of P. aeruginosa isolated from Iranian burn patients.

Characterization and evolution of antibiotic resistance of Salmonella in municipal wastewater treatment plants.

The objective of this study was to investigate the evolution of antibiotic resistance phenotypes, antibiotic resistance genes (ARGs) and Class 1 integron of Salmonella in municipal wastewater treatment plants (WWTPs). A total of 221 Salmonella strains were isolated from different stages of three WWTPs. After the susceptibility testing, high frequency of resistance was observed for tetracycline (TET, 47.5% of isolates) and sulfamethoxazole (SMZ, 38.5%), followed by ampicillin (AMP, 25.3%), streptomycin (STP,...

General practitioners' perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study.

Antibiotic use is a major driver of antibiotic resistance. Although delayed antibiotic prescription is a recommended strategy to reduce antibiotic use, practices vary; it appears less commonly used in southern European countries where antibiotic consumption is highest. Despite these variations, few qualitative studies have explored general practitioners' perceptions of delayed antibiotic prescription. We therefore aimed to explore and describe the perceptions of delayed antibiotic prescription for respirato...


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