PubMed Journals Articles About "Pfenex Alvogen Face Delay Teriparatide Equivalence Rating" RSS

16:37 EDT 15th September 2019 | BioPortfolio

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Showing "Pfenex Alvogen Face Delay Teriparatide Equivalence Rating" PubMed Articles 1–25 of 3,000+

Is Teriparatide Beneficial to Spinal Fusion Surgery in the Older Patient?: A Narrative Review.

Since FDA approval in 2002, teriparatide has gained popularity as an anabolic therapy for the treatment of osteoporosis. Animal studies have suggested a role for teriparatide in spine surgery. Several recent studies have demonstrated adjunctive use of teriparatide in osteoporotic patients undergoing spine fusions improves fusion rates, decreases time to union, and decreases osteoporosis-related complications such as proximal junctional kyphosis. On the basis of the available literature, we outline an algori...

Comparison of Teriparatide and Denosumab in Patients Switching from Long-Term Bisphosphonate Use.

Teriparatide and denosumab are effective treatments for osteoporosis and typically reserved as second-line options after patients have used bisphosphonates. However, limited head-to-head comparative effectiveness data exist between teriparatide and denosumab.

Memory across a short-delay: Systematic biases in memory for faces.

From geometric figures to human faces, many visual stimuli vary along a continuum in featural space, anchored at one end by a highly distinctive constellation of features, at the other by a neutral set. Here we used a continuum of morphed faces to test whether errors in visual short-term memory are symmetric in feature space around the target or systematically biased toward one or the other end of the continuum. Participants were shown a face for 1 s. After a brief delay, participants were asked to choose...

Successful treatment of pathologic femoral shaft fracture associated with large arteriovenous malformations using a 3-dimensional external fixator and teriparatide: a case report.

Arteriovenous malformations (AVMs) are rare congenital vascular lesions associated with early quiescence, late expansion, and, ultimately, infiltration and destruction of local soft tissue and bone. The extremities are a common location. Incidence of bony involvement by AVM has been reported as high as 31%. However, there are few reports on management of pathologic fracture associated with AVM. Teriparatide is a recombinant parathyroid hormone (PTH) analogue consisting of the 1-34 fragment of PTH. Recently,...

Standard vs Cyclic Teriparatide and Denosumab Treatment for Osteoporosis: A Randomized Trial.

In the absence of an intervening antiresorptive agent, cyclic administration of teriparatide does not increase BMD more than standard daily therapy. Since denosumab is a potent antiresorptive agent with a rapid off-effect, we hypothesized that it might be the optimal agent to help maximize bone gains with cyclic teriparatide. In this 3 year protocol, 70 postmenopausal women with osteoporosis were randomized to: 18 months teriparatide followed by 18 months denosumab (Standard) or 3 separate 12 month cycles o...

Teriparatide improves alveolar bone modelling after tooth extraction in orchiectomized rats.

The aim of this study was to evaluate bone metabolism in the alveolar repair process in orchiectomized male rats treated with teriparatide.

Are kin and group selection rivals or friends?

Kin selection and group selection were once seen as competing explanatory hypotheses but now tend to be seen as equivalent ways of describing the same basic idea. Yet this 'equivalence thesis' seems not to have brought proponents of kin selection and group selection any closer together. This may be because the equivalence thesis merely shows the equivalence of two statistical formalisms without saying anything about causality. W.D. Hamilton was the first to derive an equivalence result of this type. Yet Ham...

Content and Face Validity of the Mackey Childbirth Satisfaction Rating Scale Questionnaire Cross-culturally Adapted to Brazilian Portuguese.

 The aim of this study was to determine the content and face validity of the Mackey Childbirth Satisfaction Rating Scale (MCSRS) questionnaire cross-culturally adapted to Brazilian Portuguese.

Air blast TNT equivalence factors of high explosive material PETN for bare charges.

The concept of TNT equivalence is often invoked to predict the blast parameters generated from explosions, in which high explosives other than Trinitrotoluene (TNT) are used. This paper discusses the TNT equivalence concept for bare charges using Pentaerythritol tetranitrate (PETN). At first, a review of different methods to derive TNT equivalence factors is given. After that, numerical simulations are conducted in order to obtain overpressure and impulse data, which is fitted by using the curve-fitting met...

Hunger increases delay discounting of food and non-food rewards.

How do our valuation systems change to homeostatically correct undesirable psychological or physiological states, such as those caused by hunger? There is evidence that hunger increases discounting for food rewards, biasing choices towards smaller but sooner food reward over larger but later reward. However, it is not understood how hunger modulates delay discounting for non-food items. We outline and quantitatively evaluate six possible models of how our valuation systems modulate discounting of various co...

Image Gallery: Segmental neurofibromatosis type 1 on the face. A 30-year delay in diagnosis.

How would patients with psychosis like to be in contact with a volunteer: Face-to-face or digitally?

Volunteer befriending can be used to address social isolation in patients with psychosis. Traditionally this involves face-to-face encounters between a volunteer and a patient, but modern digital technology also makes it possible to have these interactions remotely. This study aimed to explore the views and interests of patients with psychosis about different formats of volunteering, face-to-face or digitally.

Is your own face more than a highly familiar face?

This study aimed to elucidate whether distinct early processes underlie the perception of our own face. Alternatively, self-face perception might rely on the same processes that realize the perception of highly familiar faces. To this end, we recorded EEG activity while participants performed a facial recognition task in which they had to discriminate between their own face, a friend's face, and an unknown face. We analyzed the event-related potentials (ERPs) to characterize the time course of neural proces...

Equivalence limit scaled differences for untargeted safety assessments: Comparative analyses to guard against unintended effects on the environment or human health of genetically modified maize.

Safety assessments guard against unintended effects for human health and the environment. When new products are compared with accepted reference products by broad arrays of measurements, statistical analyses are usually summarised by significance tests or confidence intervals per endpoint. The traditional approach is to test for statistical significance of differences. However, absence or presence of significant differences is not a statement about safety. Equivalence limits are essential for safety assessm...

Safety Profiles, Pharmacokinetics, and Changes in Bone Turnover Markers After Twice-Weekly Subcutaneous Administration of Teriparatide in Healthy Japanese Postmenopausal Women: A Single-Blind Randomized Study.

Once-weekly injection of 56.5-μg teriparatide formulation is a potent therapeutic agent for osteoporosis treatment. However, this treatment has an issue of difficulty in continuing the treatment by its adverse side effects including nausea, vomiting, and headaches. To reduce these adverse side effects, we conducted a randomized, single-blind, placebo-controlled study to examine the pharmacokinetics, changes in bone turnover markers, and safety profiles of twice-weekly 28.2-μg teriparatide injections. Diff...

Patients' perspectives on acromegaly diagnostic delay: a qualitative study.

Context Acromegaly has a substantial diagnostic delay associated with an increased risk of comorbidities and psychosocial deterioration. Qualitative methods which focus on the ways that individuals understand and relate to what they are experiencing, are the best methods for exploring patients' perspectives. To the best of our knowledge, they have not been developed in the context of acromegaly. Objectives This study aimed to explore the experience of the diagnostic pathway of patients with acromegaly. Desi...

A retrospective bicenter comparative study of surgical outcomes of atypical femoral fracture: Potential effect of teriparatide on fracture healing and callus formation.

The main purpose of the present study was to assess the radiologic effect of teriparatide on fracture healing, including union rate, union time, and callus formation, by quantitative measurements using serial follow-up X-ray imaging examinations in patients with complete atypical femoral fractures (AFFs) treated using closed intramedullary nailing.

Sampled-data control for linear time-delay distributed parameter systems.

Some real systems have spatiotemporal dynamics and are time-delay distributed parameter systems (DPSs). The existence of time-delay may lead to system instability. The analysis and design of DPSs with time-delay is essentially more complicated. To take into account the factor of time-delay and fully enjoy the benefits of the digital technology in control engineering, it is a theoretical and practical value to consider the sampled-data control (SDC) problem of DPSs with time-delay. However, there are few att...

Comparative Effectiveness Study of Face-to-Face and Teledermatology Workflows for Diagnosing Skin Cancer.

The effectiveness and value of teledermatology and face-to-face workflows for diagnosing lesions are not adequately understood.

Therapeutic equivalence evaluated by in vitro studies of multisource pharmaceutical products: case studies of amoxicillin, doxycycline and fluconazole in Lima, Peru.

The objective of the study was to determine the therapeutic equivalence evaluated through in vitro studies of four brands of drugs containing amoxicillin, doxycycline, and fluconazole purchased at pharmaceutical facilities in Metropolitan Lima, and to establish their interchangeability with a reference product (RP). A validated method of visible ultraviolet spectrophotometry was used to determine the dissolution profile. The similarity factor (f2) was used to establish the therapeutic equivalence, being con...

A nutraceutical composition containing diosmin and hesperidin has osteogenic and anti-resorptive effects and expands the anabolic window of teriparatide.

A combination of diosmin and hesperidin (9:1 ratio) is marketed as a dietary supplement/nutraceutical for cardiovascular health. We studied the skeletal effect of this combination (90% diosmin and 10% hesperidin, henceforth named as DH). We showed that a) in rats with femur osteotomy, DH stimulated callus bone regeneration, b) in growing rats, DH promoted peak bone mass achievement and c) in OVX rats rendered osteopenic, DH completely restored femur trabecular bones and strength along with the increases in ...

Associations of Device-Measured Sitting, Standing, and Stepping Time with Informal Face-to-Face Interactions at Work.

This cross-sectional study examined the interrelationships between workplace movement (sitting, standing, and stepping), availability of discussion space, and face-to-face (FTF) interactions between workers.

Automatically computed rating scales from MRI for patients with cognitive disorders.

The aims of this study were to examine whether visual MRI rating scales used in diagnostics of cognitive disorders can be estimated computationally and to compare the visual rating scales with their computed counterparts in differential diagnostics.

Efficacy and safety of abaloparatide for the treatment of post-menopausal osteoporosis.

Osteoporosis is a skeletal disorder characterized by loss of bone mass and strength affecting up to 30-50% of postmenopausal women worldwide. Current therapeutic options include antiresorptives such as aminobisphosphonates or denosumab and osteoanabolic compounds such as teriparatide. Areas covered: In this review, the authors summarize the clinical development, safety and efficacy profile of abaloparatide, a new osteoanabolic agent recently marketed in the US for the treatment of postmenopausal osteoporosi...

Cost-related delay in filling prescriptions and health care ratings among medicare advantage recipients.

Despite higher health care needs, older adults often have limited and fixed income. Approximately a quarter of them report not filling or delaying prescription medications due to cost (cost-related prescription delay, CRPD). To ascertain the association between CRPD and satisfaction with health care, secondary analysis of the 2012 Consumer Assessment of Healthcare Providers and Systems (CAHPS) Medicare Advantage Survey was performed.Regression models quantified the association between CRPD and rating of per...

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