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10:19 EDT 17th September 2019 | BioPortfolio

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Showing "Pathogens find safe harbor deep gastric glands" PubMed Articles 1–25 of 11,000+

A deep neural network improves endoscopic detection of early gastric cancer without blind spots.

 Gastric cancer is the third most lethal malignancy worldwide. A novel deep convolution neural network (DCNN) to perform visual tasks has been recently developed. The aim of this study was to build a system using the DCNN to detect early gastric cancer (EGC) without blind spots during esophagogastroduodenoscopy (EGD).

Outcomes of Endoscopic Submucosal Dissection for Intestinal-type Adenocarcinoma with Anastomosing Glands of the Stomach.

Gastric intestinal-type adenocarcinoma with anastomosing glands (IAAG) is characterized by architectural abnormality with frequent anastomosing glands and low-grade cytological atypia. Clinicopathologic features and long-term outcomes of endoscopic submucosal dissection (ESD) for IAAG remain unclear.

P2RX7 functions as a putative biomarker of gastric cancer and contributes to worse prognosis.

The mechanism of gastric cancer is highly complex, accompanied by a variety of genetic abnormalities. It is of great significance to elucidate the pathogenesis of gastric cancer, find its markers and therapeutic targets in the fight against this fatal disease. In this study, we identified P2RX7 as a putative target of gastric cancer, which was overexpressed in gastric cancer tissues and had relationship with worse prognosis. We also elucidated the roles of P2RX7 on the growth and metastasis of gastric cance...

Phenylephrine Alleviates I Radiation Damage in Submandibular Gland through Maintaining Mitochondrial Homeostasis.

The impairment of the salivary glands is a permanent side effect of I ablation therapy for patients with differentiated thyroid cancer (DTC). Effective and safe treatments for protecting the salivary glands against I are currently not available. Mitochondria are susceptible to ionizing radiation, but its alterations after I exposure are unknown. Here we investigated the mechanisms of I damage in submandibular glands (SMGs) and evaluated the cytoprotective effect of phenylephrine (PE) on the mitochondrial ra...

Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands.

Spasmolytic polypeptide-expressing metaplasia (SPEM) is present in more than 90% of resected gastric cancer tissues. However, although widely regarded as a pre-cancerous tissue, its genetic characteristics have not been well studied.

Ulcerative colitis associated with gastric heterotopia in the rectum: a case report.

Gastric heterotopia is defined as the presence of morphologically normal gastric tissue at a non-physiological site, coexisting with the original tissue. Although it is not uncommon to see it in the esophagus, duodenum or small intestine, it is exceptionally rare to discover gastric mucosa in the rectum. Here we report the case of a 46-year old male with a 10-year history of ulcerative colitis in whom the surveillance rectosigmoidoscopy detected a Mayo score of 1 for ulerative colitis activity and a middle ...

Appearances can be deceiving: A case of Intestinal Metaplasia and heterotopic gastric mucosa in colon.

An asymptomatic 60-year-old woman, without previous history of endoscopic examinations, underwent a screening colonoscopy. A 15-mm sessile polyp located in the hepatic flexure (Fig 1) was found and removed in block by endoscopic mucosal resection. Histological examination revealed a heterotopic gastric mucosa (HGM) with structures resembling pyloric glands and focal intestinal metaplasia (IM) (Fig 2A, 2B and 2C). Immunohistochemistry (IHC) showed positivity of pyloric glands for MUC5, MUC6 (Fig 2D) and CK7 ...

Downregulation of Notch Signaling in Kras-Induced Gastric Metaplasia.

Activating mutations and amplification of Kras and, more frequently, signatures for Kras activation are noted in stomach cancer. Expression of mutant Kras in the mouse gastric mucosa has been shown to induce hyperplasia and metaplasia. However, the mechanisms by which Kras activation leads to gastric metaplasia are not fully understood. Here we report that Kras;Pdx1-cre, a mouse model known for pancreatic cancer, also mediates Kras expression in the stomach, causing gastric hyperplasia and metaplasia prior ...

IRF-2 Inhibits Gastric Cancer Invasion and Migration by Down-Regulating MMP-1.

The interferon regulatory factor 2 (IRF-2) acted as a tumor suppressor. We inspected IRF-2 as a predictor of prognosis in gastric cancer (GC) patients and tried to find out the potential molecular mechanism.

A New Safe Harbor - Turning Drug Rebates into Discounts in Medicare Part D.

Cytological diagnosis of a rare case of alpha-fetoprotein producing gastric-type adenocarcinoma of the uterine cervix.

The fourth edition of the World Health Organization classification recently described two types of cervical adenocarcinoma: usual type and gastric type. These two sets differ with histology, immunostaining, HPV status, and prognosis. The tumor of a gastric-type cervical adenocarcinoma consists of mucinous epithelium invading the endocervical stroma in variably sized, simple, and often angulated cystic glands, with some solid areas and folded papillae. This article is protected by copyright. All rights reser...

MicroRNA expression profiling provides novel insights into immune-related pathways involved in gastric cancer.

Gastric cancer is one of the most common cancers, and an increasing number of studies have found that microRNAs (miRNAs) play essential roles in gastric cancer progression; however, the roles of specific miRNAs involved in the immune response to this disease remain unclear. We compared the miRNA expression in tissues from primary gastric cancer patients and healthy controls to find miRNAs dysregulated in gastric cancer and used bioinformatics tools to determine potential roles of these miRNAs in the immune ...

Efficiency of Laparoscopic One-Step Revision of Failed Adjusted Gastric Banding to Gastric Sleeve: a Retrospective Review of 101 Consecutive Patients.

Until recently, laparoscopic adjustable gastric banding (LAGB) was one of the most commonly performed bariatric surgeries worldwide. Today, its high rate of complications and failure rates up to 70% requires revisional surgery. The one-stage conversion from LAGB to laparoscopic sleeve gastrectomy (LSG) has been shown to be safe, although there are some concerns on efficacy and long-term weight loss.

-induced DNA Methylation as an Epigenetic Modulator of Gastric Cancer: Recent Outcomes and Future Direction.

Gastric cancer is ranked fifth in cancer list and has the third highest mortality rate. is a class I carcinogen and a predominant etiological factor of gastric cancer. infection may induce carcinogenesis via epigenetic alterations in the promoter region of various genes. is known to induce hypermethylation-silencing of several tumor suppressor genes in -infected cancerous and -infected non-cancerous gastric mucosae. This article presents a review of the published literature mainly from the last year 15 y...

Fantastic yeasts and where to find them: the hidden diversity of dimorphic fungal pathogens.

Dimorphic fungal pathogens are a significant cause of human disease worldwide. Notably, the dimorphic fungal pathogens within the order Onygenales are considered primary pathogens, causing disease in healthy hosts. Current changes in taxonomy are underway due to advances in molecular phylogenetics, population genetics, and new emerging dimorphic fungal pathogens causing human disease. In this review, we highlight evolutionary relationships of dimorphic fungal pathogens that cause human disease within the or...

Does Vibrissal Innervation Patterns and Investment Predict Hydrodynamic Trail Following Behavior of Harbor Seals (Phoca vitulina)?

Our understanding of vibrissal function in pinnipeds is poor due to the lack of comparative morphological, neurobiological, and psychophysical performance data. In contrast, the function of terrestrial mammalian vibrissae is better studied. Pinnipeds have the largest vibrissae of all mammals, and phocids may have the most modified vibrissae. The tactile performance for pinniped vibrissae is well known for harbor seals (Phoca vitulina). Harbor seals display at least two types of tactile behavior involving th...

The modification of ferroptosis and abnormal lipometabolism through overexpression and knockdown of potential prognostic biomarker perilipin2 in gastric carcinoma.

To investigate the biological relationship, mechanism between perilipin2 and the occurrence, advancement of gastric carcinoma, and explore the mechanism of lipid metabolism disorder leading to gastric neoplasm, and propose that perilipin2 is presumably considered as a potential molecular biomarker of gastric carcinoma.

Long-term oncologic outcomes of a randomized controlled trial comparing laparoscopic versus open gastrectomy with D2 lymph node dissection for advanced gastric cancer.

Laparoscopy-assisted gastrectomy is a feasible and safe procedure for treating advanced gastric cancer in terms of short-term outcomes. However, concern about long-term oncologic outcomes has limited the adoption of laparoscopy-assisted gastrectomy for advanced gastric cancer.

A Novel Gastric Spheroid Co-Culture Model Reveals Chemokine-Dependent Recruitment of Human Dendritic Cells to the Gastric Epithelium.

Gastric dendritic cells (DCs) control the adaptive response to infection with Helicobacter pylori, a major risk factor for peptic ulcer disease and gastric cancer. We hypothesize that DC interactions with the gastric epithelium position gastric DCs for uptake of luminal H. pylori and promote DC responses to epithelial-derived mediators. The aim of this study was to determine whether the gastric epithelium actively recruits DCs, using a novel co-culture model of human gastric epithelial spheroids and monocyt...

Proximal Gastric Resection with Posterior Esophago-Gastrostomy and Partial Neo-Fundoplication in the Treatment of Advanced Upper Gastric Carcinoma.

Proximal gastric resection (PGR) is rarely used in western countries because of frequent postoperative reflux and uncommon diagnosis of early gastric cancer (GC).

False Gastric Diverticulum Arising from the Pylorus Associated with Gastric Outlet Obstruction.

A gastric diverticulum is an outpouching from the stomach wall. It is usually seen in the posterior gastric wall and the gastric antrum. Diverticula arising from the pyloric region are extremely rare. A 59-year-old female presented with progressively worsening symptoms of gastric outlet obstruction associated with dyspepsia and vague abdominal pain for 5 years. A large, thin-walled, wide-mouthed, false gastric diverticulum (filled with undigested food) arising from the pylorus associated with gastric outlet...

Distributions and relationships of chemically defined enteroendocrine cells in the rat gastric mucosa.

This paper provides quantitative data on the distributions of enteroendocrine cells (EEC), defined by the hormones they contain, patterns of colocalisation between hormones and EEC relations to nerve fibres in the rat gastric mucosa. The rat stomach has three mucosal types: non-glandular stratified squamous epithelium of the fundus and esophageal groove, a region of oxyntic glands in the corpus, and pyloric glands of the antrum and pylorus. Ghrelin and histamine were both contained in closed cells, not cont...

RMDL: Recalibrated multi-instance deep learning for whole slide gastric image classification.

The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite challenging during the automatic diagnosis process. The multi-instance learning based on the most discriminative instances can be of great benefit for whole slide gastric image diagnosis. In this paper, we design a recalibrated multi-instance deep learning method (RMDL) to ad...

Concise Review: A critical evaluation of criteria used to define salivary gland stem cells.

In the effort to develop cell-based therapies to treat salivary gland dysfunction, many different populations of cells in the adult salivary glands have been proposed as stem cells. These cell populations vary, depending on the assay used, and are often non-overlapping, leading to the conclusion that salivary glands harbor multiple stem cells. The goal of this review is to critically appraise the assays and properties used to identify stem cells in the adult salivary gland, and to consider the caveats of ea...

Comparative study of the eyelids and orbital glands morphology in the okapi (Okapia johnstoni, Giraffidae), Père David's deer (Elaphurus davidianus, Cervidae) and the Philippine mouse-deer (Tragulus nigricans, Tragulidae).

The accessory organs of the eye represent part of the protective system of the eyeball. In the present study, an examination of the accessory organs of the eye of three species of captive ruminants was performed using light microscopy. In the okapi, the superficial gland of the third eyelid and lacrimal gland were complex branched multilobar tubular glands formed by mucous units with tubular secretory portions and no plasma cells. The deep gland of the third eyelid was absent in the okapi and present in bot...

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