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13:56 EDT 24th August 2019 | BioPortfolio

Novo Nordisk PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Novo Nordisk articles that have been published worldwide.

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Showing "Novo Nordisk" PubMed Articles 1–25 of 690

FIXing postinfusion monitoring: Assay experiences with N9-GP (nonacog beta pegol; Refixia ; Rebinyn ).

N9-GP (nonacog beta pegol; Refixia ; Rebinyn , Novo Nordisk A/S, Bagsvaerd, Denmark) is a glycoPEGylated extended half-life recombinant factor IX (rFIX) that exhibits efficacy and potency comparable to unmodified FIX molecules in non-clinical models. Phase 3 clinical trials have confirmed the efficacy and tolerability of N9-GP for the prevention and on-demand treatment of bleeding episodes in patients with haemophilia B. Recent studies have shown that PEGylation affects clotting times in activated partial t...

Innovating to increase access to diabetes care in Kenya: an evaluation of Novo Nordisk's base of the pyramid project.

: The Base of the Pyramid (BoP) project is a public-private partnership initiated by Novo Nordisk that aims to facilitate access to diabetes care for people at the base of the economic pyramid in low- and middle-income countries (LMICs). In Kenya, the BoP, through a partnership model, aims to strengthen five pillars of diabetes care: increased awareness of diabetes; early diagnosis of diabetes; access to quality care by trained professionals; stable and affordable insulin supply; and improved self-managemen...

De novo transcriptome assembly: A comprehensive cross-species comparison of short-read RNA-Seq assemblers.

In recent years, massively parallel complementary DNA sequencing (RNA sequencing [RNA-Seq]) has emerged as a fast, cost-effective, and robust technology to study entire transcriptomes in various manners. In particular, for non-model organisms and in the absence of an appropriate reference genome, RNA-Seq is used to reconstruct the transcriptome de novo. Although the de novo transcriptome assembly of non-model organisms has been on the rise recently and new tools are frequently developing, there is still a...

Formation of de Novo Symptomatic Premedullary Arachnoid Cyst in Adult.

Intracranial de novo arachnoid cysts in adults are very rare, suggesting the involvement of head trauma and inflammatory diseases. We report a symptomatic adult case of nontraumatic de novo arachnoid cyst on the ventral medulla oblongata.

AMCP Partnership Forum: Integrated Delivery Networks' Role in Pharmaceutical Value-Based Agreements.

Health care payment models that reward value over volume have the potential to improve patient care and control rising costs. These payment models are increasingly being implemented by a range of care delivery providers in the United States. Integrated delivery networks (IDNs)-systems of providers and sites (e.g., group practices and hospitals) that care for and provide health care services and health insurance plans to patients in a specific region or market-present special opportunities and challenges for...

De novo aneurysm formation after a Wingspan stenting of intracranial carotid stenosis: a computational hemodynamic analysis.

The pathophysiology of de novo aneurysm after stenting is poorly understood. Hemodynamic effects may play an important role. We report and discuss the hemodynamic analysis of de novo aneurysm after intracranial stenting.

Somatic mosaicism by a de novo MLH1 mutation as a cause of Lynch syndrome.

Lynch syndrome (LS) is caused by germline mismatch repair (MMR) gene mutations. De novo MMR gene mutations are rare, and somatic mosaicism in LS is thought to be infrequent. We describe the first case of somatic mosaicism by a de novo MLH1 mutation for a patient diagnosed with a rectosigmoid adenocarcinoma at age 31.

Kevlar: A Mapping-Free Framework for Accurate Discovery of De Novo Variants.

De novo genetic variants are an important source of causative variation in complex genetic disorders. Many methods for variant discovery rely on mapping reads to a reference genome, detecting numerous inherited variants irrelevant to the phenotype of interest. To distinguish between inherited and de novo variation, sequencing of families (parents and siblings) is commonly pursued. However, standard mapping-based approaches tend to have a high false-discovery rate for de novo variant prediction. Kevlar is a ...

REPLY: Predictors of de novo Non-alcoholic Fatty Liver Disease (NAFLD) post-Liver Transplantation and Associated Fibrosis.

We thank Dr. Saigal and colleagues for their interest in our article entitled "Predictors of De Novo Nonalcoholic Fatty Liver Disease after Liver Transplantation and Associated Fibrosis". We agree that the bias towards the limited clinical significance of de novo NAFLD in prior studies is likely related to small cohorts and relatively short duration follow up. However, our study noted a trend toward a shorter long-term survival in the de novo NAFLD and NASH cohorts (log rank 0.54 and 0.18 respectively), but...

Integrating resistance functions to predict response to induction chemotherapy in de novo acute myeloid leukemia.

This study explored resistance functions and their interactions in de novo AML treated with the "7+3" induction regimen.

De novo generation of a functional human thymus from induced pluripotent stem cells.

Patient-specific, human thymus organoids that support de novo T cell development may lead to new therapeutic options for diseases with severely diminished thymic function.

De Novo DNA Methylation at Imprinted Loci during Reprogramming into Naive and Primed Pluripotency.

CpG islands (CGIs) including those at imprinting control regions (ICRs) are protected from de novo methylation in somatic cells. However, many cancers often exhibit CGI hypermethylation, implying that the machinery is impaired in cancer cells. Here, we conducted a comprehensive analysis of CGI methylation during somatic cell reprogramming. Although most CGIs remain hypomethylated, a small subset of CGIs, particularly at several ICRs, was often de novo methylated in reprogrammed pluripotent stem cells (PSCs)...

Immunohistochemical expression of mammaglobin in salivary duct carcinomas (SDC) de novo and SDC ex pleomorphic adenoma.

Mammaglobin is expressed in breast and salivary gland secretory carcinomas; however, its expression in salivary duct carcinomas (SDC) still not well established. Therefore, the aim of this study was to investigate the presence and distribution of mammaglobin immunoexpression in SDC ex-PA in different phases of the adenoma to carcinoma sequence evaluating its possible involvement in carcinogenesis and tumor progression, as well as to determine its expression in SDC de novo. Mammaglobin immunohistochemistry w...

Towards functional de novo designed proteins.

Our ability to design completely de novo proteins is improving rapidly. This is true of all three main approaches to de novo protein design, which we define as: minimal, rational and computational design. Together, these have delivered a variety of protein scaffolds characterised to high resolution. This is truly impressive and a major advance from where the field was a decade or so ago. That all said, significant challenges in the field remain. Chief amongst these is the need to deliver functional de novo ...

SKA1 induces de novo MTX-resistance in osteosarcoma through inhibiting FPGS transcription.

De novo methotrexate (MTX)-resistance, whose underlying mechanism remains largely unknown, usually leads to very poor prognosis in patients with osteosarcoma (OS). In this study, we established the de novo MTX-resistant OS cell line SF-86 and identified the candidate gene Spindle and Kinetochore Associated complex subunit 1 (SKA1) as potentially related to de novo MTX-resistance. Analysis of a cohort of 95 OS patients demonstrated that SKA1 overexpression significantly correlated with de novo MTX-resistance...

Formation of intracranial de novo aneurysms and recurrence after neck clipping: a systematic review and meta-analysis.

OBJECTIVEIncidence rates of de novo aneurysm formation and recurrence after clip ligation remain controversial. In this meta-analysis, the authors provide data on pooled annual incidence rates and the association of patient characteristics with time to formation of de novo aneurysms and time to recurrence after clipping.METHODSA search of the literature up to June 15, 2016, on PubMed and a systematic review were performed. The association of age, aneurysm rupture status, aneurysm multiplicity, and anatomica...

Management trends and outcomes of breast angiosarcoma: Is breast conservation feasible?

We queried the National Cancer Database for nonmetastatic breast angiosarcoma, yielding 808 patients (202 de novo, 606 secondary). The median survival was 53.7 months. Secondary tumors were more likely to undergo mastectomy than de novo lesions (OR = 3.99, P 

Early Onset Neovascular Inflammatory Vitreoretinopathy Due to a De Novo CAPN5 Mutation: Report of a Case.

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a rare autoimmune condition that typically presents as progressive uveitis and vitreoretinal degeneration between the second and third decades of life. Though traditionally attributed to inherited mutations of the CAPN5 gene, few reports of de novo variants exist. This report of vision and hearing loss in a 3 year-old girl describes the youngest documented case of ADNIV due to a de novo pathogenic c.865C>T (p.Arg289Trp) CAPN5 variant, ...

The de novo design of α-helical peptides for supramolecular self-assembly.

One approach to designing de novo proteinaceous assemblies and materials is to develop simple, standardised building blocks and then to combine these symmetrically to construct more-complex higher-order structures. This has been done extensively using β-structured peptides to produce peptide fibres and hydrogels. Here, we focus on building with de novo α-helical peptides. Because of their self-contained, well-defined structures and clear sequence-to-structure relationships, α helices are highly programma...

Predictors of De Novo Nonalcoholic Fatty Liver Disease After Liver Transplantation: many unanswered questions.

Post transplant non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) is very common. The progression of fibrosis is accelerated in these patients as compared to NASH in general population. A meta-analysis including 2166 patients showed a 26% pooled prevalence of de novo NAFLD. The majority of studies have not shown a clear association between recurrent or de novo NAFLA/NASH and survival, however quality of evidence is low. This article is protected by copyright. All rights reser...

Effect of choroidal collateral vessels on de novo hemorrhage in moyamoya disease: analysis of nonhemorrhagic hemispheres in the Japan Adult Moyamoya Trial.

OBJECTIVEFollowing hemorrhagic stroke in moyamoya disease, de novo intracranial hemorrhage can occur in the previously unaffected nonhemorrhagic hemisphere. In the present analysis the authors intended to determine whether the presence in the nonhemorrhagic hemisphere of choroidal collateral vessels, which have been the focus of attention as a source of bleeding, affects the risk of de novo hemorrhage.METHODSThe subject of focus of the present cohort study was the nonhemorrhagic hemispheres of adult patient...

Cytogenetic profile of a representative cohort of young adults with de novo acute myéloblastic leukaemia in Morocco.

We analyzed the cytogenetic characteristics of a representative population of young adults with de novo acute myéloblastic leukemia (AML) treated in a single center institution.

Performance of gene expression analyses using de novo assembled transcripts in polyploid species.

Quality of gene expression analyses using de novo assembled transcripts in species that experienced recent polyploidization remains unexplored.

Heavy-atom labeling of RNA by PLOR for de novo crystallographic phasing.

Due to the paucity of known RNA structures, experimental phasing is crucial for obtaining three-dimensional structures of RNAs by X-ray crystallography. Covalent attachment of heavy atoms to RNAs is one of the most useful strategies to facilitate phase determination. However, this approach is limited by the inefficiency or inability to synthesize large RNAs (>60 nucleotides) site-specifically labeled with heavy atoms using traditional methods. Here, we applied our recently reported method, PLOR (position-se...

De-novo mutations in patients with chronic ultra-refractory epilepsy with onset after age five years.

We set out to investigate whether a de-novo paradigm could explain genetic causes of chronic ultra-refractory epilepsy, with onset later than the typical age for the epileptic encephalopathies. We performed exome sequencing on nine adult patients with MRI-negative epilepsy and no preceding intellectual disability. All had an onset of seizures after five years old and had chronic ultra-refractory epilepsy defined here as having failed more than six anti-epileptic drugs and currently experiencing ≥4 disabli...

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