PubMed Journals Articles About "Photo Release First Appoints Jonathan McGrain Lead Marketing" RSS

15:47 EDT 24th March 2018 | BioPortfolio

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Showing "Photo Release First Appoints Jonathan McGrain Lead Marketing" PubMed Articles 1–25 of 9,500+

The mechanism for photo-promoted release of vanadium from vanadium titano-magnetite.

The release of V from vanadium titano-magnetite, a predominant natural source of V, was studied under light irradiation. The release rate of V from vanadium titano-magnetite was accelerated by light irradiation, and the oxidation of V was detected. The essence of the photo-promoted release of V is that the immobile low valence V is transformed to the mobile V(V) by photo-induced active species generated from the photocatalysis process of magnetite. Among the photo-induced active species, •OH and H2O2 were...

Synthesis and Characterization of Nitric Oxide-Releasing Platinum (IV) Prodrug and Polymeric Micelle Triggered by Light.

Herein, we report the proof of concept of photo-responsive chemotherapeutics comprising nitric oxide-releasing platinum prodrugs and polymeric micelles. Photo-activatable nitric oxide-releasing donors were integrated into the axial positions of a platinum (IV) prodrug, and the photo-labile hydrophobic groups were grafted in the block copolymers. The hydrophobic interaction between nitric oxide donors and the photo-labile groups allowed for the loading of platinum drugs and nitric oxide-releasing donors in t...

Hierarchical supramolecular hydrogels: self-assembly by peptides and photo-controlled release via host-guest interaction.

A hierarchical supramolecular hydrogel was self-assembled from a Fmoc-RGDS tetrapeptide and showed photo-controlled release directed by host-guest interaction. Multiple payloads, including vesicles, were successively released from a single peptide hydrogel.

Rapid Capture and Release of Nucleic Acids through a Reversible Photo-cycloaddition Reaction in the Psoralen-functionalized Hydrogel.

Reversible immobilization of DNA and RNA is of great interest to researchers who seek to manipulate DNA or RNA in applications such as microarrays, DNA hydrogels and gene therapeutics. However, there is no existing system that can rapidly capture and release intact nucleic acids. To meet this unmet need, we develop a functional hydrogel for rapid DNA/RNA capture and release based on the reversible photo-cycloaddition of psoralen and pyrimidines. The functional hydrogel can be easily fabricated through copol...

UK government appoints next chief scientific adviser.

Food marketing to children in Canada: a settings-based scoping review on exposure, power and impact.

Food marketing impacts children's food knowledge, behaviours and health. Current regulations in Canada focus on restricting promotional aspects of food marketing with little-to-no consideration of the places where children experience food. Understanding food marketing in children's everyday settings is necessary to protect children. This scoping review describes the current literature on food marketing to children in Canada by setting.

Photo-triggered N2-generating submicron particles for selective killing of cancer cells.

Killing of cancer cells by applying mechanical disruption is an appealing emerging strategy for cancer treatment in recent years. In this study, photo-responsive submicron particles based on diazo-resin (DZR) which are able to release N2 under UV irradiation were prepared through a polyamine-salt aggregation method. After surface modification with hyaluronic acid (HA), the particles could be internalized selectively by cancer cells and mainly located in lysosomes after 6 h incubation. The viability of cance...

Preparation of photo-responsive poly(ethylene glycol) microparticles and their influence on cell viability.

Intelligent colloidal particles have been widely used as carriers for delivery of bioactive molecules due to the ability of controlled release. However, attention is mainly paid to the effects of their payloads, whereas the impacts of carriers are largely ignored. In this study, photo-responsive polyethylene glycol (PEG) microparticles were fabricated by using 8-arm-PEG with terminal amine groups (8-arm-PEG-NH2) and a photo-cleavable cross-linker. Due to the cleavable CO bond in the cross-linker, under UV i...

Photo and Thermo Dual-Responsive Copolymer Surfaces for Efficient Cell Capture and Release.

To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface - poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays - by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing efficiencies of cancer cell capture and release. These enhanced efficiencies of cancer cell capture and release probably originate from the binary cooperative effect of two responsive building units: NiPAAm unit...

Social marketing targeting Indigenous peoples: a systematic review.

Social marketing is a discipline focused on the application of marketing principles to induce socially desirable behaviour change. As social marketing remains one of the main behaviour change approaches pursued by governments and international organisations, it is important to consider its use in relation to vulnerable groups that are particularly exposed to discriminatory practices, marginalisation, exclusion and destitution. The aim of this systematic review is to identify the extent to which Andreasen's ...

Worldwide, 3-Year, Post-Marketing Surveillance Experience with Tofacitinib in Rheumatoid Arthritis.

Post-marketing surveillance (PMS) is an integral part of monitoring adverse events (AEs) following approval of new drugs. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). An analysis of PMS reports was conducted to evaluate the safety of tofacitinib in a post-marketing setting.

Regulated basal and bolus insulin release from glucose-responsive core-shell microspheres based on concanavalin A-sugar affinity.

Individual insulin therapy considering the heterogeneity of insulin resistance between patients may bring more benefits than conventional therapy. Therefore, in glucose-responsive insulin delivery systems, more attention should be paid on further regulation of insulin release to meet individual requirements. Our study shows the feasibility of using a photo-crosslinkable shell layer to regulate basal and bolus insulin release from glucose-responsive Con A-polysaccharides network. Core-shell microspheres were...

Evaluation of the Relative Abuse of an OROS® Extended-release Hydromorphone HCI Product: Results from three Post-market Surveillance Studies.

Formulating prescription opioids to limit abuse remains a priority. OROS® extended-release (ER) hydromorphone HCl (EXALGO®) may have low abuse potential. Three post-marketing studies of the relative abuse liability of OROS hydromorphone ER were conducted.

Professional, generational, and gender differences in perception of organisational values among Israeli physicians and nurses: Implications for retention.

The global health workforce today is more age diverse than ever before and spans three generations: baby boomers, X and Y generations. Each generation has a distinct set of characteristics, values, and beliefs. This diversity can lead to increased creativity and a greater richness of values and skills, but at the same time it can also lead to value clashes, disrespect, and conflicts. This study aimed to examine professional, generational, and gender differences in the perception of the importance of organis...

Niels Voigt talks to W. Jonathan Lederer, keynote lecturer at the "Göttingen Channels" Symposium 2017.

Ethnic and Socioeconomic Disparities in Recalled Exposure to and Self-Reported Impact of Tobacco Marketing and Promotions.

The role of tobacco marketing in tobacco use, particularly among the vulnerable ethnic and socioeconomic sub-populations is a regulatory priority of the U.S. Food and Drug Administration. There currently exist both ethnic and socioeconomic disparities in the use of tobacco products. Monitoring such inequalities in exposure to tobacco marketing is essential to inform tobacco regulatory policy that may reduce known tobacco-related health disparities. We use data from the Population Assessment of Tobacco and H...

Tuning and predicting mesh size and protein release from step growth hydrogels.

Hydrogel-based depots are of growing interest for release of biopharmaceuticals; however, a priori selection of hydrogel compositions that will retain proteins of interest and provide desired release profiles remains elusive. Toward addressing this, in this work, we have established a new tool for the facile assessment of protein release from hydrogels and applied it to evaluate the effectiveness of mesh size estimations on predicting protein retention or release. Poly(ethylene glycol) (PEG)-based hydrogel ...

Perspectives of ruthenium(ii) polyazaaromatic photo-oxidizing complexes photoreactive towards tryptophan-containing peptides and derivatives.

RuII polyazaaromatic complexes have been studied with the aim of developing molecular tools for DNA and oligonucleotides. In this context, RuII-TAP (TAP = 1,4,5,8-tetraazaphenanthrene) complexes have been developed as specific photoreagents targeting the genetic material. The advantage of such compounds is due to the formation of photo-addition products between the Ru-TAP complex and the biomolecule, originating from a photo-induced electron transfer process that takes place between the excited Ru-TAP compl...

Exposure to Point-of-Sale Marketing of Cigarettes and E-Cigarettes as Predictors of Smoking Cessation Behaviors.

Cue-reactivity theory suggests smoking-related visual cues such as point-of-sale (POS) marketing (e.g., advertising, product displays) may undermine cessation attempts by causing an increase in nicotine cravings among users. This study examined the relationship between recall of exposure to POS marketing and subsequent cessation behaviors among young adult cigarette smokers.

Photochemical oxidation of dimethylsulphide to dimethylsulphoxide in estuarine and coastal waters.

Dimethylsulphide (DMS) photo-oxidation and dimethylsulphoxide (DMSO) photoproduction were estimated in 26 laboratory irradiations of coastal samples from NE England (Tyne estuary) and W Scotland (Loch Linnhe and River Nant at Taynuilt). Pseudo-first order rate constants of DMS photo-oxidation (0.038 h(-1) to 0.345 h(-1)) and DMSO photo-production (0.017 h(-1) to 0.283 h(-1)) varied by one order of magnitude and were lowest in the coastal North Sea. Estuarine samples (salinity S 

Visible Light-Cured Glycol Chitosan Hydrogel Containing a Beta-Cyclodextrin-Curcumin Inclusion Complex Improves Wound Healing In Vivo.

Scarless wound healing is ideal for patients suffering from soft tissue defects. In this study, we prepared a novel wet dressing (β-CD-ic-CUR/GC) based on the visible light-cured glycol chitosan (GC) hydrogel and inclusion complex between beta-cyclodextrin (β-CD) and curcumin (CUR). We also evaluated its efficacy in the acceleration of wound healing as compared to that of CUR-loaded GC (CUR/GC). The conjugation of glycidyl methacrylate (GM) to GC for photo-curing was confirmed by ¹H-NMR measurement, and ...

The Improvement of Skin Whitening of Phenylethyl Resorcinol by Nanostructured Lipid Carriers.

Phenylethyl resorcinol (4-(1-phenylethyl)1,3-benzenediol) (PR) is a new whitening agent that has been found to have the ability to inhibit tyrosinase activity. However, the application of PR is limited by photo instability and poor solubility. PR-loaded nanostructured lipid carriers (PR-NLCs) were prepared by the hot-melted ultrasonic method. Glycerol monostearate and olive oil were selected as the solid lipid and liquid lipid for considering the solubility of PR in liquid lipid and partition coefficient of...

The impact of operational strategies on the performance of a photo-EBPR system.

A novel Phototrophic - Enhanced Biological Phosphorus Removal (Photo-EBPR) system, consisting of a consortium of photosynthetic organisms and polyphosphate accumulating organisms (PAOs), was studied in this work. A sequencing batch reactor was fed with a mixture of acetate and propionate (75%-25%) and subjected to dark/light cycles in order to select a photo-EBPR system containing PAOs and photosynthetic organisms, the latter likely providers of oxygen to the system. The results from the selection period (s...

A Community-Based Marketing Campaign at Farmers Markets to Encourage Fruit and Vegetable Purchases in Rural Counties With High Rates of Obesity, Kentucky, 2015-2016.

Availability of farmers markets may increase fruit and vegetable consumption among rural residents of the United States. We conducted a community-based marketing campaign, Plate it Up Kentucky Proud (PIUKP), in 6 rural communities over 2 years to determine the association between exposure to the campaign and fruit and vegetable purchases, adjusted for Supplemental Nutrition Assistance Program recipient status. Logistic regression was used to examine the odds of the PIUKP campaign influencing purchases. Awar...

Photochemical acceleration of DNA strand displacement using ultrafast DNA photo-cross-linking.

DNA strand displacement is an essential reaction in genetic recombination, biological processes, and DNA nanotechnology. In our body, DNA strand displacement is regulated and accelerated by enzymes. Furthermore, acceleration of DNA strand displacement is required for a rapid response of biological processes. In this study, we evaluated the DNA strand displacement using DNA photo-cross-linking to accelerate this displacement. The DNA photo-cross-linking of CNVK was accelerated at least 20 times, showing a fa...

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