PubMed Journals Articles About "Moderna MRNA Phane Bancel 2019 Results Earnings Call" RSS

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Showing "Moderna MRNA phane Bancel 2019 Results Earnings Call" PubMed Articles 1–25 of 42,000+

Sex-Based Disparities in the Hourly Earnings of Surgeons in the Fee-for-Service System in Ontario, Canada.

Sex-based income disparities are well documented in medicine and most pronounced in surgery. These disparities are commonly attributed to differences in hours worked. One proposed solution to close the earnings gap is a fee-for-service payment system, which is theoretically free of bias. However, it is unclear whether a sex-based earnings gap persists in a fee-for-service system when earnings are measured on the basis of hours worked.

Stéphane Hacquard.

Constriction canal assisted artificial lateral line system for enhanced hydrodynamic pressure sensing.

With the assistance of mechanosensory lateral line system, fish can perceive minute water motions in complex underwater environments. Inspired by the constriction within canal nearby canal neuromast in fish lateral line system, we proposed a novel canal artificial lateral line (CALL) device with constriction in canal nearby the sensing element. The designed CALL device consisted of poly(vinylidene fluoride-trifluoroethylene)/polyimide cantilever as sensing element and polydimethylsiloxane (PDMS) microfluid ...

Association Between Childhood Behaviors and Adult Employment Earnings in Canada.

Specifying the association between childhood behaviors and adult earnings can inform the development of screening tools and preventive interventions to enhance social integration and economic participation.

Alternative measures of body composition and wage premium: New evidence from Indonesia.

This paper examines the relationship between body composition and earnings in a developing country setting. We use body mass index, waist circumference and hip circumference. Exploiting the panel structure of our longitudinal survey, we find that along with BMI, waist circumference is related to higher earnings in Indonesia.

Standardized metrics are key for assessing drought severity.

In their letter to the editor commenting on our call for improved characterization and quantification of drought in ecological studies (Slette et al., 2019), Zang et al. (2019) take issue with the use of standardized drought indices, one of the options we suggested for providing needed climatic context for drought studies.

Night Call in a Teaching Hospital: 1979 and 2019.

High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups.

There have been several reports that individuals with Fragile X syndrome (FXS) and animal models of FXS have communication deficits. The present study utilized two different call classification taxonomies to examine the sex-specificity of ultrasonic vocalization (USV) production on postnatal day (PD8) in the FVB strain of Fmr1 knockout (KO). One classification protocol requires the investigator to score each call by hand, while the other protocol uses an automated algorithm. Results using hand-scoring proto...

Supercharge your on-call bag: 4 must-have items for dermatology residents.

The contents of a dermatology resident's on-call bag can make or break their inpatient experience. This article explores 4 outside-the-box items to carry when on call (or in clinic): a hemostatic powder, antimicrobial marker, portable Wood lamp, and substitute for Michel solution.

One Message, Many Translations: Heterogeneity Revealed with Multicolor Imaging.

mRNA translation and its regulation shape the human proteome. Lyon et al. (2019) and Boersma et al. (2019) introduce new orthogonal peptide-tagging systems to study translation in multiple reading frames. Both groups discovered diverse translation behavior of single mRNAs derived from the same genes.

Should Trolleys Be Scared of Mice? Replies to Evans and Brandt (2019); Białek, Turpin, and Fugelsang (2019); Colman, Gold, and Pulford (2019); and Plunkett and Greene (2019).

The impact of anticipating a stressful task on sleep inertia when on-call.

Sleep inertia, the state of reduced alertness upon waking, can negatively impact on-call workers. Anticipation of a stressful task on sleep inertia, while on-call was investigated. Young, healthy males (n = 23) spent an adaptation, control and two counterbalanced on-call nights in the laboratory. When on-call, participants were told they would be woken to a high or low stress task. Participants were not woken during the night, instead were given a 2300-0700 sleep opportunity. Participants slept ∼7.5-h...

Social calls of Myotis nattereri during swarming: Call structure mirrors the different behavioral context.

Swarming is a characteristic behavior of bats that occurs in different social contexts. We studied the swarming behavior of Myotis nattereri at a maternity colony and at an autumn swarming site in South-West Germany by using synchronized sound and video recordings. Swarming was always associated with social vocalizations consisting of four frequently occurring call types. Call type A was a short call with a broadband steep-shallow-steep downward frequency modulation. Call type B consisted of two elements be...

NMD Takes the Immune Road to NDD.

Proper mRNA quality control prevents immune activation; when it goes awry, mice and flies develop abnormal behavioral phenotypes. In this issue of Neuron, Johnson et al. (2019) report that inhibiting nonsense-mediated mRNA decay (NMD) contributes to the pathogenesis of neurodevelopmental disorder (NDD) phenotypes by triggering aberrant immune activation.

The effects of on-call work on mental health issues among wage workers in the Republic of Korea.

On-call workers are often on standby at night or on weekends and are called to perform work when unanticipated incidents occur. However, the effects of on-call duty on the mental health has received little attention. The objective of this study was to investigate the effects of on-call work on mental health problems among Korean wage workers. Korean wage workers (56,553) from the 2011-2014 Korean Working Condition Survey were enrolled. The outcome measures included insomnia or sleep disorder and depression ...

Overnight heart rate variability and next day cortisol response during simulated on-call conditions.

This study had two specific objectives, 1) to investigate the impact of being on-call on overnight heart rate variability during sleep and; 2) to examine whether being on-call overnight impacted next-day salivary cortisol concentrations.

Meeting Report: Clinical Challenge and Call for Research on Keloid Disorder The 3rd International Keloid Research Foundation Symposium, Beijing 2019.

Improved translation efficiency of therapeutic mRNA.

Recent developments in the field of the messenger RNA and its advantages versus DNA have led to a renewed interest in mRNA-based technologies. Despite its advantages, mRNA therapy has a number of drawbacks including low amount of mRNA production, short-term existence of mRNA and mRNA-mediated protein within the cell, severe mRNA cytotoxicity, and immune response activation following mRNA transfection. Here, we applied untranslated regions of human beta-globin to increase the stability and translation effici...

Simplicity, Flexibility, and Interpretability in a Model of Dendritic Protein Distributions.

In this issue of Neuron, Fonkeu et al. (2019) present a mathematical model of mRNA and protein synthesis, degradation, diffusion, and trafficking in neuronal dendrites. The model can predict the spatial distribution and temporal dynamics of proteins along dendrites. The authors use the model to account for in situ imaging data of CaMKII⍺ mRNA and protein in hippocampal neurons.

Web Exclusive. Annals On Call - Firearm Violence: A Call to Action.

ALKBH1 demethylates N3-methylcytidine in mRNA of mammals.

RNA contains diverse modifications that exert important influences in a variety of cellular processes. So far more than 150 modifications have been identified in various RNA species, mainly in rRNA and tRNA. Recent research advances in RNA modifications have been sparked by the discovery of dynamic and reversible modifications in mRNA. Moving beyond the abundant tRNA and rRNA to mRNA is opening new directions in understanding RNA modification-mediated regulation of gene expression. Recently, it was reported...

Mechanism and Regulation of Co-transcriptional mRNP Assembly and Nuclear mRNA Export.

mRNA is the "hermes" of gene expression as it carries the information of a protein-coding gene to the ribosome. Already during its synthesis, the mRNA is bound by mRNA-binding proteins that package the mRNA into a messenger ribonucleoprotein particle (mRNP). This mRNP assembly is important for mRNA stability and nuclear mRNA export. It also often regulates later steps in the mRNA lifetime such as translation and mRNA degradation in the cytoplasm. Thus, mRNP composition and accordingly the assembly of nuclea...

Sahamalaza Sportive Lemur, Lepilemur sahamalaza, Vocal Communication: Call Use, Context and Gradation.

Stereotypical vocalisations can facilitate long-distance communication in dense and, thus, sound-degrading forest habitats. Despite this, primate vocal repertoires often also include gradations between different call types that are used in social interactions. Because many nocturnal primates show a solitary social structure, it has been difficult to assess the role vocalisations play in mediating their social encounters. Here we aim to expand on the call types of Sahamalaza sportive lemurs, Lepilemur sahama...

Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.

Protein kinase B (AKT) is a serine/threonine kinase that functions as an important downstream effector of phosphoinositide 3-kinase. We have recently shown that MK-2206 and triciribine, two highly selective AKT inhibitors increase the level of low density lipoprotein receptor (LDLR) mRNA which leads to increased amount of cell-surface LDLRs. However, whereas MK-2206 induces transcription of the LDLR gene, triciribine stabilizes LDLR mRNA, raising the possibility that the two inhibitors may actually affect o...

Corrigendum to"Ketamine metabolite pilot study in a suicidal depression trial" J Psychiatr Res 117 (2019) 129-134. doi: 10.1016/j.jpsychires.2019.08.005. Epub 2019 Aug 9.

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