PubMed Journals Articles About "Phase 1 Study Of HBN-1" RSS

17:28 EST 25th January 2020 | BioPortfolio

Phase 1 Study Of HBN-1 PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Phase 1 Study Of HBN-1 articles that have been published worldwide.

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Showing "Phase Study" PubMed Articles 1–25 of 64,000+

Accurate phase-shift estimation for fringe-pattern profilometry.

Fringe-pattern profilometry (FPP) has been widely used for phase reconstruction. It involves the use of phase shifting for phase retrieval. Phase-shift errors can affect the accuracy of phase reconstruction, and limited studies have been dedicated to studying phase-shift errors due to experimental, human, or environmental factors. We propose a simple and yet accurate phase-shift estimation method. Our study shows that the method is able to accurately estimate the actual phase shifts used in the FPP techniqu...

Euclidean matrix norm algorithm for simultaneous dual-wavelength phase-shifting interferometry with blind phase shifts.

In this study, a simultaneous dual-wavelength phase-shifting interferometry system using two reference arms was built, and a simple phase retrieval method for the system with blind phase shifts was proposed using five phase-shifted interferograms. First, the unknown phase shifts were controlled independently to separate the information of single wavelength, which can be calculated directly by using the Euclidean matrix norm algorithm. Second, a wrapped phase of a single wavelength was obtained using a three...

Improvements of phase linearity and phase flicker of phase-only LCoS devices for holographic applications.

Significant phase distortion corrections were achieved by optimizing the digital driving patterns of phase-only liquid crystal on silicon devices for digital holographic applications. Nearly perfect phase linearity and phase flicker of 0.09% over 256 addressed phase levels in respect to the total modulation range of 2 were realized, enabling a meaningful increase of phase levels from 8 bits (256 levels) to 9 bits (512 levels). Tests were carried out to evaluate the qualities of optically reconstructed holog...

Efficacy and Safety of OTX-101, a Novel Nanomicellar Formulation of Cyclosporine A, for the Treatment of Keratoconjunctivitis Sicca: Pooled Analysis of a Phase 2b/3 and Phase 3 Study.

OTX-101 (CEQUA™) is approved in the United States for treatment of keratoconjunctivitis sicca (KCS). This pooled analysis of 2 studies (phase 2b/3 and phase 3) evaluates the efficacy and safety of OTX-101 0.09% in the intent-to-treat (ITT) population and the subgroup of patients with a baseline Schirmer score less than 10 mm.

Phase Transition and Superconductivity Enhancement in Se-Substituted MoTe Thin Films.

Consecutively tailoring few-layer transition metal dichalcogenides MX from 2H to T phase may realize the long-sought topological superconductivity in a single material system by incorporating superconductivity and the quantum spin Hall effect together. Here, this study demonstrates that a consecutive structural phase transition from T to 1T' to 2H polytype can be realized by increasing the Se concentration in Se-substituted MoTe thin films. More importantly, the Se-substitution is found to dramatically enha...

Clinical importance of cold polypectomy during the insertion phase in the left side of the colon and rectum: a multicenter randomized controlled trial (PRESECT STUDY).

Colorectal polyps are often detected during insertion phase of colonoscopy, but they are commonly removed during withdrawal phase. We aimed to investigate the clinical advantages of instant removal of colorectal polyps during insertion phase to determine the appropriate strategy for polyps detected upon insertion.

Stereotactic body radiation therapy to the prostate bed: results of a phase I dose escalation trial.

The primary objectives of this study were to evaluate toxicity of escalating doses of prostate bed SBRT and provide dose recommendations for phase II study.

Randomized phase II study of chemoradiotherapy with cisplatin + S-1 versus cisplatin + pemetrexed for locally advanced non-squamous non-small cell lung cancer: SPECTRA study.

SPECTRA is a multicenter, randomized phase II study of chemotherapy with cisplatin (CDDP) plus S-1 versus CDDP plus pemetrexed (PEM) in combination with thoracic radiotherapy (TRT) for locally advanced non-squamous non-small cell lung cancer, in order to determine which of these two regimens might be preferable for comparison with standard therapies in a future phase III study.

Nutrient Behavior in Hydrothermal Carbonization Aqueous Phase following Recirculation and Reuse.

Hydrothermal carbonization (HTC) has received much attention in recent years as a process to convert wet organic waste into carbon-rich hydrochar. The process also generates an aqueous phase that is still largely considered a burden. The success of HTC is dependent on finding solutions for the aqueous phase. In the present study, we provide the first investigation of recirculation of the aqueous phase from HTC of poultry litter as a means to concentrate nutrients, and its subsequent application to agricultu...

Quantitative investigation on morphology and intracellular transport dynamics of migrating cells.

In this paper, we present a phase correlation imaging technique employing quantitative phase microscopy to study the migration properties of living cells. The phase correlation map relies on time-lapse quantitative phase stacks, which are achieved by single-shot quantitative phase imaging based on the transport of intensity equation. The phase correlation imaging maps can reveal tiny fluctuations in cellular optical path length and dynamic subdomains in living cells. We find that the morphology dynamics and...

Optimal processing scheme for restoration of phase data corrupted by strong decorrelation noise and dislocations.

The presence of speckle noise and dislocations makes phase restoration potentially difficult in quantitative phase imaging and metrology. Unfortunately, there is no appropriate approach to deal with phase data corrupted by high speckle noise and phase dislocations. Usually, processing schemes may deal with low-pass phase filtering, phase unwrapping, or phase inpainting. This paper discusses the efficient processing to deal with noisy phase maps corrupted with phase dislocations. Six processing schemes, comb...

Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis.

Interleukin 23 (IL23) contributes to pathogenesis of ulcerative colitis (UC). We investigated the effects of mirikizumab, a monoclonal antibody against the p19 subunit of IL23, in a phase 2 study of patients with UC.

Phase II study of CC-486 (oral azacitidine) in previously treated patients with locally advanced or metastatic nasopharyngeal carcinoma.

Treatment options are limited for recurrent nasopharyngeal carcinoma (NPC). We report results from a phase II study of CC-486 (oral azacitidine) in advanced NPC.

Results of a prospective phase 2 study of pazopanib in patients with surgically unresectable or metastatic chondrosarcoma.

This single-arm, multicenter, phase 2 study evaluated the safety and antitumor activity of pazopanib in patients with unresectable or metastatic conventional chondrosarcoma.

Relationship between gain rate during the growing phase and forage allowance in the finishing phase in Nellore cattle.

The study evaluated the effect of gain rates during the growing phase and the possible interaction with finishing phase forage allowance in beef cattle. In Exp. 1, eighty Nellore cattle (386 ± 7.90 kg; divided into 16 paddocks) were used in a randomized block design in a 2 × 2 factorial arrangement of treatments: (1) gain rate during the growing phase (low and high); (2) forage allowance during the finishing phase (low and high). In Exp. 2, twelve cannulated animals were used to evaluate ruminal ...

Feasibility and Acceptability of a Mobile Technology Intervention to Support Postabortion Care (The FACTS Study Phase II) After Surgical Abortion: User-Centered Design.

Human-centered design is a methodology that applies an iterative participatory process that engages the end-user for whom an innovation or intervention is designed for from start to end. There is general evidence to support the use of human-centered design for development of tools to affect health behavior, but specifically for family planning provision. This study is part two of a three-phase study that uses a user-centered design methodology which uses the findings from Phase I to design, develop, and tes...

Information geometric analysis of long range topological superconductors.

The Uhlmann connection is a mixed state generalization of the Berry connection. The latter has a very important role in the study of topological phases at zero temperature. Closely related, the quantum fidelity is an information theoretical quantity which is a measure of distinguishability of quantum states. Moreover, it has been extensively used in the analysis of quantum phase transitions. In this work, we study topological phase transitions in 1D and 2D topological superconductors with long-range hopping...

New paradigm for expediting drug development in Asia.

Some Asian regulators currently require Phase I data in Asians before joining global Phase II/III trials. Here, we discuss inherent limitations of Phase I ethnic sensitivity studies (ESS) to identify potential interethnic differences. We review recent new drug applications (NDAs) for Japan and China to critically assess the value of separate ESSs in Asian populations. Given that the observed value of ESS was limited, we propose a new global drug development paradigm: if relevant safety, pharmacokinetic (PK)...

Laser phase plate for transmission electron microscopy.

Transmission electron microscopy (TEM) of rapidly frozen biological specimens, or cryo-EM, would benefit from the development of a phase plate for in-focus phase contrast imaging. Several types of phase plates have been investigated, but rapid electrostatic charging of all such devices has hindered these efforts. Here, we demonstrate electron phase manipulation with a high-intensity continuous-wave laser beam, and use it as a phase plate for TEM. We demonstrate the laser phase plate by imaging an amorphous ...

G-quadruplex structures trigger RNA phase separation.

Liquid-liquid phase separation plays an important role in a variety of cellular processes, including the formation of membrane-less organelles, the cytoskeleton, signalling complexes, and many other biological supramolecular assemblies. Studies on the molecular basis of phase separation in cells have focused on protein-driven phase separation. In contrast, there is limited understanding on how RNA specifically contributes to phase separation. Here, we described a phase-separation-like phenomenon that SHORT ...

MRI and PET Guided Interstitial Brachytherapy for post-surgical vaginal recurrences of cervical cancer: Results of phase II study.

This phase II study evaluated the utility of MRI and PET for planning radiation and brachytherapy in patients with post-surgical recurrence of cervical cancer.

Correction to: Phase II study to evaluate the efficacy of Trastuzumab in combination with Capecitabine and Oxaliplatin in first-line treatment of HER2-positive advanced gastric cancer: HERXO trial.

Phase II study to evaluate the efficacy of Trastuzumab in combination with Capecitabine.

Effectiveness and safety of an inactivated enterovirus 71 vaccine in children aged 6-71 months in a phase IV study.

Evaluation of a licensed inactivated EV71 vaccine is needed in a phase IV study with a large population to identify its effectiveness and safety for further application.

Report of phase I and II trials of melphalan, prednisolone, and thalidomide triplet combination therapy versus melphalan and prednisolone doublet combination therapy in Japanese patients with newly diagnosed multiple myeloma ineligible for autologous stem cell transplantation.

We conducted a phase I study to determine the recommended dose of thalidomide combined with melphalan plus prednisolone (MPT) and a phase II study evaluating the efficacy and safety of this MPT regimen in transplant-ineligible Japanese patients with untreated multiple myeloma. The recommended dose was determined to be 100 mg/day in the phase I study. In the phase II, randomized, double-blind, parallel-group study, patients were allocated to either MPT (n = 52) or MP (n = 51), with 21 and 29 patient...

Efficacy and safety results from a phase 1b/2, multicenter, open-label study of oprozomib and dexamethasone in patients with relapsed and/or refractory multiple myeloma.

Oprozomib is an oral proteasome inhibitor with activity in multiple myeloma (MM). Our phase 1b/2 study examined the safety and efficacy of oprozomib with dexamethasone in patients with relapsed and refractory MM. Oprozomib was administered with a 5/14 or 2/7 schedule with dexamethasone. Phase 1b primary objectives were to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D) of oprozomib; phase 2 primary objectives were to determine overall response rate (ORR) and safety/tolerabilit...

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