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PubMed Journals Articles About "Open Systems Technologies∨derfield=score∨derval=DESC" RSS

17:55 EDT 20th July 2019 | BioPortfolio

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Showing "Open Systems Technologies derfield score derval DESC" PubMed Articles 1–25 of 17,000+

Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases.

Most treatments for cancer cause a decline in patients' health-related quality of life (HRQoL). Limiting this decline is a universal goal for healthcare providers. Using minimally invasive instead of open surgical techniques might be one way to achieve this. The aim of this study was to compare postoperative HRQoL after open and laparoscopic liver resection.


Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure-Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin-Mediated (hATTR) Amyloidosis.

Hereditary transthyretin-mediated (hATTR) amyloidosis is an inherited, rapidly progressive, life-threatening disease caused by deposition of abnormal transthyretin protein. Patisiran is an RNA interference therapeutic comprising a novel, small interfering ribonucleic acid (ALN-18328) formulated in a lipid nanoparticle targeted to inhibit hepatic transthyretin protein synthesis. The lipid nanoparticle also contains 2 novel lipid excipients (DLin-MC3-DMA and PEG -C-DMG). Here we report patisiran pharmacokinet...

Density functional theory for molecular and periodic systems using density fitting and continuous fast multipole method: Stress tensor.

A full implementation of the analytical stress tensor for periodic systems is reported in the TURBOMOLE program package within the framework of Kohn-Sham density functional theory using Gaussian-type orbitals as basis functions. It is the extension of the implementation of analytical energy gradients (Lazarski et al., Journal of Computational Chemistry 2016, 37, 2518-2526) to the stress tensor for the purpose of optimization of lattice vectors. Its key component is the efficient calculation of the Coulomb c...


Perylene π-Bridges that Equally Delocalize Anions and Cations: Quinoidal and Aromatic Contents in the Right Proportion.

A complete experimental and theoretical study has been carried out for aromatic and quinoidal perylene-based bridges, either substituted with bis(diarylamine) or bis(arylimine) groups. The through-bridge inter-redox site electronic couplings (VAB) have been calculated, for their respective mixed-valence radical cation and radical anion species. The unusual similitudes of the resulting VAB values for the given structures reveal the intervention of molecular shapes with balanced semi-quinoidal/semi-aromatic s...

Comparative studies of mitochondrial reactive oxygen species in animal longevity: Technical pitfalls and possibilities.

The mitochondrial oxidative theory of aging has been repeatedly investigated over the past 30 years by comparing the efflux of hydrogen peroxide (H O ) from isolated mitochondria of long- and short-lived species using horseradish peroxidase-based assays. However, a clear consensus regarding the relationship between H O production rates and longevity has not emerged. Concomitantly, novel insights into the mechanisms of reactive oxygen species (ROS) handling by mitochondria themselves should have raised conc...

Metformin reduces risk of varicose veins in type 2 diabetes patients.

This population-based retrospective cohort study compared the incidence of varicose veins in an unmatched cohort and a cohort of 1:1 propensity score (PS)-matched pairs of ever and never users of metformin in type 2 diabetes patients.

Atomic-Layer Deposition-Assisted Double-Side Interfacial Engineering for High-Performance Flexible and Stable CsPbBr Perovskite Photodetectors toward Visible Light Communication Applications.

Self-powered photodetectors (PDs) based on inorganic metal halide perovskites are regarded as promising alternatives for the next generation of photodetectors. However, uncontrollable film growth and sluggish charge extraction at interfaces directly limit the sensitivity and response speed of perovskite-based photodetectors. Herein, by assistance of an atomic layer deposition (ALD) technique, CsPbBr perovskite thin films with preferred orientation and enlarged grain size are obtained on predeposited interfa...

Advancing Metal-Phenolic Networks for Visual Information Storage.

We report a facile inking strategy for visual information storage (e.g., writing, printing and beyond), via surface modification of substrates with polyphenols and subsequent in-situ formation of metal-phenolic networks (MPNs) on the substrates. The reported technique has several advantages compared with current printing techniques. Diverse substrates can be used to fulfill the requirements for different applications (e.g., printing, writing, painting, stamping). A range of colors (e.g., yellow, blue, green...

Bright G-Quadruplex Nanostructures Functionalized with Porphyrin Lanterns.

The intricate arrangement of numerous and closely placed chromophores on nanoscale scaffolds can lead to key photonic applications ranging from optical waveguides and antennas to signal-enhanced fluorescent sensors. In this regard, the self-assembly of dye-appended DNA sequences into programmed photonic architectures is promising. However, the dense-packing of dyes can result in not only compromised DNA assembly (leading to ill-defined structures and precipitates) but also to essentially non-fluorescent sys...

Magnesium exchanged zirconium metal-organic frameworks with improved detoxification properties of nerve agents.

UiO-66, MOF-808 and NU-1000 metal-organic frameworks exhibit a differentiated reactivity to-wards [Mg(OMe)2(MeOH)2]4 related to the accessi-bility of the pore structure. Microporous UiO-66 remains unchanged while mesoporous MOF-808 and hierarchical micro/mesoporous NU-1000 mate-rials give rise to the formation of doped systems containing exposed MgZr5O2(OH)6 heterometallic clusters in the mesoporous cavities. This modifica-tion is responsible for a remarkable enhancement of the catalytic activity towards th...

Chitosan and Oregano Oil Treatments, Individually or in Combination, Used To Increase the Shelf Life of Vacuum-Packaged, Refrigerated European Eel () Fillets.

We investigated the impact of chitosan and oregano essential oil (EO) individually or in combination on the quality of eel fillets in vacuum packaging (VP) and stored under refrigeration (4°C). Treatments studied were (i) control eel fillets stored in VP (E), (ii) eel fillets treated with 0.3% (v/w) oregano EO and stored in VP (E-OR), (iii) eel fillets treated with 2.0% (w/v) chitosan and stored in VP (E-CH), and (iv) eel fillets treated with 2.0% (w/v) chitosan and 0.3% (v/w) oregano EO and stored in VP (...

What Is the Optimal Method to Perform Bone Biopsy (Method, Location, Imaging Use) for Patients With Foot and Ankle Infections?

A bone biopsy should generally be performed in a percutaneous fashion, particularly in cases where surgical debridement is not considered necessary. If surgical debridement is considered necessary, then an open biopsy can be performed as part of the debridement. Percutaneous biopsy should be performed under sterile conditions by an interventional radiologist or other physician trained in image-guided techniques. The location of the biopsy will depend upon the clinical and radiographic evaluations, with a go...

Care Coordination of Autism Spectrum Disorder: A Solution-Focused Approach.

The expanding practice of multi-disciplinary care to address the complex nature of Autism Spectrum Disorder (ASD) suggests that there is a need for a means of coordinating care that transcends the disciplinary distinctions of relevant ASD treatment providers. As ASD services become more specialized, there is a growing need for effective care coordination with providers across the systems of care. Nursing professionals are ideally qualified to support families affected by ASD, as they provide a necessary hol...

Biophysics at the coffee shop: lessons learned working with George Oster.

Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that ...

Simulated microgravity enhances CDDP-induced apoptosis signal via p53-independent mechanisms in cancer cells.

Although the biological systems in the human body are affected by the earth's gravity, information about the underlying molecular mechanisms is limited. For example, apoptotic signaling is enhanced in cancer cells subjected to microgravity. We reasoned that signaling regulated by p53 may be involved because of its role in apoptosis. Therefore, we aimed to clarify the molecular mechanisms of modified cis-diamminedichloroplatinum (CDDP)-sensitivity under simulated microgravity by focusing on p53-related cell ...

Diversification of the type IV filament superfamily into machines for adhesion, protein secretion, DNA uptake, and motility.

Processes of molecular innovation require tinkering and shifting in the function of existing genes. How this occurs in terms of molecular evolution at long evolutionary scales remains poorly understood. Here, we analyse the natural history of a vast group of membrane-associated molecular systems in Bacteria and Archaea-the type IV filament (TFF) superfamily-that diversified in systems involved in flagellar or twitching motility, adhesion, protein secretion, and DNA uptake. The phylogeny of the thousands of ...

Reorganization of 3D genome structure may contribute to gene regulatory evolution in primates.

A growing body of evidence supports the notion that variation in gene regulation plays a crucial role in both speciation and adaptation. However, a comprehensive functional understanding of the mechanisms underlying regulatory evolution remains elusive. In primates, one of the crucial missing pieces of information towards a better understanding of regulatory evolution is a comparative annotation of interactions between distal regulatory elements and promoters. Chromatin conformation capture technologies hav...

Modeling global geometric spatial information for rotation invariant classification of satellite images.

The classification of high-resolution satellite images is an open research problem for computer vision research community. In last few decades, the Bag of Visual Word (BoVW) model has been used for the classification of satellite images. In BoVW model, an orderless histogram of visual words without any spatial information is used as image signature. The performance of BoVW model suffers due to this orderless nature and addition of spatial clues are reported beneficial for scene and geographical classificati...

The day after: correlates of patient-reported outcomes with actigraphy-assessed sleep in cancer patients at home (inCASA project).

Subjective sleep assessment in cancer patients poorly correlates with actigraphy parameters that usually encompass multiple nights. We aimed to determine the objective actigraphy measures that best correlated with subjective sleep ratings on a night-by-night basis in cancer patients. Thirty-one cancer patients daily self-rated sleep disturbances using the single dedicated item of the MD Anderson Symptom Inventory (0-10 scale) with 18 other items, and continuously wore a wrist actigraph for 30 days. Objectiv...

Spatial updating of attention across eye movements: A neuro-computational approach.

While we are scanning our environment, the retinal image changes with every saccade. Nevertheless, the visual system anticipates where an attended target will be next and attention is updated to the new location. Recently, two different types of perisaccadic attentional updates were discovered: predictive remapping of attention before saccade onset (Rolfs, Jonikaitis, Deubel, & Cavanagh, 2011) and lingering of attention after saccade (Golomb, Chun, & Mazer, 2008; Golomb, Pulido, Albrecht, Chun, & Mazer, 201...

Timing of Treatment of Open Fractures of the Distal Radius in Patients Younger Than 65 Years.

The authors aimed to characterize surgical and functional outcomes of open fractures of the distal radius in patients younger than 65 years. At their level I trauma center, the authors conducted a retrospective review of 92 patients (age range, 16-64 years) who had 94 open fractures of the distal radius (average follow-up, 30 months; range, 3-95 months). Sixty-four fractures received definitive treatment at the time of initial débridement; 30 received definitive fixation and soft tissue coverage after stag...

Radial-to-Axillary Nerve Transfer Resolves Symptoms of Axillary Nerve Injury Due to Proximal Humerus Fracture-Dislocation in an Elderly Patient Treated With Hemiarthroplasty.

Proximal humerus fractures in elderly patients are a common injury that can often be treated nonoperatively. However, surgery is indicated with some fracture patterns. Arthroplasty is an attractive option with poor bone quality, when there is a low likelihood of success with open reduction and internal fixation, and due to a timely return to function and weight bearing of the extremity in this patient population. A prerequisite for shoulder function for both native and replacement joints is a functional del...

Development of a measure of genome sequencing knowledge for young people: the kids-KOGS.

Genome sequencing is increasingly being used to diagnose rare diseases in paediatric patients, however, no measures exist to evaluate their knowledge of this technology. We aimed to develop a robust measure of knowledge about genome sequencing (the kids-KOGS') suitable for use in the paediatric setting as well as for general public education. The target age was 11 to 15 year olds. An iterative process involving six sequential stages was conducted to develop a set of draft true/false items. These were then a...

Measuring continuous compositional change using decline and decay in zeta diversity.

Incidence, or compositional, matrices are generated for a broad range of research applications in biology. Zeta diversity provides a common currency and conceptual framework that links incidence-based metrics with multiple patterns of interest in biology, ecology and biodiversity science. It quantifies the variation in species (or OTU) composition of multiple assemblages (or cases) in space or time, to capture the contribution of the full suite of narrow, intermediate and wide-ranging species to biotic hete...

Plants alter their vertical root distribution rather than biomass allocation in response to changing precipitation.

Elucidating the variation of allocation pattern of ecosystem net primary productivity (NPP) and its underlying mechanisms are critically important for understanding the changes of aboveground and belowground ecosystem functions. Under optimal partitioning theory, plants should allocate more NPP to the organ that acquires the most limiting resource, and this expectation has been widely used to explain and predict NPP allocation under changing precipitation. However, confirmatory evidence for this theory has ...


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