PubMed Journals Articles About "Pilot Study Of Closed-Loop Glucose Control In People With Type 1 Diabetes" RSS

00:24 EST 18th January 2019 | BioPortfolio

Pilot Study Of Closed-Loop Glucose Control In People With Type 1 Diabetes PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Pilot Study Of Closed-Loop Glucose Control In People With Type 1 Diabetes articles that have been published worldwide.

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Showing "Pilot Study Closed Loop Glucose Control People With" PubMed Articles 1–25 of 74,000+

Effect of 6 months of hybrid closed-loop insulin delivery in adults with type 1 diabetes: a randomised controlled trial protocol.

Manual determination of insulin dosing largely fails to optimise glucose control in type 1 diabetes. Automated insulin delivery via closed-loop systems has improved glucose control in short-term studies. The objective of the present study is to determine the effectiveness of 6 months' closed-loop compared with manually determined insulin dosing on time-in-target glucose range in adults with type 1 diabetes.

Closed-loop control of the centre of pressure in post-stroke patients with balance impairments.

When a lightly touched surface is moved according to a closed-loop control law, it has been shown in young adults that the Centre of Pressure (CoP) can be displaced in a controllable way without the conscious cooperation of participants. In this closed-loop paradigm, the surface velocity was continuously adjusted according to the CoP position. Since the closed-loop control of the CoP does not require the participant's voluntary cooperation, it could be of interest for the development of innovative biofeedba...

Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care.

Background In patients with diabetes, hospitalization can complicate the achievement of recommended glycemic targets. There is increasing evidence that a closed-loop delivery system (artificial pancreas) can improve glucose control in patients with type 1 diabetes. We wanted to investigate whether a closed-loop system could also improve glycemic control in patients with type 2 diabetes who were receiving noncritical care. Methods In this randomized, open-label trial conducted on general wards in two tertiar...

Adaptability of Closed Loop During Labor, Delivery, and Postpartum: A Secondary Analysis of Data from Two Randomized Crossover Trials in Type 1 Diabetes Pregnancy.

Tight glucose control during labor and delivery is recommended for pregnant women with type 1 diabetes. This can be challenging to achieve using the current treatment modalities. The automated nature of closed loop and its ability to adapt to real-time glucose levels make it well suited for use during labor, delivery, and the immediate postpartum period. We report observational data of participants from two randomized crossover trials who chose to continue using closed loop during labor, delivery, and postp...

Glucose Control Using a Standard Versus an Enhanced Hybrid Closed Loop System: A Randomized Crossover Study.

Hybrid closed loop (HCL) insulin delivery with the Medtronic Minimed 670G system is effective and safe in people with type 1 diabetes (T1D). This study compared glucose control, closed loop (CL) exits, and alarm frequency with the standard HCL (s-HCL) versus enhanced HCL (e-HCL) Medtronic system. Pump-experienced T1D adults (n = 11; 9 female; mean [SD] age: 51 years [15 years]; HbA1c 7.5% [1.0%] or 58 mmol/mol [7.7 mmol/mol]) were assigned, in random order, s-HCL or e-HCL for 1 week each in a superv...

The International Diabetes Closed-Loop Study: Testing Artificial Pancreas Component Interoperability.

Use of artificial pancreas (AP) requires seamless interaction of device components, such as continuous glucose monitor (CGM), insulin pump, and control algorithm. Mobile AP configurations also include a smartphone as computational hub and gateway to cloud applications (e.g., remote monitoring and data review and analysis). This International Diabetes Closed-Loop study was designed to demonstrate and evaluate the operation of the inControl AP using different CGMs and pump modalities without changes to the us...

Performance of Medtronic Hybrid Closed-Loop Iterations, Results from a Randomized Trial in Adolescents with Type 1 Diabetes.

This study investigates the performance of an iteration of the Medtronic hybrid closed-loop (HCL) algorithm, which utilizes sensor glucose values non-adjunctively for bolus advice, recognizes sustained hyperglycemia, suggests insulin bolus correction, and includes more accommodative SmartGuard™ automode parameters that aim to improve function and usability. Adolescents aged 13-17 years with type 1 diabetes >1 year, glycated hemoglobin (HbA) 7.0%-10%, currently using Continuous Subcutaneous Insulin Infusio...

Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial.

The achievement of glycaemic control remains challenging for patients with type 1 diabetes. We assessed the effectiveness of day-and-night hybrid closed-loop insulin delivery compared with sensor-augmented pump therapy in people with suboptimally controlled type 1 diabetes aged 6 years and older.


Intensive glucose management with insulin pump and continuous glucose monitoring therapy in insulin-treated patients with diabetes poses many challenges in all aspects of daily life. Automated insulin delivery (AID) is the ultimate goal of insulin replacement therapy to reduce the burden of managing this condition. Many systems are being tested in the clinical research setting, and one hybrid closed-loop (HCL) system has received Food and Drug Administration (FDA) approval for use in type 1 diabetes patient...

Glucose Control, Disease Burden, and Educational Gaps in People With Type 1 Diabetes: Exploratory Study of an Integrated Mobile Diabetes App.

Self-monitoring and self-management, crucial for optimal glucose control in type 1 diabetes, requires many disease-related decisions per day and imposes a substantial disease burden on people with diabetes. Innovative technologies that integrate relevant measurements may offer solutions that support self-management, decrease disease burden, and benefit diabetes control.

Optimizing a Hybrid Closed Loop System in Type 1 Diabetes: A Case Report.

We present the optimization of a hybrid closed-loop (HCL) insulin pump system in a type 1 diabetes (T1D) patient in the first 3 months of using the Minimed 670G. An 11-year-old female with 7 years of T1D history started using the Minimed 670G HCL system at our center. The patient had been using the Medtronic Veo insulin pump without a sensor for almost 4 years with HbA1c levels between 7.8% and 10.2%. We introduced the Minimed 670G to improve overall glucose control, improve quality of life and lessen th...

Modeling and Control of Single-Cell Migration Induced by a Chemoattractant-Loaded Microbead.

Cell migration plays an essential role in cancer cell study. Investigation of a novel method for controlling cell migration movement can help develop new therapeutic strategies. In this paper, a chemoattractant-loaded microbead, which is controlled by optical tweezers, is used to stimulate a target cell to accomplish automated migration along a desired path while avoiding obstacles. Models of both tweezers-bead and bead-cell interactions are investigated. A dual closed-loop control strategy is proposed, whi...

Research on the Clinical Alarm Management Mechanism Based on Closed-loop Control Theory.

This paper proposes a clinical alarm management system based on the theory of the closed loop control. The alarm management mechanism can be divided into the expected standard, improving execution rule, rule execution, medical devices with alarm functions, results analysis strategy and the output link. And, we make relevant application and discussion. Results showed that the mechanism can be operable and effective.

Closed-Loop Insulin for Glycemic Control in Noncritical Care.

Closed-Loop Insulin for Glycemic Control in Noncritical Care.

Closed-Loop Insulin for Glycemic Control in Noncritical Care.

Impact of an inpatient multidisciplinary glucose control management program.

Glycemic control has been increasingly recognized as a critical element in inpatient care, but optimal management of blood glucose in the hospital setting remains challenging. The aims of this study were to describe and evaluate the impact of the implementation of an inpatient multidisciplinary glucose control management program on glucose control in hospitalized patients.

Closing the Loop on Managing Youth With Type 1 Diabetes: Children Are Not Just Small Adults.

As hybrid closed-loop (HCL) insulin delivery systems permeate clinical practice, it is critical to ensure all with diabetes are afforded the opportunity to benefit from this technology. Indeed, due to the suboptimal control achieved by the vast majority of youth with type 1 diabetes (T1D), pediatric patients are positioned to see the greatest benefit from automated insulin delivery systems. To ensure these systems are well poised to deliver the promise of more targeted control, it is essential to understand...

Glycemic Control of People with Type 1 Diabetes based on Probabilistic Constraints.

The objective of the paper is to develop an open loop insulin infusion profile which is capable of controlling the blood glucose level of people with Type 1 diabetes in the presence of broad uncertainties such as inter-patient variability and unknown meal quantity. For illustrative purposes, the Bergman model in conjunction with a gut-dynamics model is chosen to represent the human glucose-insulin dynamics. A recently developed sampling based uncertainty quantification approach is used to determine the stat...

Enlarging the loop: closed-loop insulin delivery for type 1 diabetes.

Gain-scheduled predictive extended state observer for time-varying delays systems with mismatched disturbances.

In this paper, a novel control scheme for systems with input and output time-varying delays is provided in discrete-time domain. The control strategy combines predictor-like techniques with a delay-dependent gain-scheduled extended state observer. The main goal is twofold: (i) to minimize the negative effect of time-varying delays in the closed-loop performance and, (ii) to actively compensate the effect of mismatched disturbances in the controlled output. Moreover, a sufficient condition based on Linear Ma...

Event-Based Adaptive NN Tracking Control of Nonlinear Discrete-Time Systems.

This paper is concerned with the simultaneous design of a neural network (NN)-based adaptive control law and an event-triggering condition for a class of strict feedback nonlinear discrete-time systems. The stability and tracking performance of the closed-loop network control system under the event-triggering strategy is formally proven based on the Lyapunov theory in a hybrid framework. The proposed Lyapunov formulation yields an event-triggered algorithm to update the control input and NN weights based on...

Intensifying sleep slow oscillations does not improve metabolic control in healthy men.

Impaired sleep quality and sleep loss compromise glucose homeostasis and metabolic function, but the mechanisms linking sleep and metabolic health are largely unclear. In order to gain insight into the relevance of specific electrophysiological sleep characteristics for metabolic control, we assessed the acute effect on glucose homeostasis as well as energy intake and expenditure of enhancing slow oscillatory activity, a hallmark of slow-wave sleep, by closed-loop auditory stimulation in healthy men. Twenty...

Conformational flexibility of pore loop-1 gives insights into substrate translocation by the AAA protease FtsH.

Two crystal structures of a transmembrane helix-lacking FtsH construct from Aquifex aeolicus have been determined at 2.9 Å and 3.3 Å resolution in space groups R32 and P312, respectively. Both structures are virtually identical despite different crystal packing contacts. In both structures, the FtsH hexamer is created from two different subunits of the asymmetric unit by the three-fold symmetry of the crystals. Similar to other published structures, all subunits are loaded with ADP and the two subunit in ...

Perioperative Considerations for Evolving Artificial Pancreas Devices.

Type 1 diabetes mellitus is a lifelong condition. It requires intensive patient involvement including frequent glucose measurements and subcutaneous insulin dosing to provide optimal glycemic control to decrease short- and long-term complications of diabetes mellitus without causing hypoglycemia. Variations in insulin pharmacokinetics and responsiveness over time in addition to illness, stress, and a myriad of other factors make ideal glucose control a challenge. Control-to-range and control-to-target artif...

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