PubMed Journals Articles About "Researchers Create Druggable Love Hormone" RSS

02:00 EST 27th February 2020 | BioPortfolio

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Showing "Researchers create druggable love hormone" PubMed Articles 1–25 of 4,900+

Self-Reported Health and Patterns of Romantic Love in Adolescents from Eight European Countries and Regions.

Sexual minority youth (SMY) are at increased risk of poor health, but it remains unclear whether this phenomenon is universal. In this study, nationally representative samples of 15-year olds from eight European countries and regions were investigated to test if adolescents who have been in love with same- or both-gender partners report poorer health than those exclusively in love with opposite-gender partners or who have never been in love. A subsample of 13,674 adolescents participating in the 2014 Healt...

The Structure of the Concepts Related to Love Spectrum: Emotional Verbal Fluency Technique Application, Initial Psychometrics, and Its Validation.

Love has been thoroughly studied and a variety of definitions as well as types of love have been described in the literature. Given the data presenting natural language of love concept, the aim of the two present studies is to demonstrate a new technique which enables description of the structure of emotion concepts within love spectrum. This technique is based on emotional verbal fluency tasks. The procedure and the coding system used are reported in the article along with the data on reliability and stand...

Structure-based view of the druggable genome.

International efforts are underway to develop chemical probes for specific protein families, and a 'Target 2035' call to expand these efforts towards a comprehensive chemical coverage of the druggable human genome was recently announced. However, what is the druggable genome? Here, we systematically review structures of proteins bound to drug-like ligands available from the Protein Data Bank (PDB) and use ligand desolvation upon binding as a druggability metric to draw a landscape of the human druggable gen...

Sexual Attraction and Falling in Love in Persons with Pedohebephilia.

Few studies of pedophilia or hebephilia have included questions about romantic attraction. We conducted an anonymous online survey of 306 men who self-reported as sexually attracted to children. The majority (72%) of participants reported they had fallen in love with a child in their lifetime. Participants reported greater feelings of attachment to children than feelings of infatuation. Though sexual attraction and falling in love were strongly correlated, they were not synonymous. Participants who reported...

Druggable genome in attention deficit/hyperactivity disorder and its co-morbid conditions. New avenues for treatment.

Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder with only symptomatic care available. Genome-wide association (GWA) studies can provide a starting point in the search for novel drug targets and possibilities of drug repurposing. Here, we explored the druggable genome in ADHD by utilising GWA studies on ADHD and its co-morbid conditions. First, we explored whether the genes targeted by current ADHD drugs show association with the disorder and/or its co-morbidities. Sec...

: open-source mobile software for distributed studies of hearing.

The recent emphasis on outcomes-based medical research has motivated a need for technology that allows researchers and clinicians to reach a larger and more diverse subject population for recruitment and testing. This article reports on open-source mobile software () that enables researchers to administer customised hearing tests and questionnaires on tablets located across multiple sites. Researchers create and modify test protocols using text-based templates and deploy it to the tablets via a cloud-based ...

Model informed quantification of the feed-forward stimulation of growth hormone by growth hormone releasing hormone.

Growth hormone (GH) secretion is pulsatile and secretion varies highly between individuals. To understand and ultimately predict GH secretion, it is important to first delineate and quantify the interaction and variability in the biological processes underlying stimulated GH secretion. This study reports on the development of a population non-linear mixed effects model for GH stimulation, incorporating individual GH kinetics and the stimulation of GH by GH releasing hormone (GHRH).

Growth hormone replacement in adults: Real-world data from two large studies in US and Europe.

This report describes the effectiveness and safety of growth hormone replacement in 3180 adult patients with growth hormone deficiency followed-up for 0.0-12.2 years in two completed, complementary, non-interventional, multicentre studies, NordiNet® International Outcome Study (IOS) (NCT00960128) and the American Norditropin® Studies: Web-Enabled Research (ANSWER) Program (NCT01009905).

I love my dog.

Microorganisms and metals: a love-hate relationship ?

Can an Off-Nominal Landing by an MMRTG-Powered Spacecraft Induce a Special Region on Mars When No Ice Is Present?

This work aims at addressing whether a catastrophic failure of an entry, descent, and landing event of a Multimission Radioisotope Thermoelectric Generator-based lander could embed the heat sources into the martian subsurface and create a local environment that (1) would temporarily satisfy the conditions for a martian Special Region and (2) could establish a transport mechanism through which introduced terrestrial organisms could be mobilized to naturally occurring Special Regions elsewhere on Mars. Two mo...

Painless destructive thyroiditis in a patient with resistance to thyroid hormone: a case report.

Resistance to thyroid hormone (RTH) usually features a syndrome of inappropriate secretion of thyroid-stimulating hormone (SITSH) without suppression of the typical high thyroid hormone levels. However, some patients with RTH show thyroid-stimulating hormone (TSH) suppression due to thyrotoxicosis. We report a case of painless thyroiditis in a patient with RTH that was misdiagnosed as Graves' disease because of TSH-suppressed thyrotoxicosis.

The vaccine hesitation in France or the story of a disappointed love?

Sarcopenia is not 'Love': You Have to Look Where You Lost it!

Ethnography for Radiographers: A Methodological Insight for Prospective Researchers.

In recent years, ethnography has become a methodology of choice for exploring radiographic practices. This article adds to the existing evidence base by providing detailed methodological accounts of two experienced researchers. It aims to provide a critical methodological lens to prospective researchers who may also use ethnography as their methodology of choice. The author's reflect on their experiences of utilising ethnography as a methodological approach. Here, accounts of the original tools aligned to u...

Soft-tissue injuries simply need PEACE and LOVE.

The LGBT traveller - Love, liberty and local laws.

Clinical recognition and evaluation of patients with inherited serum thyroid hormone-binding protein mutations.

There are three important thyroid hormone-binding proteins in human serum, thyroxine-binding globulin, transthyretin, and albumin. Genetic variation in these proteins can lead to altered thyroid hormone binding and abnormalities in serum tests of thyroid hormone. Importantly, patients harboring these mutations are euthyroid; thus, the recognition of these conditions is crucial to prevent unnecessary repeated testing and treatment. This article provides an updated overview of serum thyroid hormone transport ...

Love will tear us apart: traumatic mating through consumption of body parts in a sea slug.

There is growing evidence that "traumatic mating"-a copulation that involves wounding the partner's tegument (Lange et al. 2013)-is a widespread phenomenon. Traumatic mating may have evolved associated with several distinct fitness benefits, from physical anchorage during mating to fertilization advantages (Lange et al. 2013). Currently, two hypotheses explain how traumatic mating may lead to fertilization advantages. First, the trauma inflicted during mating may be "collateral"-a by-product of another st...

From dwarves to giants: South American's contribution to the history of growth hormone and related disorders.

The aim of this article is to present a historical review on giants and dwarves living in South America and the contribution of South America's researchers to scientific advances on growth hormone (GH) and human disorders related to GH excess and GH deficiency (GHD). We went back in time to investigate facts and myths stemming from countless reports of giants who lived in the Patagonia region, focusing on what is currently known about gigantism in South America. Additionally, we have reviewed the exceptiona...

Academic research integrity: exploring researchers' perceptions of responsibilities and enablers.

In this paper, we explore academic researchers' perceptions of the relative importance of the individual responsibilities in the 'Singapore Statement on Research Integrity'. The way researchers view those responsibilities affects the role that research integrity enablers can play in achieving responsible research conduct. Hence, we also explore researchers' perceptions of five such integrity enablers in this paper: country and university codes of conduct, staff training, mentoring and peer pressure.Using da...

Bystander Ethics and Good Samaritanism: A Paradox for Learning Health Organizations.

In 2012, a U.S. Institute of Medicine report called for a different approach to health care: "Left unchanged, health care will continue to underperform; cause unnecessary harm; and strain national, state, and family budgets." The answer, they suggested, would be a "continuously learning" health system. Ethicists and researchers urged the creation of "learning health organizations" that would integrate knowledge from patient-care data to continuously improve the quality of care. Our experience with an ongoin...

Efficacy and safety of a biosimilar recombinant human growth hormone (r-hGH Cristalia) compared with reference r-hGH in children with growth hormone deficiency (CERES study): A randomized, multicentric, investigator-blind, phase 3 trial.

The CERES study was a randomized, multicenter, investigator-blind trial aimed to evaluate the efficacy and safety of a recombinant human growth hormone (r-hGH) developed by Cristalia, as a biosimilar product, with analytical, functional and pharmacokinetics similarities comparable to Genotropin™, in children with growth hormone deficiency (GHD).

Bioactive growth hormone in humans: Controversies, complexities and concepts.

To revisit a finding, first described in 1978, which documented existence of a pituitary growth factor that escaped detection by immunoassay, but which was active in the established rat tibia GH bioassay.

Beyond the challenge hypothesis: The emergence of the dual-hormone hypothesis and recommendations for future research.

The challenge hypothesis makes specific predictions about the association between testosterone and status-seeking behaviors, but the findings linking testosterone to these behaviors are inconsistent. The dual-hormone hypothesis was developed to help explain these inconsistencies. Specifically, according to this hypothesis, testosterone's association with status-seeking behavior depends on levels of cortisol. Here, we (1) describe the dual-hormone hypothesis in relation to the challenge hypothesis; (2) revie...

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