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PubMed Journals Articles About "Optimal Timing For Performing Loop Electrosurgical Excision Procedure" RSS

08:58 EDT 18th July 2019 | BioPortfolio

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Showing "Optimal Timing Performing Loop Electrosurgical Excision Procedure" PubMed Articles 1–25 of 9,900+

Effects of Co-Administration of Bone Marrow Stromal Cells and L-Carnitine on The Recovery of Damaged Ovaries by Performing Chemotherapy Model in Rat.

L-carnitine (Lc) as a type of flavonoid antioxidants and bone marrow stromal cells (BMSCs) as a type of mesenchymal stem cells may recover damaged ovaries. It seems that Lc has favorable effects on differentiation, increasing lifespan and decreasing apoptosis in BMSCs. The aim of this study was to investigate effects of co-administration of BMSC+Lc on damaged ovaries after creating a chemotherapy model with cyclophosphamide in rats.


Efficacy of Intraoperative Mitomycin-C in Vasovasostomy Procedure: A Randomized Clinical Trial.

Two-six percentage of vasectomized men will ultimately seek vasectomy reversal, which late stricture and obstruction after operation are relatively common. To find a method for improving vasovasostomy outcomes, we used intra-operative local mitomycin-C (MMC) preventing possible fibrosis and stricture.

Efficacy of Ultra-Early (<12 hours), Early (12-24 hours), and Late (>24-138.5 hours) Surgery with MRI-Confirmed Decompression in AIS grades A, B, and C Cervical Spinal Cord Injury.

In cervical traumatic spinal cord injury (TSCI), the therapeutic effect of timing of surgery on neurological recovery remains uncertain. Additionally, the relationship between extent of decompression, imaging biomarker evidence of injury severity, and outcome is incompletely understood. We investigated the effect of timing of decompression on long-term neurological outcome in patients with complete spinal cord decompression confirmed on postoperative MRI. AIS grade conversion was determined in 72 AIS grades...


Percutaneous Image-Guided Cryoablation of Osteoblastoma.

The aim of this observational study was to assess safety and clinical outcomes of percutaneous image-guided cryoablation (CA) to treat osteoblastomas (OBs) at various osseous sites. A retrospective search was performed to identify patients presenting with painful OBs who underwent CA at the University Hospitals of Strasbourg between March 2007 and December 2018. Ten patients (seven men, three women; median age, 21 years old) were identified and included. Medical records were reviewed to assess complication...

Distinct roles of striatal direct and indirect pathways in value-based decision making.

The striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct- and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a...

A La-doped ZnO ultra-flexible flutter-piezoelectric nanogenerator for energy harvesting and sensing applications: a novel renewable source of energy.

Zinc oxide nanorods synthesized via a wet chemical approach were used to fabricate an ultra-flexible flutter-piezoelectric nanogenerator (UF-PENG). The UF-PENG has demonstrated good capabilities to act as not only an energy generator but also a wind velocity/direction sensor. Using the same procedure, the ZnO nanorods have been doped with lanthanum, and the doped device was found to exhibit three times the output of intrinsic PENG. Furthermore, through the process of annealing, the output of the PENG was en...

The prevalence of tattooing and motivations in five major countries over the World.

Tattoos are common in Western countries [1, 2]. There is a growing interest in tattoos in other parts of the globe such as Latin America [3] but overall data are scarce. We report an international online survey among a representative sample of the general population from five major countries (Brazil 209 million inhabitants, China 1 386 million, France 67 million, Russia 144 million and United-States, USA, 325 million) [4]. The data collection procedure was identical to previous studies [1,5,6] and has been...

A multistate model for early decision-making in oncology.

The development of oncology drugs progresses through multiple phases, where after each phase, a decision is made about whether to move a molecule forward. Early phase efficacy decisions are often made on the basis of single-arm studies based on a set of rules to define whether the tumor improves ("responds"), remains stable, or progresses (response evaluation criteria in solid tumors [RECIST]). These decision rules are implicitly assuming some form of surrogacy between tumor response and long-term endpoints...

Codon usage of human hepatitis C virus clearance genes in relation to its expression.

Hepatitis C virus (HCV) infection is among the leading causes of hepatocellular carcinoma and liver cirrhosis globally, with a high economic burden. The disease progression is well established, but less is known about the spontaneous HCV infection clearance. This study tries to establish the relationship between codon biasness and expression of HCV clearance candidate genes in normal and HCV infected liver tissues. A total of 112 coding sequences comprising 151 679 codons were subjected to the computation...

TEMPRANILLO is a direct repressor of the microRNA miR172.

In the age-dependent pathway, the microRNA 156 (miR156) is essential for the correct timing of developmental transitions. MiR156 negatively regulates several SPL genes, which promote the juvenile-to-adult and floral transitions in part through up-regulation of miR172. The transcriptional repressors TEMPRANILLO1 (TEM1) and TEM2 delay flowering in Arabidopsis thaliana at least through direct repression of FLOWERING LOCUS T (FT) and gibberellins biosynthetic genes, and have also been reported to participate in...

His bundle pacing, learning curve, procedure characteristics, safety and feasibility: insights from a large international observational study.

His-bundle pacing (HBP) provides physiological ventricular activation. Observational studies have demonstrated the techniques feasibility however, data has come from a limited number of centres.

Acute Kidney Injury after Cardiac Surgery: Risk Factors and Novel Biomarkers.

Acute kidney injury (AKI) is a common and severe complication after cardiac surgery. Currently, a series of novel biomarkers have favored the assessment of AKI after cardiac surgery in addition to the conventional indicators. The biomartkers, such as urinary liver fatty acid binding protein (L-FABP), urinary neutrophil gelatinase-associated lipocalin (NGAL), serum L-FABP, heart-type FABP, kidney injury molecule 1 (KIM-1), and interleukin-18 were found to be significantly higher in patients who developed AKI...

Prosthesis-Patient Mismatch after Surgical Aortic Valve Replacement: Neither Uncommon nor Harmless.

Prosthesis-patient mismatch (PPM) after surgical aortic valve replacement (SAVR) is an issue that has been overlooked (not to say neglected). Cardiac surgeons must bear in mind that this is a real problem that we must tackle. The purpose of this paper is to be a wake-up call to the surgical community by giving a brief overview of what PPM is, its incidence and impact on the outcomes. We also discuss the increasing role played by imaging for predicting and assessing PPM after SAVR (with which surgeons must b...

The global repair profile of human alkyladenine DNA glycosylase on nucleosomes reveals DNA packaging effects.

Alkyladenine DNA glycosylase (AAG) is the only known human glycosylase capable of excising alkylated purines from DNA, including the highly mutagenic 1,N6-ethenoadenine (εA) lesion. Here we examine AAG's ability to excise εA from a nucleosome core particle (NCP), which is the primary repeating unit of DNA packaging in eukaryotes. Using chemical synthesis techniques, we assembled a global population of NCPs in which A is replaced with εA. While each NCP contains no more than one εA lesion, the total popu...

Sequencing of Sulfopeptides Using Negative-Ion Tandem Mass Spectrometry with Hydrogen Attachment/Abstraction Dissociation.

Tandem mass spectrometry (MS/MS) with radical-based fragmentation involving the attachment or abstraction of hydrogen to peptides, in a process called hydrogen attachment/abstraction dissociation (HAD), has been recently developed. HAD-MS/MS is considered a useful method for the analysis of proteins with post-translational modification (PTM) because of its ability to determine the PTM site on proteins. In the present investigation, we analyzed highly acidic sulfopeptides and sulfoprotein digests using negat...

Structural and Spectroscopic Investigation of Novel 2D and 3D Uranium Oxo-Silicates/Germanates and Some Statistical Aspects of Uranyl Coordination in Oxo-Salts.

Synthesis, structural and spectroscopic characterization, and topological analysis of five novel uranyl-based silicates and germanates have been performed. The open-framework K(UO)SiO·4HO has been synthesized under hydrothermal conditions and is based upon [USi] heptamers interconnected via edge-sharing. Its structure is composed of sechser silicate layers with 4-, 8-, and 16-membered rings. The largest 16-membered rings have an average dimension of ∼8.93 × 9.42 Å. β-K(UO)SiO has been obtained by the ...

A Supramolecular Strategy for Selective Catalytic Hydrogenation Independent of Remote Chain Length.

Performing selective transformations on complex substrates remains a challenge in synthetic chemistry. These difficulties often arise due to cross-reactivity, particularly in the presence of similar functional groups at multiple sites. Therefore, there is a premium on the ability to perform selective activation of these functional groups. We report here a supramolecular strategy where encapsulation of a hydrogenation catalyst enables selective olefin hydrogenation, even in the presence of multiple sites of ...

Design of bile-based vesicles (BBVs) for hepatocytes specific delivery of Daclatasvir: Comparison of ex-vivo transenterocytic transport, in-vitro protein adsorption resistance and HepG2 cellular uptake of charged and β-sitosterol decorated vesicles.

Daclatasvir is a new direct acting antiviral used in treatment of Hepatitis C virus, in an attempt to increase its hepatocytes specificity and uptake. It was encapsulated within bile based vesicles (BBVs) containing egg phosphatidyl choline, cholesterol and sodium deoxycholate fabricated by thin-film hydration method. A D-optimal mixture design was applied to study the effect of formulation variables on vesicular characteristics. The dependent variables picked were the particle size, polydispersity index, z...

Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks.

Once biological systems are modeled by regulatory networks, the next step is to include external stimuli, which model the experimental possibilities to affect the activity level of certain network's nodes, in a mathematical framework. Then, this framework can be interpreted as a mathematical optimal control framework such that optimization algorithms can be used to determine external stimuli which cause a desired switch from an initial state of the network to another final state. These external stimuli are ...

Crossover Dynamics of Culex (Diptera: Culicidae) Vector Populations Determine WNV Transmission Intensity.

First introduced into the United States in 1999, West Nile virus (WNV) has become endemic and has established itself as the predominant mosquito-borne arbovirus in North America. Transmitted by mosquitoes of the genus Culex, regional landscapes influence local vector species abundance, creating different mosquito ecologies that drive local transmission dynamics. In central Iowa, two mosquito species, Culex restuans Theobald and Culex pipiens Linnaeus, serve as the predominant mosquito vectors. Importantly, ...

When the "selfish herd" becomes the "frozen herd": spatial dynamics and population persistence in a colonial seabird.

Aggregations are common in ecological systems at a range of scales and may be driven by exogenous constraints such as environmental heterogeneity and resource availability or by 'self-organizing' interactions among individuals. One mechanism leading to self-organized animal aggregations is captured by Hamilton's 'selfish herd' hypothesis, which suggests that aggregations may be driven by an individual's effort to minimize their risk of predation by surrounding themselves with conspecifics. We demonstrate th...

Engineering Pore Size of Pillared-Layer Coordination Polymers Enables Highly Efficient Adsorption Separation of Acetylene from Ethylene.

The pore size of adsorbents plays a vital role in determining the overall adsorption separation performance of gas mixtur¬es. In this work, the pore apertures of coordination pillared-layer (CPL) was systematically controlled by adjusting the length of pillared ligands. We used pyrazine, 4, 4'-bipyridine and 1,2-di-(4-pyridil)-ethylene with increased length to synthesize CPL-1(L= pyrazine), CPL-2(L= 4, 4'-bipyridine), and CPL-5[L=1, 2-di-(4-pyridil)-ethylene], respectively. The aperture size of these CPLs ...

Do women's faces become more attractive near ovulation?

There have been mixed findings regarding whether raters judge women's natural faces more attractive when the women were photographed near ovulation relative to when photographed in other cycle regions. Bobst and Lobmaier (2012) isolated shape cues associated with ovulatory timing via computer morphing techniques and found that men judged face shapes characteristic of the fertile window as more attractive than those characteristic of the luteal phase. Here, we tested replication of their findings but also ad...

Intravenous administration of ghrelin increases serum cortisol and aldosterone concentrations in heavy-drinking alcohol-dependent individuals: Results from a double-blind, placebo-controlled human laboratory study.

Increasing evidence supports the role of appetite-regulating hormones, including ghrelin, in alcohol use disorder (AUD). Effects of ghrelin administration on cortisol and aldosterone, two hormones known to influence the development and maintenance of AUD, have been observed in ghrelin-exposed tissues or cells, as well as rodents and healthy volunteers, however whether these effects replicate in individuals with AUD is unknown. Here, we tested the hypothesis that intravenous administration of ghrelin leads t...

Early prediction of cardiovascular risk post hematopoietic cell transplantation: are we there yet?

Cardiovascular (CV) events have emerged as a major cause of morbidity and mortality among hematopoietic cell transplantation (HCT) survivors Accumulating evidence supports the presence of increased CV risk in HCT recipients. The majority of studies have focused mainly on traditional CV risk factors, such as the metabolic syndrome and hypertension. However, detection of these factors suggests the development of irreversible overt clinical atherosclerosis. Therefore, earlier prediction of CV risk is needed in...


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