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PubMed Journals Articles About "Noblegen Announces Opening Second Round Financing Peterborough Based" RSS

09:39 EDT 19th September 2018 | BioPortfolio

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Showing "Noblegen Announces Opening Second Round Financing Peterborough Based" PubMed Articles 1–25 of 32,000+

Financing the Primary Care Behavioral Health Model.

The PCBH model of integrated care blends behavioral health professionals into the primary care team, thereby enhancing the scope of primary care and expanding the range of services provided to the patient. Despite promising evidence in support of the model and a growing number of advocates and practitioners of PCBH integration, current reimbursement policies are not always favorable. As the nation's healthcare system transitions to value-based payment models, new financing strategies are emerging which will...


"Pay for Success" Financing and Home-Based Multicomponent Childhood Asthma Interventions: Modeling Results From the Detroit Medicaid Population.

Policy Points: The Pay for Success (PFS) financing approach has potential for scaling the implementation of evidence-based prevention interventions in Medicaid populations, including a range of multicomponent interventions for childhood asthma that combine home environment risk mitigation with medical case management. Even though this type of intervention is efficacious and cost-saving among high-risk children with asthma, the main challenges for implementation in a PFS context include legal and regulatory ...

A novel image-based system for risk stratification in patients with desmoplastic small round cell tumor.

Desmoplastic small round cell tumor (DSRCT) is an aggressive soft tissue sarcoma affecting children and young adults with 5-year overall survival (OS) of approximately 20%. Despite generally poor prognosis, long-term survival does occur. However, no evidence-based system exists to risk-stratify patients at diagnosis.


Carbon Emission Reduction with Capital Constraint under Greening Financing and Cost Sharing Contract.

Motivated by the industrial practices, this work explores the carbon emission reductions for the manufacturer, while taking into account the capital constraint and the cap-and-trade regulation. To alleviate the capital constraint, two contracts are analyzed: greening financing and cost sharing. We use the Stackelberg game to model four cases as follows: (1) in Case A1, the manufacturer has no greening financing and no cost sharing; (2) in Case A2, the manufacturer has greening financing, but no cost sharing...

VA Announces Plan to Improve Worst-Performing Medical Centers.

Table tennis playing styles require specific energy systems demands.

The aim of the present study was to investigate the differences in energy system contributions and temporal variables between offensive and all-round playing styles. Fifteen male table tennis players (Offensive players: N = 7; All-round players: N = 8) participated in the study. Matches were monitored by a portable gas analyzer and the blood lactate responses was also measured. The contributions of the oxidative (WOXID), phosphagen (WPCr), and glycolytic (W[La]) energy systems were assumed as the oxygen con...

Quantifying the Physical Response to a Contemporary Amateur Boxing Simulation.

Finlay, MJ, Greig, M, and Page, RM. Quantifying the physical response to a contemporary amateur boxing simulation. J Strength Cond Res 32(4): 1005-1012, 2018-This study examined the physical response to a contemporary boxing-specific exercise protocol (BSEP), based on notational analysis of amateur boxing. Nine male senior elite amateur boxers completed a 3 × 3-minute BSEP, with a 1-minute passive recovery period interspersing each round. Average (HRave) and peak (HRpeak) heart rates, average (V[Combining ...

Radical Cascade-Triggered Controlled Ring-Opening Polymerization of Macrocyclic Monomers.

A strategy for the controlled radical ring-opening polymerization of macrocyclic monomers is reported. Key to this approach is an allyl alkylsulfone-based ring-opening trigger that can undergo a radical cascade reaction to extrude sulfur dioxide and generate an alkyl radical for controlled chain propagation. A systematic study correlating reaction conditions and polymer molecular weight and molecular weight distribution allowed excellent control over polymerization. The versatility of this radical cascade-t...

Ring-opening of Indoles: An Unconventional Route for the Transformation of Indoles to 1H-Pyrazoles using Lewis Acid.

An unusual transformation of indoles to pyrazoles via an aromatic ring-opening strategy has been developed. The salient feature of this strategy involves the C2-N1 bond opening and concomitant cyclization reaction of the C2=C3 bond of the indole moiety with the tosylhydrazone which proceeds under transition-metal and ligand free conditions. This ring-opening functionalization of indoles provides a wide scope of differently substituted pyrazoles.

Corn-Based Distillers' Grains in Diets for Feedlot Cattle are Associated with the Burden of Escherichia coli O157 in Feces.

Inclusion of distillers' grains (DGs) has been associated with increased prevalence of Escherichia coli O157:H7 in cattle housed in research settings. Our objective was to quantify the relationship between inclusion of DGs in commercial feedlot rations and the burden of E. coli O157. A convenience sample of 10 feedlots was enrolled based on DG use in finishing diets; 1 cohort included 5 feedlots in which DGs were greater than 15% of the dietary dry matter and the other cohort consisted of 5 feedlots at a co...

Disease-specific out-of-pocket and catastrophic health expenditure on hospitalization in India: Do Indian households face distress health financing?

Rising non-communicable diseases (NCDs) coupled with increasing injuries have resulted in a significant increase in health spending in India. While out-of-pocket expenditure remains the major source of health care financing in India (two-thirds of the total health spending), the financial burden varies enormously across diseases and by the economic well-being of the households. Though prior studies have examined the variation in disease pattern, little is known about the financial risk to the families by ty...

Social Determinants As Public Goods: A New Approach To Financing Key Investments In Healthy Communities.

Good research evidence exists to suggest that social determinants of health, including access to housing, nutrition, and transportation, can influence health outcomes and health care use for vulnerable populations. Yet adequate, sustainable financing for interventions that improve social determinants of health has eluded most if not all US communities. This article argues that underinvestment in social determinants of health stems from the fact that such investments are in effect public goods, and thus bene...

Context matters (but how and why?) A hypothesis-led literature review of performance based financing in fragile and conflict-affected health systems.

Performance-based financing (PBF) schemes have been expanding rapidly across low and middle income countries in the past decade, with considerable external financing from multilateral, bilateral and global health initiatives. Many of these countries have been fragile and conflict-affected (FCAS), but while the influence of context is acknowledged to be important to the operation of PBF, there has been little examination of how it affects adoption and implementation of PBF. This article lays out initial hypo...

Community-based mass treatment with azithromycin for the elimination of yaws in Ghana-Results of a pilot study.

The WHO yaws eradication strategy consists of one round of total community treatment (TCT) of single-dose azithromycin with coverage of > 90%.The efficacy of the strategy to reduce the levels on infection has been demonstrated previously in isolated island communities in the Pacific region. We aimed to determine the efficacy of a single round of TCT with azithromycin to achieve a decrease in yaws prevalence in communities that are endemic for yaws and surrounded by other yaws-endemic areas.

Chromatin Accessibility Dynamics during Chemical Induction of Pluripotency.

Despite its exciting potential, chemical induction of pluripotency (CIP) efficiency remains low and the mechanisms are poorly understood. We report the development of an efficient two-step serum- and replating-free CIP protocol and the associated chromatin accessibility dynamics (CAD) by assay for transposase-accessible chromatin (ATAC)-seq. CIP reorganizes the somatic genome to an intermediate state that is resolved under 2iL condition by re-closing previously opened loci prior to pluripotency acquisition...

PAX7 Immunohistochemical Evaluation of Ewing Sarcoma and Other Small Round Cell Tumors.

Ewing sarcoma is a small round cell tumor that affects bone and soft tissues. Although the detection of the specific fusion gene is a robust method of its diagnosis, immunohistochemistry may serve as a practical surrogate. Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was consistently expressed in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma. Here, we evaluated the utility of PAX7 immunohistochemistry in whole-tissue sections of an expanded array o...

Banking for health: the role of financial sector actors in investing in global health.

The world faces multiple health financing challenges as the global health burden evolves. Countries have set an ambitious health policy agenda for the next 15 years with prioritisation of universal health coverage under the Sustainable Development Goals. The scale of investment needed for equitable access to health services means global health is one of the key economic opportunities for decades to come. New financing partnerships with the private sector are vital. The aim of this study is to unlock additio...

Methanol-Assisted Phthalimide Ring Opening: Concerted or Stepwise Mechanism?

The opening of the five-membered ring is the essential step for phthalimide and its derivatives to be used as the reactants in many chemical synthetic routes. Reportedly, such ring opening follows the concerted mechanism in methanol solvent, which, however, has an unreasonably high energy barrier (36.3 kcal molat the M06-2X/6-311++G(d,p) level of theory). By density functional theory calculations, we report that this ring opening prefers the alternatively stepwise mechanism. The stepwise mechanism has a muc...

Impact of a higher fecal immunochemistry test cut-off on pathology detected in subsequent rounds of a colorectal screening program.

Fecal immunochemical test (FIT)-based colorectal cancer (CRC) screening is superior to the traditional binary fecal occult blood (FOB) test. Its quantitative nature allows the investigator to choose a positivity threshold, to match cost and endoscopic capacity. The optimal threshold is still debated. BowelScreen, the Irish national colorectal cancer screening program, has a cut-off of 45μ Hb/g feces and in this study, we investigated the impact of a this threshold on pathology detected in round 2 in indivi...

All-round utilization of biomass derived all-solid-state asymmetric carbon-based supercapacitor.

All-round utilization of resources is proposed for maximizing environmental and economic benefits. Herein, the concept of all-round utilization on biomass derivations applying to carbon-based supercapacitors is demonstrated. Orange peel is used for all subassemblies of supercapacitor, including electrodes, separator and electrolyte. A monolithic porous carbon (OPHPC) is prepared by one-step carbonization of orange peel and another composite electrode is further synthesized by a simple hydrothermal process, ...

Power cavitation-guided blood-brain barrier opening with focused ultrasound and microbubbles.

Image-guided monitoring of microbubble-based focused ultrasound (FUS) therapies relies on the accurate localization of FUS-stimulated microbubble activity (i.e. acoustic cavitation). Passive cavitation imaging with ultrasound arrays can achieve this, but with insufficient spatial resolution. In this study, we address this limitation and perform high-resolution monitoring of acoustic cavitation-mediated blood-brain barrier (BBB) opening with a new technique called power cavitation imaging. By synchronizing t...

Ward round template: enhancing patient safety on ward rounds.

Concerns had been raised at clinical governance regarding the safety of our inpatient ward rounds with particular reference to: documentation of clinical observations and National Early Warning Score (NEWS), compliance with Trust guidance for venous thromboembolism (VTE) risk assessment, antibiotic stewardship, palliative care and treatment escalation plans (TEP). This quality improvement project was conceived to ensure these parameters were considered and documented during the ward round, thereby improving...

Changing Face of Family Planning Funding in Kenya: A Cross-Sectional Survey of Two Urban Counties.

As international development partners reduce funding for family planning (FP) programs, the need to estimate the financial resources devoted to FP is becoming increasingly important both at all levels. This cross-sectional assessment examined the FP financing sources, agents, and expenditures in two counties of Kenya for fiscal years 2010/2011 and 2011/2012 to guide local decision-making on financial allocations. Data were collected through a participatory process. This involved stakeholder interviews, revi...

The financing gaps framework: using need, potential spending and expected spending to allocate development assistance for health.

As growth in development assistance for health levels off, development assistance partners must make allocation decisions within tighter budget constraints. Furthermore, with the advent of comprehensive and comparable burden of disease and health financing estimates, empirical evidence can increasingly be used to direct funding to those most in need. In our 'financing gaps framework', we propose a new approach for harnessing information to make decisions about health aid. The framework was designed to be fo...

Borinic Acid-Catalyzed, Regioselective Ring Opening of 3,4-Epoxy Alcohols.

Diarylborinic acids (ArBOH) catalyze the C3-selective ring opening of 3,4-epoxy alcohols with aniline, dialkylamine and arenethiol nucleophiles. The regiochemical outcome is consistent with a catalytic tethering mechanism in which the borinic acid interacts with both the electrophile and the nucleophile. The rate acceleration resulting from this induced intramolecularity effect is sufficient to overcome steric biases that would otherwise favor C4-selective opening of the substituted epoxy alcohols.


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