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PubMed Journals Articles About "Saphetor Leverage Genome Scale Analyses Facilitate Precision Oncology" RSS

21:06 EST 23rd November 2017 | BioPortfolio

Saphetor Leverage Genome Scale Analyses Facilitate Precision Oncology PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Saphetor Leverage Genome Scale Analyses Facilitate Precision Oncology articles that have been published worldwide.

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Showing "Saphetor Leverage Genome Scale Analyses Facilitate Precision Oncology" PubMed Articles 1–25 of 22,000+

Current views of common pediatric cancers - an update.

Advancements in pediatric cancers diagnostics clarity and treatments have greatly increased survival rates in the pediatric oncology population. Increased survival rates have turned new attention to studying psychosocial stressors and improvisation of the quality of life of the suffering cancer patients. The cancer treatment experience could be divided into three phases: diagnosis, treatment, and post-treatment/survivorship. The present review article would focus specifically on the three most common pediat...


Physician interpretation of genomic test results and treatment selection.

Genomic testing is increasingly performed in oncology, but concerns remain regarding the clinician's ability to interpret results. In the current study, the authors sought to determine the agreement between physicians and genomic annotators from the Precision Oncology Decision Support (PODS) team at The University of Texas MD Anderson Cancer Center in Houston regarding actionability and the clinical use of test results.

Host preference and network properties in biotrophic plant-fungal associations.

Analytical methods can offer insights into the structure of biological networks, but mechanisms that determine the structure of these networks remain unclear. We conducted a synthesis based on 111 previously published datasets to assess a range of ecological and evolutionary mechanisms that may influence the plant-associated fungal interaction networks. We calculated the relative host effect on fungal community composition and compared nestedness and modularity among different mycorrhizal types and endophyt...


Medical industry at tumor board: Three-years analysis of the open payments database and comparison of oncologic specialties.

To analyze and contrast medical industry payments across U.S. oncologic providers, including hematology-oncology (HO), surgical oncology (SO), interventional radiology (IR), and radiation oncology (RO).

Synovial sarcoma of the shoulder: A series of 14 cases.

Synovial sarcoma is a rare soft tissue sarcoma with poor long-term prognosis due to late recurrence and metastasis. Synovial sarcoma arises in less than 6% from the shoulder. As a result, there is limited information in the literature about synovial sarcoma of the shoulder (SSS).

A novel and validated prognostic nomogram based on liver fibrosis and tumor burden for patients with hepatocellular carcinoma after curative resection.

Most conventional staging systems were formulated concerning the tumor burden rather than the severity of liver fibrosis, which plays a central role in tumor promotion. The aim of this study was to formulate a prognostic nomogram comprehensively considering these two aspects for HCC after hepatectomy.

Radiation therapy in retroperitoneal sarcoma management.

Surgery is potentially curative for primary non-metastatic retroperitoneal soft tissue sarcomas (RPS), although patients remain at risk for local recurrence. To reduce this risk, the addition of radiotherapy to radical surgery may be considered. Nevertheless, level I evidence to support radiotherapy is currently lacking. The results from the EORTC-STBSG 62092-22092 studying this question are awaited. This manuscript addresses issues to consider when radiation-oncologists engage in a multidisciplinary treatm...

Prospective phase II trial of combination hepatic artery infusion and systemic chemotherapy for unresectable colorectal liver metastases: Long term results and curative potential.

Combination hepatic artery infusion (HAI) and systemic (SYS) chemotherapy for unresectable CRLM results in high tumor-response rates. This study represents an update of long-term survival and conversion to resectability in patients with unresectable CRLM treated with HAI and SYS chemotherapy in a phase II study.

Delivering quality lung cancer care in crisis-wracked Greece.

Metastasectomy following incomplete response to high-dose interleukin-2.

To evaluate our experience with metastasectomy following partial response or stable disease after treatment with high-dose interleukin-2 (HD IL-2).

Identification of predisposing factors for osteonecrosis of the jaw after marginal mandibulectomy in the surgical management of oral squamous cell carcinoma.

The aim of this study is to evaluate osteonecrosis of the jaw (ONJ) with the extent of marginal mandibulectomy.

Ecological disturbance influences adaptive divergence despite high gene flow in golden perch (Macquaria ambigua): implications for management and resilience to climate change.

Populations that are adaptively divergent but maintain high gene flow may have greater resilience to environmental change as gene flow allows the spread of alleles that have already been tested elsewhere. In addition, populations naturally subjected to ecological disturbance may already hold resilience to future environmental change. Confirming this necessitates ecological genomic studies of high dispersal, generalist species. Here we perform one such study on golden perch (Macquaria ambigua) in the Murray-...

The TCP4 transcription factor regulates trichome cell differentiation by directly activating GLABROUS INFLORESCENCE STEMS in Arabidopsis thaliana.

Trichomes are the first cell type to be differentiated during the morphogenesis of leaf epidermis and serve as an ideal model to study cellular differentiation. A large number of genes involved in the patterning and differentiation of trichome cells have been studied over past decades, and the majority of these genes encode transcription factors that specifically regulate epidermal cell development. However, the upstream regulators of these genes that link early leaf morphogenesis with cell type differentia...

Shipping Living Donor Kidneys and Transplant Recipient Outcomes.

Kidney paired donation (KPD) is an important tool to facilitate living donor kidney transplantation (LDKT). Concerns remain over prolonged cold ischemia times (CIT) associated with shipping kidneys long distances through KPD. We examined the association between CIT and delayed graft function (DGF), allograft survival, and patient survival for 1,267 shipped and 205 non-shipped/internal KPD LDKTs facilitated by the National Kidney Registry in the United States from 2008-2015, compared to 4,800 unrelated, non-...

Manganese Dioxide Coated WS2 @Fe3 O4 /sSiO2 Nanocomposites for pH-Responsive MR Imaging and Oxygen-Elevated Synergetic Therapy.

Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attac...

Adaptation and validation of the Turkish version of the Nasal Obstruction Symptom Evaluation scale.

The Nasal Obstruction Symptom Evaluation (NOSE) scale is a questionnaire used to assess the quality of life in patients with nasal obstruction. The aim of this study was to validate the Turkish translation of the NOSE questionnaire.

Micelle-assisted electrodeposition of mesoporous Fe-Pt smooth thin films onto various substrates and their electrocatalytic activity towards hydrogen evolution reaction.

Mesoporous Fe-Pt thin films are obtained by micelle-assisted electrodeposition onto metallic substrates with dissimilar activity (namely, gold, copper, and aluminum seed-layers evaporated on Si/Ti) under constant applied potential (E= -1.1 V vs. Ag/AgCl) and deposition time (600 s). The amphiphilic triblock copolymer Pluronic P-123 is used as a soft-template to guide the formation of mesopores. The occurrence of pores (ca. 7 nm in diameter) with narrow size distribution, regularly distributed over the surfa...

Impact of Flue Gas Compounds on Microalgae and Mechanisms for Carbon Assimilation and Utilization - A Review.

In order to shift the world to a more sustainable future, it is necessary to phase out the use of fossil fuels and focus on the development of low-carbon alternatives. However, this transition is slow so there still exists a large dependence on fossil-derived power and therefore CO2 release. Owing to the potential for assimilating and utilizing CO2 to generate carbon neutral products such as biodiesel, the application of microalgae technology to capture CO2 from flue gases has gained significant attention o...

Spatial population genomics of the brown rat (Rattus norvegicus) in New York City.

Human commensal species such as rodent pests are often widely distributed across cities and threaten both infrastructure and public health. Spatially-explicit population genomic methods provide insights into movements for cryptic pests that drive evolutionary connectivity across multiple spatial scales. We examined spatial patterns of neutral genome-wide variation in brown rats (Rattus norvegicus) across Manhattan, New York City (NYC) using 262 samples and 61,401 SNPs to understand: 1) relatedness among nea...

Measurements of Self-Efficacy in Patients with Chronic Kidney Disease: A Literature Review.

This article reviews the literature addressing assessment instruments about various aspects of self-efficacy in patients with chronic kidney disease (CKD). Each scale's structure, reliability, validity, and clinical application are described in detail. When selecting assessment tools to measure the self-efficacy level of patients with CKD, we should take the suitable subjects and application scope into account. With valid and reliable measurement tools, researchers and clinical nurses can assess and stimula...

Addressing challenges and scalability in the synthesis of thin uniform metal shells on large metal nanoparticle cores: Case study of Ag-Pt core-shell nanocubes.

Bimetallic nanoparticles in which a metal is coated with an ultrathin (~1 nm) layer of a second metal are often desired for their unique chemical and physical properties. Current synthesis methods for producing such core-shell nanostructures often require incremental addition of a shell metal precursor which is rapidly reduced onto metal cores. A major shortcoming of this approach is that it necessitates precise concentrations of chemical reagents making it difficult to perform at large scales. To address t...

On-chip lipid extraction using super absorbent polymers for mass spectrometry.

Pre-treatment of samples is the one of most important steps in analytical methods for efficient and accurate results. Typically, an extraction method used for lipid analysis with mass spectrometry is accompanied by complex liquid-liquid extraction. We have devised a simple, rapid, and efficient lipid extraction method using super absorbent polymers (SAPs) and developed a high-throughput lipid extraction platform based on a microfluidic system. Since SAPs can rapidly absorb an aqueous solution from a raw sam...

Nanoscale Dynamics of Amyloid Beta-42 Oligomers as Revealed by High-Speed Atomic Force Microscopy.

Amyloid β-protein (Aβ) oligomers are emerging as potent neurotoxic species in Alzheimer's disease pathogenesis. Detailed characterization of oligomer structure and dynamics are necessary to develop oligomer-specific therapeutic agents. However, oligomers exist transiently, which complicates their structural analysis. One approach to mitigate these problems has been photochemical cross-linking of native oligomers. In these states, the oligomers can be isolated and purified for physical and chemical studies...

Scalable Low-Bandgap Sb2Se3 Thin-Film Photocathodes for Efficient Visible-Near-Infrared Solar Hydrogen Evolution.

A highly efficient low-bandgap (1.2-0.8 eV) photoelectrode is critical for accomplishing efficient conversion of visible-near-infrared sunlight into storable hydrogen. Herein, we report Sb2Se3 polycrystalline thin film photocathode having a low-bandgap (1.2-1.1 eV) for efficient hydrogen evolution for wide solar-spectrum utilization. The photocathode was fabricated by a facile thermal evaporation of single Sb2Se3 powder source onto the Mo-coated soda-lime glass substrate, followed by annealing under Se vapo...

Magnetic Particle Imaging for Highly Sensitive, Quantitative and Safe in vivo Gut Bleed Detection in a Murine Model.

Gastrointestinal (GI) bleeding causes more than 300,000 hospitalizations per year in the United States. Imaging plays a crucial role in accurately locating the source of the bleed for timely intervention. Magnetic Particle Imaging (MPI) is an emerging clinically translatable imaging modality that images superparamagnetic iron-oxide (SPIO) tracers with extraordinary contrast and sensitivity. This linearly quantitative modality has zero background tissue signal and zero signal depth attenuation. MPI is also s...


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