PubMed Journals Articles About "Novel Mechanism Might Explain MDMA Facilitated Psychotherapy" RSS

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Showing "Novel Mechanism Might Explain MDMA Facilitated Psychotherapy" PubMed Articles 1–25 of 12,000+

Efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for posttraumatic stress disorder: A systematic review and meta-analysis.

Posttraumatic stress disorder (PTSD) is a common psychiatric condition that can develop following a traumatic experience. PTSD is associated with significant disability, a large economic burden, and despite the range of therapies to treat PTSD, response to antidepressants is limited. A growing body of clinical research suggests the efficacy of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy in individuals with treatment-refractory PTSD.

Perceived Benefits of MDMA-Assisted Psychotherapy beyond Symptom Reduction: Qualitative Follow-Up Study of a Clinical Trial for Individuals with Treatment-Resistant PTSD.

We present select findings from a long-term follow-up qualitative study of MDMA-assisted psychotherapy for veterans, firefighters, and police officers suffering from chronic, treatment-resistant PTSD. Semi-structured qualitative interviews were conducted at participants' one-year follow-up after a recently completed phase 2 clinical trial. Available interviews from 19 of 24 participants were analyzed. This qualitative analysis sought to complement, clarify, and expand upon the quantitative findings obtained...

Locomotor sensitization in male Sprague-Dawley rats following repeated concurrent treatment with 4-methylmethcathinone and 3,4-methylenedioxymethamphetamine.

Recreational abuse of illicit synthetic cathinones is an ongoing public health concern. Recent studies indicate that the methcathinone derivative 4-methylmethcathinone (4-MMC) produces behavioral and neurochemical effects similar to the entactogen 3,4-methylenedioxymethamphetamine (MDMA). Whereas polysubstance abuse is common, most preclinical studies of drug abuse liability only evaluate the effects of single drugs. Utilizing the locomotor sensitization paradigm, the present study assessed the combined loc...

Variability in content and dissolution profiles of MDMA tablets collected in the UK between 2001 and 2018 - a potential risk to users?

MDMA ('ecstasy') tablets are widely used recreationally, and not only vary in their appearance, but also in MDMA content. Recently, the prevalence of high-content tablets is of concern to public health authorities. To compare UK data with other countries, we have evaluated MDMA content of 412 tablets collected from the UK, 2001-2018, and have investigated within-batch content variability for a sub-set of these samples. In addition, we have investigated dissolution profiles of tablets using pharmaceutical in...

Autophagy Inhibition Plays a Protective Role against 3, 4-Methylenedioxymethamphetamine (MDMA)-induced Loss of Serotonin Transporters and Depressive-like Behaviors in Rats.

The 3,4-methylenedioxymethamphetamine (MDMA) is a popular recreational drug, which ultimately leads to serotonergic (5-HT) neurotoxicity and psychiatric disorders. Previous in vitro studies have consistently demonstrated that MDMA provokes autophagic activation, as well as damage of 5-HT axons and nerve fibers. So far, whether autophagy, a well-conserved cellular process that is critical for cell fate, also participates in MDMA-induced neurotoxicity in vivo remains elusive. Here, we first examined time-cour...

Two-Year Follow-Up after Treatment with the Cognitive Behavioral Analysis System of Psychotherapy versus Supportive Psychotherapy for Early-Onset Chronic Depression.

Evidence on the long-term efficacy of psychotherapeutic approaches for chronic depression is scarce.

What is the appropriate time to measure outcome and process factors in psychodynamic psychotherapy?

Different instruments and methods for measuring factors related to the progress and effectiveness of psychodynamic psychotherapy (PDT) have been widely discussed in the literature. However, there are no established guidelines on the most appropriate time to perform these measurements.

Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA.

One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on functional connectivity (FC) using a novel multimodal method (Receptor-Enriched Analysis of functional Connectivity by Targets - REACT). This approach enriches the resting stat...

Development and validation of the relational depth frequency scale.

The Relational Depth Frequency Scale (RDFS) was developed to measure the frequency of specific moments of profound contact and engagement in psychotherapy.

Development of Brazilian prototypes for child psychodynamic psychotherapy and cognitive-behavioral therapy.

This study developed Brazilian psychodynamic psychotherapy (PDT) and cognitive-behavioral therapy (CBT) prototypes for children with internalizing disorders (ID) and externalizing disorders (ED).

Interaction structures in the psychodynamic psychotherapy of a patient with chronic diseases and somatic symptoms.

This study aimed to identify and analyze the interaction structures (ISs) (patterns of reciprocal interaction between the patient-therapist dyad) that characterize the process of a successful long-term psychodynamic psychotherapy (28 months) of a patient with chronic diseases (lupus and fibromyalgia) and somatic symptoms.

Three Dangers: Phenomenological Reflections on the Psychotherapy of Psychosis.

This paper offers a hermeneutic-phenomenological perspective on three dangers relevant to the psychotherapy of an underserved and often poorly understood population: persons with schizophrenia and other psychotic conditions.

The role of long-term psychodynamic psychotherapy in improving attachment patterns, defense styles, and alexithymia in patients with depressive/anxiety disorders.

Long-term psychodynamic psychotherapy (LTPP) emphasizes the centrality of intrapsychic and unconscious conflicts and their relation to development. Although there is evidence supporting the efficacy of LTPP in mental disorders, little research has been published on the efficacy of LTPP for depressive and anxiety disorders.

The Altered States of Consciousness in Transpersonal Approach Psychotherapy: Systematic Review and Guidelines for Research and Clinical Practice.

Transpersonal approach in psychotherapy is a controversial field, and there is a lack in scientific information. A search of Embase, Web of Science, Scopus, PubMed, PsycINFO and SciELO databases using: ["Altered states of consciousness" AND "Psychotherapy"] and ["Transpersonal" AND "Psychotherapy"] in December 2017 was conducted. From 629 articles found, 14 empirical studies were analyzed. Studies were conducted with adults, most of them women. The benefits were improvement in the treatment of substance use...

Toward a Phenomenological Psychotherapy for Schizophrenia.

During the last decades, research in phenomenological psychopathology has provided a vast array of insights that are invaluable for understanding the experiential worlds of patients with schizophrenia. Precisely, knowledge of patients' experiences is a necessary basis for a sound and thoughtful psychotherapy. This is especially important in psychotherapy for schizophrenia, where patients' experiences may not always be easily accessible or understandable. In the available literature, we found only scattered ...

Computer-assisted psychological assessment and psychotherapy for collegians.

This article reviews research on computerized and computer-assisted psychological assessment and psychotherapy for college and university students.

Call for papers: Psychology and Psychotherapy: Theory, Research and Practice special online-only issue on Cognitive Analytic Therapy: Special issue editors: Samantha Hartley and Peter Taylor.

The Future of Spiritually Integrated Psychotherapy in the AAPC Tradition.

The consolidation of AAPC and ACPE created an opportunity to advance the discipline and practice of spiritually integrated psychotherapy in a distinctive, sustainable way. AAPC's way of educating and forming counselors is like a tree whose root system is strong, but its previous location was no longer viable. This article expands the metaphor of transplanting the AAPC tree and outlines how the consolidation will facilitate the growth of spiritually integrated psychotherapy in the AAPC tradition into the fut...

Creative arts in psychotherapy for traumatized children in South Africa: An evaluation study.

To evaluate the feasibility and effect of a 10-session creative arts in psychotherapy group programme on posttraumatic stress symptoms, behavioural problems, and posttraumatic growth, in children who experienced a traumatic event.

Psychotherapy research: an interplay between inner and outer and a succession of meanings.

Psychotherapy research is a rapidly developing area of study that aims to explore the integration of inner and outer conditions of an individual's experience, the interplay between subjective and objective, as well as between individual and collective. Questions regarding a more integrative view and qualitative research in psychotherapy are discussed in the paper. The author introduces some ideas from the studies on psychotherapy effectiveness that were done at Vilnius University by a group of researchers w...

Lessons to be learned from toxicological analyses in intoxicated patients and seized materials at an electronic music dance festival.

Medical problems related to illicit drug use are frequently encountered at electronic dance music (EDM) events. In this prospective study, the medical problems and toxicological analyses on intoxicated persons and seized materials are described jointly. The aim of this study is to find out to what extent these efforts may assist in developing prevention strategies and organising on-site care at EDM events. The most frequently encountered clinical presentation in the 121 included patients was: agitation/aggr...

Group psychotherapy for borderline personality disorder: A meta-analysis of randomized-controlled trials.

Treatment guidelines for borderline personality disorder (BPD) recommend psychotherapy as an important, if not essential, component of patient care. The current study is a meta-analysis of randomized controlled trials comparing group psychotherapy for BPD with treatment as usual (TAU). We included moderator analysis to examine how outcomes differ based on group and patient characteristics, risk of bias variables, and treatment elements of the TAU comparison condition (e.g., whether psychotherapy was include...

Introduction: Novel perspectives on the psychology and psychotherapy of eating disorders.

The aim of this introduction to this issue is to review and summarize significant new psychological perspectives and psychotherapeutic interventions in the treatment of eating disorder (EDs). In this issue, five novel therapeutic strategies for the treatment of EDs are presented. These include a combination of psychodynamic psychotherapy and neuropsychology, two recent modifications of cognitive behavioral therapy (the MANTRA, and the conceptualization of change in patients with ED in terms of sense of agen...

Meta-Analysis: 13-Year Follow-Up of Psychotherapy Effects on Youth Depression.

Youth depression is a debilitating condition that constitutes a major public health concern. A 2006 meta-analysis found modest benefits for psychotherapy vs. control. Has 13 more years of research improved that picture? We sought to find out.

Changes in the sense of agency: Implications for the psychotherapy of bulimia nervosa- A case study.

A sense of agency is a transtheoretical concept that increases our understanding of important processes in psychotherapy. Agency can be described in terms of how strongly the person believes that she can have an impact on her problematic experiences and behaviors. In this case study, a patient's sense of agency in relation to symptoms of bulimia nervosa was assessed during 3 years of psychotherapy. Five distinct phases of agency in relation to eating disorder symptoms were identified: A false sense of agenc...

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