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PubMed Journals Articles About "PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=DESC" RSS

19:08 EDT 19th July 2019 | BioPortfolio

PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=DESC PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest PARP Inhibition Appears Promising CRPC Questions Remain∨derfield=score∨derval=DESC articles that have been published worldwide.

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Showing "PARP Inhibition Appears Promising CRPC Questions Remain derfield" PubMed Articles 1–25 of 18,000+

Rice Black-Streaked Dwarf Virus encoded P5-1 Regulates the Ubiquitination Activity of SCF E3 Ligases and Inhibits Jasmonate Signaling to Benefit Its Infection in Rice.

SCF (Skp1/Cullin1/F-box) complexes, are key regulators of many cellular processes. Virus encodes specific factor(s) to interfere or hijack these complexes to ensure its infection in plants. The molecular mechanism(s) controlling this interference or hijack are currently largely unknown. Here, we present evidence to show a novel strategy used by Rice black-streaked dwarf virus (RBSDV) to regulate ubiquitination in rice through interfering the activity of OsCSN5A. Furthermore, we have also demonstrated that R...


Critical Time, Space, and Decision-Making Agent Considerations in Human-Centered Interdisciplinary Hurricane-Related Research.

In hazard and disaster contexts, human-centered approaches are promising for interdisciplinary research since humans and communities feature prominently in many definitions of disaster and the built environment is designed and constructed by humans to serve their needs. With a human-centered approach, the decision-making agent becomes a critical consideration. This article discusses and illustrates the need for alignment of decision-making agents, time, and space for interdisciplinary research on hurricanes...

Postnatal human enteric neurospheres show a remarkable molecular complexity.

The enteric nervous system (ENS), a complex network of neurons and glial cells, coordinates major gastrointestinal functions. Impaired development or secondary aberrations cause severe enteric neuropathies. Neural crest-derived stem cells as well as enteric neuronal progenitor cells, which form enteric neurospheres, represent a promising tool to unravel molecular pathomechanisms and to develop novel therapy options. However, so far little is known about the detailed cellular composition and the proportional...


Isomer Effects of Fullerene Derivatives on Organic Photovoltaics and Perovskite Solar Cells.

Solar energy conversion is one of the most important issues for creating and maintaining a future sustainable society. In this regard, photovoltaic technologies have attracted much attention because of their potential to solve energy and environmental issues. In particular, thin-film solar cells, such as organic photovoltaics (OPVs) and perovskite solar cells (PSCs), are highly promising owing to their flexibility, light weight, and low-cost production. One of the most important factors used to evaluate sol...

High-Modulus Hexagonal Boron Nitride Nanoplatelet Gel Electrolytes for Solid-State Rechargeable Lithium-Ion Batteries.

Solid-state electrolytes based on ionic liquids and a gelling matrix are promising for rechargeable lithium-ion batteries due to their safety under diverse operating conditions, favorable electrochemical and thermal properties, and wide processing compatibility. However, gel electrolytes also suffer from low mechanical moduli, which imply poor structural integrity and thus an enhanced probability of electrical shorting, particularly under conditions that are favorable for lithium dendrite growth. Here, we r...

Toward stable electrode/electrolyte interphase of P2-layered oxide for rechargeable Na-ion batteries.

The electrochemical properties of P2- NaMnFeTiO layered oxide, which is a promising cathode material for rechargeable Na-ion batteries (NIBs), are evaluated with with an optimized in-house ionic liquid (IL)-based electrolyte and compared with its performance when using carbonate-based electrolyte. The IL-based system reveals better electrochemical performance at room temperature than the carbonate electrolyte-based one at 0.1C and 1C, especially in terms of cycling stability, with a 97% capacity retention a...

Design Principles, Sensing Mechanisms, and Applications of Highly Specific Fluorescent Probes for HOCl/OCl.

Hypochlorous acid/hypochlorite (HOCl/OCl), one of the most important reactive oxygen species (ROS), plays vital roles in various physiological and pathological processes. At normal concentrations, OCl acts as part of an immune defense system by destroying invasive bacteria and pathogens. However, nonproperly located or excessive amounts of OCl are related to many diseases, including cancers. Thus, detection of OCl has great importance. Owing to their high sensitivities, selectivities, fast response times, t...

Incorporating 2-thiouracil into short dsRNA-binding PNAs for enhanced recognition of A-U pairs and for targeting a microRNA hairpin precursor.

Chemically-modified short Peptide Nucleic Acids (PNAs) recognize RNA duplexes at near physiological conditions by major-groove PNA·RNA-RNA triplex formation and show a great promise in developing RNA-targeting probes and therapeutics. Thymine (T) and uracil (U) are often incorporated into PNAs to recognize A-U pairs through major-groove T·A-U and U·A-U triple formation. Incorporation of a modified nucleobase, 2-thiouracil (s2U), into triplex-forming oligonucleotides (TFOs) stabilizes both DNA and RNA tri...

Metal-Organocatalyst for Detoxification of Phosphorothioate Pesticides: Demonstration of Acetylcholine Esterase Activity.

In recent years, transition metal complexes have been developed for catalytical degradation of a phosphate ester bond, particularly in RNA and DNA; however, less consideration has been given for development of complexes for the degradation of a phosphorothioate bond, as they are the foremost used pesticides in the environment and are toxic to human beings. In this context, we have developed copper complexes of benzimidazolium based ligands for catalytical degradation of a series of organophosphates (parathi...

Mechanism of single-stranded DNA activation of recombinase intein splicing.

Inteins, or intervening proteins, are mobile genetic elements translated within host polypeptides and removed through protein splicing. This auto-catalytic process breaks two peptide bonds and rejoins the flanking sequences, called N- and C-exteins, with the intein scarlessly escaping the host protein. Traditionally viewed as purely selfish genetic elements, recent work has demonstrated that the conditional protein splicing (CPS) of several naturally occurring inteins can be regulated by a variety of enviro...

Coordination of Eu(III) with 1,10-Phenanthroline-2,9-dicarboxamide Derivatives: A Combined Study by MS, TRLIF, and DFT.

Tetradentate 1,10-phenanthroline-2,9-dicarboxamide (PDAM) derivatives have been well documented as effective binding ligands toward MA(III) and Ln(III), while the structural analysis and species determination of the complexes are still limited. Herein, we report a combined study on the coordination of Eu(III) with PDAM derivatives using electrospray ionization mass spectrometry (ESI-MS), time-resolved laser-induced fluorescence (TRLIF), and density functional theory (DFT) calculations. PDAM derivatives here...

An Efficient Implementation of the Second-Order Quasidegenerate Perturbation Theory with Density-Fitting and Cholesky Decomposition Approximations: Is It Possible to Use Hartree-Fock Orbitals for a Multiconfigurational Perturbation Theory?

The high cost of common multireference second-order perturbation theory (MRPT2) methods compared with the single-reference variant (MP2) arises from the expensive complete active space self-consistent field (CASSCF) orbital optimization step. Furthermore, the use of conventional four-index electron repulsion integrals (ERIs) prevents their application to larger molecular systems due to expensive I/O procedures. To address these bottlenecks of the multiconfigurational second-order quasidegenerate perturbatio...

Car-Parrinello Monitor for more robust Born-Oppenheimer molecular dynamics.

Born-Oppenheimer molecular dynamics (BOMD) is a promising simulation method for exploring the possible reaction pathways of a chemical system, but one significant challenge is the increased difficulty of converging the self-consistent field (SCF) calculation that often accompanies the breaking and forming of chemical bonds. To address this challenge, we developed an enhancement to the BOMD simulation method called the Car-Parrinello monitor (CPMonitor) that uses Car-Parrinello molecular dynamics (CPMD) to r...

Feeling Your Neighbours Across the Walls: How Inter-Pore Ionic Interactions Affect the Capacitive Energy Storage.

The progress in low dimensional carbon materials intensified the research on supercapacitors with nanostructured/nanoporous electrodes. The theoretical and simulation work so far has focused on charging single nanopores or nanoporous networks, and the effects due to ionic interactions inside the pores, while the effect of \emph{inter-pore} ion-ion correlations received less attention. Herein, we study how the interactions between the ions in the neighbouring pores across the pore walls affect the capacitive...

Enhancing the efficacy of melanocortin 1 receptor-targeted radiotherapy by pharmacologically upregulating the receptor in metastatic melanoma.

Melanocortin 1 receptor (MC1R) is under investigation as a target for drug delivery for metastatic melanoma therapy and imaging. The purpose of this study was to determine the potential of using BRAF inhibitors (BRAF) and histone deacetylase inhibitors (HDAC) to enhance the delivery of MC1R-targeted radiolabeled peptide ([Pb]DOTA-MC1L) by pharmacologically upregulating MC1R expression in metastatic melanoma cells and tumors. MC1R expression was analyzed in de-identified melanoma biopsies by immunohistochemi...

A successful history: probiotics and their potential as antimicrobials.

: Probiotics are living, non-pathogenic microorganisms (bacteria) that enter through diet in the human body, live during their passage through the gastrointestinal (GI) tract and are beneficial to health. They have become popular in recent years as a way of improving human health through nutrition. This review aims to discuss the efficacy of probiotics for the supportive therapy of certain clinical conditions, especially infectious diseases, as reported in a number of studies, even though some concerns abou...

Tracking Public Health Workforce Retention: Observations From CDC's Public Health Associate Program.

To describe the career trajectories of 1 cohort of US Public Health Associate Program (PHAP) alumni over 3 years since completing PHAP. We distributed a Web-based survey at 3 time points between 2014 and 2017 (response rate = 76%). We calculated descriptive statistics in SPSS. At all time points, most alumni were employed. Of those, the percentage employed in public health was 100% at program completion, 86% at year 1, and 68% at year 3. Most alumni were employed in public health jobs at each time po...

Down-regulated RBM5 inhibits bladder cancer cell apoptosis by initiating an miR-432-5p/β-catenin feedback loop.

RNA-binding motif protein 5 (RBM5) acts as a tumor suppressor in various human cancers and presents with several important characteristics, such as the potentiation of apoptosis, inhibition of the cell cycle, and alternative splicing of Fas and caspase-2 precursor mRNA. However, its role in bladder urothelial carcinoma (BUC) remains unknown. In this study, we found that RBM5 expression was significantly down-regulated in BUC tissues when compared with the adjacent nontumor tissues. The down-regulation of RB...

Characterization of performance fatigability during a self-paced exercise.

Pacing during a high-intensity cycling time trial (TT) appears to prevent premature task failure, but the performance fatigability during a self-paced exercise is currently unknown. Therefore, the current study characterized the time-course of performance fatigability during a 4-km TT. Eleven male cyclists performed three separated TTs in a crossover counterbalanced design. The TTs lasted until the end of the fast-start (FS, 600 ± 205 m), even-pace (EP, 3600 ± 190 m) and end-spurt (ES, 4000 m) phases. Per...

Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.

Macroautophagy/autophagy is an essential cellular response in the fight against intracellular pathogens. Although some viruses can escape from or utilize autophagy to ensure their own replication, the responses of autophagy pathways to viral invasion remain poorly documented. Here, we show that peste des petits ruminants virus (PPRV) infection induces successive autophagic signalling in host cells via distinct and uncoupled molecular pathways. Immediately upon invasion, PPRV induced a first transient wave o...

Phase 3 DREAM-HF Trial of Mesenchymal Precursor Cells in Chronic Heart Failure.

Advanced heart failure (HF) is a progressive disease characterized by recurrent hospitalizations and high risk of mortality. Indeed, outcomes in late stages of HF approximate those seen in patients with various aggressive malignancies. Clinical trials assessing beneficial outcomes of new treatments in patients with cancer have used innovative approaches to measure impact on total disease burden or surrogates to assess treatment efficacy. Although most cardiovascular outcomes trials continue to use time-to-f...

Cysteine, glutathione and a new genetic code: biochemical adaptations of the primordial cells to spread into the open water and survive biospheric oxygenation.

Life likely developed under hyperthermic and anaerobic conditions in close vicinity to a stable geochemical source of energy. Epitomizing this conception, the first cells may have arisen in submarine hydrothermal vents in the middle of a gradient established by the hot and alkaline hydrothermal fluid and the cooler and more acidic water of the ocean. To enable their escape from this energy-providing gradient layer, the early cells must have overcome a whole series of obstacles. Beyond the loss of their ener...

Exosome-encapsulated microRNAs as promising biomarkers for Alzheimer's disease.

Alzheimer's disease (AD) is a chronic neurodegenerative disease that locks into long clinical latency and low curative ratio. Therefore, early diagnosis before the clinical phase is quite essential and may be effective for therapeutic prevention. Peripheral blood or cerebrospinal fluid biomarkers symbolizing functional neuronal impairment are gradually applied to diagnose AD in research studies. Exosomes have generated immense interest in the diagnosis field of neurodegenerative disorders after confirmation...

Graphdiyne doped with sp-hybridized nitrogen atoms at acetylenic sites as potential metal-free electrocatalysts for oxygen reduction reaction.

Exploring metal-free electrocatalysts with high efficiency and lower cost for oxygen reduction reaction (ORR) is necessary to realize the commercialization of fuel cells. In this paper, the ORR mechanisms on nitrogen-doped graphdiyne (GDY) are investigated using the first principles calculations. It is found that the GDY doped with sp-hybridized N at acetylenic sites can activate molecular oxygen (O2). The kinetically most favorable reaction pathway is O2→OOH→O+H2O→OH→H2O, which is an efficient four...

Prolonged activated partial thromboplastin time due to plasma prekallikrein deficiency: a case study and literature review on its clinical significance.

: Activated partial thromboplastin time is a test assessing the intrinsic and common pathways of the coagulation cascade. We presented an asymptomatic case with isolated activated partial thromboplastin time prolongation. After excluding coagulation factor deficiency and lupus anticoagulant, the patient was diagnosed with plasma prekallikrein (PPK) deficiency. We reviewed the literature regarding effects of PPK deficiency which could have both antithrombotic and prothrombotic effects. At the moment, researc...


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