Advertisement

Topics

PubMed Journals Articles About "Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry" RSS

23:37 EDT 25th September 2018 | BioPortfolio

Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry articles that have been published worldwide.

More Information about "Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry" on BioPortfolio

We have published hundreds of Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry news stories on BioPortfolio along with dozens of Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry Clinical Trials and PubMed Articles about Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry Companies in our database. You can also find out about relevant Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry Drugs and Medications on this site too.

Showing "Reaction Monitoring Market Technology Spectroscopy Raman Chromatography Calorimetry" PubMed Articles 1–25 of 19,000+

In situ monitoring of cocrystals in formulation development using low-frequency Raman spectroscopy.

In recent years, to guarantee a quality-by-design approach to the development of pharmaceutical products, it is important to identify properties of raw materials and excipients in order to determine critical process parameters and critical quality attributes. Feedback obtained from real-time analyses using various process analytical technology (PAT) tools has been actively investigated. In this study, in situ monitoring using low-frequency (LF) Raman spectroscopy (10-200cm), which may have higher discrimina...


Monitoring mAb Cultivations with In-Situ Raman Spectroscopy: The influence of spectral selectivity on calibration models and industrial use as reliable PAT Tool.

Raman spectroscopy is a suitable monitoring technique for CHO cultivations. However, a thorough discussion of peaks, bands and region assignments to key metabolites and culture attributes, and the interpretability of produced calibrations is scarce. That understanding is vital for the long-term predictive ability of monitoring models, and to facilitate lifecycle management that comply with regulatory guidelines. Several fed-batch lab-scale mAb mammalian cultivations were carried out, with in-situ Raman spec...

Label-free Raman characterization of bacteria calls for standardized procedures.

Raman spectroscopy has gained relevance in single-cell microbiology for its ability to detect bacterial (sub)populations in a non-destructive and label-free way. However, the Raman spectrum of a bacterium can be heavily affected by abiotic factors, which may influence the interpretation of experimental results. Additionally, there is no publicly available standard for the annotation of metadata describing sample preparation and acquisition of Raman spectra. This article explores the importance of sample man...


Critical-depth Raman spectroscopy enables home-use non-invasive glucose monitoring.

One of the most ambitious endeavors in the field of diabetes technology is non-invasive glucose sensing. In the past decades, a number of different technologies have been assessed, but none of these have found its entry into general clinical use. We report on the development of a table-top confocal Raman spectrometer that was used in the home of patients with diabetes and operated for extended periods of time unsupervised and without recalibration. The system is based on measurement of glucose levels at a '...

Predicting post-mortem meat quality in porcine longissimus lumborum using Raman, near infrared and fluorescence spectroscopy.

Spectroscopic techniques can provide valuable information about post-mortem meat quality. In the current study, Raman, NIR and fluorescence spectroscopy was used to analyze pH, drip loss and intramuscular fat in pork longissimus lumborum (n = 122) at 4-5 days post-mortem. Results were promising for partial least squares regression (PLSR) from Raman spectroscopy, giving coefficients of determination from cross validation (r) ranging from 0.49 to 0.73 for all attributes examined. Important regions in th...

Optimization of Sample Preparation processes of Bone Material for Raman Spectroscopy.

Raman spectroscopy has recently been investigated for use in the calculation of postmortem interval from skeletal material. The fluorescence generated by samples, which affects the interpretation of Raman data, is a major limitation. This study compares the effectiveness of two sample preparation techniques, chemical bleaching and scraping, in the reduction of fluorescence from bone samples during testing with Raman spectroscopy. Visual assessment of Raman spectra obtained at 1064 nm excitation following th...

Monitoring of Hydrogenation by Benchtop NMR with Parahydrogen-Induced Polarization.

Reaction monitoring using nuclear magnetic resonance (NMR) spectroscopy is a powerful tool that provides detailed information on the characteristics and mechanism of the reaction. Although high-field NMR provides more accurate and abundant data, which can be explained in terms of Boltzmann factors, benchtop NMR is commonly used because of its low cost and simple maintenance. Therefore, hyperpolarization of the sample in benchtop NMR is a suitable protocol for real-time reaction monitoring. Herein, the princ...

Raman chemical imaging, a new tool in kidney stone structure analysis: Case-study and comparison to Fourier Transform Infrared spectroscopy.

The kidney stone's structure might provide clinical information in addition to the stone composition. The Raman chemical imaging is a technology used for the production of two-dimension maps of the constituents' distribution in samples. We aimed at determining the use of Raman chemical imaging in urinary stone analysis.

Stimulated Raman spectroscopy of analytes evanescently probed by a silicon nitride photonic integrated waveguide.

We report, to the best of our knowledge, the first demonstration of stimulated Raman spectroscopy enhanced by a nanophotonic integrated circuit. The Raman response of low-concentration dimethyl sulfoxide is evanescently probed via centimeter-long wire waveguides. A signal enhancement of close to five orders of magnitude, as compared to the case of on-chip spontaneous Raman scattering, is demonstrated. This significant enhancement factor allows for the use of continuous-wave lasers with milliwatt-level power...

Comparison of multivariate data analysis techniques to improve glucose concentration prediction in mammalian cell cultivations by Raman spectroscopy.

In-situ Raman spectroscopy is frequently applied to monitor and even control the glucose concentration of monoclonal antibody producing mammalian cell cultivations. Previous studies used the PLSR algorithm only, however other multivariate algorithms were applied successfully for different protein production processes. In this study, four mammalian cell cultivation runs were followed with Raman spectroscopy and the spectra were analysed quantitatively and qualitatively as well. The PCA analysis showed that o...

Broadband Fourier-transform coherent Raman spectroscopy with an ytterbium fiber laser.

We demonstrate a Fourier transform (FT) coherent anti-Stokes Raman scattering (CARS) spectroscopy system based on fiber technology with ultra-broad spectral coverage and high-sensitivity. A femtosecond ytterbium fiber oscillator is amplified and spectrally broadened in a photonic crystal fiber to synthesize pulses with energy of 14 nJ at 1040 nm, that are compressed to durations below 20 fs. The resulting pulse train is coupled to a FT-CARS interferometer enabling measurement of high-quality CARS spectra wi...

Effect of Intermolecular Distance on Surface-Plasmon-Assisted Catalysis.

4-Aminothiophenol (PATP) and 4-aminophenyl disulfide (APDS) in contact with silver will form H2N-C6H4-S-Ag (PATP-Ag), and under the conditions of surface-enhanced Raman spectroscopy (SERS) a coupling reaction will generate 4,4-dimercaptoazobenzene (DMAB). DMAB is strongly Raman-active, showing strong peaks at 1140, 1390, and 1432 cm-1, and is widely used in surface-plasmon-assisted catalysis. Using APDS, PATP, PNTP, and NPDS as probe molecules, Raman spectroscopy and imaging techniques have been used ...

Raman Optical Activity and Raman spectroscopy of carbohydrates in solution.

This comprehensive study on selected 14 carbohydrates in water solution is an extension of previously published one focused only on solid state analysis. Here, Raman spectroscopy was used as a dedicated method for analysis of carbohydrates in solution, both using a normal effect (RS) and its chiral analogue: Raman Optical Activity spectroscopy (ROA). The compounds were selected as biologically important and representative of all groups: monosaccharides, disaccharides, trisaccharides, cyclodextrines and poly...

Assessment of physiological responses and growth phases of different microalgae under environmental changes by Raman spectroscopy with chemometrics.

The assessment for cell physiology and growth phases of microalgae plays important roles in ecological and environmental fields since it can be used to forecast water eutrophication level worldwidely. Herein, growth phases and environmental conditions of microalgae were assessed by combining resonance Raman mapping spectroscopy with multivariate analysis methods. And, primary Raman characteristic peaks of microalgae were mined with two-dimensional synchronous spectra. Thereafter, algal growth phases and env...

β-NaTeO: Phase Transition from an Orthorhombic to a Monoclinic Form. Reversible CO Capture.

The present work concerns the tellurate NaTeO which has a 1D structure and could then present a CO capture ability. It has been synthesized in a powder form via a solid-state reaction and structurally characterized by thermal X-ray diffraction experiments, Raman spectroscopy, and differential scanning calorimetry. The room temperature structure corresponds to the β-NaTeO orthorhombic form, and we show that it undergoes a reversible structural transition near 420 °C toward a monoclinic system. Ab initio co...

Long term stability of a HIV-1 neutralizing monoclonal antibody using isothermal calorimetry.

Different factors affect the long term stability of monoclonal antibodies, among them denaturation or partial denaturation that is often followed by aggregation. Isothermal calorimetry is capable of quantifying the kinetics of denaturation/aggregation of an antibody by measuring the heat that is released or absorbed by the process over a period of days or weeks, at temperatures below its denaturation temperature, T. The denaturation/aggregation kinetics of the anti-HIV monoclonal antibody VRC07-523LS was me...

Raman spectroscopy based differentiation of typhoid and dengue fever in infected human sera.

This study investigated the potential of Raman spectroscopy, to differentiate between two different types of human pathological conditions with some symptom similarity; typhoid and dengue. Raman spectra were recorded from 20 Salmonella Typhi infected and 22 dengue virus (DENV) infected sera samples using laser wavelength 785 nm. When Raman spectrum (540 to 1830 cm) of serum samples was compared it showed significant variations. Twelve characteristic Raman bands at 562, 649, 716, 780, 838, 1099, 1144, 11...

New High Pressure Phases of Energetic Material TEX: Evidence from Raman Spectroscopy, X-ray Diffraction and First Principles Calculations.

Samples of energetic material TEX (C6H6N4O8) are studied using Raman spectroscopy and X-ray diffraction (XRD) up to 27GPa pressure. There are clear changes in the Raman spectra and XRD patterns around 2 GPa related to a conformational change in the TEX molecule, and a phase transformation above 11 GPa. The molecular structures and vibrational frequencies of TEX are calculated by density functional theory based Gaussian 09W and CASTEP programs. The computed frequencies compare well with Raman spectroscopic r...

Tracing hematopoietic progenitor cell neutrophilic differentiation via Raman spectroscopy.

A major challenge to experimental studies and therapeutic uses of hematopoietic stem cells (HSC) is the limited options for analytical tools that can reliably resolve functional differences in heterogeneous HSC subpopulations at the single cell level. Currently available methods require the use of external labels and/or separate clonogenic and transplantation assays to identify bona fide stem cells, necessitating the harvest of bulk cell populations and long incubation time that obscure how individual HSCs ...

Methionine oxidation by hydrogen peroxide in peptides and proteins: A theoretical and Raman spectroscopy study.

The oxidation of proteins results in their deterioration via the oxidation of reactive amino acids. Oxidation of the amino acid, methionine plays an important role during biological conditions of oxidative stress, and equally a role in protein stability. In this study the oxidation of the methionine residue using the tripeptide GlyMetGly with respect to hydrogen peroxide has been studied using both Raman spectroscopy and DFT calculations. Spectral modifications following the formation of methionine sulfoxid...

Discrimination Between Infant and Adult Bloodstains Using Micro-Raman Spectroscopy: A Preliminary Study.

In the present study, we used micro-Raman spectroscopy with high-resolution analysis to discriminate between bloodstains from infants and bloodstains from adults. Raman peaks were detected at 674, 754, 976, 1002, 1105, 1127, 1176, 1248, 1340, 1368, 1390, 1560, and 1611 cm ; these peaks were derived from hemoglobin, albumin, and glucose. However, a peak was obtained at 1105 cm , which was assigned to histidine; this peak was observed only for bloodstains from adults. Human adult hemoglobin (HbA) is compose...

Time domain diffuse Raman spectrometer based on a TCSPC camera for the depth analysis of diffusive media.

We present a time domain diffuse Raman spectrometer for depth probing of highly scattering media. The system is based on, to the best of our knowledge, a novel time-correlated single-photon counting (TCSPC) camera that simultaneously acquires both spectral and temporal information of Raman photons. A dedicated non-contact probe was built, and time domain Raman measurements were performed on a tissue mimicking bilayer phantom. The fluorescence contamination of the Raman signal was eliminated by early time ga...

Determination of nutritional parameters of yoghurts by FT Raman spectroscopy.

FT-Raman quantitative analysis of nutritional parameters of yoghurts was performed with the help of partial least squares models. The relative standard errors of prediction for fat, lactose and protein determination in the quantified commercial samples equalled to 3.9, 3.2 and 3.6%, respectively. Models based on attenuated total reflectance spectra of the liquid yoghurt samples and of dried yoghurt films collected with the single reflection diamond accessory showed relative standard errors of prediction val...

Monitoring of blood oxygenation in brain by resonance Raman spectroscopy.

Blood oxygenation in cerebral vessels is an essential parameter to evaluate brain function and to investigate the coupling between local blood flow and neuronal activity. We apply resonance Raman spectroscopy in vivo to study hemoglobin oxygenation in cortex vessels of anesthetized ventilated mice. We demonstrate that the pairs of Raman peaks at 1355 and1375 cm(symmetric vibrations of pyrrol half-rings in the heme molecule), 1552 and 1585 cmand 1602 and 1638 cm(vibrations of methine bridges in heme molecule...

Surface-enhanced Raman spectroscopy of two-dimensional tin diselenide nanoplates.


Advertisement
Quick Search
Advertisement
Advertisement