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Showing "Proposes Subscription Model Prod Antibiotic Development" PubMed Articles 1–25 of 36,000+

FDA calls for subscription model to pay for anti-infectives.

Use of Antibiotics for Dermatologic Procedures From 2008 to 2016.

Although overall antibiotic use among dermatologists is decreasing, there has been an increase in use associated with dermatologic procedures during the past decade. This higher antibiotic use may increase antibiotic-associated adverse events and promote the development of antibiotic resistance.

Development of actionable quality indicators and an action implementation toolbox for appropriate antibiotic use at intensive care units: A modified-RAND Delphi study.

Extensive antibiotic use makes the intensive care unit (ICU) an important focus for antibiotic stewardship programs. The aim of this study was to develop a set of actionable quality indicators for appropriate antibiotic use at ICUs and an implementation toolbox, which can be used to assess and improve the appropriateness of antibiotic use in the treatment of adult patients at an ICU.

Ensuring antibiotic development, equitable availability and responsible use of effective antibiotics: recommendations for multisectoral action.

Antibiotic resistance is a growing threat to global public health. The WHO Global Action Plan on Antimicrobial Resistance recommends engaging multisectoral stakeholders to tackle the issue. However, so far, few studies have addressed barriers to antibiotic development, equitable availability and responsible antibiotic use from the perspective of stakeholders outside healthcare facilities or patient communities: the so-called third-party stakeholders. Third-party stakeholders include, inter alia, governments...

Short-course versus long-course antibiotic treatment for community-acquired pneumonia: a literature review.

It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate if the effectiveness of a short-course antibiotic is comparable to a longer course of antibiotics in adults with CAP and to assess if the duration of an antibiotic course influences the development of resistant bacteria.

Inhibiting conjugation as a tool in the fight against antibiotic resistance.

Hit, Lead & Candidate Discovery Antibiotic resistance, especially in gram-negative bacteria, is spreading globally and rapidly. Development of new antibiotics lags behind; therefore, novel approaches to the problem of antibiotic resistance are sorely needed and this commentary highlights one relatively unexplored target for drug development: conjugation. Conjugation is a common mechanism of horizontal gene transfer in bacteria that is instrumental in the spread of antibiotic resistance among bacteria. Most ...

Antibiotic prophylaxis in TURP: a prospective analysis concerning antibiotic stewardship and a potential reduction of antibiotic use in TURP.

Antibiotic prophylaxis is standard procedure in transurethral resection of the prostate (TURP). We evaluated the necessity of antibiotic (AB) prophylaxis in TURP due to increasing microbial antibiotic resistance.

Emergence of antibiotic resistance in immunocompromised host populations: A case study of emerging antibiotic resistant tuberculosis in AIDS patients.

The evolution of antibiotic resistance is far outpacing the development of new antibiotics, causing global public health concern about infections that will increasingly be unresponsive to antimicrobials. This risk of emerging antibiotic resistance may be meaningfully altered in highly AIDS-immunocompromised populations. Such populations fundamentally alter the bacterial evolutionary landscape in two ways, which we seek to model and analyze. First, widespread, population-level immunoincompetence creates a no...

Impact of pharmacist-led antibiotic stewardship interventions on compliance with surgical antibiotic prophylaxis in obstetric and gynecologic surgeries in Nigeria.

Inappropriate and excessive use of surgical antibiotic prophylaxis are associated with the emergence of antibiotic resistance. Antibiotic prophylaxis malpractices are common in obstetrics and gynecology settings and antibiotic stewardship is used to correct such malpractice.

Optimal Control of Environmental Cleaning and Antibiotic Prescription in an Epidemiological Model of Methicillin-resistant Staphylococcus aureus Infections in Hospitals.

We consider a deterministic model of Methicillin-resistant Staphylococcus aureus infections in hospitals with seasonal oscillations of the antibiotic prescription rate. The model compartments consist of uncolonized patients with or without antibiotic exposure, colonized patients with or without antibiotic exposure, uncontaminated or contaminated healthcare workers, and free-living bacteria in the environment. We apply optimal control theory to this seven-compartment periodic system of ordinary differential ...

The Relative Impact of Community and Hospital Antibiotic Use on the Selection of Extended-Spectrum Beta-lactamase-Producing Escherichia coli.

Antibiotic stewardship programs have traditionally focused on reducing antibiotic use in hospital. However, reducing community antibiotic prescribing could have substantial impacts in both the hospital and community settings. We developed a deterministic model of transmission of ESBL-producing Escherichia coli in the community and hospital. We fit the model to existing national-level antibiotic use and resistance prevalence data from Sweden. Across a range of conditions, a given relative change in antibioti...

Antibiotic Use in Pregnancy, Abnormal Fetal Growth, and Development of Gestational Diabetes Mellitus.

 Antibiotics are commonly used in pregnancy. Prior studies have indicated that antibiotic use in pregnancy may affect birth weight, whereas data in nonpregnant individuals suggest that antibiotic exposure may increase diabetes risk. We evaluated the impact of antibiotic prescriptions during pregnancy on the prevalence of small for gestational age (SGA) and large for gestational age (LGA) birth weight and gestational diabetes mellitus (GDM).

Principles and Practice of Antibiotic Stewardship in the ICU.

In the face of emerging drug resistant pathogens and a decrease in the development of new antimicrobial agents, antibiotic stewardship should be practiced in all critical care units. Antibiotic stewardship should be a core competency of all critical care practitioners in conjunction with a formal Antibiotic Stewardship Program (ASP). Prospective audit and feedback, and antibiotic time outs are effective components of an ASP in the ICU. As rapid diagnostics are introduced in the ICU, assessment of performanc...

Impact of a Prescriber-driven Antibiotic Time-out on Antibiotic Use in Hospitalized Patients.

A multicenter quasi-experimental study of a provider-driven antibiotic "time-out" in 3470 antibiotic courses showed no difference in antibiotic use before and after implementation, but did show a decrease in inappropriate therapy (45% vs 31%, P < .05). Single time-outs without input from antibiotic stewardship teams are insufficient to optimize prescribing.

Peculiarities of antibiotic-associated diarrhea development in children with acute respiratory infections.

Introduction: Acute respiratory infections (ARI) are the main cause of morbidity in most countries. The probability of complications and age determine antibiotics administration. Antibiotic associated diarrhea (AAD) is one of the side effects of antibiotics. The aim: The study of the prevalence rate of AAD and the characteristics of its development in children with ARI.

Introducing the Joint EEG-Development Inference (JEDI) Model: A Multi-way, Data Fusion Approach for Estimating Paediatric Developmental Scores Via EEG.

Accounting for developmental changes in children is a key consideration for adapting neurorehabilitation technologies to paediatric populations. Using well-established clinical tests and questionnaires can be resource and time intensive. With many data-driven rehabilitation approaches relying on EEG data, a means to rapidly assess and infer developmental status of children directly from these recordings could be critical. This manuscript proposes a new model for estimating classic developmental diagnostic s...

Antibiotic use practice and predictors of hospital outcome among patients with systemic bacterial infection: Identifying targets for antibiotic and health care resource stewardship.

Malpractice and excess use of antimicrobials have been associated with multiple costs, including the development of resistant bacteria, which has become a threat to the human health. The aim of this study, therefore, was to assess the antibiotic use practice and to identify predictors of hospital outcome to uncover targets for stewardship.

Effects of iron oxide (Fe O ) nanoparticles on Escherichia coli antibiotic-resistant strains.

Antibiotic resistance of different bacteria requires the development of alternative approaches for overcoming this phenomenon. The antibacterial effects of iron oxide (Fe O ) nanoparticles (NPs) (from 50 μg mL to 250 μg mL ) on Escherichia coli antibiotic-resistant strains have been aimed.

A mini review and implementation model for using ataluren to treat nonsense mutation Duchenne muscular dystrophy.

Ataluren has been approved for treating nonsense mutation Duchenne muscular dystrophy (nmDMD) and there are currently discussions concerning drug access and applications beyond the development programme. This study provides an overview of nmDMD and ataluren, stipulates clinical rules for treatment initiation and discontinuation and proposes a model the implementation of orphan drugs in clinical practice in Sweden.

Quality of Research Practice - An interdisciplinary face validity evaluation of a quality model.

There are few acknowledged multidisciplinary quality standards for research practice and evaluation. This study evaluates the face validity of a recently developed comprehensive quality model that includes 32 defined concepts based on four main areas (credible, contributory, communicable, and conforming) describing indicators of research practice quality. Responses from 42 senior researchers working within 18 different departments at three major universities showed that the research quality model was-overal...

Hepatic decompensation during paritaprevir/ritonavir/ombitasvir/dasabuvir treatment for genotype 1b chronic hepatitis C patients with advanced fibrosis and compensated cirrhosis.

Hepatic decompensation is a severe on-treatment adverse event for chronic hepatitis C treated with paritaprevir/ritonavir/ombitasvir and dasabuvir (PrOD). Till now, few papers regarding on-treatment hepatic decompensation have been reported. The study aims to analyze the general feature and predictive factors of on-treatment hepatic decompensation in hepatitis C virus (HCV) genotype 1b-infected patients with advanced fibrosis and compensated cirrhosis who receive treatment with PrOD.

Altering polymerization temperature of antibiotic-laden cement can increase porosity and subsequent antibiotic elution.

To examine the role of polymerization temperature on the cement porosity and antibiotic elution to optimize antibiotic release from antibiotic-laden cement (ABLC).

Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea.

Antibiotic-resistant Neisseria gonorrhoeae has prompted the development of new therapies. Zoliflodacin is a new antibiotic that inhibits DNA biosynthesis. In this multicenter, phase 2 trial, zoliflodacin was evaluated for the treatment of uncomplicated gonorrhea.

Prolonged initial empirical antibiotic treatment and the risk of morbidity and mortality in very low birthweight infants.

The objective of this study is to evaluate the association between the duration of ini tial empirical antibiotic treatment and the subsequent development of late-onset sepsis, necrotizing enterocolitis (NEC) and death in very low birth weight (VLBW) infants.

Pig as a large animal model for posterior fossa surgery in oto-neurosurgery: A cadaveric study.

This study proposes a practical model for a new approach to the posterior fossa in common domestic pigs. Several surgical procedures can be simulated in the nonliving pig model, including soft tissue dissection, drilling of temporal bone, dural incision, access to the cerebellopontine angle, exposure of cranial nerves and drilling of the internal auditory canal. The pig model perfectly simulates standard otological and neurosurgical procedures, and we highlight the feasibility of our approach for further ex...

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