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21:19 EDT 20th March 2019 | BioPortfolio

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Showing "Sangamo Sell Amarin Pending Trial Idea Guide" PubMed Articles 1–25 of 6,800+

Sangamo's landmark genome editing trial gets mixed reception.

Sangamo poised for CAR-T race.

Opportunities and Challenges in Mendelian Randomization Studies to Guide Trial Design.


Is Genetic Exceptionalism Past Its Sell-By Date? On Genomic Diaries, Context, and Content.

Measuring the time course of selection during visual search.

In visual search tasks, observers can guide their attention towards items in the visual field that share features with the target item. In this series of studies, we examined the time course of guidance toward a subset of items that have the same color as the target item. Landolt Cs were placed on 16 colored disks. Fifteen distractor Cs had gaps facing up or down while one target C had a gap facing left or right. Observers searched for the target C and reported which side contained the gap as quickly as pos...

The soul as the 'guiding idea' of psychology: Kant on scientific psychology, systematicity, and the idea of the soul.

A mobile device application to reduce medication errors and time to drug delivery during simulated paediatric cardiopulmonary resuscitation: a multicentre, randomised, controlled, crossover trial.

Vasoactive drug preparation for continuous infusion in children is both complex and time consuming and places the paediatric population at higher risk than adults for medication errors. We developed a mobile device application (app) as a step-by-step guide for the preparation to delivery of drugs requiring continuous infusion. The app has been previously tested during simulation-based resuscitations in a previous single-centre trial. In this trial, our aim was to assess this app in various hospital settings...

When the Muses Strike: Creative Ideas of Physicists and Writers Routinely Occur During Mind Wandering.

How often are creative ideas generated during episodes of mind wandering, and do they differ from those generated while on task? In two studies ( N = 98, N = 87), professional writers and physicists reported on their most creative idea of the day, what they were thinking about and doing when it occurred, whether the idea felt like an "aha" moment, and the quality of the idea. Participants reported that one fifth of their most significant ideas of the day were formed during spontaneous task-independent mind ...

The application of 'valence' to the idea of household food insecurity in Canada.

Household food insecurity (HFI), lack of access to adequate food due to financial constraint, has been studied extensively in Canada and is well-recognized for its negative impacts on population health. Despite considerable high-level political recognition, the issue has evoked little substantive policy deliberation. We suggest that Béland and Cox's recently articulated construct of 'valence' may be useful in examining why the idea of HFI has motivated little policy response. Valence is defined as the emot...

Computer aided design and three-dimensional printing for apicoectomy guide template.

To establish an apicoectomy guide template design and manufacturing method, based on multi-source data fusion, computer aided design (CAD) and fused deposition modeling (FDM). The feasibility of the guide template was preliminary evaluated by the in vitro model experiment.

The Optimal Duration of Adjuvant Therapy for Stage III Colon Cancer: the European Perspective.

The International Duration Evaluation of Adjuvant Therapy (IDEA) collaboration was created to pool data from different studies worldwide in order to assess whether a shorter duration of adjuvant treatment in colon cancer could maintain the expected benefit while reducing toxicity. The results of the IDEA trials were clinically relevant. They confirmed a two- to sixfold reduction in neurotoxicity for the shorter duration across trials. Overall, the 3-year disease-free survival was very similar: only 0.9% low...

Effect of balloon guide catheter on clinical outcomes and reperfusion in Trevo thrombectomy.

The Solitaire stent retriever registry showed improved reperfusion, faster procedure times, and better outcome in acute stroke patients with large vessel occlusion treated with a balloon guide catheter (BGC) and Solitaire stent retriever compared with a conventional guide catheter. The goal of this study was to evaluate whether use of a BGC with the Trevo stent retriever improves outcomes compared with a conventional guide catheter.

Improving the control of snakebite envenomation in Latin America and the Caribbean: a discussion on pending issues.

Trial Versus No Trial of Spinal Cord Stimulation for Chronic Neuropathic Pain: Cost Analysis in United Kingdom National Health Service.

The aim of the current project was to evaluate the spinal cord stimulation (SCS) screening trial success rate threshold to obtain the same cost impact across two identical sets of patients following either a prolonged screening trial prior to implantation strategy or a full implant without a screening trial.

Going global: the adoption of the World Health Organization's enabling recommendation on oral pre-exposure prophylaxis for HIV.

In September 2015, the World Health Organization (WHO) launched evidence-based guidelines by recommending that any person at substantial HIV risk should be offered oral pre-exposure prophylaxis (PrEP) containing tenofovir disoproxil fumarate (TDF) as an additional prevention choice. Since 2017, PrEP medicines have also been listed in the WHO's Essential Medicines List, including TDF/emtricitabine (FTC) and TDF in combination with lamivudine (3TC). A descriptive policy review and analysis of countries adopti...

Bone tumor resection guide using three-dimensional printing for limb salvage surgery.

The three-dimensional (3D)-printed bone tumor resection guide can be personalized for a specific patient and utilized for bone tumor surgery. It is noninvasive, eidetic, and easy to use. We aimed to categorize the use of the 3D-printed guide and establish in vivo accuracy data.

Generalizability of the FOURIER trial to routine clinical care: Do trial participants represent patients in everyday practice?

In the FOURIER trial, evolocumab, a proprotein convertase subtilisin-kexin type 9 inhibitor, reduced cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD). We aimed to examine how closely patients in routine practice resemble the FOURIER trial participants and to assess the observed cardiovascular risks based on trial eligibility and underrepresentativeness.

Refocusing the Lens: Caring and Compassion in an Online Nursing Environment.

The concept of compassionate caring in an online nursing education environment is an idea that has limited research. The College of Nursing at Sacred Heart University has adopted a caring model and philosophy to foster an engaged, mutually beneficial environment and guide how faculty and students interact in the online environment. Examples of how faculty engage students in these behaviors are offered.

Implementing patient-reported outcome measures in clinical practice: a companion guide to the ISOQOL user's guide.

The use of patient-reported outcome (PRO) measures in clinical practice is increasing. Following the creation of a 'User's Guide to Implementing PRO Assessment in Clinical Practice' by the International Society for Quality of Life Research (ISOQOL), volunteers from ISOQOL sought to create a Companion Guide to assist health care providers with the scientific and practical considerations involved in implementing and using PRO measures in clinical care by using information from real-world case studies. This pa...

Systematic Review and Meta-Analysis of the Magnitude of Structural, Clinical, and Physician and Patient Barriers to Cancer Clinical Trial Participation.

Barriers to cancer clinical trial participation have been the subject of frequent study, but the rate of trial participation has not changed substantially over time. Studies often emphasize patient-related barriers, but other types of barriers may have greater impact on trial participation. Our goal was to examine the magnitude of different domains of trial barriers by synthesizing prior research.

Global PrEP roll-out: recommendations for programmatic success.

Pre-exposure prophylaxis (PrEP) is being adopted and rolled out in diverse regions, communities, and groups. Although it has been shown to be effective, in some settings PrEP roll-out has lagged, in part due to flawed messaging. Lessons can be learned and principles applied from marketing to highlight the potential pitfalls of current roll-out strategies focused on selective and siloed service provision. After exploration of the way PrEP is promoted in awareness messaging (the sell), marketed to select and ...

Nuances of carotid artery stenting under flow arrest with dual-balloon guide catheter.

Cerebral protection device utilization during carotid artery stenting (CAS) has been demonstrated to decrease the risk of perioperative stroke. The ProximAl Protection with the MO.MA Device During CaRotid Stenting (ARMOUR) Trial had the lowest event rates of any independently adjudicated study. In this video of two cases of severe carotid artery stenosis, the authors present the nuances of the CAS procedure utilizing a dual-balloon guide catheter device (MO.MA). This device has the benefit of being in place...

Preparation to a quick whole-body action: control with referent body orientation and multi-muscle synergies.

We examined the control of postural stability in preparation to a discrete, quick whole-body sway toward a target and back to the initial position. Several predictions were tested based on the theory of control with referent body orientation and the notion of multi-muscle synergies stabilizing center of pressure (COP) coordinate. Healthy, young adults performed fast, discrete whole-body motion forward-and-back and backward-and-back under visual feedback on the COP. We used two methods to assess COP stabilit...

Memory, Emotion, and Intersubjectivity: beyond the Information Given, and beyond the Individual Mind.

This commentary reflects on papers assembled for a special issue about the impact of Bruner's idea of "beyond the information given." The assembled papers are examined in relation to three cross-cutting issues that they illustrate: 1) processes of reflection in autobiographical recollection; 2) links between meaning and emotion; and 3) the idea of going beyond the individual mind as well as beyond the given information.

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