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03:08 EDT 23rd September 2018 | BioPortfolio

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Showing "Pioneer Bred International" PubMed Articles 1–25 of 16,000+

Adalimumab Alleviates Skin Pain in Patients with Moderate to Severe Hidradenitis Suppurativa: Secondary Efficacy Results from the PIONEER I and PIONEER II Randomized Controlled Trials.


The Pioneer Schools of Occupation: Reflections for Current Practice.

The Pioneer Schools of Occupation: Can They Teach Us Anything Today? This study reviews the development of the pioneer schools of occupation and their curriculum or program design between 1906 and 1923. The purposes are to document the existence of the schools, to explore the issues in establishing the schools, and to compare and contrast concepts stated in early curriculum models with those in current models of practice. The dates were selected to examine ideas before the passage of the Minimum Standards f...

A Nitrous-Oxide Pioneer Peddles His Own Dentifrice: "Dr Colton's Vegetable Dentonic".

During the latter half of the six-year long "Panic of 1873," nitrous-oxide pioneer G.Q. Colton developed, advertised, and sold his dentifrice, "Dr Colton's Vegetable Dentonic" to supplement his dental anesthetic enterprise.


Resolving the predator first paradox: arthropod predator food webs in pioneer sites of glacier forelands.

Primary succession on bare ground surrounded by intact ecosystems is, during its first stages, characterized by predator-dominated arthropod communities. However, little is known on what prey sustains these predators at the start of succession and which factors drive the structure of these food webs. As prey availability can be extremely patchy and episodic in pioneer stages, trophic networks might be highly variable. Moreover, the importance of allochthonous versus autochthonous food sources for these pion...

The mechanistic basis for chromatin regulation by pioneer transcription factors.

Pioneer transcription factors play a primary role in establishing competence for gene expression and initiating cellular programming and reprogramming, and their dysregulation causes severe effects on human health, such as promoting tumorigenesis. Although more than 200 transcription factors are expressed in each cell type, only a small number of transcription factors are necessary to elicit dramatic cell-fate changes in embryonic development and cell-fate conversion. Among these key transcription factors, ...

Jean-Louis Petit (1674-1750): a pioneer anatomist and surgeon and his contribution to orthopaedic surgery and trauma surgery.

The purpose of this review is to summarize the life and work of Jean-Louis Petit, his inventions, his discoveries, and his impact on the evolution of surgery of his era.

Wilhelm Schulthess, Pioneer in the Treatment of Spinal Deformities: The Testimony of the Rizzoli Orthopedic Institute.

The manuscript describes the testimony of the Rizzoli Orthopedic Institute about Wilhelm Schulthess, a pioneer in the treatment of spinal deformities.

Secretory organelle trafficking in Toxoplasma gondii: A long story for a short travel.

Toxoplasma gondii (T. gondii) possesses a highly polarized secretory system, which efficiently assembles de novo micronemes (MIC) and rhoptries (ROP) during parasite replication. Pioneer works have studied the sorting motifs within MIC and ROP proteins, required for their trafficking towards their final destination. These studies led to the conclusion that protein processing and protein sorting are inter-dependent activities. More recent works have revealed the trafficking routes taken by the MIC and ROP pr...

Dulcie Coleman: a pioneer of cytology in the UK and Europe.

We sadly announce the death earlier this year of Professor Dulcie V Coleman, the driving force behind the publication of Cytopathology in 1990 and pioneer of cytology in the UK and throughout Europe (Figure 1). She died peacefully in Naples, Florida on Sunday 4th February 2018 surrounded by her family including her husband of 60 years (Jack Poznansky), their four children and two of their 13 grandchildren several of whom contributed to her academic work and publications. She had moved to Florida to be neare...

Reflections of a 'Pioneer': A Somewhat Different Path.

Cryptosporidium occurrence in ruminants from the North Pioneer mesoregion of Paraná, Brazil.

The aim of this study was to investigate the occurrence of Cryptosporidium in cattle and sheep from the North Pioneer mesoregion of the state of Paraná. For this, 317 stool samples were collected from cattle and sheep on 16 properties in six municipalities in the North Pioneer mesoregion of Paraná. For detection of Cryptosporidium species, molecular analysis was performed using nested-PCR techniques targeting the 18S rRNA gene. Of the 37 beef cows and 115 calves analyzed, four (10.8%) and 14 (12.2%), resp...

Mini-biography for Mr. Xitao Cai: the pioneer botanist of the plant kingdom.

Dominique Jean Larrey (1766-1842) and his Contributions to Military Medicine and Early Neurosurgery.

Dr. Dominique Jean Larrey was a pioneer in the field of military surgery. His creative innovation and drive to improve the quality of medical services available to those injured during war guided his achievements in medicine. Dr. Larrey is often referred to as: 'the father of emergency medical services' or 'the father of modern military medicine.' His contributions to medicine continue to live on in common procedures and health care systems today, such as aspiration of pericardial effusion and drainage of h...

Dr David Donaldson, BDS, FDSRCS, MDS, FADSA, FAAD, Dental Educator and Sedation Pioneer, Dies at 76.

William Morton: pioneer of general anaesthesia.

University Flunk-Out to Genomics Pioneer: An Interview with George Church, PhD.

Marin Cureau de La Chambre (1594-1669), a 17th-century pioneer in neuropsychology.

Marin Cureau de La Chambre (1594-1669) was a physician from Le Mans who advised and treated two French Kings, Louis XIII and Louis XIV, as well as his patron, Chancellor Pierre Séguier. As both a physician and a philosopher, he was among the first members of the Académie Française and the Académie des Sciences. His key role in dethroning Latin and using French in its place would have sufficed to ensure his notoriety, as French then became a vehicle for disseminating the sciences throughout Europe. Howev...

Were the "Pioneer" Clinical Ethics Consultants "Outsiders"? For Them, Was "Critical Distance" That Critical?

"Clinical ethics consultants" have been practicing in the United States for about 50 years. Most of the earliest consultants-the "pioneers"-were "outsiders" when they first appeared at patients' bedsides and in the clinic. However, if they were outsiders initially, they acclimated to the clinical setting and became "insiders" very quickly. Moreover, there was some tension between traditional academics and those doing applied ethics about whether there was sufficient "critical distance" for appropriate refl...

Mehmet Haberal, MD: Transplant Pioneer, Entrepreneur, President-elect, The Transplantation Society.

Klaus Apel (1942-2017): a pioneer of photosynthesis research.

We present here a Tribute to Klaus Apel (1942-2017), a photosynthesis pioneer-an authority on plant molecular genetics-in five parts. The first section is a prologue. The second section deals with a chronological discussion of Apel's research life, prepared by the editor Govindjee; it is based on a website article at the Boyce Thompson Institute (BTI) by Patricia Waldron ( https://btiscience.org/explore-bti/news/post/bti-says-goodbye-klaus-apel/ ), as approved for use here by Keith C. Hannon and David Stern...

Mitochondrial haplotypes are not associated with mice selectively bred for high voluntary wheel running.

Mitochondrial haplotypes have been associated with human and rodent phenotypes, including nonshivering thermogenesis capacity, learning capability, and disease risk. Although the mammalian mitochondrial D-loop is highly polymorphic, D-loops in laboratory mice are identical, and variation occurs elsewhere mainly between nucleotides 9820 and 9830. Part of this region codes for the tRNAgene and is associated with mitochondrial densities and number of mtDNA copies. We hypothesized that the capacity for high lev...

Remembering a pioneer of environmental health science: Colleagues honor Bernard "Bernie" Weiss (1925-2018)-a remarkable scientist, thinker, visionary and writer.

Pioneer women in Pediatric Nephrology in Poland.

Robert J. Genco: Pioneer in Oral Science Advancement.

Professor Robert J. Genco made extraordinary research advances in immunology, periodontology, and microbiology research, pioneering major advances in oral science. In addition to his extraordinary research advancements in oral biology, his pioneering advances in oral science leadership at the local/university, national, and international levels are recognized worldwide, as are his educational advancements. In his era, he is truly the "father" of oral science.

The Association Between Hospital ACO Participation and Readmission Rates.

Accountable care organizations (ACOs) were established as part of the Affordable Care Act to reduce costs, improve the patient experience, and increase the quality of care. While previous studies have examined the quality, costs, and patient experience among ACOs, the relationship between hospitals' ACO participation and its effects on hospitals' performance have been incompletely characterized. The main purpose of this study is to measure the association between hospitals' participation in Medicare Pioneer...


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