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PubMed Journals Articles About "Molecular Templates Inc." RSS

01:13 EST 10th December 2018 | BioPortfolio

Molecular Templates Inc. PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Molecular Templates Inc. articles that have been published worldwide.

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Showing "Molecular Templates" PubMed Articles 1–25 of 17,000+

Shadow Mask Templates for Site-Selective Metal Exchange in Magnesium Porphyrin Nanorings.

Molecular templates can be used in many different ways to control the outcome of chemical reactions. Here we present a new type of template-directed synthesis. We show that templates can be used as shadow masks: the shape of the template becomes imprinted on the product because reaction only occurs at sites not masked by the template. We demonstrate this effect by using oligopyridine templates to dictate the sites of demetallation when a magnesium porphyrin nanoring is treated with acid. Magnesium centers t...


Assembly of multicomponent protein filaments using engineered subunit interfaces.

Exploiting the ability of proteins to self-assemble into architectural templates may provide novel routes for the positioning of functional molecules in nanotechnology. Here we report the engineering of multicomponent protein templates composed of distinct monomers that assemble in repeating orders into a dynamic functional structure. This was achieved by redesigning the protein-protein interfaces of a molecular chaperone with helical sequences to create unique subunits that assemble through orthogonal coil...

Self-Assembled Monolayers as Templates for Linearly Nanopatterned Covalent Chemical Functionalization of Graphite and Graphene Surfaces.

A new approach for nanoscale covalent functionalization of graphite surfaces employing self-assembled molecular monolayers of n-alkanes as templating masks is presented. Linearly aligned aryl groups with a lateral periodicity of 5 or 7 nm is demonstrated utilizing molecular templates of different lengths. The key feature of this approach is the use of a phase separated solution double layer consisting of a thin organic layer containing template molecules topped by an aqueous layer containing aryldiazonium m...


Design of DNA rolling-circle templates with controlled fork topology to study mechanisms of DNA replication.

Rolling-circle DNA amplification is a powerful tool employed in biotechnology to produce large from small amounts of DNA. This mode of DNA replication proceeds via a DNA topology that resembles a replication fork, thus also providing experimental access to the molecular mechanisms of DNA replication. However, conventional templates do not allow controlled access to multiple fork topologies, which is an important factor in mechanistic studies. Here we present the design and production of a rolling-circle sub...

Site-specific adsorption of aromatic molecules on a metal/ metal oxide phase boundary.

Nano-structured surfaces are ideal templates to control the self-assembly of molecular structures towards well-defined functional materials. To understand the initial adsorption process, we have investigated the arrangement and configuration of aromatic hydrocarbon molecules on nano-structured substrates composed of an alternating arrangement of Cu(110) and oxygen-reconstructed stripes. Scanning tunneling microscopy reveals a preferential adsorption of molecules at oxide phase boundaries. Non-contact atomic...

Three-dimensional planning and use of individualized osteotomy guiding templates for surgical correction of kyphoscoliosis: a technical case report.

To describe the use of 3D virtual planning and 3D printed patient specific osteotomy templates in the surgical correction of a complex spinal deformity.

Template-Directed Synthesis of Molecular Nanorings and Cages.

This Account is about templates as construction tools: molecules for making molecules. A template organizes the reactants and provides information to promote formation of a specific product, but it is not part of the final product. We have developed many different strategies for using oligopyridines as templates for the synthesis of alkyne-linked π-conjugated metalloporphyrin oligomers. These compounds include some of the largest macrocycles ever synthesized, such as a 50-porphyrin ring with a diameter of ...

Barcoding blood meals: New vertebrate-specific primer sets for assigning taxonomic identities to host DNA from mosquito blood meals.

The transmission dynamics of mosquito-vectored pathogens are, in part, mediated by mosquito host-feeding patterns. These patterns are elucidated using blood meal analysis, a collection of serological and molecular techniques that determine the taxonomic identities of the host animals from which blood meals are derived. Modern blood meal analyses rely on polymerase chain reaction (PCR), DNA sequencing, and bioinformatic comparisons of blood meal DNA sequences to reference databases. Ideally, primers used in ...

Discovering privileged topologies of molecular knots with self-assembling models.

Despite the several available strategies to build complex supramolecular constructs, only a handful of different molecular knots have been synthesised so far. Here, in response to the quest for further designable topologies, we use Monte Carlo sampling and molecular dynamics simulations, informed by general principles of supramolecular assembly, as a discovery tool for thermodynamically and kinetically accessible knot types made of helical templates. By combining this approach with the exhaustive enumeratio...

Effects of integrated feedback and movement templates on discrete bimanual movements in simple reaction time.

The purpose of the current study was to investigate whether integrated visual feedback and movement templates could facilitate bimanual movements with different patterns of spatiotemporal coupling and decoupling. Knowing when Lissajous feedback and movement templates improve bimanual movements, and when they do not, will help determine the mechanisms of task conceptualisation. We tested two bimanual asymmetric conditions where different movement templates were used to encourage the movements to travel diffe...

Interfacial self-assembly of functional bilayer templates comprising porphyrin arrays and graphene oxide.

Fabricating of solid-supported hybrid nanostructures remains a challenging problem because it is difficult to control all interfacial interactions influencing the structure and stability of these systems. The most widely used approach to solving this problem is a bottom-up assembly on the surface templates such as self-assembled monolayers (SAMs). Herein we suggest an alternative approach to tailoring solid surfaces by a formation of an interlayer anchoring the nanostructured film to the solid substrate. We...

Correction: PEG-nanotube liquid crystals as templates for construction of surfactant-free gold nanorods.

Correction for 'PEG-nanotube liquid crystals as templates for construction of surfactant-free gold nanorods' by Naohiro Kameta et al., Chem. Commun., 2018, 54, 4665-4668.

Visual Working Memory Load Disrupts Template-guided Attentional Selection during Visual Search.

Mental representations of target features (attentional templates) control the selection of candidate target objects in visual search. The question where templates are maintained remains controversial. We employed the N2pc component as an electrophysiological marker of template-guided target selection to investigate whether and under which conditions templates are held in visual working memory (vWM). In two experiments, participants memorized one or four shapes (low vs. high vWM load) before either being tes...

An environmentally-responsive reciprocal replicating network.

A reciprocal replication system is constructed from four building blocks, A, B, C, and D, which react in a pairwise manner through either a 1,3-dipolar cycloaddition or the condensation reaction between an amine and an aldehyde to create two templates, trans-TAB and TCD. These templates are equipped with complementary recognition sites-two carboxylic acids (trans-TAB) or two 4,6-dimethylamidopyridines (TCD)-that enable each template to direct the formation of its complementary partner through two mutually-r...

Electronic states of deep trap levels in a-plane GaN templates grown on r-plane sapphire by HVPE.

We report on the defect states incorporated in a-plane GaN crystals grown on r-plane sapphire substrates by hydride vapor phase epitaxy (HVPE), using deep level transient spectroscopy (DLTS). Two defect states were observed at 0.2 eV and 0.55 eV below the conduction band minimum with defect densities of 5 × 10/cm and 4.7 × 10/cm, respectively. The size of capture cross section, non-linear relation of trap densities from the depth profile, filling pulse width, and PL measurements indicated that...

Comparative Modeling and Evaluation of Leukotriene B4 Receptors for Selective Drug Discovery Towards the Treatment of Inflammatory Diseases.

Leukotriene B4 (LTB4) exerts its biological effects through stimulation of specific G protein-coupled receptors (GPCRs)-namely BLT1 and BLT2. Due to the absence of human BLT1 and BLT2 crystal structures, the current study was set to predict the 3D structures of these two receptors for structure-based anti-inflammatory drug discovery. Homology modeling of the BLT1 receptor was first constructed, based on various X-ray and NMR GPCR templates, followed by molecular dynamics (MD) refinement. Using a single-temp...

Construction of a neonatal cortical surface atlas using Multimodal Surface Matching in the Developing Human Connectome Project.

We propose a method for constructing a spatio-temporal cortical surface atlas of neonatal brains aged between 36 and 44 weeks of post-menstrual age (PMA) at the time of scan. The data were acquired as part of the Developing Human Connectome Project (dHCP), and the constructed surface atlases are publicly available. The method is based on a spherical registration approach: Multimodal Surface Matching (MSM), using cortical folding for driving the alignment. Templates have been generated for the anatomical cor...

Imaging neurodegeneration in Down syndrome: brain templates for amyloid burden and tissue segmentation.

The focus of Alzheimer's disease (AD) neuroimaging research has shifted towards an investigation of the earliest stages of AD pathogenesis, which manifests in every young adult with Down syndrome (DS; trisomy 21) resulting from a deterministic genetic predisposition to amyloid precursor protein overproduction. Due to morphological differences in brain structure in the DS population, special consideration must be given to processing pipelines and the use of normative atlases developed for the non-DS populati...

Electrospun poly(ε-caprolactone) nanofiber shish kebabs mimic mineralized bony surface features.

Electrospinning of nanofiber is of growing interest especially in bone tissue engineering because of its similar fibrous properties to the extracellular matrix. To this end, we have fabricated polycaprolactone (PCL) nanofiber shish kebab (NFSK) templates. The novelty of this work is the ability to control the mineral orientation and spatial location on the nanofiber, mimicking natural collagen fibers. However, NFSK templates have properties that need to be investigated in terms of cellular response includin...

Molecularly Imprinted Artificial Biointerface for Enzyme-Free Glucose Transistor.

A platform based on a highly selective and sensitive detection device functionalized with a well-designed artificial biointerface is required for versatile biosensors. We develop a molecularly imprinted polymer (MIP)-coated gate field-effect transistor (FET) biosensor for low-concentration-glucose detection in biological fluid samples such as tears in an enzyme-free manner. The MIP includes glucose templates (GluMIP), in which glucose binds to vinylphenylboronic acid (VPBA) in the copolymerized membrane res...

An Efficient Model for Designing Medical Countermeasure Just-in-Time Training During Public Health Emergencies.

Rapidly training numerous staff and volunteers to distribute and dispense medical countermeasures is challenging because of limited resources and evolving information during public health emergencies. The Applied Learning and Development Team within the Division of State and Local Readiness at the Centers for Disease Control and Prevention (CDC) proposes just-in-time training (JITT) templates that can be rapidly customized and implemented early in any public health emergency. The proposed template model ali...

Differential Activities of DNA Polymerases in Processing Ribonucleotides during DNA Synthesis in Archaea.

Consistent with the fact that ribonucleotides (rNTPs) are in excess over deoxyribonucleotides (dNTPs) in vivo, recent findings indicate that replicative DNA polymerases (DNA Pols) are able to insert ribonucleotides (rNMPs) during DNA synthesis, raising crucial questions about the fidelity of DNA replication in both Bacteria and Eukarya. Here, we report that the level of rNTPs is 20-fold higher than that of dNTPs in Pyrococcus abyssi cells. Using dNTP and rNTP concentrations present in vivo, we recorded rNMP...

Direct Chirality Recognition of Single-Crystalline and Single-Walled Transition Metal Oxide Nanotubes on Carbon Nanotube Templates.

Chirality is a significant structural feature for chemistry, biology, physics, and materials science, and especially determines the electrical, mechanical, and optical properties of diverse tubular structures, such as carbon nanotubes (CNTs). To recognize the chirality of nanotubes, templates are introduced as potential tools to obtain crystalline samples with visible chiral fringes under electron microscopes. However, few efforts show optimistic results, and new understanding is desired to control the samp...

Precision Imprinting of Glycopeptides for Facile Preparation of Glycan-Specific Artificial Antibodies.

Antibodies specific to glycans are essential in many areas for many important fields, including disease diagnostics, therapeutics and fundamental researches. However, due to their low immunogenicity and poor availability, glycans pose serious challenges to antibody development. Although molecular imprinting has developed into important methodology for creating antibody mimics with low cost and better stability, glycan-specific molecularly imprinted polymers (MIPs) still remain rather rare. Herein, we report...

Generation of sanitation system options for urban planning considering novel technologies.

The identification of appropriate sanitation systems is particularly challenging in developing urban areas where local needs are not met by conventional solutions. While structured decision-making frameworks such as Community-Led Urban Environmental Sanitation (CLUES) can help facilitate this process, they require a set of sanitation system options as input. Given the large number of possible combinations of sanitation technologies, the generation of a good set of sanitation system options is far from trivi...


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