PubMed Journals Articles About "Safety Study Of Zileuton Injection In Patients With Asthma" RSS

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Showing "Safety Study Zileuton Injection Patients With Asthma" PubMed Articles 1–25 of 84,000+

Efficacy and safety of the combination fluticasone propionate plus salmeterol in asthmatic preschoolers: An observational study.

Inhaled Corticosteroids (ICS) are the cornerstone of asthma management in pediatric patients. However, in some cases, asthma is not adequately controlled on ICS alone. Long-acting beta-agonists (LABA) are one of the available additional therapies but their use has rarely been studied among children younger than 5 years.

Treatment patterns and related clinical consequences in adults with asthma.

A stepwise therapeutic management is recommended for asthma patients by the Global Initiative for Asthma (GINA). Little is known about the recommendations applied in real world settings. This study aims to associate Treatment Step with clinical events in patients with mild or severe asthma.

Dupilumab safety and efficacy in uncontrolled asthma: a systematic review and meta-analysis of randomized clinical trials.

We aimed to perform a meta-analysis evaluating the efficacy and safety of dupilumab in patients with uncontrolled asthma.

Fall episodes in elderly patients with asthma and COPD - a pilot study.

Evidence of an increased risk of falls in patients with chronic obstructive pulmonary disease (COPD) exists; however, this has not been studied in elderly asthmatic patients. The aim of the study was to determine the incidence of falls in elderly patients who were diagnosed with bronchial asthma compared to subjects with COPD.

Comparing the effect of pulmonary rehabilitation in patients with uncontrolled and partially controlled asthma.

Pulmonary rehabilitation (PR) is an important therapeutic approach in asthmatic patients. Lack of asthma control is associated with high morbidity, poor health outcomes, and decrease in quality of life (QOL). However, there is no clear information about the effectiveness of PR in patients with differing levels of asthma control. This study aimed to compare the efficacy of PR in patients with uncontrolled and partially controlled asthma.

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma.

Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma. Methods We randomly assigned 1902 patients 12 years of age or older with uncontrolled asthma in a 2:2:1:1 ratio to receive add-on subcutaneous dupilumab at a dose of 200 or 300 mg every 2 weeks or matched-volume placebos for 52 weeks. The primary end points were the annualized rate of se...

Prospective Open-Label Study of 48-Week Subcutaneous Administration of Mepolizumab in Japanese Patients with Severe Eosinophilic Asthma.

Long-term efficacy and safety of mepolizumab in patients with severe eosinophilic asthma has been evaluated by large-scale double-blinded placebo control studies. However, a prospective open-label study of a long-term subcutaneous administration of mepolizumab in Japanese patients with severe eosinophilic asthma has not been reported.

Asthma control and adherence in newly diagnosed young and elderly adult patients with asthma in Turkey.

This study aimed to evaluate the factors that affect asthma control and adherence to treatment in newly diagnosed elderly asthmatics in Turkey compared with younger patients.

Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.

Human 5-Lipoxygenase (5-LOX) is a key enzyme targeted for asthma and inflammation. Zileuton, the only drug against 5-LOX, was withdrawn from the market due to several problems. In the present study, the performance of rationally designed conjugates of thiazole (2) and thiourea (3) scaffolds from our previously reported 2-amino-4-aryl thiazole (1) is reported. They are synthesized (total 31 derivatives), characterized, and tested against the 5-LOX enzyme in vitro and the mode of action of the most active on...

Short-term effect of air pollution on asthma patient visits in Shanghai area and assessment of economic costs.

Shanghai, in China, is one of the highest incidence cities for asthma morbidity. However, few studies have systemically explored the association of ambient air pollutants and asthma patients with economic costs.

Considerations for the Correct Diagnosis of Chronic Obstructive Pulmonary Disease and Its Management With Bronchodilators.

Chronic obstructive pulmonary disease (COPD) is often misdiagnosed and inappropriately treated in many patients. COPD is a distinct disease from adult-onset asthma; however, some patients with COPD may present with several forms of airway disease described as asthma-COPD overlap (ACO). Bronchodilators and inhaled corticosteroids (ICS) both have a place in standard maintenance treatment of COPD and asthma; however, recommendations for use differ widely. In patients with COPD, long-acting bronchodilators are ...

Increased Group 2 Innate Lymphoid Cells Are Correlated with Eosinophilic Granulocytes in Patients with Allergic Airway Inflammation.

The T helper 2 (Th2)-type response was considered the hypostasis of allergic airway diseases, including asthma and allergic rhinitis (AR). However, more recent studies have suggested that allergic airway inflammation also depends on innate immunity and is closely related to group 2 innate lymphoid cells (ILC2s). This study evaluated the ILC2 levels of asthma subjects, patients with asthma and AR, and healthy individuals, regarding how to investigate the relationship between clinical data and ILC2 levels. It...

A retrospective study of the treatment of patients hospitalized for asthma exacerbation in China.

To study the treatment of patients hospitalized for asthma exacerbation in China.This was a retrospective study and involved patients hospitalized for asthma exacerbation in 29 hospitals throughout China during Jan 2013 to Dec 2014. Information of the demographic features, the severity of the exacerbation, the medicine prescribed during the hospitalization and the use of mechanical ventilation were collected and analyzed.During the study period, there were 3 240 patients hospitalized for asthma exacerbation...

Efficacy and safety of anti-interleukin-5 therapy in patients with asthma: A pairwise and Bayesian network meta-analysis.

Anti-interleukin-5 therapy has been proposed as a novel and promising treatment option in asthma treatment. However, the optimum monoclonal antibodies for asthma treatment remain uncertain.

Predictors of prior asthma specialist care among pediatric patients seen in the emergency department for asthma.

Asthma guidelines recommend specialist care for patients experiencing poor asthma outcomes during emergency department (ED) visits. The prevalence and predictors of asthma specialist care among an ED population seeking pediatric asthma care are unknown.

Depression symptoms and quality of life among individuals with Aspirin-Exacerbated Respiratory Disease.

Patients with aspirin-exacerbated respiratory disease (AERD) have high disease burden due to the severity of asthma and sinonasal symptoms. There is limited research on the psychological well-being and subjective experiences of patients with AERD. This study examined levels of depression symptoms, asthma-related quality of life, and asthma control among AERD patients.

Telemonitoring in Asthma Control: A Randomized Controlled Trial.

Telemonitoring seems to be a useful tool for patients' management. The aim of our project was to test the applicability and potential effects of a 12-months telemonitoring of patients with asthma supported by information and communication technologies.

Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?

Since respiratory tract infections (RTIs) precede most exacerbations, better understanding of the risk factors of RTIs and RTI-associated exacerbations in patients with asthma is a pressing public health need. Obesity in patients with asthma is associated with worse asthma control and higher asthma-associated healthcare utilization but its effect on RTI risk is unknown.

Benralizumab for the add-on maintenance treatment of patients with severe asthma aged 12 years and older with an eosinophilic phenotype.

Asthma is an airway disease characterized by airway inflammation. It is associated with significant morbidity, mortality, and costs to the healthcare system and society. Eosinophils and interleukin-5 (IL-5) play a key role in the inflammatory response in T helper 2-high asthma. IL-5 is pivotal for eosinophil development, maturation, and survival in tissues. Asthma severity has been related to both airway and peripheral blood eosinophilia. Areas covered: In this review, we present the pharmacokinetics and ph...

Efficacy, safety and acceptability of the new pen needle 34G × 3.5 mm: a cross-over randomized non-inferiority trial; AGO 02 study.

Insulin injection aspects, such as fear of injection and pain, directly affect glycemic control, patient adherence, and quality of life. Use of thinner and shorter needles could increase acceptance of injections. Aim of the study is to evaluate the non-inferiority of the new 34Gx3.5 mm needle compared to a 32GX4mm in patients with diabetes treated with insulin.

Clinical Approach to the Therapy of Asthma-COPD Overlap.

Over the past few years there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinical outcomes and increased healthcare utilization than those with asthma or COPD. Therefore, there is a critical need to set a framework for the therapeutic approach of such patients. There are ke...

Interleukin-17 Gene Expression and Serum Levels in AsthmaDegenerative Model.

Asthma is one of the most common chronic respiratory diseases. It is associated with significant morbidity and shows an increasing prevalence over time. Accumulating evidence suggests that interleukin (IL)-17 has a key role in severe asthma. The aim of the study was to determine quantitatively gene expression of IL-17 in peripheral blood mononuclear cells (PBMN) & the level of IL-17 in the serum of asthmatic patients, to correlate the level of IL-17 with the severity of asthma and to compare between gene ex...

Seasonal changes influence the improvement in asthma symptoms by exercise training in subjects with asthma.

To investigate whether patients with moderate to severe asthma who commence an exercise training program in winter or summer show differences in exercise capacity, health-related quality of life (HRQoL) and asthma symptoms.

Rates of asthma exacerbations and mortality and associated factors in Uganda: a 2-year prospective cohort study.

Data on asthma treatment outcomes in Africa are limited. 449 patients with asthma (age 5-93 years) in Uganda were followed up for 2 years to determine rates of exacerbations and mortality and associated factors. During follow-up the median number of exacerbations per patient was 1 (IQR 0-5) and 17 patients died (3.7%, 27.3 deaths per 1000 person years). Considering only the first year of follow-up, 59.6% of the patients experienced at least one exacerbation, 32.4% experienced three or more exacerbations. A ...

Incorrect use of inhalation devices among patients with bronchial asthma. A hospital-based cross-sectional study in Rio de Janeiro, Brazil.

Treatment of asthma implies inhalation of specific drugs to reach high concentrations in the respiratory tree and ensure low drug bioavailability and few adverse effects. This study aimed to evaluate the effectiveness of the inhalation technique among outpatients with asthma.

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