PubMed Journals Articles About "Player Steve Gleason Given Congressional Gold Medal Work" RSS

00:54 EDT 30th March 2020 | BioPortfolio

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Showing "Player Steve Gleason Given Congressional Gold Medal Work" PubMed Articles 1–25 of 12,000+

Mortality-to-incidence ratios by US Congressional District: Implications for epidemiologic, dissemination and implementation research, and public health policy.

The mortality-to-incidence ratio (MIR) can be computed from readily accessible, public-use data on cancer incidence and mortality, and a high MIR value is an indicator of poor survival relative to incidence. Newly available data on congressional district-specific cancer incidence and mortality from the U.S. Cancer Statistics (USCS) database from 2011 to 2015 were used to compute MIR values for overall (all types combined), breast, cervix, colorectal, esophagus, lung, oral, pancreas, and prostate cancer. Con...

Reflections on Randomized Trials and Observational Studies: "Big Is Beautiful" A Conversation With Sir Rory Collins, FRS.

Rory Collins is the Head, Nuffield Department of Population Health, University of Oxford, Principal Investigator and Chief Executive, UK Biobank, and the British Heart Foundation Professor of Medicine and Epidemiology at the University of Oxford. He was born in Hong Kong and received his medical degree from St Thomas's Hospital Medical School, University of London. He was Knighted for Services to Science in 2011 and became a Fellow of the Royal Society in 2015. He has delivered the Paul Dudley White Interna...

A policy mapping analysis of goals, target populations, and punitive notions in the U.S. congressional response to the opioid epidemic.

The U.S. Congress has proposed numerous bills and resolutions in response to the opioid epidemic unfolding over the past decade. Although this legislative response has been the subject of considerable media attention and commentary, very little research has systematically analyzed congressional opioid-related legislation in terms of primary goals, focal populations, and the extent to which it includes punitive mechanisms.

MRI of the Prostate With and Without Endorectal Coil at 3 T: Correlation With Whole-Mount Histopathologic Gleason Score.

The purpose of this article is to prospectively compare image quality and diagnostic accuracy of clinically significant prostate cancer with and without endorectal coil (ERC) at 3 T using a combination of T2-weighted and diffusion-weighted MRI. Twenty-three patients with biopsy-proven prostate cancer underwent MRI with and without ERC at the same visit. Patients subsequently underwent radical prostatectomy. Specimens were assessed by whole-mount histopathologic examination. Two radiologists reviewed MR ima...

Overall, specific, and metastasis-free survival of Afro-Caribbean men with pathological Gleason 6 prostate cancer.

Several studies in the Caucasian population have shown that patients with Gleason 6 prostate cancer, based on surgical specimens, have low or no risk of metastasis. However, there is no data for men of African ancestry. The objective of this study was to estimate the overall, specific, and metastasis-free survival (MFS) of patients with a Gleason 6 score, based on the surgical specimen.

Evolution of prostate cancer histopathology.

During the last 15 years several updates in the Gleason grading have been made. With the help of pertinent research results pathologists have gained a better insight into the meanings of several prostate cancer (PCa) patterns and know better how to classify them in the Gleason grade system.

Proportion of cores with the highest Gleason grade group among positive cores on prostate biopsy: does this affect the probability of upgrading or downgrading?

This study assessed the ability to predict the probability of pathologic upgrading or downgrading based on the proportion of cores with the highest Gleason grade on prostate biopsy. From 2002-2017, 494 patients with multiple positive cores on prostate biopsy who underwent radical prostatectomy were included for the analysis. The proportion of cores with the highest Gleason grade group among positive cores was calculated and patients were divided into three groups based on the proportion (≤33% vs >33% and ...

Marine mammal vet's dedication marked by prestigious award.

Vet pathologist has been awarded the ZSL Silver Medal for his outstanding work in the field of wildlife conservation involving marine mammals. Jan Loveridge explains why the award is so well deserved.

Gold(I)-Catalyzed Highly Diastereo- and Enantioselective Cyclization/4+3 Annulation Cascades between 2-(1-Alkynyl)-2-alken-1-ones and Anthranils.

This work reports gold-catalyzed [4+3]-annulations of 2-(1-alkynyl)-2-alken-1-ones with anthranils to yield epoxybenzoazepine products with excellent exo-diastereoselectivity (dr > 25:1). The utility of this new gold catalysis is manifested by applicable substrates over a broad scope. More importantly, the enantioselective versions of these [4+3]-cycloadditions have been developed satisfactorily with chiral gold catalysts under ambient conditions (DCM, 0 °C); the ee levels range from 88.0-99.9%. With DFT c...

Investigating association of perineural invasion on prostate biopsy with Gleason score upgrading at prostatectomy: A multi-institutional analysis.

The significance of perineural invasion (PNI) in prostate cancer (PC) is unclear. A recent report of patients with pT2N0R0 PC found that PNI at prostatectomy was independently associated with higher Gleason score and more diffuse prostatic disease. We aimed to test our hypothesis that PNI on prostate biopsy in pT2N0R0 patients is associated with increased Gleason score upgrading at prostatectomy.

Gleason Pattern 4 with Cribriform Morphology on Biopsy is Associated with Adverse Clinicopathological Findings in a Prospective Radical Prostatectomy Cohort.

The prognostic significance of the Gleason grading system has been well established. However, individual Gleason pattern comprise heterogeneous morphologies which might add additional prognostic information. Recent evidence suggests that Gleason pattern 4 with cribriform growth pattern is associated with an adverse prognosis. To determine the association between cribriform pattern on biopsies and pathological findings on subsequent prostatectomies we evaluated the presence of cribriform architecture in a pr...

Greater SERS Activity of Ligand-Stabilized Gold Nanostars with Sharp Branches.

Sharp branches of gold nanostars are critical in tuning the plasmonic properties of these nanostars and maximizing the ac-tivities in surface enhanced Raman scattering (SERS). The interaction between the capping ligands and nanostars plays an essential role in determining the morphology of the branches on the gold nanostars. In this paper, we show that 4-mercapto benzoic acid can effectively control the morphology of branched gold nanostars and these gold nanostars can be used for the colloidal SERS detecti...

Expression of stromal elements of prostatic adenocarcinoma in different gleason scores.

To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control).

Maladaptive player-game relationships in problematic gaming and gaming disorder: A systematic review.

While certain player vulnerabilities are known to increase risk of gaming disorder (GD), the topic of maladaptive player × game relationships in GD has received limited attention. This review aimed to: (1) identify game types associated with GD symptomatology; and (2) evaluate individual differences (e.g., age, personality, depression) in the relationship between gaming and GD symptomatology. A systematic review of six databases identified 23 studies of the relations between game types and GD, includin...

DNA Origami Catenanes Templated by Gold Nanoparticles.

Mechanically interlocked molecules have marked a breakthrough in the field of topological chemistry and boosted the vigorous development of molecular machinery. As an archetypal example of the interlocked molecules, catenanes comprise macrocycles that are threaded through one another like links in a chain. Inspired by the transition metal-templated approach of catenanes synthesis, the hierarchical assembly of DNA origami catenanes templated by gold nanoparticles is demonstrated in this work. DNA origami cat...

Association of statin use with risk of Gleason score-specific prostate cancer: A hospital-based cohort study.

Conflicting evidence suggests that statins act chemopreventively against prostate cancer (PCa). Whether the association of statin use with PCa risk is Gleason score-dependent, time-, dose-respondent is not well studied.

Gold-catalyzed Iminations of Terminal Propargyl Alcohols with Anthranils with Atypical Chemoselectivity for C(1)-Additions and 1,2-Carbon Migration.

This work reports gold-catalyzed iminations of terminal propargyl alcohols with anthranils or isoxazoles to yield E-configurated α-amino-2-en-1-ones and -1-als with complete chemoselectivity. These catalytic iminations occur exclusively with the C(1)-nucleophilic additions on terminal alkynes, in contrast to a typical C(2)-route.  For 3,3-dialkylprop-1-yn-3-ols, a methyl substituent is superior to long alkyl chains as the 1,2-migration groups toward α-imino gold carbenes. For secondary prop-1-yn-3-ols, p...

Gold-Catalyzed Silyl-Migrative Cyclization of Homopropargylic Alcohols Enabled by Bifunctional Biphenyl-2-ylphosphine and DFT Studies.

The development of novel ligands specifically tailored for homogeneous gold catalysis permits the development of new gold catalysis. In this work, we report that a remotely functionalized biphenyl-2-ylphosphine ligand enables gold-catalyzed cyclization of homopropargylic alcohols accompanied by an unusual silyl migration, which provides efficient access to 3-silyl-4,5-dihydrofurans. DFT studies of the mechanism of this novel transformation suggest the synergy between the steric bulk of the ligand and its pr...

The German Society for Social Medicine and Prevention (DGSMP) confers the Salomon Neumann Medal for outstanding merit in the field of Preventive and Social Medicine. The Salomon Neumann Medal 2017 was awarded to Gerhard Trabert, founder and chairman of the association "Poverty and Health in Germany" and professor for social medicine und social psychiatry at the RheinMain University of applied sciences in Wiesbaden. It honours a physician in the field of social medicine, whose personality and activity as "do...

Expansile cribriform Gleason pattern 4 has histopathologic and molecular features of aggressiveness and greater risk of biochemical failure compared to glomerulation Gleason pattern 4.

Molecular testing of prostate cancer biopsies with Gleason pattern 4 suggests the expansile cribriform pattern is more aggressive than the glomerulation pattern. These two extreme patterns have not been compared at prostatectomy. We hypothesized that at prostatectomy the expansile cribriform pattern would be associated with histopathologic and molecular features of aggressiveness and with greater risk of biochemical recurrence (BCR) than the glomerulation pattern.

Gleason score 5+3=8 (grade group 4) prostate cancer - a rare occurrence with contemporary grading.

Grade Group (GG) 4 prostate cancer includes Gleason scores (GS) 3+5=8, 4+4=8, and 5+3=8. Some studies without pathology re-review of historical cohorts proposed that the presence of pattern 5 worsens prognosis compared to GS 4+4=8 cancer. We assessed how often historically graded GS 5+3=8 cancers retain this grade with contemporary grading recommendations. Sixteen prostate biopsies and 24 radical prostatectomies (RP) reported from 2005 to 2019 as GS 5+3=8 were re-reviewed and graded according to contemporar...

What Medical Students Teach: The Healing Skill of Being a Team Player.

The question, what makes a clinician a healer? may evoke the image of a devoted physician paying a critically important home visit at the end of a long day or the image of an astute nurse-steadfast, empathic, anticipating the patient's needs before they become apparent to others. But health care is no longer provided by lone doctors or nurses. In the modern health care system, multiple professionals must work together to provide safe and effective care. The moral nature of healing has not changed. But what ...

Nanoscale induced formation of silicide around gold nanoparticles encapsulated in a-Si.

Decorating thin film solar cells with plasmonic nanoparticles is being pursued, in order to improve device efficiency through increased scattering and local field enhancement. Gold nanoparticles are in particular interesting, due to their chemical inertness and plasmon resonance in the visible range of the spectrum. In this work, gold nanoparticles fabricated by a gas aggregation nanoparticle source and embedded in a-Si (a commercial solar cell material) are studied using x-ray photo-electron spectroscopy, ...

Ultrasound-assisted cyanide extraction of gold from gold concentrate at low temperature.

A sonochemical reactor was developed to study the ultrasound-assisted cyanide extraction of gold from gold ore at low temperature. The effects of ultrasound on gold leaching in low temperature and conventional conditions were investigated. At the low temperature of 10 °C, ultrasound-assisted extraction increased extraction rate of gold by 0.6%-0.8% and reduced the gold content of cyanide tailings to 0.28 g/t in the leaching of gold concentrate and cyanide tailings, respectively. At the conventional tempe...

Prevalence Of Positive Quantiferon-Tb Gold In-Tube Test In Uveitis And Its Clinical Implications In A Country Non-Endemic For Tuberculosis.

To report on the prevalence and clinical implications of positive QuantiFERON-Gold (QFT-G) test results in the diagnostic work-up of a large cohort of consecutive patients with uveitis in the Netherlands.

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