PubMed Journals Articles About "Noblegen Announces Opening Second Round Financing Peterborough Based" RSS

13:46 EST 10th December 2018 | BioPortfolio

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Showing "Noblegen Announces Opening Second Round Financing Peterborough Based" PubMed Articles 1–25 of 32,000+

"Pay for Success" Financing and Home-Based Multicomponent Childhood Asthma Interventions: Modeling Results From the Detroit Medicaid Population.

Policy Points: The Pay for Success (PFS) financing approach has potential for scaling the implementation of evidence-based prevention interventions in Medicaid populations, including a range of multicomponent interventions for childhood asthma that combine home environment risk mitigation with medical case management. Even though this type of intervention is efficacious and cost-saving among high-risk children with asthma, the main challenges for implementation in a PFS context include legal and regulatory ...

Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: A Sarcoma With Polyphenotypic Differentiation.

The evolving classification of round cell sarcomas is driven by molecular alterations. EWSR1-PATZ1 fusion positive spindle and round cell sarcoma is one such new tumor entity. Herein, we report 2 EWSR1-PATZ1 fusion positive spindle and round cell sarcomas with overlapping histologic features and polyphenotypic differentiation. The intra-abdominal tumors affected female patients, 31-and 53-year old. Both tumors showed sheets and nests of round to spindle cells, fine chromatin, tiny conspicuous nucleoli, mode...

Nutritional and meat quality characteristics of seven primal cuts from 9-month old female veal calves: a preliminary study.

Beef is a highly nutritious and valuable food. In order to complete its nutritional information, in this study was determined the chemical and physico-chemical parameters and fatty acids, amino acids and minerals contents in seven primal cuts from veal carcasses (shoulder clod [SC], inside round [IR], eye of round [ER], bottom round [BR], heel of round [HR], knuckle [KK] and tenderloin [TL]).

Country-specific costs of implementing the WHO FCTC tobacco control policies and potential financing sources.

One of the major obstacles to the full implementation of the World Health Organization (WHO) Framework Convention of Tobacco Control (FCTC) tobacco control measures is the lack of sustainable financing resources.

Table tennis playing styles require specific energy systems demands.

The aim of the present study was to investigate the differences in energy system contributions and temporal variables between offensive and all-round playing styles. Fifteen male table tennis players (Offensive players: N = 7; All-round players: N = 8) participated in the study. Matches were monitored by a portable gas analyzer and the blood lactate responses was also measured. The contributions of the oxidative (WOXID), phosphagen (WPCr), and glycolytic (W[La]) energy systems were assumed as the oxygen con...

Beat-to-beat detection of aortic valve opening in heartware left ventricular assist device patients.

cfLVADs result in a significant reduction in aortic valve (AV) opening, which have been associated with several complications. Reliable monitoring of AV opening is needed to determine whether pump speed adjustment may be able to minimize adverse outcomes.

Prevalence of Different Types of Apical Root Canal Morphology and their Treatment Recommendations in an Institute.

Canals can be of different shapes in cross section including round canals, oval canals, long oval canals or ribbon shaped canals. Recesses of nonround canals may not be included in the round preparation created by rotary instruments and thus they remain unprepared. The aim of this study included determination of shape and taper of the apical root canal based on diameter at different levels. Measurement of the diameter of the root canal at one, two and three mm cross sections from the apex of the tooth were ...

Radical Cascade-Triggered Controlled Ring-Opening Polymerization of Macrocyclic Monomers.

A strategy for the controlled radical ring-opening polymerization of macrocyclic monomers is reported. Key to this approach is an allyl alkylsulfone-based ring-opening trigger that can undergo a radical cascade reaction to extrude sulfur dioxide and generate an alkyl radical for controlled chain propagation. A systematic study correlating reaction conditions and polymer molecular weight and molecular weight distribution allowed excellent control over polymerization. The versatility of this radical cascade-t...

Ring-opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles using Lewis Acid.

An unusual transformation of indoles to pyrazoles via an aromatic ring-opening strategy has been developed. The salient feature of this strategy involves the C2-N1 bond opening and concomitant cyclization reaction of the C2=C3 bond of the indole moiety with the tosylhydrazone which proceeds under transition-metal and ligand free conditions. This ring-opening functionalization of indoles provides a wide scope of differently substituted pyrazoles.

Disease-specific out-of-pocket and catastrophic health expenditure on hospitalization in India: Do Indian households face distress health financing?

Rising non-communicable diseases (NCDs) coupled with increasing injuries have resulted in a significant increase in health spending in India. While out-of-pocket expenditure remains the major source of health care financing in India (two-thirds of the total health spending), the financial burden varies enormously across diseases and by the economic well-being of the households. Though prior studies have examined the variation in disease pattern, little is known about the financial risk to the families by ty...

Social Determinants As Public Goods: A New Approach To Financing Key Investments In Healthy Communities.

Good research evidence exists to suggest that social determinants of health, including access to housing, nutrition, and transportation, can influence health outcomes and health care use for vulnerable populations. Yet adequate, sustainable financing for interventions that improve social determinants of health has eluded most if not all US communities. This article argues that underinvestment in social determinants of health stems from the fact that such investments are in effect public goods, and thus bene...

Chemometric characterization of the trace element profile of raw meat from Rubia Gallega x Holstein Friesian calves from an intensive system.

This study was conducted to compare the essential and toxic element content of seven veal cuts: shoulder clod (SC), inside round (IR), eye of round (ER), bottom round (BR), heel of round (HR), knuckle (KK) and tenderloin (TL). Eighty-four meat samples were determined by ICP-MS. Overall, essential trace elements (Co, Cu, Fe, Mn and Zn), except Se, varied significantly between the different meat cuts. By contrast, there were no significant variations for the minor trace elements (Cr, Mo and Ni) or the toxic e...

Unexpected Oxidative Ring-Opening of Electron-Rich 3-Aminobenzofurans into α-Ketoimines Derivatives.

An unexpected ring-opening of 3-aminobenzofurans promoted by NaOtBu in hot toluene, leading to a variety of α-ketoimines is described. In the presence of 3-iodobenzofurans, NaOtBu mediates the 3-aminobenzofurans ring-opening via a possible radical pathway without the help of any external radical sources.

PAX7 Immunohistochemical Evaluation of Ewing Sarcoma and Other Small Round Cell Tumors.

Ewing sarcoma is a small round cell tumor that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was consistently expressed in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. Here, we evaluated the utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array o...

Banking for health: the role of financial sector actors in investing in global health.

The world faces multiple health financing challenges as the global health burden evolves. Countries have set an ambitious health policy agenda for the next 15 years with prioritisation of universal health coverage under the Sustainable Development Goals. The scale of investment needed for equitable access to health services means global health is one of the key economic opportunities for decades to come. New financing partnerships with the private sector are vital. The aim of this study is to unlock additio...

The Function and Mechanism of Preactivated Thiomers in Triggering Epithelial Tight Junctions Opening.

As a unique macromolecular permeation enhancer, thiolated polymers (thiomers), especially the preactivated thiomers, have demonstrated great merits in oral delivery of protein/peptide drugs by triggering epithelial tight junctions (TJs) opening. However, the underlying molecular mechanism remains unclear. To clarify this issue, preactivated thiomers were synthesized and their TJs opening function as well as signaling pathways on MDCK and Caco-2 cell monolayers was investigated. The results showed that preac...

Factors enabling comprehensive maternal health services in the benefits package of emerging financing schemes: A cross-sectional analysis from 1990 to 2014.

Maternal delivery is the costliest event during pregnancy, especially if a complicated delivery occurs that requires emergency hospital services. A health financing scheme or program that covers comprehensive maternal services, including specialized hospital services in the benefits health package, enhances maternal survival and improves financial risk protection.

Impact of a higher fecal immunochemistry test cut-off on pathology detected in subsequent rounds of a colorectal screening program.

Fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening is superior to the traditional binary fecal occult blood (FOB) test. Its quantitative nature allows the investigator to choose a positivity threshold, to match cost and endoscopic capacity. The optimal threshold is still debated. BowelScreen, the Irish national colorectal cancer screening program, has a cut-off of 45μ Hb/g feces and in this study, we investigated the impact of a this threshold on pathology detected in round 2 in indivi...

The Economic Transition of Health in Africa: A Call for Progressive Pragmatism to Shape the Future of Health Financing.

Abstract-The new financing landscape for the Sustainable Development Goals has a larger emphasis on domestic resource mobilization. But, given the significant role of donor assistance for health, the fungibility of government health spending, and the downward revision of global growth, this article looks at what is possible with regard to a country's own ability to finance priority health services. Using cross-sectional and longitudinal economic and health spending data, we employ a global multilevel model ...

All-round utilization of biomass derived all-solid-state asymmetric carbon-based supercapacitor.

All-round utilization of resources is proposed for maximizing environmental and economic benefits. Herein, the concept of all-round utilization on biomass derivations applying to carbon-based supercapacitors is demonstrated. Orange peel is used for all subassemblies of supercapacitor, including electrodes, separator and electrolyte. A monolithic porous carbon (OPHPC) is prepared by one-step carbonization of orange peel and another composite electrode is further synthesized by a simple hydrothermal process, ...

Bone and joint mycobacterial infection: a retrospective review of cases presenting to a UK district hospital.

Peterborough has one of the highest rates of tuberculosis (TB) in the east of England. We reviewed the epidemiology, management and outcome of all cases of bone and joint TB (BJTB) diagnosed since 2000.

Kerma area product (KAP) and scatter measurements for intraoral X-ray machines using three different types of round collimation compared with rectangular beam limiter.

The objective of the study was to determine the radiation dose reduction achieved when rectangular collimation was used on various round collimators. In addition, we evaluated the tissue doses imparted to various head and neck organs.

Novel MXD4-NUTM1 fusion transcript identified in primary ovarian undifferentiated small round cell sarcoma.

Primary ovarian sarcomas are extremely rare tumors, and their genomic and transcriptomic alterations remain to be elucidated. We performed whole exome sequencing of primary tumor and matched normal blood samples derived from one patient with ovarian undifferentiated small round cell sarcoma. We identified 8 nonsynonymous somatic mutations, and all mutations were missense or nonsense changes. Next, we performed RNA sequencing of the tumor sample and identified two in-frame fusion transcripts: MXD4-NUTM1 and ...

Ward round template: enhancing patient safety on ward rounds.

Concerns had been raised at clinical governance regarding the safety of our inpatient ward rounds with particular reference to: documentation of clinical observations and National Early Warning Score (NEWS), compliance with Trust guidance for venous thromboembolism (VTE) risk assessment, antibiotic stewardship, palliative care and treatment escalation plans (TEP). This quality improvement project was conceived to ensure these parameters were considered and documented during the ward round, thereby improving...

Characterization of Ring-opening Reaction of Succinimide Linkers in ADCs.

A new class of highly potent biopharmaceutical drugs, antibody-drug conjugates (ADCs), has been proven to be clinically effective to treat oncology diseases. ADCs contain three major components: the monoclonal antibody, cytotoxic drug, and chemical linker. THIOMAB drug conjugates and interchain-cysteine ADCs are common ADC platforms that apply thiol-maleimide chemistry via Michael addition to conjugate linker-drugs to cysteine residues. However, the resulting succinimide ring in the linker is susceptible to...

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