PubMed Journals Articles About "Photo Release First Appoints Jonathan McGrain Lead Marketing" RSS

21:44 EDT 21st June 2018 | BioPortfolio

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Showing "Photo Release First Appoints Jonathan McGrain Lead Marketing" PubMed Articles 1–25 of 9,500+

The mechanism for photo-promoted release of vanadium from vanadium titano-magnetite.

The release of V from vanadium titano-magnetite, a predominant natural source of V, was studied under light irradiation. The release rate of V from vanadium titano-magnetite was accelerated by light irradiation, and the oxidation of V was detected. The essence of the photo-promoted release of V is that the immobile low valence V is transformed to the mobile V(V) by photo-induced active species generated from the photocatalysis process of magnetite. Among the photo-induced active species, •OH and H2O2 were...

Synthesis and Characterization of Nitric Oxide-Releasing Platinum (IV) Prodrug and Polymeric Micelle Triggered by Light.

Herein, we report the proof of concept of photo-responsive chemotherapeutics comprising nitric oxide-releasing platinum prodrugs and polymeric micelles. Photo-activatable nitric oxide-releasing donors were integrated into the axial positions of a platinum (IV) prodrug, and the photo-labile hydrophobic groups were grafted in the block copolymers. The hydrophobic interaction between nitric oxide donors and the photo-labile groups allowed for the loading of platinum drugs and nitric oxide-releasing donors in t...

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host-guest interaction.

A hierarchical supramolecular hydrogel was self-assembled from a Fmoc-RGDS tetrapeptide and showed photo-controlled release directed by host-guest interaction. Multiple payloads, including vesicles, were successively released from a single peptide hydrogel.

Rapid Capture and Release of Nucleic Acids through a Reversible Photo-cycloaddition Reaction in the Psoralen-functionalized Hydrogel.

Reversible immobilization of DNA and RNA is of great interest to researchers who seek to manipulate DNA or RNA in applications such as microarrays, DNA hydrogels and gene therapeutics. However, there is no existing system that can rapidly capture and release intact nucleic acids. To meet this unmet need, we develop a functional hydrogel for rapid DNA/RNA capture and release based on the reversible photo-cycloaddition of psoralen and pyrimidines. The functional hydrogel can be easily fabricated through copol...

UK government appoints next chief scientific adviser.

Photo-triggered N2-generating submicron particles for selective killing of cancer cells.

Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cance...

Preparation of photo-responsive poly(ethylene glycol) microparticles and their influence on cell viability.

Intelligent colloidal particles have been widely used as carriers for delivery of bioactive molecules due to the ability of controlled release. However, attention is mainly paid to the effects of their payloads, whereas the impacts of carriers are largely ignored. In this study, photo-responsive polyethylene glycol (PEG) microparticles were fabricated by using 8-arm-PEG with terminal amine groups (8-arm-PEG-NH2) and a photo-cleavable cross-linker. Due to the cleavable CO bond in the cross-linker, under UV i...

Photo and Thermo Dual-Responsive Copolymer Surfaces for Efficient Cell Capture and Release.

To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface - poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays - by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing efficiencies of cancer cell capture and release. These enhanced efficiencies of cancer cell capture and release probably originate from the binary cooperative effect of two responsive building units: NiPAAm unit...

Photo-identification as a tool to study small-spotted catshark Scyliorhinus canicula.

Photo-identification (photo-ID) was tested as a means to identify individual small-spotted catsharks Scyliorhinus canicula. The spotting pattern of the caudal region of S. canicula was used for the tests and revealed that photo-ID is an efficient method to identify individuals. Photo-ID is logistically simple, making it a potential alternative to traditional tagging to provide information on the distribution patterns and population dynamics of S. canicula and related species.

Worldwide, 3-Year, Post-Marketing Surveillance Experience with Tofacitinib in Rheumatoid Arthritis.

Post-marketing surveillance (PMS) is an integral part of monitoring adverse events (AEs) following approval of new drugs. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). An analysis of PMS reports was conducted to evaluate the safety of tofacitinib in a post-marketing setting.

Contemporary Aspects of Marketing in Clinical Trials Including Segments of IT and Technology Transfer.

The aim of this paper is to present the marketing strategy and the application of management (marketing management) and advertising in order to increase the efficiency of innovative approach in clinical trials that include and involve the use of new technologies and transfer of technologies.

Regulated basal and bolus insulin release from glucose-responsive core-shell microspheres based on concanavalin A-sugar affinity.

Individual insulin therapy considering the heterogeneity of insulin resistance between patients may bring more benefits than conventional therapy. Therefore, in glucose-responsive insulin delivery systems, more attention should be paid on further regulation of insulin release to meet individual requirements. Our study shows the feasibility of using a photo-crosslinkable shell layer to regulate basal and bolus insulin release from glucose-responsive Con A-polysaccharides network. Core-shell microspheres were...

A Comparative Review of Marketing Authorization Decisions in Switzerland, the EU, and the USA.

In this study we compared Swissmedic's (SMC's) regulatory marketing authorization decisions to those of the US Food and Drug Administration (FDA) and European drug regulatory authorities (EU). We investigated the overall similarity of the regulatory decisions, approval, and postmarketing withdrawal rates in the 3 jurisdictions. In case regulatory decisions diverged, we analyzed the reasons for rejection of marketing authorization applications (MAAs).

Light Driven Electron Transfer in Methyl-Bipyridine Phenol Complexes Is Not Proton Coupled.

The pursuit of systems that undergo optical electron proton transfer (photo-EPT) is very attractive, due to the wealth of information contained in the absorption spectra of such complexes. However, separating photo-EPT transitions from conventional charge transfer states remains a major challenge. In this study, we show that optical charge transfer in a complex between 4-methoxyphenol and N-methyl-4,4'-bipyridyl, previously assigned to occur through photo-EPT involving a hydrogen bond between the reactants ...

Evaluation of the Relative Abuse of an OROS® Extended-release Hydromorphone HCI Product: Results from three Post-market Surveillance Studies.

Formulating prescription opioids to limit abuse remains a priority. OROS® extended-release (ER) hydromorphone HCl (EXALGO®) may have low abuse potential. Three post-marketing studies of the relative abuse liability of OROS hydromorphone ER were conducted.

Policy Approaches for Regulating Alcohol Marketing in a Global Context: A Public Health Perspective.

Alcohol consumption is responsible for 3.3 million deaths globally or nearly 6% of all deaths. Alcohol use contributes to both communicable and noncommunicable diseases, as well as violence and injuries. The purpose of this review is to discuss, in the context of the expansion of transnational alcohol corporations and harms associated with alcohol use, policy options for regulating exposure to alcohol marketing. We first provide an overview of the public health problem of harmful alcohol consumption and des...

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads.

We report the preparation of photo- and reduction-responsive diblock copolymers through reversible addition fragmentation chain transfer (RAFT) polymerization of a coumarin-based disulfide-containing monomer (i.e., CSSMA) using a poly(ethylene oxide) (PEO)-based macroRAFT agent. The resulting amphiphilic PEO-b-PCSSMA copolymers self-assembled into polymersomes with hydrophilic PEO shielding coronas and hydrophobic bilayer membranes. Upon irradiating the polymersomes with visible light (e.g., 430 nm), the co...

State-Level Guidance and District-Level Policies and Practices for Food Marketing in US School Districts.

State agencies play a critical role in providing school districts with guidance and technical assistance on school nutrition issues, including food and beverage marketing practices. We examined associations between state-level guidance and the policies and practices in school districts regarding food and beverage marketing and promotion. State policy guidance was positively associated with districts prohibiting advertisements for junk food or fast food restaurants on school property. Technical assistance fr...

Niels Voigt talks to W. Jonathan Lederer, keynote lecturer at the "Göttingen Channels" Symposium 2017.

European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States.

The European Union (EU) has created a regulatory framework for herbal medicinal products (HMPs) since the enforcement of Directive 2004/24/EC. Substantial achievements have been made, with 1719 traditional use marketing registrations (TURs) and 859 well-established use marketing authorizations (WEU-MAs) for HMPs granted by the end of 2016. Apparently, the European regulation model has worked out well and in that the essential feature is the use of EU herbal monographs into those granted WEU-MAs and TURs.

Pathway diversity leads to 2D-nanostructure in photo-triggered supramolecular assembly.

This communication reports photo-triggered supramolecular assembly of a naphthalene-diimide (NDI) derivative, appended with a photo-labile ortho-nitrobenzyl (ONB)-ester protected carboxylic acid. Photo-irradiation produces the free COOH group which facilitates H-bonding driven face-to-face stacking of the NDI chromophores producing an ultra-thin (height < 2.0 nm) two-dimensional (2D) nano-sheet. In contrast, spontaneous supramolecular assembly of the same active monomer exhibits entirely different features ...

Ethnic and Socioeconomic Disparities in Recalled Exposure to and Self-Reported Impact of Tobacco Marketing and Promotions.

The role of tobacco marketing in tobacco use, particularly among the vulnerable ethnic and socioeconomic sub-populations is a regulatory priority of the U.S. Food and Drug Administration. There currently exist both ethnic and socioeconomic disparities in the use of tobacco products. Monitoring such inequalities in exposure to tobacco marketing is essential to inform tobacco regulatory policy that may reduce known tobacco-related health disparities. We use data from the Population Assessment of Tobacco and H...

Perspectives of ruthenium(ii) polyazaaromatic photo-oxidizing complexes photoreactive towards tryptophan-containing peptides and derivatives.

RuII polyazaaromatic complexes have been studied with the aim of developing molecular tools for DNA and oligonucleotides. In this context, RuII-TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes have been developed as specific photoreagents targeting the genetic material. The advantage of such compounds is due to the formation of photo-addition products between the Ru-TAP complex and the biomolecule, originating from a photo-induced electron transfer process that takes place between the excited Ru-TAP compl...

Exposure to Point-of-Sale Marketing of Cigarettes and E-Cigarettes as Predictors of Smoking Cessation Behaviors.

Cue-reactivity theory suggests smoking-related visual cues such as point-of-sale (POS) marketing (e.g., advertising, product displays) may undermine cessation attempts by causing an increase in nicotine cravings among users. This study examined the relationship between recall of exposure to POS marketing and subsequent cessation behaviors among young adult cigarette smokers.

DNA Photo-cross-linking Using Pyranocarbazole and Visible Light.

This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ > 400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.

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