PubMed Journals Articles About "Poxel Present Results From Phase Study PXL065 Liver" RSS

03:41 EST 11th December 2019 | BioPortfolio

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Showing "Poxel Present Results From Phase Study PXL065 Liver" PubMed Articles 1–25 of 94,000+

In vitro metabolic activation of triphenyl phosphate leading to the formation of glutathione conjugates by rat liver microsomes.

The present study investigated the metabolism of the flame retardant and plasticizer chemical, triphenyl phosphate (TPHP), in a rat liver microsome-based in vitro assay with glutathione (GSH) in order to elucidate metabolic pathways leading to formation of conjugates. A highly sensitive and efficient method was developed for the detection and characterization of GSH reactive metabolites using LC-Q-TOF-MS/MS both in the negative and positive electrospray ionization modes. Seven GSH conjugates formed as a re...

Phase-contrast computed tomography: A correlation study between portal pressure and three dimensional microvasculature of ex vivo liver samples from carbon tetrachloride-induced liver fibrosis in rats.

Microvascular changes in liver fibrosis are considered as an important pathophysiological characteristic. Now, there is a lack of high-resolution three-dimensional (3D) imaging methods for observing the microvasculature throughout the entire livers. This study aims to investigate the 3D microvascular changes in the whole fibrotic livers via X-ray phase-contrast computed tomography (PCCT) and explore the correlations between portal pressures and microvascular changes in liver fibrosis progression.

Skin metabolism phase I and phase II enzymes in native and reconstructed human skin: a short review.

Understanding skin metabolism is important when considering drug discovery and safety assessment. This review compares xenobiotic skin metabolism in ex vivo skin to reconstructed human skin and reconstructed human epidermis models, concentrating on phase I and phase II enzymes. Reports on phase I enzymes are more abundant than for phase II enzymes with mRNA and protein expression far more reported than enzyme activity. Almost all of the xenobiotic metabolizing enzymes detected in human skin are also present...

Extensive Thrombectomy as a Legitimate Strategy in Living Donor Liver Transplantation with Advanced Portal Vein Thrombosis.

We read with great interest the article recently published in Liver Transplantation by Ikegami and colleagues (1). This study compared the clinical results of patients with and without portal vein thrombosis (PVT) underwent liver transplantation (LT). We would like to share our opinion and criticisms about this valuable work as follows.

Phase angle as a severity indicator for liver diseases.

The aim of this study was to evaluate the applicability of phase angle (PhA) as a severity indicator of chronic liver diseases.

MRI-based risk factors of hepatocellular carcinoma in patients with chronic liver disease: A prospective observational study.

MR-based metrics, including hepatobiliary phase (HBP) hypointense nodules without arterial phase hyperenhancement (APHE), and liver stiffness as measured by MR elastography are useful markers to stratify the risk of hepatocellular carcinoma (HCC) development in chronic liver disease patients. However, prospective studies are needed to clarify their utility.

Copper, Iron, Manganese, Zinc, Cobalt, Arsenic, Cadmium, Chrome, and Lead Concentrations in Liver and Muscle in Iranian Camel (Camelus dromedarius).

Camel meat as healthy food has received much attention for human consumption. In the present study, liver and muscle from 60 camels (Camelus dromedarius) including 26 males and 34 females were sampled to determine the concentration of As, Cd, Pb, Cr, Cu, Fe, Mn, Zn, and Co using the inductively coupled plasma-optical emission spectrometry (ICP-OES). Based on the obtained results, the average content of essential or toxic elements in the liver and muscle was as follows: 111.2 ± 26.51, 38.57 ± 7.97 (Zn), 3....

Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress.

The present study aimed to investigate the anti‑ferroptosis effects of the HMGB1 inhibitor glycyrrhizin (GLY). The present study used a cell and animal model of acute liver failure (ALF), induced using tumor necrosis factor‑α, lipopolysaccharide and D‑galactosamine, to investigate the effects of GLY. The expression of glutathione peroxidase 4 (GPX4) and high mobility group protein B1 (HMGB1), heme oxygenase‑1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf2) were detected were detec...

Considerations on "Nonagenarian Grafts for Liver Transplantation".

We read with great interest the recently published article by Ghinolfi et al entitled "Nonagenarian Grafts for Liver Transplantation" [1]. This study compared the outcomes of 16 nonagenarian graft recipients to a matched control population and results showed no major differences across the two groups. Authors concluded that the use of old donors allowed to drastically reduce waitlist mortality and drop-out rate, supporting the hypothesis that no age cut-off should be applied to deceased donors, despite age...

Combined gadoxetic acid and gadobenate dimeglumine enhanced liver MRI: a parameter optimization study.

To demonstrate the feasibility of combined delayed-phase gadoxetic acid (GA) and gadobenate dimeglumine (GD) enhanced liver MRI for improved detection of liver metastases, and to optimize contrast agent dose, timing, and flip angle (FA).

Procoagulant imbalance influences cardiovascular and liver damage in chronic hepatitis C independently of steatosis.

Patients with chronic HCV infection besides hepatitis often present cardiovascular damage, the pathogenesis of which is not defined. In chronic liver diseases, including NAFLD and cirrhosis, a procoagulant imbalance, potentially responsible for atherosclerosis has been reported. We aimed at evaluating whether a procoagulant imbalance is present also in non-cirrhotic patients with HCV infection and whether the procoagulant imbalance correlates with cardiovascular damage. The correlation between the procoagul...

The Differential Impact of Age Among Liver Transplant Candidates With and Without HCC.

Hepatocellular carcinoma (HCC) is the fastest rising cause of cancer-related mortality in the US and a leading indication for liver transplantation (LT). Changes in chronic liver disease burden have led to aging of the chronic liver disease population, but how this affects patients with HCC is unknown. This study aims to characterize trends and transplant-associated outcomes among patients ≥65y listed for LT with HCC.

Altered expression and activity of phase I and II biotransformation enzymes in human liver cells by perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS).

Human exposure assessments for perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) have been mostly limited to the quantification of these chemicals in different environmental matrices, but only a few studies have addressed toxicological aspects associated with them. It has been suggested that both PFOA and PFOS are highly stable chemicals that are not metabolized, yet previous reports have described abnormal activity of important biotransformation pathways. Therefore, the goal of the present stu...

Hepatic upregulation of fetuin-A mediates acetaminophen-induced liver injury through activation of TLR4 in mice.

Acetaminophen (APAP)-induced liver injury (AILI) is initiated by the generation of a reactive metabolite and ultimately leads to hepatocyte necrosis. Necrotic cells secrete damage-associated molecular patterns that activate hepatic nonparenchymal cells and induce an inflammatory response. Fetuin-A is a hepatokine with reported involvement in low-grade inflammation in many diseases, due to acting as an endogenous ligand for TLR4. However, little is known about the role of fetuin-A in AILI. In this study, we ...

The additional value of the arterial phase in the CT assessment of liver vascular injuries after high-energy blunt trauma.

In the literature, no consensus exists about which CT protocol is to be adopted in patients who underwent high-energy blunt trauma. The aim of the study is to evaluate the additional value of the arterial phase in the CT assessment of vascular injuries of the liver.

Nutrient Behavior in Hydrothermal Carbonization Aqueous Phase following Recirculation and Reuse.

Hydrothermal carbonization (HTC) has received much attention in recent years as a process to convert wet organic waste into carbon-rich hydrochar. The process also generates an aqueous phase that is still largely considered a burden. The success of HTC is dependent on finding solutions for the aqueous phase. In the present study, we provide the first investigation of recirculation of the aqueous phase from HTC of poultry litter as a means to concentrate nutrients, and its subsequent application to agricultu...

Factors related to the quality of life in liver cancer patients during treatment phase: A follow-up study.

This study aims to explore the predictive value of demographic and clinical factors in changes in quality of life (QoL) in liver cancer (LC) patients over time.

Thymosinβ4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways.

Liver fibrosis is an important health problem without adequate and effective therapeutics. In this study, effects of thymosinβ4 (Tβ4) on hepatic fibrogenesis and the underlying molecular mechanisms were explored in bile duct ligation (BDL)-induced mice cholestatic liver fibrosis model. Results showed exogenous Tβ4 significantly reduced the mortality and liver/body weight ratio in BDL mice. Histological examinations and biochemical analyses demonstrated that BDL induced evident portal fibrosis and a signi...

Transient cold storage prior to normothermic liver perfusion may facilitate adoption of a novel technology.

We read with interest the paper by Ceresa et al. reporting results of a multicenter, prospective trial to evaluate safety and feasibility of pre-static cold storage (pSCS) followed by normothermic machine perfusion (pSCS-NMP) versus continuous NMP in liver transplantation (LT).(1) The topic is of extreme interest and avoiding NMP at donor hospital has the potential to simplify logistics of procurement and reduce overall costs. However, the paper shows some methodological biases limiting the significance and...

Transcriptome analysis in normal human liver cells exposed to 2, 3, 3', 4, 4', 5 - Hexachlorobiphenyl (PCB 156).

Polychlorinated biphenyls are persistent environmental pollutants associated with the onset of non-alcoholic fatty liver disease in humans, but there is limited information on the underlying mechanism. In the present study, we investigated the alterations in gene expression profiles in normal human liver cells L-02 following exposure to 2, 3, 3', 4, 4', 5 - hexachlorobiphenyl (PCB 156), a potent compound that may induce non-alcoholic fatty liver disease.

Liver MR relaxometry at 3T - segmental normal T and T* values in patients without focal or diffuse liver disease and in patients with increased liver fat and elevated liver stiffness.

Magnetic resonance (MR) T and T* mapping allows quantification of liver relaxation times for non-invasive characterization of diffuse liver disease. We hypothesized that liver relaxation times are not only influenced by liver fibrosis, inflammation and fat, but also by air in liver segments adjacent to the lung - especially in MR imaging at 3T. A total of 161 study participants were recruited, while 6 patients had to be excluded due to claustrophobia or technically uninterpretable MR elastography. Resulting...

A Phase I Pharmacokinetic Study of Belinostat in Patients with Advanced Cancers and Varying Degrees of Liver Dysfunction.

The histone deacetylase (HDAC) inhibitor belinostat has activity in various cancers. Because belinostat is metabolized by the liver, reduced hepatic clearance could lead to excessive drug accumulation and increased toxicity. Safety data in patients with liver dysfunction are needed for this drug to reach its full potential in the clinic.

The potential of glycomics as prognostic biomarkers in liver disease and liver transplantation.

The study of glycomics is a novel and fascinating approach for the development of biomarkers. It has become clear that in the field of liver disease specific glycomic patters are present in specific disease states, which has led to the development of diagnostic biomarkers. In this manuscript, we will describe two new applications of this technology for the development of prognostic biomarkers. The first biomarker is associated with the risk of hepatocellular carcinoma development in patients with compensate...

Liver transplantation for Acute Liver Failure due to Dengue fever: first successful reported case worldwide.

Fever with jaundice and acute liver failure (ALF) like presentation may occur due to several infectious agents in addition to hepatotropic viruses, the list includes dengue virus, malaria, enteric fever, leptospirosis and scrub typhus. Generally acute liver failure is part of systemic infections in these infections. The Dengue virus is a non-hepatotropic virus, liver dysfunction is frequently present and ranges from transaminitis to acute liver failure. Liver transplantation for ALF associated with systemic...

Machine perfusion strategies in liver transplantation.

Machine perfusion is a hot topic in liver transplantation and several new perfusion concepts are currently developed. Prior to introduction into routine clinical practice, however, such perfusion approaches need to demonstrate their impact on liver function, post-transplant complications, utilization rates of high-risk organs, and cost benefits. Therefore, based on results of experimental and clinical studies, the community has to recognize the limitations of this technology. In this review, we summarize cu...

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