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01:40 EDT 24th September 2018 | BioPortfolio

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Showing "Photo Release First Appoints Jonathan McGrain Lead Marketing" PubMed Articles 1–25 of 9,800+

A tribute to professor Jonathan C Peter.

Emeritus Professor Jonathan Clemence Peter passed away in Wynberg, Cape Town, on April 02, 2018, after an illness confronted with quiet courage and dignity. A beloved father, husband, neurosurgeon, leader, teacher, mentor and friend, he is remembered with deep respect and affection throughout the world of paediatric neurosurgery.

UV-mediated solid-state cross-linking of electrospinning nanofibers of modified collagen.

The modified collagen with double bonds was electrospun into nanofibers membrane cured with photo-initiated polymerization under UV irradiation. The morphology and chemical structures were characterized by SEM and FTIR. Both the water resistance and mechanical properties were improved after UV-crosslinking. Then 5-Fluorouracil (5-FU) was used as a model drug to prepare drug-loaded collagen nanofiber membrane cured with photo-initiated polymerization under UV irradiation. In vitro release results showed that...

The magnitude and impact of tobacco marketing exposure in adolescents' day-to-day lives: An ecological momentary assessment (EMA) study.

Research indicates that tobacco marketing contributes to higher pro-tobacco attitudes and behaviors among adolescents, but no studies have been able to assess the impact of real-world tobacco marketing exposures in real-time. The purpose of this study was to examine the magnitude and impact of tobacco marketing exposure on adolescents using ecological momentary assessment (EMA). Our primary hypotheses were that (1) youth would most frequently report tobacco marketing at the retail points-of-sale and (2) gre...

Photo and Thermo Dual-Responsive Copolymer Surfaces for Efficient Cell Capture and Release.

To overcome the low efficiency of single-responsive smart surfaces, we have constructed a dual-responsive smart surface - poly(spiropyran-co-N-isopropylacrylamide) (poly(SP-co-NiPAAm))-grafted silicon nanowire arrays - by combining photo-responsive SP and thermo-responsive NiPAAm units for enhancing efficiencies of cancer cell capture and release. These enhanced efficiencies of cancer cell capture and release probably originate from the binary cooperative effect of two responsive building units: NiPAAm unit...

Worldwide, 3-Year, Post-Marketing Surveillance Experience with Tofacitinib in Rheumatoid Arthritis.

Post-marketing surveillance (PMS) is an integral part of monitoring adverse events (AEs) following approval of new drugs. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). An analysis of PMS reports was conducted to evaluate the safety of tofacitinib in a post-marketing setting.

Photo-identification as a tool to study small-spotted catshark Scyliorhinus canicula.

Photo-identification (photo-ID) was tested as a means to identify individual small-spotted catsharks Scyliorhinus canicula. The spotting pattern of the caudal region of S. canicula was used for the tests and revealed that photo-ID is an efficient method to identify individuals. Photo-ID is logistically simple, making it a potential alternative to traditional tagging to provide information on the distribution patterns and population dynamics of S. canicula and related species.

Contemporary Aspects of Marketing in Clinical Trials Including Segments of IT and Technology Transfer.

The aim of this paper is to present the marketing strategy and the application of management (marketing management) and advertising in order to increase the efficiency of innovative approach in clinical trials that include and involve the use of new technologies and transfer of technologies.

Gold Nanostars Coated with Mesoporous Silica are Effective and Non-Toxic Photothermal Agents Capable of Gate Keeping and Laser Induced Drug Release.

Herein, a novel drug photo-release system based on gold nanostars (AuNSts) coated with a mesoporous silica shell and capped with paraffin as thermo-sensitive molecular gate, is reported. Direct measurements of the surface temperature of a single gold nanostar irradiated by a tightly focused laser beam, are performed via a heat-sensitive biological matrix. The surface temperature of an AuNSt increases by hundreds of degrees Celsius even at low laser powers. AuNSts coated with a mesoporous silica shell using ...

Regulated basal and bolus insulin release from glucose-responsive core-shell microspheres based on concanavalin A-sugar affinity.

Individual insulin therapy considering the heterogeneity of insulin resistance between patients may bring more benefits than conventional therapy. Therefore, in glucose-responsive insulin delivery systems, more attention should be paid on further regulation of insulin release to meet individual requirements. Our study shows the feasibility of using a photo-crosslinkable shell layer to regulate basal and bolus insulin release from glucose-responsive Con A-polysaccharides network. Core-shell microspheres were...

A Comparative Review of Marketing Authorization Decisions in Switzerland, the EU, and the USA.

In this study we compared Swissmedic's (SMC's) regulatory marketing authorization decisions to those of the US Food and Drug Administration (FDA) and European drug regulatory authorities (EU). We investigated the overall similarity of the regulatory decisions, approval, and postmarketing withdrawal rates in the 3 jurisdictions. In case regulatory decisions diverged, we analyzed the reasons for rejection of marketing authorization applications (MAAs).

Lacosamide efficacy and tolerability in clinical practice - Post marketing analysis from a single dedicated epilepsy center.

Post marketing analysis of anti-epileptic drug (AED) efficacy and tolerability is of great value to the clinician since it is more representative of clinical practice than clinical trial data. We analyzed our experience with lacosamide (LCM) in patients treated after marketing.

Conjugated Polymer Nanoparticles Appending Photo-Responsive Units for Controlled Drug Delivery, Release and Imaging.

Carriers that can afford tunable physical and structural changes are envisioned to address critical issues in controlled drug delivery applications. Herein, we report photo-responsive conjugated polymer nanoparticles (CPNs) functionalized with donor-acceptor Stenhouse adduct (DASA) and folic acid units for controlled drug delivery, release and imaging. Upon visible light (λ = 550 nm) irradiation, CPNs undergo structure, color, and polarity changes simultaneously that swell and open-up CPNs to release encap...

Light Driven Electron Transfer in Methyl-Bipyridine Phenol Complexes Is Not Proton Coupled.

The pursuit of systems that undergo optical electron proton transfer (photo-EPT) is very attractive, due to the wealth of information contained in the absorption spectra of such complexes. However, separating photo-EPT transitions from conventional charge transfer states remains a major challenge. In this study, we show that optical charge transfer in a complex between 4-methoxyphenol and N-methyl-4,4'-bipyridyl, previously assigned to occur through photo-EPT involving a hydrogen bond between the reactants ...

Policy Approaches for Regulating Alcohol Marketing in a Global Context: A Public Health Perspective.

Alcohol consumption is responsible for 3.3 million deaths globally or nearly 6% of all deaths. Alcohol use contributes to both communicable and noncommunicable diseases, as well as violence and injuries. The purpose of this review is to discuss, in the context of the expansion of transnational alcohol corporations and harms associated with alcohol use, policy options for regulating exposure to alcohol marketing. We first provide an overview of the public health problem of harmful alcohol consumption and des...

Photo- and Reduction-Responsive Polymersomes for Programmed Release of Small and Macromolecular Payloads.

We report the preparation of photo- and reduction-responsive diblock copolymers through reversible addition fragmentation chain transfer (RAFT) polymerization of a coumarin-based disulfide-containing monomer (i.e., CSSMA) using a poly(ethylene oxide) (PEO)-based macroRAFT agent. The resulting amphiphilic PEO-b-PCSSMA copolymers self-assembled into polymersomes with hydrophilic PEO shielding coronas and hydrophobic bilayer membranes. Upon irradiating the polymersomes with visible light (e.g., 430 nm), the co...

Release of phosphorus from sediments under wave-induced liquefaction.

The endogenous release of nutrients from marine or lacustrine sediment is an important factor in water eutrophication. Overlying water dynamic actions (waves) may lead to sediment resuspension and even sediment liquefaction, especially under strong wind-induced waves, which may subsequently lead to the release of nutrients from sediments and contribution to water eutrophication. A wave flume simulator was used to study changes in the phosphorus concentrations in the overlying water at different consolidatio...

State-Level Guidance and District-Level Policies and Practices for Food Marketing in US School Districts.

State agencies play a critical role in providing school districts with guidance and technical assistance on school nutrition issues, including food and beverage marketing practices. We examined associations between state-level guidance and the policies and practices in school districts regarding food and beverage marketing and promotion. State policy guidance was positively associated with districts prohibiting advertisements for junk food or fast food restaurants on school property. Technical assistance fr...

Quantifying the Nature and Extent of Children's Real-time Exposure to Alcohol Marketing in Their Everyday Lives Using Wearable Cameras: Children's Exposure via a Range of Media in a Range of Key Places.

Children's exposure to alcohol marketing is typically measured using self-report data, television viewing data or street marketing audits, which are subject to bias and often do not provide quantifiable measures of daily exposure. This article describes an innovative methodology to capture the world in which children live using wearable cameras.

European regulation model for herbal medicine: The assessment of the EU monograph and the safety and efficacy evaluation in marketing authorization or registration in Member States.

The European Union (EU) has created a regulatory framework for herbal medicinal products (HMPs) since the enforcement of Directive 2004/24/EC. Substantial achievements have been made, with 1719 traditional use marketing registrations (TURs) and 859 well-established use marketing authorizations (WEU-MAs) for HMPs granted by the end of 2016. Apparently, the European regulation model has worked out well and in that the essential feature is the use of EU herbal monographs into those granted WEU-MAs and TURs.

Pathway diversity leads to 2D-nanostructure in photo-triggered supramolecular assembly.

This communication reports photo-triggered supramolecular assembly of a naphthalene-diimide (NDI) derivative, appended with a photo-labile ortho-nitrobenzyl (ONB)-ester protected carboxylic acid. Photo-irradiation produces the free COOH group which facilitates H-bonding driven face-to-face stacking of the NDI chromophores producing an ultra-thin (height < 2.0 nm) two-dimensional (2D) nano-sheet. In contrast, spontaneous supramolecular assembly of the same active monomer exhibits entirely different features ...

Biocompatible, drug-loaded anti-adhesion barrier using visible-light curable furfuryl gelatin derivative.

Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To solve current problems, we prepared a biocompatible drug-loaded anti-adhesion barrier using a visible-light curable furfuryl gelatin derivative. We used riboflavin as a photo-initiator in the ph...

The Use of Lead Isotope Analysis to Identify Potential Sources of Lead Toxicosis in a Juvenile Bald Eagle ( Haliaeetus leucocephalus) With Ventricular Foreign Bodies.

A male juvenile bald eagle ( Haliaeetus leucocephalus) was admitted to the Wildlife Center of Virginia with a left humeral fracture a large quantity of anthropogenic debris in the ventriculus, a blood lead level of 0.616 ppm, and clinical signs consistent with chronic lead toxicosis. Because of the poor prognosis for recovery and release, the eagle was euthanatized. Lead isotope analysis was performed to identify potential anthropogenic sources of lead in this bird. The lead isotope ratios in the eagle's fe...

DNA Photo-cross-linking Using Pyranocarbazole and Visible Light.

This report presents a novel photo-cross-linker that can cross-link to pyrimidines in nucleic acids under visible light irradiation (λ > 400 nm). This method offers ultrafast photo-cross-linking without any cytotoxicity due to UV irradiation.

The mechanism of enhanced wastewater nitrogen removal by photo-sequencing batch reactors based on comprehensive analysis of system dynamics within a cycle.

To understand the mechanism of enhanced nitrogen removal by photo-sequencing batch reactors (photo-SBRs), which incorporated microalgal photosynthetic oxygenation into the aerobic phases of a conventional cycle, this study performed comprehensive analysis of one-cycle dynamics. Under a low aeration intensity (about 0.02 vvm), a photo-SBR, illuminated with light at 92.27 μ·mol·m·s, could remove 99.45% COD, 99.93% NH-N, 90.39% TN, and 95.17% TP, while the control SBR could only remove 98.36% COD, 83.51% N...

Review of Jonathan Ives, Michael Dunn, and Alan Cribb, eds., Empirical Bioethics: Theoretical and Practical Perspectives.

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