PubMed Journals Articles About "Revance Announces BELMONT Phase Clinical Data Presented 2017" RSS

03:03 EST 19th January 2019 | BioPortfolio

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Showing "Revance Announces BELMONT Phase Clinical Data Presented 2017" PubMed Articles 1–25 of 60,000+

Births in the United States, 2017.

This report presents selected highlights from 2017 final birth data on key demographic, health care utilization, and infant health indicators. General fertility rates (the number of births per 1,000 females aged 15-44 years) and teen birth rates are presented by race and Hispanic origin. The use of Medicaid as the source of payment for the delivery and preterm birth rates are presented by the age of the mother. Data for 2017 are compared with 2016 for each indicator.

Advances in Clinical Cardiology 2017: A Summary of Key Clinical Trials.

Numerous important cardiology clinical trials have been published or presented at major international meetings during 2017. This paper aims to summarize these trials and place them in clinical context.

Developments in urologic oncology "OncoForum": The best of 2017.

To put forth new findings of urologic oncology with impact on clinical practice presented during 2017 in the main annual meetings.

Data on mutations and Clinical features in SCN1A or SCN2A gene.

Mutations in and are associated with a wide spectrum of epilepsy related disorders in human. This dataset presented variants and clinical features of SCN1A and SCN2A genes. A total of 48 cases were presented, including 33 mutations and 14 mutations. While 22 mutations were novel in and 11 were novel in . The clinical features were included of gender, birth history, family history, seizure onset age, seizure types, frequency of seizures, initial and follow-up EEGs, brain MRI findings, antiepileptic drug...

The Belmont Report at 40: Reckoning With Time.

It was the summer of 1972 when a stunned nation first learned of the infamous Tuskegee Syphilis Study, during which hundreds of poor, disease-stricken black men from Macon County Alabama, had been deliberately left untreated for 40 years. Coming on the heels of multiple, earlier examples of unethical human experimentation, the Tuskegee Syphilis Study made it plain that the moral foundation of human subject research was in desperate need of repair. Blind reliance on the Nuremberg Code and the Declaration of ...

A Hybrid Phase I-II/III Clinical Trial Design Allowing Dose Re-Optimization in Phase III.

Conventionally, evaluation of a new drug, A, is done in three phases. Phase I is based on toxicity to determine a \maximum tolerable dose" (MTD) of A, phase II is conducted to decide whether A at the MTD is promising in terms of response probability, and if so a large randomized phase III trial is conducted to compare A to a control treatment, C; usually based on survival time or progression free survival time. It is widely recognized that this paradigm has many flaws. A recent approach combines the first t...

A report was presented on all four Hot Line: Late-Breaking Clinical Trials sessions of the European Society of Cardiology Congress 2017 on the results of new clinical research in cardiology.

Re: 'Clearance of carbapenemase-producing Enterobacteriaceae (CPE) carriage: a comparative study of NDM-1 and KPC CPE' by Lim et al. (2018).

LIM ET AL: presented data on the clearance of CPE carriage and stated that NDM-1 isolates are cleared at higher rates than KPC isolates. However, we provide evidence that this conclusion cannot be easily drawn, as important data are missing. From the presented data it is likely that many of the 147 cases were the result of a nosocomial transmission and therefore some clones are probably overrepresented, which could distort results. No molecular characterization of isolates was performed to exclude transmiss...

A comparison between phase-III trials and a phase-IV study of nalmefene in alcohol use disorder patients. Is there a difference?

Concerns regarding the external validity of phase-III trials are common to many medical disciplines, with relevant discrepancies found between experimental and clinical samples in some diseases such as hypertension. The aim of this study was to compare the samples included in the pivotal, phase-III clinical trials of nalmefene with that of a recently conducted phase-IV trial. Baseline characteristics of the studies were compared through univariate analysis. Significant differences were found in the percenta...

Learning Domain Shift in Simulated and Clinical Data: Localizing the Origin of Ventricular Activation from 12-Lead Electrocardiograms.

Building a data-driven model to localize the origin of ventricular activation from 12-lead electrocardiograms (ECG) requires addressing the challenge of large anatomical and physiological variations across individuals. The alternative of a patientspecific model is, however, difficult to implement in clinical practice because training data must be obtained through invasive procedures. Here, we present a novel approach that overcomes this problem of the scarcity of clinical data by transferring the knowledge ...

Evolution of near-ground optical turbulence over concrete runway throughout multiple days in summer and winter.

Experimental data are presented that demonstrate the evolution of the anisotropy/isotropy of atmospheric statistics throughout the course of four days (two winter, two summer) near the ground over a concrete runway in Florida. In late January and early February of 2017, a 532 nm near-plane-wave beam was propagated 1 and 2 km at a height of 2 m above the runway, and irradiance fluctuations were captured on a CCD array. In August of 2017, a 532 nm Gaussian beam was propagated 100 m at a height of near 2...

Quality-based UnwRap of SUbdivided Large Arrays (URSULA) for high-resolution MRI data.

In Magnetic Resonance Imaging, mapping of the static magnetic field and the magnetic susceptibility is based on multidimensional phase measurements. Phase data are ambiguous and have to be unwrapped to their true range in order to exhibit a correct representation of underlying features. High-resolution imaging at ultra-high fields, where susceptibility and phase contrast are natural tools, can generate large datasets, which tend to dramatically increase computing time demands for spatial unwrapping algorith...

National surveys on 15 quality indicators for the total testing process in clinical laboratories of China from 2015 to 2017.

Background As effective quality management tools, quality indicators (QIs) are widely used in laboratory medicine. This study aimed to analyze the results of QIs, identify errors and provide quality specifications (QSs) based on the state-of-the-art. Methods Clinical laboratories all over China participated in the QIs survey organized by the National Health Commission of People' Republic of China from 2015 to 2017. Most of these QIs were selected from a common model of QIs (MQI) established by the Internati...

Autocalibrated multiband CAIPIRINHA with through-time encoding: Proof of principle and application to cardiac tissue phase mapping.

In conventional multiband (MB) CAIPIRINHA, additional reference scans are acquired to allow the separation of the excited slices. In this study, an acquisition-reconstruction technique that makes use of the MB data to calculate these reference data is presented. The method was integrated into a 2D time-resolved phase-contrast MR sequence used to assess velocities of the myocardium.

A systematic review of patient reported outcomes in phase II or III clinical trials of myelodysplastic syndromes and acute myeloid leukemia.

The purpose of this systematic literature review was to identify clinical trials of MDS and AML that included patient-reported outcome (PRO) instruments, and to summarize the symptom and other health related quality of life (HRQOL) concepts most frequently assessed and the PRO instruments that were used. Sixteen manuscripts describing 14 distinct trials met all criteria (i.e., phase 2 or 3 clinical trial for MDS or AML which included PRO assessment) and were published between 1996-2017. In trials evaluating...

Chemoprevention agents for melanoma: a path forward into phase 3 clinical trials.

Recent progress in the treatment of advanced melanoma has led to unprecedented improvements in overall survival and, as these new melanoma treatments have been developed and deployed in the clinic, much has been learned about the natural history of the disease. Now is the time to apply that knowledge toward the design and clinical evaluation of new chemoprevention agents. Melanoma chemoprevention has the potential to reduce dramatically both the morbidity and the high costs associated with treating patients...

Feature issue introduction: light, energy and the environment, 2017.

The editors introduce the feature issue on "Energy, Light and the Environment (LEE) 2017", which is based on the topics presented at a congress of the same name held in Boulder, CO, US, from November 6 to November 9. This feature issue presents 13 papers selected from the voluntary submissions by attendees who presented at the progress and have extended their work into complete research articles. The feature issue highlights contributions from authors who presented their research at this congress.

Nontuberculous mycobacteria strains isolated from patients between 2013 and 2017 in Poland. Our data with respect to the global trends.

During the last decades the prevalence of NTM infections has increased, especially in developed countries. The aim of the study was to provide an overview on all NTM isolated from clinical samples in Poland between 2013 and 2017.

Dynamic features of tumefactive demyelinating lesions in different clinical stages by contrast-enhanced magnetic resonance imaging.

To explore the dynamic features of tumefactive demyelinating lesions (TDLs) in different clinical stages by contrast-enhanced magnetic resonance imaging (MRI). Thirty-five patients with TDLs proven by pathological studies were prospectively recruited from January 2015 to January 2017.Brain contrast-enhanced MRI of the patients in different clinical stages including acute phase, subacute phase and chronic phase were completed after enrollment.The characteristics of contrast-enhanced MRI in different clinica...

Minority recruitment trends in phase III prostate cancer clinical trials (2003-2014): progress and critical areas for improvement.

U.S. minority groups have been historically underrepresented in phase III prostate cancer clinical trials despite often having higher risk disease. This study analyzes enrollment trends of major U.S. racial/ethnic groups in phase III prostate cancer trials between 2003-2014 compared to Surveillance, Epidemiology, and End Results (SEER) incidence data.

Emergence of African Swine Fever in China, 2018.

African swine fever (ASF) is a highly contagious disease manifesting clinical symptoms of hemorrhagic fever caused by African swine fever virus (ASFV) and leads to almost 100% mortality in domestic pigs (Galindo and Alonso, 2017, Quembo et al., 2018). Since ASF was first identified in Kenya in the 1920s, it has rapidly spread in Africa and Eurasia and presented as 24 genotypes (Galindo and Alonso, 2017, Quembo et al., 2018). For instance, a genotype II ASFV derived from eastern Africa has resulted in subs...

Identifying the "Blip on the Radar Screen": Leveraging Big Data in Defining Drug Safety and Efficacy in Pediatric Practice.

The immense amount of electronic health data (pharmacy and administrative claims, electronic health records, and clinical registries) that is being generated every day in the care of patients has the potential to be leveraged for improving clinical decisions at the point of care, uncovering or validating drug efficacy and drug safety. The potential use of big data for improving safe and effective use of medications is especially important in children because of their low drug exposure relative to adults. El...

Phase I Dose-Escalation Study of Once Weekly or Once Every Two Weeks Administration of High-Dose Sunitinib in Patients With Refractory Solid Tumors.

Dose and schedule optimization of treatment with tyrosine kinase inhibitors is of utmost importance. On the basis of preclinical data, a phase I clinical trial of once weekly or once every 2 weeks administration of high-dose sunitinib in patients with refractory solid malignancies was conducted.

Did relaxing clinical trial regulation enhance the stock of scientific knowledge in India? Not necessarily.

The increasing amount of clinical research conducted outside the "traditional" countries raises questions about the benefits of hosting offshored clinical research. The extent to which trials contribute to the scientific knowledge base and, in particular, whether there are differences between different types of trials remain open questions. By examining a change in clinical trial regulations in India, a country often viewed as a first-choice offshoring location, we study how the relaxation of clinical trial...

Opportunities and challenges to utilization of quantitative imaging: Report of the AAPM practical big data workshop.

This article is a summary of the quantitative imaging subgroup of the 2017 AAPM Practical Big Data Workshop (PBDW-2017) on progress and challenges in big data applied to cancer treatment and research supplemented by a draft white paper following an American Association of Physicists in Medicine FOREM meeting on Imaging Genomics in 2014.

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