PubMed Journals Articles About "Opinion From Bench Bedside Biologics Require Excellence Every" RSS

16:18 EDT 3rd April 2020 | BioPortfolio

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Showing "Opinion From bench bedside biologics require excellence every" PubMed Articles 1–25 of 4,500+

From Bench to Bedside: Doing No Harm Is Sweet.

Emergency bedside ultrasound: benefits as well as caution - part 1. General.

The use of bedside or point-of-care ultrasound (POCUS) in medical emergencies is rapidly becoming more established as an effective acute diagnostic tool. The purpose of this review is to provide an overview of the various techniques currently used that are readily available, as well as several in development. Possible caveats are also addressed.

From Bench to Bedside: How Do We Improve Education in Sex- and Gender-Based Health?

From Bench to Bedside: Implementation of Endobronchial Valve Treatment for Patients with Advanced Emphysema in Routine Clinical Care.

The neuropharmacology of social behavior: from bench to bedside.

Cerclage para-Hisian septal pacing through the septal perforator branch of the great cardiac vein: bedside-to-bench development of a novel technique and lead.

A Global Approach Addressing the Double Burden of Malnutrition in Pediatric Oncology: A Bench to Bedside Paradigm. A Report from the State of the Science Meeting, Children's Oncology Group.

The use of large animals to facilitate the process of MSC going from laboratory to patient-'bench to bedside'.

Large animal models have been widely used to facilitate the translation of mesenchymal stem cells (MSC) from the laboratory to patient. MSC, with their multi-potent capacity, have been proposed to have therapeutic benefits in a number of pathological conditions. Laboratory studies allow the investigation of cellular and molecular interactions, while small animal models allow initial 'proof of concept' experiments. Large animals (dogs, pigs, sheep, goats and horses) are more similar physiologically and struc...

A multicentre prospective audit of bedside hydration in hospital.

access to water at the bedside is a cornerstone of patient care. Among bedbound inpatients, water within reach at the bedside is a basic human dignity and one that ought not to be neglected.

Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis: A Randomized Clinical Trial.

Biologics revolutionized the treatment of psoriasis. Biologics are given in a fixed dose, but lower doses might be possible.

Oxymatrine Exerts Organ- and Tissue-Protective Effects by Regulating Inflammation, Oxidative Stress, Apoptosis, and Fibrosis: From Bench to Bedside.

Oxymatrine is a quinazine alkaloid extracted from Sophora flavescens with various therapeutic effects such as organ- and tissue-protective, anti-inflammatory, anti-cancer, and anti-viral effects. In this review, we summarize the protective effects of oxymatrine on damaged organs and tissues by analyzing both in vivo and in vitro studies. The mechanisms of protective effects of oxymatrine are mainly related to its anti-inflammatory, anti-oxidative stress, anti- or pro-apoptotic, anti-fibrotic, metabolism-reg...

The road taken -changing One's professional focus at a large research university.

The scientific endeavor has many facets, extending well beyond the experimental research bench. However, in most fields, especially in the biomedical sciences, the traditional career pathway for scientists is first joining and later leading an experimental research laboratory or program. As a result, scientific education is often focused on training new bench researchers. My own journey from a traditional bench scientist to that of an educator and educational researcher will be discussed in the context of a...

How can we manage the safety concerns associated with the increase in biologics for psoriasis?

Perspective and Experience of Hospital Operating Room Nurses with the Concept of Excellence: A Qualitative Study.

The provision of care according to the code of ethics is of the highest priority in operating rooms (OR). However, the exposure of the surgical team to a high level of stress may result in unethical behavior and undermine their pursuit of excellence. Since the concept of excellence is complex and there are limited published studies in the nursing literature, there was a need for in-depth research.

Safety considerations with biologics and new inflammatory bowel disease therapies.

The safety profile of therapies is an important issue that should always be shared with patients when choosing their treatment. The introduction of biologics over the past 2 decades represented a breakthrough in the management of inflammatory bowel diseases (IBDs). With better understanding of the pathophysiology of the disease, emerging therapies targeting different mechanisms of action have been developed including targeted monoclonal antibodies and small molecules. However, increasing concerns about the ...

Parental experience of bedside handover during childbirth: A qualitative interview study.

It has been described that bedside reporting can contribute to patient safety and increase patient involvement in healthcare. To our knowledge, however, there is no existing research on bedside handover during labour.

Incorporating Biologics Into Your Practice: The New Horizon in Sports Medicine.

Orthobiologics continue to be one of the most discussed and trending topics in orthopaedic surgery today. Pathology of tendons, ligaments, bone, cartilage, and meniscal tissue are all theoretically treatable with biologics. Ultimately, the hope for biologics is to provide symptom relief and improve tissue healing with the potential to treat some conditions without the need for surgery. It is important to review the current state of biologic therapies available for musculoskeletal disease, discuss government...

Blocking HbS Polymerization in SCD.

Sickle cell disease (SCD) is caused by a point mutation in the β-globin gene that creates hemoglobin S (HbS). Upon deoxygenation, HbS forms long polymers that distort the shape of red blood cells, causing hemolysis and vaso-occlusion. Voxelotor inhibits HbS polymerization, the root cause of SCD complications. To view this Bench to Bedside, open or download the PDF.

Cancer biologics made in plants.

Plants are routinely utilized as efficient production platforms for the development of anti-cancer biologics leading to novel anti-cancer vaccines, immunotherapies, and drug-delivery modalities. Various biosimilar/biobetter antibodies and immunogens based on tumor-associated antigens have been produced and optimized for plant expression. Plant virus nanoparticles, including those derived from cowpea mosaic virus or tobacco mosaic virus in particular have shown promise as immunotherapies stimulating tumor-as...

Validity and Reliability of the Isometric Prone Bench Pull Test.

Isometric strength tests are gaining popularity in recent years. However, no study has validated any isometric strength tests to assess upper body pulling ability. The aim of this study was to investigate the validity and reliability of isometric prone bench pull. Twenty-three resistance trained athletes (age: 26±4 years, height: 1.75±0.07 m, body mass: 78.6±11.5 kg) were required to perform prone bench pull 1 repetition maximum and isometric prone bench pull tests during the familiarization and actu...

Balancing benefits and risks in the era of biologics.

Biologics are substances synthetized from biological sources used in the prevention and treatment of several diseases. Rheumatologists have many years of experience with biologics for the treatment of immune-mediated diseases and osteoporosis. Randomized clinical trials and postmarketing studies have demonstrated that treatment with biologics can result, albeit infrequently, in serious adverse events. To date, several risk mitigation strategies have been identified and implemented. The objective of the pres...

Siponimod Chips Away at Progressive MS.

Progressive multiple sclerosis (PMS) causes slow accumulation of neurologic disability and has been refractory to treatment with the immunomodulatory medications that effectively control relapsing MS. Siponimod modestly slowed the rate of disability progression among PMS patients who had inflammatory disease activity, evidenced by new or gadolinium-enhancing MRI lesions. To view this Bench to Bedside, open or download the PDF.

On a journey to excellence.

, Chief Nurse, Oxford University Hospitals, describes a global programme to promote a nursing excellence framework to create a positive working environment for nurses.

The pharmacotherapeutic management of pediatric Crohn's disease.

: Crohn's disease (CD) is a chronic inflammatory condition that can occur throughout the gastrointestinal tract. The aims of treatment of children with CD are to induce and maintain clinical remission of disease, optimize nutrition and growth, minimize adverse effects of therapies, and if possible, achieve mucosal healing. : This review summarizes evidence for the various therapeutic options in the treatment of children with CD. Exclusive enteral nutrition, corticosteroids, and biologics may be used for ind...


The articles appearing in this issue, authored by physicians from the 7 dermatology departments in Israel, reflect the evolution of the field of dermatology in recent years, from a mainly descriptive and quite narrow specialty with a relatively limited treatment arsenal to a multidimensional discipline encompassing a wide range of subspecialties. The accompanying advances in intense translational research have led to important breakthroughs in our understanding of the pathogenesis of skin diseases and the d...

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