PubMed Journals Articles About "Samsung Bioepis Takeda Sign Strategic Agreement" RSS

08:15 EST 11th December 2018 | BioPortfolio

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Showing "Samsung Bioepis Takeda Sign Strategic Agreement" PubMed Articles 1–25 of 2,400+

Reliability of and Correlation Between Measurements of Acetabular Morphology.

The authors sought to determine the intra- and interrater reliability of contemporary measures of acetabular morphology among a group of hip surgeons and to determine the correlations between measures of acetabular morphology. On 2 separate occasions, 3 hip surgeons independently performed blinded evaluations of anteroposterior pelvic radiographs of 40 patients. The lateral center-edge angle, medial center-edge angle, acetabular arc, extrusion index, acetabular index, Sharp's angle, posterior wall sign, cro...

Should I sign this form my patient asked me to sign?

Registered nurses and nurse practitioners may be asked by patients to sign many different types of forms. These forms may be government-issued, employer-related or exist due to certain legislation. You may be asked to sign forms related to disability, injury or the provision of reimbursement from an insurance carrier or board, including worker's compensation. When you are asked to sign a form, should you sign it?

The Tobacco Master Settlement Agreement - Strategic Lessons for Addressing Public Health Problems.

Measurement of three-dimensional wavefronts using the Ichikawa-Lohmann-Takeda solution to the irradiance transport equation.

In this paper, we use the irradiance transport equation and the Fourier transform-based experimental solution given by Ichikawa-Lohmann-Takeda. We analyze experimental factors such as the digital filter, the introduced error for the rotation and period of the Ronchi ruling, and a new method is demonstrated for the measurement of 3D wavefront information.

Lazarević-Lasègue sign.

Charles Lasègue is reputed to have described the test/sign bearing his name, but he never wrote about it and misinterpreted its mechanism. The purpose of this note is to highlight the work of the Serbian, Laza Lazarević, who was first to present the original report of this seminal sign in sciatica and provide its appropriate pathophysiological interpretation.

Evaluation of similar quality attribute characteristics in SB5 and reference product of adalimumab.

Biosimilars are biologic products that are highly similar to a licensed reference product in terms of quality, safety, and efficacy. SB5 is a biosimilar of Humira® (adalimumab) developed by Samsung Bioepis. To demonstrate its biosimilarity in quality to Humira®, we performed a comprehensive characterization in terms of structure, physicochemical properties, and biological properties following the International Conference on Harmonization, US Food and Drug Administration, and European Medicines Agency guid...

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.

Naclerio's V sign and continuous diaphragm sign after endoscopy.

Evaluating the predictive value of island sign and spot sign for hematoma expansion in spontaneous intracerebral hemorrhage.

Hematoma expansion (HE) is closely related to poor outcome in spontaneous intracerebral hemorrhage (sICH). Island sign (IS) is a novel HE predictor based on non-contrast computed tomography (NCCT). This study is aimed to confirm the accuracy of IS for predicting HE and compare it to the spot sign (SS) on computed tomography angiography (CTA).

Keys to the Gate? Equal Sign Knowledge at Second Grade Predicts Fourth-Grade Algebra Competence.

Algebraic competence is a major determinant of college access and career prospects, and equal sign knowledge is taken to be foundational to algebra knowledge. However, few studies have documented a causal effect of early equal sign knowledge on later algebra skill. This study assessed whether second-grade students' equal sign knowledge prospectively predicts their fourth-grade algebra knowledge, when controlling for demographic and individual difference factors. Children (N = 177; M = 7.61) were assesse...

Multiband Mechanism for the Sign Reversal of Coulomb Drag Observed in Double Bilayer Graphene Heterostructures.

Coupled 2D sheets of electrons and holes are predicted to support novel quantum phases. Two experiments of Coulomb drag in electron-hole (e-h) double bilayer graphene (DBLG) have reported an unexplained and puzzling sign reversal of the drag signal. However, we show that this effect is due to the multiband character of DBLG. Our multiband Fermi liquid theory produces excellent agreement and captures the key features of the experimental drag resistance for all temperatures. This demonstrates the importance o...

Developing a bilingual mobile dictionary for Indian Sign Language and gathering users experience with SignDict.

Availability of a sign language dictionary is very important for the literacy of deaf people. But the intricacies involved in the representation of the sign language impede attempts at representing it in a printed format. A video based solution helps to solve this problem. This article discusses the development of a bilingual mobile sign language dictionary which has features for converting camera captured text into sign language and translating simple sentences from a spoken language into their correspondi...

Visual field plasticity in hearing users of Sign Language.

Studies have observed that deaf signers have a larger Visual Field (VF) than hearing non-signers with a particular large extension in the lower part of the VF. This increment could stem from early deafness or from the extensive use of sign language, since the lower VF is critical to perceive and understand linguistics gestures in sign language communication. The aim of the present study was to explore the potential impact of sign language experience without deafness on the VF sensitivity within its lower pa...

Life on the other side: moving from clinical nursing to strategic management.

Alan Nobbs reflects on his decision to move into a more strategic nursing role rather than stay by the bedside, and the feelings of apprehension that followed.

"Hyperdense artery sign" in early ischemic stroke: diagnostic value of model-based reconstruction approach in comparison with standard hybrid iterative reconstruction algorithm.

Hyperdense artery sign is the earliest sign of ischemic stroke on non-enhanced computed tomography and it can be visible long before parenchymal changes. The aim of our study was to compare diagnostic value of model-based iterative reconstruction algorithm (IMR) with that of iterative reconstruction algorithm (iDose4) in identifying hyperdense artery sign.

Fermions at Finite Density in 2+1 Dimensions with Sign-Optimized Manifolds.

We present Monte Carlo calculations of the thermodynamics of the (2+1)-dimensional Thirring model at finite density. We bypass the sign problem by deforming the domain of integration of the path integral into complex space in such a way as to maximize the average sign within a parameterized family of manifolds. We present results for lattice sizes up to 10^{3} and we find that at high densities and/or temperatures the chiral condensate is abruptly reduced.

A new optimal marker to evaluate the effectiveness of endoscopic third ventriculostomy (ETV) during operation. - 'Folding sign'-.

Endoscopic third ventriculostomy (ETV) remains the mainstay treatment for non-communicating hydrocephalus these days. However, there has been no sufficient clue for intraoperative assessment of ETV efficacy until now. This time, we propose a newly defined finding, 'folding sign', which is visible and enable us to confirm penetration of both third ventricle floor and Liliequist membrane (LM) during operation. In this report, we investigated consecutive ETV cases and discussed the mechanism of folding sign an...

Mechanistic insights into the modulatory role of the mechanoreflex on central hemodynamics using passive leg movement in humans.

The aim of this study was to examine the independent contributions of joint range of motion (ROM), muscle fascicle length (MFL) and joint angular velocity on mechanoreceptor mediated central cardiovascular dynamics using passive leg movement (PLM) in humans. Twelve healthy males (age: 23{plus minus}2 yrs, body mass index: 23.7 kg/m) performed continuous PLM at various randomized joint angles ROM (0-50{degree sign} vs. 50-100{degree sign} vs. 0-100{degree sign}) and joint angular velocities ('fast': 200{degr...

The comparative study of island sign and the spot sign in predicting short-term prognosis of patients with intracerebral hemorrhage.

It is well known that early hematoma expansion is associated with short-term prognosis of patients with intracranial hemorrhage (ICH). And spot sign is recognized as a reliable computed tomography angiography (CTA) predictor for early hematoma expansion. Recently, island sign is also reported as a novel computed tomography (CT) predictor for early hematoma growth. Here, we compared the predictive abilities of these two signs for short-term outcomes of ICH patients.

Island sign predicts long-term poor outcome and mortality in patients with intracerebral hemorrhage.

and Purpose: Island sign is a novel imaging predictor for early hematoma growth, implying multifocal active bleeding. And the prognostic value of island sign for long-term outcome in patients with intracranial hemorrhage (ICH) remains unrevealed. The aim of this study is to investigate associations between the island land and long-term prognosis in ICH patients.

Association Between the Frank Sign and Cardiovascular Events.

Clinicians have attempted to find early preclinical physical diagnosis signs to detect vascular diseases at the preclinical stage and to prevent clinical deterioration in time. An interesting example of such signs is the Frank sign, which was first described by Dr Sonders T. Frank in 1973. Our goal was to summarize the clinical trials and observational studies that had examined the association between the Frank sign and cardiovascular diseases. Summarizing the 57 studies we found showed that this associatio...

Hyperglycemia is associated with island sign in patients with intracerebral hemorrhage.

Prognostic value of admission serum glucose for early hematoma growth in patients with intracranial hemorrhage (ICH) remains controversial. Island sign is a novel imaging predictor for early hematoma growth, implying multifocal active bleeding. The aim of this study is to investigate the potential associations between hyperglycemia and early hematoma expansion in ICH patients with or without island sign.

Communication skills of deaf and hard-of-hearing college students: Objective measures and self-assessment.

Objectively measured speech reception, speech production and expressive and receptive sign skills were compared with the self-assessment ratings of those skills in 96 college students with hearing loss. Participants with no aidable hearing used cochlear implants (CIs) or nothing. Participants with aidable hearing used either hearing aids (HAs) or nothing. Results revealed that individuals using CIs had speech reception and production skills that were as good as or better than students with more hearing who ...

Gastric wall fat halo sign in patients without intestinal disease.

To investigate the relationship between gastric wall fat halo sign and visceral obesity with potentially associated diseases.

Neutrophil to lymphocyte ratio predicts island sign in patients with intracranial hemorrhage.

Our previously studies indicated that inflammatory responses are involved in the hematoma expansion (HE) after intracranial hemorrhage (ICH) ictus. Here, we aim to evaluate the correlations among the ratio of neutrophil to lymphocyte ratio (NLR), HE, and island sign in patients with ICH.Patients with spontaneous ICH were retrospectively included. Clinical characteristics, imaging features, and laboratory parameters were obtained. Multivariable analysis was performed to evaluate the association of NLR with H...

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