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PubMed Journals Articles About "Open Source Pharma - Blog" RSS

14:01 EDT 14th October 2019 | BioPortfolio

Open Source Pharma - Blog PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Open Source Pharma - Blog articles that have been published worldwide.

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We have published hundreds of Open Source Pharma - Blog news stories on BioPortfolio along with dozens of Open Source Pharma - Blog Clinical Trials and PubMed Articles about Open Source Pharma - Blog for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Open Source Pharma - Blog Companies in our database. You can also find out about relevant Open Source Pharma - Blog Drugs and Medications on this site too.

Showing "Open Source Pharma Blog" PubMed Articles 1–25 of 8,600+

6 years of bladder blog: chances and benefits of a tool within the "new media".

 Web-based information about urinary incontinence is rather rare, especially including features of a "blog" with periodically published "teasers", small informative articles for patients. The contemporary blog "the bladder" is operated by Dr. Pfleger, Bamberg and attended by Prof. Dr. A. Wiedemann and Dr. G. Naumann as consulting experts. Acceptance and status of the "bladder blog" should be re-assessed.


Open source software security vulnerability detection based on dynamic behavior features.

Open source software has been widely used in various industries due to its openness and flexibility, but it also brings potential security problems. Therefore, security analysis is required before using open source software. The current mainstream open source software vulnerability analysis technology is based on source code, and there are problems such as false positives, false negatives and restatements. In order to solve the problems, based on the further study of behavior feature extraction and vulnerab...

Technical Note: An open source solution for improving TG-263 compliance.

Compliance with TG-263 nomenclature standards can be challenging. We introduce an open source solution to this problem and evaluate its impact on compliance within our institution.


Data science tools and applications on the way to Pharma 4.0.

Multiple obstacles are driving the digital transformation of the biopharmaceutical industry. Novel digital techniques, often marketed as 'Pharma 4.0', are thought to solve some long-existing obstacles in the biopharma life cycle. Pharma 4.0 concepts, such as cyberphysical systems and dark factories, require data science tools as technological core components. Here, we review current data science applications at various stages of the bioprocess life cycle, including their scopes and data sources. We are conv...

Development and validation of an open source Monte Carlo dosimetry model for wide-beam CT scanners using Fluka.

Development and validation of an open source Fluka-based Monte Carlo source model for diagnostic patient dose calculations.

Honoring the Moral Concerns of Caregivers Afraid of Giving Morphine.

: Updated several times a week with posts by a wide variety of authors, AJN's blog Off the Charts allows us to provide more timely-and often more personal-perspectives on professional, policy, and clinical issues. Best of the Blog will be a regular column to draw the attention of AJN readers to posts we think deserve a wider audience. To read more, please visit: www.ajnoffthecharts.com.

Science by social media: Attitudes towards climate change are mediated by perceived social consensus.

Internet blogs have become an important platform for the discussion of many scientific issues, including climate change. Blogs, and in particular the comment sections of blogs, also play a major role in the dissemination of contrarian positions that question mainstream climate science. The effect of this content on people's attitudes is not fully understood. In particular, it is unknown how the interaction between the content of blog posts and blog comments affects readers' attitudes. We report an experimen...

A guide to Open-JIP, a low-cost open-source chlorophyll fluorometer.

Chlorophyll a fluorescence is the most widely used method to study photosynthesis and plant stress. While several commercial fluorometers are available, there is a need for a low-cost and highly customisable chlorophyll fluorometer. Such a device would aid in performing high-throughput assessment of photosynthesis, as these instruments can be mass-produced. Novel investigations into photosynthesis can also be performed as a result of the user's ability to modify the devices functionality for their specific ...

III. THE ROLE OF THE RESEARCH ETHICS COMMITTEES IN THE REGULATION OF PHARMA-SPONSORED STUDIES.

Participants of Pharma-sponsored research are exposed to risks, benefits, and uncertainties that do not occur in other forms of clinical studies. Ethics committees represent the subjects' first line of protection. This responsibility begins with the study review and ends after all study subjects finish the intervention. The objective of this paper is to review the most common controversial issues found in Pharma-sponsored studies. Potential solutions are proposed to prevent or resolve the polemical aspects....

NaPLeS: a natural products likeness scorer-web application and database.

Natural products (NPs), often also referred to as secondary metabolites, are small molecules synthesised by living organisms. Natural products are of interest due to their bioactivity and in this context as starting points for the development of drugs and other bioactive synthetic products. In order to select compounds from virtual libraries, Ertl et al. developed a natural product likeness score which was later published as an open data, open source implementation. Here we present NaPLeS, an easily portabl...

A Champion for the Unestablished.

As a student in bioethics, I knew that The Hastings Center and its founders were the height of excellence in this field, and therefore I found them both intimidating and intriguing. When I began working there, Dan Callahan was supportive of my endeavors to provide a venue for students and other young writers to express their views on bioethics. I started my own blog called Bioethx under 25 that featured short essays by anyone who wished to submit, generally individuals who had a genuine philosophical intere...

Open Source Infrastructure for Health Care Data Integration and Machine Learning Analyses.

We have created a cloud-based machine learning system (CLOBNET) that is an open-source, lean infrastructure for electronic health record (EHR) data integration and is capable of extract, transform, and load (ETL) processing. CLOBNET enables comprehensive analysis and visualization of structured EHR data. We demonstrate the utility of CLOBNET by predicting primary therapy outcomes of patients with high-grade serous ovarian cancer (HGSOC) on the basis of EHR data.

Nonlinear mixed-effects model development and simulation using nlmixr and related R open source packages.

nlmixr is a free and open source R package for fitting nonlinear pharmacokinetic (PK), pharmacodynamic (PD), joint PK/PD and quantitative systems pharmacaology (QSP) mixed-effects models. Currently, nlmixr is capable of fitting both traditional compartmental PK models as well as more complex models implemented using ordinary differential equations (ODEs). We believe that, over time, it will become a capable, credible alternative to commercial software tools, such as NONMEM, Monolix, and Phoenix NLME. This a...

Open-source pipeline for multi-class segmentation of the spinal cord with deep learning.

This paper presents an open-source pipeline to train neural networks to segment structures of interest from MRI data. The pipeline is tailored towards homogeneous datasets and requires relatively low amounts of manual segmentations (few dozen, or less depending on the homogeneity of the dataset). Two use-case scenarios for segmenting the spinal cord white and grey matter are presented: one in marmosets with variable numbers of lesions, and the other in the publicly available human grey matter segmentation c...

The Art of Virtualizing Pharma R&D.

Physicians in the pharmaceutical industry: their roles, motivations, and perspectives.

Although physicians occupy a significant number of key positions in the pharmaceutical industry, practicing clinicians are often unaware of the variety of career paths within this industry, or of the structure of a pharmaceutical company. Here, we address questions that practicing clinicians frequently ask their colleagues in the pharmaceutical industry. In addition to providing an overview of the common roles occupied by physicians in pharma, we also describe the various motivations for transitioning into ...

Establishing and Maintaining a Robust Sample Management System.

This paper has been written by the SLAS Sample Management Special Interest Group to serve as a guide to the best practices and methods in establishing and maintaining a high-quality sample management system. The topics covered are applicable to sample types ranging from small molecules to biologics to tissue samples. It has been put together using the collective experience of the authors in start-up companies, small pharma, agricultural research, IT, academia, biorepositories, and large pharma companies. Ou...

Open collaborative writing with Manubot.

Open, collaborative research is a powerful paradigm that can immensely strengthen the scientific process by integrating broad and diverse expertise. However, traditional research and multi-author writing processes break down at scale. We present new software named Manubot, available at https://manubot.org, to address the challenges of open scholarly writing. Manubot adopts the contribution workflow used by many large-scale open source software projects to enable collaborative authoring of scholarly manuscri...

CPPE: An Open-Source C++ and Python Library for Polarizable Embedding.

We present a modular open-source library for polarizable embedding (PE) named CPPE. The library is implemented in C++, and it additionally provides a Python interface for rapid prototyping and experimentation in a high-level scripting language. Our library integrates seamlessly with existing quantum chemical program packages through an intuitive and minimal interface. Until now, CPPE has been interfaced to three packages, Q-Chem, Psi4, and PySCF. Furthermore, we show CPPE in action using all three program p...

Exploring the "like" in the psychological interaction of users on fan community: A netnography analysis.

Little is known about the psychology behind fans joining fan community pages in a blog context; the factors driving them to like, share, and comment on posts on fan community pages; or the manner in which fans experience and interact with such pages. These topics were not given sufficient explanation in past research. This study aimed to explore the special situations and unique online experiences that fans community experience in a blog context. A netnography analysis was conducted through online interview...

Implementation of Open Textbooks in Community and Technical College Biology Courses: The Good, the Bad, and the Data.

One challenge facing students today is high textbook costs, which pose a particularly difficult obstacle at community and technical colleges, where students typically have lower incomes and textbooks constitute a larger proportion of the overall cost of education. To address this, many advocate for using open-source textbooks, which are free in a digital format. However, concerns have been raised about the quality and efficacy of open textbooks. We investigated these concerns by collecting data from general...

Integrating Hi-C links with assembly graphs for chromosome-scale assembly.

Long-read sequencing and novel long-range assays have revolutionized de novo genome assembly by automating the reconstruction of reference-quality genomes. In particular, Hi-C sequencing is becoming an economical method for generating chromosome-scale scaffolds. Despite its increasing popularity, there are limited open-source tools available. Errors, particularly inversions and fusions across chromosomes, remain higher than alternate scaffolding technologies. We present a novel open-source Hi-C scaffolder t...

Evolved Open-Endedness, Not Open-Ended Evolution.

Open-endedness is often considered a prerequisite property of the whole evolutionary system and its dynamical behaviors. In the actual history of evolution on Earth, however, there are many examples showing that open-endedness is rather a consequence of evolution. We suggest that this view, which we call evolved open-endedness (EOE), be incorporated more into research on open-ended evolution. This view should allow for systematic investigation of more nuanced, more concrete research questions about open-end...

Potential effects of increased openness in pharma: the original knowledge behind new drugs.

This study seeks to determine potential changes in the degree of openness in pharmaceutical R&D by investigating where the knowledge behind new molecular entities (NMEs) comes from in terms of type of organization, geography and time. We find that the organizations granted NMEs increasingly rely on external knowledge sources but that these are increasingly shared among NME grantees. Universities are the most important indirect knowledge contributor and their relative importance has increased with time. NME ...

Superimposition of 3D maxillary digital models using open-source software.

Historically, whether for research purposes or clinical monitoring, orthodontic evaluation of dental movements has been done using plaster study models and two dimensional (2D) radiographs. However, new frontiers for the diagnosis, planning and outcome assessment of orthodontic treatments have arisen, due to the revolutionary digital tools which enable a three dimensional (3D) computerized analysis of dental movements by means of digital models. However, the software for 3D analysis are often costly, result...


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