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PubMed Journals Articles About "Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry" RSS

17:28 EDT 18th June 2018 | BioPortfolio

Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry articles that have been published worldwide.

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Showing "Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry" PubMed Articles 1–25 of 19,000+

In situ monitoring of cocrystals in formulation development using low-frequency Raman spectroscopy.

In recent years, to guarantee a quality-by-design approach to the development of pharmaceutical products, it is important to identify properties of raw materials and excipients in order to determine critical process parameters and critical quality attributes. Feedback obtained from real-time analyses using various process analytical technology (PAT) tools has been actively investigated. In this study, in situ monitoring using low-frequency (LF) Raman spectroscopy (10-200cm), which may have higher discrimina...


Monitoring mAb Cultivations with In-Situ Raman Spectroscopy: The influence of spectral selectivity on calibration models and industrial use as reliable PAT Tool.

Raman spectroscopy is a suitable monitoring technique for CHO cultivations. However, a thorough discussion of peaks, bands and region assignments to key metabolites and culture attributes, and the interpretability of produced calibrations is scarce. That understanding is vital for the long-term predictive ability of monitoring models, and to facilitate lifecycle management that comply with regulatory guidelines. Several fed-batch lab-scale mAb mammalian cultivations were carried out, with in-situ Raman spec...

Quantitative measurement of carbon isotopic composition in CO2 gas reservoir by Micro-Laser Raman spectroscopy.

The use of Micro-Laser Raman spectroscopy technology for quantitatively determining gas carbon isotope composition is presented. In this study, 12CO2 and 13CO2 were mixed with N2 at various molar fraction ratios to obtain Raman quantification factors (F12CO2 and F13CO2), which provide a theoretical basis for calculating the δ13C value. And the corresponding values were 0.523 (0


Raman spectroscopy as a PAT for pharmaceutical blending: Advantages and disadvantages.

Raman spectroscopy has been positively evaluated as a tool for the in-line and real-time monitoring of powder blending processes and it has been proved to be effective in the determination of the endpoint of the mixing, showing its potential role as process analytical technology (PAT). The aim of this study is to show advantages and disadvantages of Raman spectroscopy with respect to the most traditional HPLC analysis. The spectroscopic results, obtained directly on raw powders, sampled from a two-axis blen...

Establishment of dual reverse phase chromatography combined parallel reaction monitoring for targeted quantitative proteomics.

Steady improvement in mass spectrometers technology has transformed the targeted proteome analysis into a new stage. Parallel reaction monitoring (PRM) technology has evolved from the basic multiple reaction monitoring (MRM) targeted proteomics methods in recent years. PRM performs with a higher sensitivity, throughput and reproducibility in targeted quantification, however its limitations in effectiveness and accurate quantification of samples with higher complexity still remain unsolved. In this study thr...

Indirect glyphosate detection based on ninhydrin reaction and surface-enhanced Raman scattering spectroscopy.

Glyphosate is one of the most commonly-used and non-selective herbicides in agriculture, which may directly pollute the environment and threaten human health. A simple and effective approach to assessment of its damage to the natural environment is thus quite necessary. However, traditional chromatography-based detection methods usually suffer from complex pretreatment procedures. Herein, we propose a simple and sensitive method for the determination of glyphosate by combining ninhydrin reaction and surface...

Raman spectroscopy studies of the terahertz vibrational modes of a DUT-8 (Ni) metal-organic framework.

Low-frequency lattice vibrational modes have been discussed to play a crucial role in the phase transformation process of flexible metal-organic frameworks (MOFs). Therefore, Raman spectroscopy was applied to study the lattice dynamics of a pillared layer DUT-8(Ni) framework (DUT - Dresden University of Technology), existing in rigid and flexible forms. Both the open and the close pore phases could be unambiguously identified by breathing mode bands at 23 cm-1 and 60 cm-1 in the corresponding Raman spectra,...

Label-free Raman characterization of bacteria calls for standardized procedures.

Raman spectroscopy has gained relevance in single-cell microbiology for its ability to detect bacterial (sub)populations in a non-destructive and label-free way. However, the Raman spectrum of a bacterium can be heavily affected by abiotic factors, which may influence the interpretation of experimental results. Additionally, there is no publicly available standard for the annotation of metadata describing sample preparation and acquisition of Raman spectra. This article explores the importance of sample man...

Two-dimensional electronic-Raman spectroscopy.

We present a new technique, two-dimensional electronic-Raman spectroscopy (2DER), which combines femtosecond stimulated Raman spectroscopy and a pulse-shaper-assisted 2D spectroscopic scheme for the actinic pump. The 2DER spectrum presents the initial actinic excitation wavelength with nanometer spectral resolution in the first axis and the detected stimulated Raman spectra in the second axis. We measured the correlation of the electronic and vibrational states in the photosynthetic accessory pigment β-car...

Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring.

One of the most ambitious endeavors in the field of diabetes technology is non-invasive glucose sensing. In the past decades, a number of different technologies have been assessed, but none of these have found its entry into general clinical use. We report on the development of a table-top confocal Raman spectrometer that was used in the home of patients with diabetes and operated for extended periods of time unsupervised and without recalibration. The system is based on measurement of glucose levels at a '...

Optimization of Sample Preparation processes of Bone Material for Raman Spectroscopy.

Raman spectroscopy has recently been investigated for use in the calculation of postmortem interval from skeletal material. The fluorescence generated by samples, which affects the interpretation of Raman data, is a major limitation. This study compares the effectiveness of two sample preparation techniques, chemical bleaching and scraping, in the reduction of fluorescence from bone samples during testing with Raman spectroscopy. Visual assessment of Raman spectra obtained at 1064 nm excitation following th...

Stimulated Raman spectroscopy of analytes evanescently probed by a silicon nitride photonic integrated waveguide.

We report, to the best of our knowledge, the first demonstration of stimulated Raman spectroscopy enhanced by a nanophotonic integrated circuit. The Raman response of low-concentration dimethyl sulfoxide is evanescently probed via centimeter-long wire waveguides. A signal enhancement of close to five orders of magnitude, as compared to the case of on-chip spontaneous Raman scattering, is demonstrated. This significant enhancement factor allows for the use of continuous-wave lasers with milliwatt-level power...

Comparison of multivariate data analysis techniques to improve glucose concentration prediction in mammalian cell cultivations by Raman spectroscopy.

In-situ Raman spectroscopy is frequently applied to monitor and even control the glucose concentration of monoclonal antibody producing mammalian cell cultivations. Previous studies used the PLSR algorithm only, however other multivariate algorithms were applied successfully for different protein production processes. In this study, four mammalian cell cultivation runs were followed with Raman spectroscopy and the spectra were analysed quantitatively and qualitatively as well. The PCA analysis showed that o...

Probing pharmaceutical mixtures during milling: the potency of low frequency Raman spectroscopy in identifying disorder.

This study uses a multimodal analytical approach to evaluate the rates of (co-)amorphization of milled drug and excipient and the effectiveness of different analytical methods in detecting these changes. Indomethacin and tryptophan were the model substances, and the analytical methods included low frequency Raman spectroscopy (785 nm excitation and capable of measuring both low- (10 to 250 cm-1) and mid-frequency (450 to 1800 cm-1) regimes, and a 830 nm system (5 to 250 cm-1)), conventional (200 - 3000 cm-1...

Effect of Intermolecular Distance on Surface-Plasmon-Assisted Catalysis.

4-Aminothiophenol (PATP) and 4-aminophenyl disulfide (APDS) in contact with silver will form H2N-C6H4-S-Ag (PATP-Ag), and under the conditions of surface-enhanced Raman spectroscopy (SERS) a coupling reaction will generate 4,4-dimercaptoazobenzene (DMAB). DMAB is strongly Raman-active, showing strong peaks at 1140, 1390, and 1432 cm-1, and is widely used in surface-plasmon-assisted catalysis. Using APDS, PATP, PNTP, and NPDS as probe molecules, Raman spectroscopy and imaging techniques have been used ...

Continuous gradient temperature Raman spectroscopy from -100 to 40°C yields new molecular models of arachidonic acid and 2-Arachidonoyl-1-stearoyl-sn-glycero-3-phosphocholine.

Despite its biochemical importance, a complete Raman analysis of arachidonic acid (AA, 20:4n-6) has never been reported. Gradient temperature Raman spectroscopy (GTRS) applies the temperature gradients utilized in differential scanning calorimetry (DSC) to Raman spectroscopy, providing a straightforward technique to identify molecular rearrangements that occur near and at phase transitions. Herein we utilize the GTRS technique for AA and 1-18:0, 2-20:4n-6 phosphatidyl choline (AAPC) from cryogenic to mammal...

Development of an in-line Raman spectroscopic method for continuous API quantification during twin-screw wet granulation.

Raman spectroscopy was evaluated as a process analytical technology (PAT) tool for continuous API quantification during twin-screw wet granulation. Therefore, a Raman probe was implemented in front of the granulator barrel. This setup enabled the collection of Raman spectra upon a constant granule flow. To develop an in-line PLS calibration model, eight binary mixtures of the API and lactose monohydrate with API contents between 5-50% were pre-blended and granulated in a twin-screw granulator with a screw s...

A Direct Bicarbonate Detection Method Based on a Near-Concentric Cavity-Enhanced Raman Spectroscopy System.

Raman spectroscopy has great potential as a tool in a variety of hydrothermal science applications. However, its low sensitivity has limited its use in common sea areas. In this paper, we develop a near-concentric cavity-enhanced Raman spectroscopy system to directly detect bicarbonate in seawater for the first time. With the aid of this near-concentric cavity-enhanced Raman spectroscopy system, a significant enhancement in HCO₃- detection has been achieved. The obtained limit of detection (LOD) is determ...

Monitoring Reaction Paths Using Vibrational Spectroscopies: The Case of the Dehydrogenation of Propane toward Propylene on Pd-Doped Cu(111) Surface.

Monitoring reaction paths is not only a fundamental scientific issue but also helps us to understand and optimize the catalytic process. Infrared (IR) and Raman spectroscopies are powerful tools for detecting particular molecules or intermediate products as a result of their ability to provide the molecular "finger-print". However, theoretical modeling for the vibrational spectra of molecular adsorbates on metallic surfaces is a long-standing challenge, because accurate descriptions of the electronic struct...

β-NaTeO: Phase Transition from an Orthorhombic to a Monoclinic Form. Reversible CO Capture.

The present work concerns the tellurate NaTeO which has a 1D structure and could then present a CO capture ability. It has been synthesized in a powder form via a solid-state reaction and structurally characterized by thermal X-ray diffraction experiments, Raman spectroscopy, and differential scanning calorimetry. The room temperature structure corresponds to the β-NaTeO orthorhombic form, and we show that it undergoes a reversible structural transition near 420 °C toward a monoclinic system. Ab initio co...

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry.

Different factors affect the long term stability of monoclonal antibodies, among them denaturation or partial denaturation that is often followed by aggregation. Isothermal calorimetry is capable of quantifying the kinetics of denaturation/aggregation of an antibody by measuring the heat that is released or absorbed by the process over a period of days or weeks, at temperatures below its denaturation temperature, T. The denaturation/aggregation kinetics of the anti-HIV monoclonal antibody VRC07-523LS was me...

Impulsive Raman spectroscopy via precision measurement of frequency shift with low energy excitation.

Stimulated Raman scattering (SRS) has recently become useful for chemically selective bioimaging. It is usually measured via modulation transfer from the pump beam to the Stokes beam. Impulsive stimulated Raman spectroscopy, on the other hand, relies on the spectral shift of ultrashort pulses as they propagate in a Raman active sample. This method was considered impractical with low energy pulses since the observed shifts are very small compared to the excitation pulse bandwidth, spanning many terahertz. He...

Analysis of Fiber-Enhanced Raman Gas Sensing Based on Raman Chemical Imaging.

Fiber enhanced Raman spectroscopy (FERS) is an arising new technique for versatile highly sensitive and selective multigas analysis in various applications, such as environmental monitoring and medical breath diagnosis. In this study, the performance of FERS was thoroughly studied with the help of a specially designed multichannel Raman chemical imaging. Several types of hollow core photonic crystal fibers were thoroughly analyzed in terms of their performance in light confinement and sensitive gas sensing....

Selectivity/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis.

Surface-enhanced Raman spectroscopy (SERS) is a powerful technique for the discrimination, identification, and potential quantification of certain compounds/organisms. However, its real application is challenging due to the multiple interference from the complicated detection matrix. Therefore, selective/specific detection is crucial for the real application of SERS technique. We summarize in this review five selective/specific detection techniques (chemical reaction, antibody, aptamer, molecularly imprinte...

Determination of nutritional parameters of yoghurts by FT Raman spectroscopy.

FT-Raman quantitative analysis of nutritional parameters of yoghurts was performed with the help of partial least squares models. The relative standard errors of prediction for fat, lactose and protein determination in the quantified commercial samples equalled to 3.9, 3.2 and 3.6%, respectively. Models based on attenuated total reflectance spectra of the liquid yoghurt samples and of dried yoghurt films collected with the single reflection diamond accessory showed relative standard errors of prediction val...


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