PubMed Journals Articles About "Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc" RSS

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Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Nivolumab With Ipilimumab Combination Added Benefit Advanced Renal∨derfield=score∨derval=desc articles that have been published worldwide.

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Showing "Nivolumab with ipilimumab Combination added benefit advanced renal" PubMed Articles 1–25 of 10,000+

Simultaneous onset of type 1 diabetes mellitus and silent thyroiditis under durvalumab treatment

Durvalumab, a human immunoglobulin G1 kappa monoclonal antibody that blocks the interaction of programmed cell death ligand 1 (PD-L1) with the PD-1 and CD80 (B7.1) molecules, is increasingly used in advanced neoplasias. Durvalumab use is associated with increased immune-related adverse events. We report a case of a 55-year-old man who presented to our emergency room with hyperglycaemia after receiving durvalumab for urothelial high-grade non-muscle-invasive bladder cancer. On presentation, he had polyuria, ...

Metastatic papillary thyroid cancer presenting with a recurrent necrotic cystic cervical lymph node

We report a case of metastatic papillary thyroid carcinoma presenting with a recurrent right-sided cervical lymph node necrotic cyst. A 55-year-old woman presented with a 3-month history of a right-sided upper neck mass following an upper respiratory tract infection. Past medical history includes a right-sided nephrectomy secondary to a benign renal tumor and hypertension. She was evaluated by Otolaryngology, and fine-needle aspiration was performed. The mass recurred 2 months following aspiration. Ultrasou...

Machine vision methods, natural language processing and machine learning algorithms for automated dispersion plot analysis and chemical identification from complex mixtures.

Gas phase trace chemical detection techniques such as ion mobility spectrometry (IMS) and differential mobility spectrometry (DMS) can be used in many settings, such as evaluating the health condition of patients or detecting explosives at airports. These devices separate chemical compounds in a mixture and provide information to identify specific chemical species of interest. Further, these types of devices operate well in both controlled lab environments and in field applications. Frequently, the commerci...

Effect of Plantaricin 163 in Combination with Thymol and Surfactin on Crucian Carp ().

The use of natural preservatives has attracted considerable attention owing to their generally safe and environmentally friendly properties. In this study, we investigated the effects of the preservative A1, composed of plantaricin 163, thymol, and surfactin, on bacterial communities and storage quality of refrigerated crucian carp. A total of 522 operational taxonomic units belonging to 20 phyla and 272 genera were identified by high-throughput sequencing, showing a comprehensive coverage of bacterial comp...

Randomized Clinical Trial of a Clinical Decision Support Tool for Improving the Appropriateness Scores for Ordering Imaging Studies in Primary and Specialty Care Ambulatory Clinics.

The objective of our study was to evaluate whether the use of a clinical decision support (CDS) tool improved the appropriateness scores of orders for advanced imaging in clinical practice. We used a stepped-wedge, cluster randomized clinical trial to evaluate the effectiveness of a CDS tool in an integrated health care system. Clinicians entered structured indications for each CT and MRI order, and the indications were electronically scored against appropriateness criteria to assign an appropriateness sco...

Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice.

Randomized clinical trials suggest benefit of endovascular-reperfusion therapy for large vessel occlusion in acute ischemic stroke (AIS) is time dependent, but the extent to which it influences outcome and generalizability to routine clinical practice remains uncertain.

Therapy of Hypoparathyroidism with rhPTH(1-84): A Prospective Eight Year Investigation of Efficacy and Safety.

Conventional treatment of hypoparathyroidism is associated with decreased renal function and increased bone mineral density (BMD).

Things not to ask an editor.

We are both editors and we are both involved in providing training in writing for publication in academic journals. We work in different countries, different cultures and even in different languages. However, we find a range of common and frequent questions from our audiences and, among these-many of which are excellent and which we are only too pleased to answer-we find questions which are increasingly unacceptable, unnecessary and which, we consider, are incompatible with good scholarly and publishing pra...

Collaborative Network to Take Responsibility for oral AntiCancer Therapy (CONTACT): Study-protocol investigating the impact of a care pathway.

To evaluate the effectiveness, feasibility, meaningfulness and appropriateness of the development and implementation of a transmural care pathway in four hospitals in Flanders to improve self-management support in healthcare professionals and self-management in patients treated with oral anticancer drugs.

Merkel cell carcinoma: a prompt diagnosis to increase survival.

Merkel cell carcinoma (MCC) is a rare, malignant tumor related to advanced age and immunusoppression . Its incidence has been increased over decades but management is still controversial . Looking for MCC cases over the last ten years, nine cases were retrieved (6 females and 3 males, median age 71 years, for clinical data see Table 1). This article is protected by copyright. All rights reserved.

Author response to Letter to the Editor: "Statins and non-alcoholic fatty liver disease".

We thank Angelico and colleagues for their interest in our recent article in which we revealed that a substantial proportion of subjects with suspected non-alcoholic fatty liver disease (NAFLD) has increased cardiovascular risk and subjects with dyslipidemias such as high low-density lipoprotein (LDL) cholesterol could benefit from lipid-lowering treatment with statins. This article is protected by copyright. All rights reserved.

The impact of pharmaceutical marketing on market access, treatment coverage, pricing, and social welfare.

Pharmaceutical spending in the United States, Canada, and the EU is growing. Public payers cover a large portion of these costs and have responded by instituting various pricing and access policies to limit their expenditure. One challenge that public payers face is additional demand induced by a manufacturer's marketing effort. We use a game theoretic approach to study the impact of pharmaceutical marketing on six practical pricing and access policies: negotiated pricing, open pricing, controlled pricing, ...

A unifying review of polymer networks: from rubbers and gels to porous frameworks.

Polymer networks, which are materials comprised of many smaller components -referred to as "junctions" and "strands"- that are connected together via covalent or non-covalent/supramolecular interactions, are arguably the most versatile, widely studied, broadly used, and important materials known. From the very first commercial polymers through the plastics revolution of the 20th century to today, there are almost no aspects of modern life that are not impacted by polymer networks. Nevertheless, there are st...

The added value of fasting blood glucose to serum squamous cell carcinoma antigen for predicting oncological outcomes in cervical cancer patients receiving neoadjuvant chemotherapy followed by radical hysterectomy.

To determine the combination of fasting blood glucose (FBG) with squamous cell carcinoma antigen (SCCA) assessments in the prediction of tumor responses to chemotherapy and pretreatment prognostication among patients receiving neoadjuvant chemotherapy (NACT) for locally advanced cervical cancer (LACC).

A Novel Bone Substitute with High Bioactivity, Strength, and Porosity for Repairing Large and Load-Bearing Bone Defects.

Acute Kidney Injury after Cardiac Surgery: Risk Factors and Novel Biomarkers.

Acute kidney injury (AKI) is a common and severe complication after cardiac surgery. Currently, a series of novel biomarkers have favored the assessment of AKI after cardiac surgery in addition to the conventional indicators. The biomartkers, such as urinary liver fatty acid binding protein (L-FABP), urinary neutrophil gelatinase-associated lipocalin (NGAL), serum L-FABP, heart-type FABP, kidney injury molecule 1 (KIM-1), and interleukin-18 were found to be significantly higher in patients who developed AKI...

Rapidly Progressive Malignant Fibrous Histiocytoma of Right Atrium: a Rare Case Report.

We are going to present a case of malignant fibrous histiocytoma in the right atrium, which is a very rare entity. The patient had a right atrial mass, which prolapsed through the tricuspid valve into the right ventricle, causing functional tricuspid valve stenosis. The tumor was completely resected and the patient had an uneventful postoperative period. Histopathological examination reported malignant fibrous histiocytoma. The patient presented to the emergency department five weeks after discharge with dy...

Response by Authors to the Letter Regarding Article "Lidocaine and Pinacidil Added to Blood Versus Crystalloid Cardioplegic Solutions: Study in Isolated Hearts".

Tailoring the Chemical Modification of Chitosan Hydrogels to Fine Tune the Release of a Synergistic Combination of Chemotherapeutics.

Combination chemotherapy with defined ratio and sequence of drug release is a clinically established and effective route to treat advanced solid tumors. In this context, a growing body of literature demonstrates the potential of hydrogels constructed with chemically modified polysaccharides as depots for controlled release of chemotherapeutics. Identifying the appropriate modification in terms of physicochemical properties of the functional group and its degree of substitution (χ) to achieve the desired re...

CO2 sensing behavior of calcium doped ZnO thin film: A study to address the cross-sensitivity of CO2 in H2 and CO environment.

CO2, CO, and H2 are the major pollutants in the environment which is primarily generated during the combustion of the organic compounds. Development of a smart sensor that could address the CO2 sensing and its cross sensitivity towards CO and H2 gas is highly advantageous. In this work, an advanced gas sensor is proposed and developed to address the cross-sensitivity of CO2 sensing in CO and H2 environment, which is based on calcium doped ZnO (Ca_ZnO) thin films. The proposed sensors were successfully synth...

Supraphysiological androgens suppress prostate cancer growth through androgen receptor-mediated DNA damage.

Prostate cancer (PC) is initially dependent on androgen receptor (AR) signaling for survival and growth. Therapeutics designed to suppress AR activity serve as the primary intervention for advanced disease. However, supraphysiological androgen (SPA) concentrations can produce paradoxical responses leading to PC growth inhibition. We sought to discern the mechanisms by which SPA inhibits PC and to determine if molecular context associates with anti-tumor activity. SPA produced an AR-mediated, dose-dependent ...

Guide dogs' navigation after a single journey: A descriptive study of path reproduction, homing, shortcut and detour.

Guide dogs are working dogs that follow the verbal instructions of owners with severe visual impairments, leading them through the environment and toward goals such as a subway entrance ("Find the subway" instruction). During this process, guide dogs incidentally familiarize themselves with their environment. As such, they provide a unique animal model for studying wayfinding abilities in the canine species. In the present descriptive study, 23 skilled guide dogs travelled along a path once and were subsequ...

The role of inoculum dispersal and plant species identity in the assembly of leaf endophytic fungal communities.

Because of disturbance and plant species loss at the local level, many arid ecosystems in the western USA benefit from revegetation. There is a growing interest in improving revegetation success by purposefully inoculating revegetation plants with mutualistic endophytic fungi that increase plant stress tolerance. However, inoculant fungi must compete against fungi that indigenous to the habitat, many of which may not be mutualistic. Our overall goal, therefore, is to learn how to efficiently colonize revege...

The association between eating difficulties and biliary sludge in the gallbladder in older adults with advanced dementia, at end of life.

In clinical settings, untreatable biliary sludge in the gallbladder can be observed in older adults with advanced dementia. The underlying cause of biliary sludge existence in patients with dementia is currently unknown. Therefore, we aimed to investigate the prevalence, risk factors, and related outcomes of biliary sludge formation in the gallbladder of older adults with dementia.

Tolerance of three Aedes albopictus strains (Diptera: Culicidae) from different geographical origins towards winter temperatures under field conditions in northern Germany.

The continuing spread of the Asian tiger mosquito Aedes albopictus, a vector of many arboviruses and some dirofilarial worms, in Europe calls for advanced investigations on its ecological ability to establish and overwinter in temperate, more northern geographic regions. To meet this purpose, eggs of Ae. albopictus laboratory strains of tropical, subtropical and temperate origin were exposed to field conditions during one or two winter seasons in northeastern Germany. After 1 to 16 weeks of outdoor exposure...

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