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Showing "Neuroplasticity cognitive psychological mechanisms depression integrative model" PubMed Articles 1–25 of 35,000+

Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorder.

Post-traumatic stress disorder (PTSD) is a stress-related condition that can be triggered by witnessing or experiencing a life-threatening event, such as a war, natural disaster, terrorist attack, major accident, or assault. PTSD is caused by dysfunction of the hippocampus and causes problems associated with brain functioning, such as anxiety, depression, and cognitive impairment. Exercise is known to have a positive effect on brain function, especially in the hippocampus. In this study, we investigated the...

Brief mindfulness, mental health, and cognitive processes: A randomized controlled trial.

The present study evaluated the impact of a brief mindfulness training program on emotional regulation, cognitive rumination, psychological well-being, and depressive symptoms. This is an experimental study, through a randomized controlled trial. A total of 103 people enrolled on a voluntary basis, of whom 51 were randomly selected to participate in the experimental group and 52 in the control group without intervention (on the waiting list). It is established that a brief, four-session mindfulness training...

Factors Associated With Response to Adapted Cognitive Behavioral Therapy for Anxiety and Depression Following Traumatic Brain Injury.

Given the high frequency and significance of anxiety and depression following traumatic brain injury (TBI), there is a need to evaluate the efficacy of psychological interventions and to understand factors influencing response to such interventions. The present study investigated factors associated with positive response to cognitive behavioral therapy adapted for cognitive impairments (CBT-ABI) for individuals with anxiety and depression following TBI, including demographic and injury-related factors, pret...

Diabetes and the link between neuroplasticity and glutamate in the aging human motor cortex.

In older adults, type-2 diabetes mellitus (T2DM) impacts cognition and increases dementia risk. Prior studies suggest that impaired neuroplasticity may contribute to the cognitive decline in T2DM, but the underlying mechanisms of altered neuroplasticity are unclear. We investigated the relationship of the concentration of glutamatergic metabolites with measures of cortical plasticity in older adults across the spectrum of glucose intolerance/insulin resistance.

Opioid receptor modulation of neural circuits in depression: What can be learned from preclinical data?

Major depressive disorder (MDD) is a heterogeneous clinical syndrome involving distinct pathological processes. Core features of MDD include anhedonia, reduced motivation, increased anxiety, negative affective bias, cognitive impairments, and dysregulated neuroplasticity mechanisms. There are multiple biological hypotheses related to MDD, including dysfunction of the opioid system. Although opium was abandoned as an antidepressant after the introduction of monoaminergic drugs, there has been renewed interes...

Socioeconomic Status and Executive Function in Early Childhood: Exploring Proximal Mechanisms.

Although there is substantial evidence that socioeconomic status (SES) predicts children's executive function, the mechanisms underlying this association are poorly understood. This study tested the utility of two theories proposed to link SES to children's executive function: the family stress model and the family investment model. Data came from the Midwestern Infant Development Study (N = 151). To measure SES, parental education and income were assessed during pregnancy, and income was also assessed wh...

Insomnia and depression: clinical associations and possible mechanistic links.

Chronic insomnia is highly comorbid with multiple psychological and physical disorders, but most notably depression. While insomnia is now viewed as a risk factor for depression, and not just a 'symptom' of the disorder, the reasons for this change in classification (from symptom to risk factor) have yet to be clearly articulated. This is one goal of the present review. Furthermore, efforts to identify the mechanisms, by which insomnia is related to increases in depression is a burgeoning area of research. ...

Verbal memory predicts treatment outcome in syndromal anxious depression: An iSPOT-D report.

Major Depressive Disorder (MDD), anxiety disorders, and high levels of anxious symptoms are associated with impaired cognitive functioning. However, little is known of how cognitive functioning is impaired in people with anxious depression. Here, we compared cognitive functioning between people with anxious depression, non-anxious depression, and healthy controls. We also tested whether anxious depression moderated the relationship between cognitive functioning and treatment outcome.

Do sleep disturbances in depressed adolescents improve following psychological treatment for depression?

Persistent sleep disturbances are one of the most common symptoms of Major Depressive Disorder (MDD) in adolescence. These are not typically targeted in psychological treatments and it is not known if psychological treatment for depression improves sleep.

RCT about mindfulness-based cognitive therapy for psychological distress in cancer patients.

Cancer patients may experience psychological distress, like anxiety and depressive symptoms. Mindfulness-based cognitive therapy (MBCT) has been shown to alleviate this psychological distress. However, patients experience barriers in participating in face-to-face MBCT. Individual internet-based MBCT (eMBCT) could be an alternative. AIM: To compare MBCT and eMBCT to treatment as usual (TAU) for psychological distress in cancer patients. METHOD: 245 cancer patients with psychological distress were randomly al...

Cognitive behavioural therapy is not effective for depression in advanced cancer but could help in anxiety or other psychological symptoms.

Neurofeedback and neuroplasticity of visual self-processing in depressed and healthy adolescents: A preliminary study.

Adolescence is a neuroplastic period for self-processing and emotion regulation transformations, that if derailed, are linked to persistent depression. Neural mechanisms of adolescent self-processing and emotion regulation ought to be targeted via new treatments, given moderate effectiveness of current interventions. Thus, we implemented a novel neurofeedback protocol in adolescents to test the engagement of circuits sub-serving self-processing and emotion regulation.

Experiential avoidance and cognitive fusion mediate the relationship between body evaluation and unhelpful body image coping strategies in individuals with visible differences.

Psychological flexibility, the capacity to be open to any internal stimuli and act in accordance with valued ends, has been identified as an explanatory variable in how people cope with body concerns. The role of psychological flexibility is unexplored in adults with an atypical appearance due to a health condition, injury, or medical treatment (collectively visible difference), who often encounter multiple day-to-day body image threats. Testing two core components of psychological flexibility, namely exper...

Eveningness is associated with greater subjective cognitive impairment in individuals with self-reported symptoms of unipolar depression.

Eveningness is associated with depression diagnosis and increased depressive symptom severity. Time-of-day preference has been linked with differences in cognitive function in the general population, with cognitive difficulties being a major factor in psychosocial impairment in depression. We therefore investigated the impact of time-of-day preference and self-reported depressed state on subjective cognitive function.

Neuroimmune and epigenetic mechanisms underlying persistent loss of hippocampal neurogenesis following adolescent intermittent ethanol exposure.

Alcohol abuse and binge drinking are common during adolescence - a maturational period characterized by heightened hippocampal neuroplasticity and neurogenesis. Preclinical rodent models of adolescent binge drinking (i.e., adolescent intermittent ethanol [AIE]) find unique vulnerability of adolescent hippocampal neurogenesis with reductions persisting into adulthood after ethanol cessation. Recent discoveries implicate increased neuroimmune signaling and decreased neurotrophic support through epigenetic mec...

Combination of Geniposide and Eleutheroside B Exerts Antidepressant-like Effect on Lipopolysaccharide-Induced Depression Mice Model.

To study the antidepressant-like effect and action mechanism of geniposide and eleutheroside B combination treatment on the lipopolysaccharide (LPS)-induced depression mice model.

Change in Defense Mechanisms and Depression in a Pilot Study of Antidepressive Medications Plus 20 Sessions of Psychotherapy for Recurrent Major Depression.

Treatment studies of major depression commonly focus on symptoms, leaving aside change in putative psychological risk factors. This pilot study examines the relationship between changes in eight depressive defenses and depressive symptoms. Twelve adults with acute recurrent major depression were given antidepressive medications and randomized to 20 sessions of either cognitive behavioral therapy or dynamic psychotherapy and followed for 1 year. Defenses were assessed using the Defense Mechanism Rating Scale...

Physical activity and depression: Towards understanding the antidepressant mechanisms of physical activity.

Physical activity can treat and prevent depressive symptoms, but its antidepressant mechanisms are yet to be established. In this review, we comprehensively assess key biological and psychosocial mechanisms through which physical activity exerts antidepressant effects, with a particular focus on exercise. Exercise, a subset of physical activity, influences a range of biological and psychosocial processes also implicated in the pathophysiology of depression. We focus on the capacity for exercise to elicit ch...

How 25 years of psychosocial research has contributed to a better understanding of the links between depression and diabetes.

This narrative review of the literature provides a summary and discussion of 25 years of research into the complex links between depression and diabetes. Systematic reviews have shown that depression occurs more frequently in people with type 1 or type 2 diabetes compared with people without diabetes. Currently, it remains unclear whether depression is also more common in people with impaired glucose metabolism or undiagnosed type 2 diabetes compared with people without diabetes. More prospective epidemiol...

Personal stigma, determinants of intention to use technology, and acceptance of internet-based psychological interventions for depression.

Despite showing comparable levels of efficacy, internet-based psychological interventions (IPI) exhibited lower acceptance and intention of use as compared to psychological treatment delivered by face-to-face methods. Surprisingly, no research has inspected whether IPI acceptance is associated with variables linked with intentions of technology use and with barriers to seeking professional psychological help, such as personal depression stigma. Informed by the Unified Theory of Acceptance and Use of Technol...

Generalized Multiplicative Model for Assessing Outcomes in Psychotherapy: Disordered Eating Behaviors and Obesity.

The study presents further development and application of generalized multiplicative models (GMultM) for assessing outcomes in psychotherapy. GMultM is a flexible nonlinear regression method which is able to predict the impact of subjects' psychological variables (common factors) as well as theirchanges on the outcomes of cognitive-behavioral therapy and rhythmic-movement therapy. The main objectives of our present study are (a) to construct GMultM with the aim to predict the impact of pre-treatment scores ...

Internet-delivered Mindfulness-Based Cognitive Therapy for anxiety and depression in cancer survivors: A randomized controlled trial.

Internet-delivered interventions may alleviate distress in cancer survivors with limited access to psychological face-to-face treatment. In collaboration with a group of cancer survivors, we developed and tested the efficacy of a therapist-assisted internet-delivered mindfulness-based cognitive therapy (iMBCT) program for anxiety and depression in cancer survivors.

The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study.

Deficits in cognitive control have been found in depression, but how they contribute to depressive symptoms remains unknown. The present study investigated whether the regulatory efficacy of cognitive control on negative emotion varies with depression level and whether the regulatory efficacy affects depressive symptoms via the mediation of rumination. Fifty participants screened by the Zung Self-Rating Depressive Scale (SDS) with high and low depression levels were selected. They were instructed to control...

Effect of Psychological Intervention on Quality of Life and Psychological Outcomes of Colorectal Cancer Patients.

: This study was undertaken to evaluate the effect of psychological interventions on quality of life (QOL) and psychological outcomes in colorectal cancer patients. : Three components-the Hospital Anxiety and Depression Scale (HADS), cancer-related distress, and QOL-were assessed at admission (T0/baseline), three-month follow-up (T1), and six-month follow-up (T2). : The general characteristics of participants were well balanced between the psychological intervention group and control group. Psychological in...

The feasibility of low-intensity psychological therapy for depression co-occurring with autism in adults: The Autism Depression Trial study - a pilot randomised controlled trial.

Low-intensity cognitive behaviour therapy including behavioural activation is an evidence-based treatment for depression, a condition frequently co-occurring with autism. The feasibility of adapting low-intensity cognitive behaviour therapy for depression to meet the needs of autistic adults via a randomised controlled trial was investigated. The adapted intervention (guided self-help) comprised materials for nine individual sessions with a low-intensity psychological therapist. Autistic adults (n = 70)...

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