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PubMed Journals Articles About "Scientists Discover Link Between Genes" RSS

07:10 EST 21st February 2020 | BioPortfolio

Scientists Discover Link Between Genes PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Scientists Discover Link Between Genes articles that have been published worldwide.

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Showing "Scientists discover link between genes" PubMed Articles 1–25 of 10,000+

Scientists' opinions and attitudes towards citizens' understanding of science and their role in public engagement activities.

The increasing perception that public communication in science and technology is an important tool to create a knowledge society is encouraging numerous public engagement activities. However, too little is known about scientists' opinions of and attitudes towards the public with whom they interact during these activities, especially in southern European countries such as Spain. If we want to establish an effective dialogue between science and society, we need to be aware of the opinions and perceptions that...


Interpreting pathways to discover cancer driver genes with Moonlight.

Cancer driver gene alterations influence cancer development, occurring in oncogenes, tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult because of their elusive context-dependent behavior. We define oncogenic mediators as genes controlling biological processes. With them, we classify cancer driver genes, unveiling their roles in cancer mechanisms. To this end, we present Moonlight, a tool that incorporates multiple -omics data to identify critical cancer driver genes. Wi...

Double triage to identify poorly annotated genes in maize: The missing link in community curation.

The sophistication of gene prediction algorithms and the abundance of RNA-based evidence for the maize genome may suggest that manual curation of gene models is no longer necessary. However, quality metrics generated by the MAKER-P gene annotation pipeline identified 17,225 of 130,330 (13%) protein-coding transcripts in the B73 Reference Genome V4 gene set with models of low concordance to available biological evidence. Working with eight graduate students, we used the Apollo annotation editor to curate 86 ...


The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms.

Advances in genomics have transformed our ability to identify the genetic causes of rare diseases (RDs), yet we have a limited understanding of the mechanistic roles of most genes in health and disease. When a novel RD gene is first discovered, there is minimal insight into its biological function, the pathogenic mechanisms of disease-causing variants, and how therapy might be approached. To address this gap, the Canadian Rare Diseases Models and Mechanisms (RDMM) Network was established to connect clinicia...

Secularism in science: The role of religious affiliation in assessments of scientists' trustworthiness.

With controversies surrounding numerous science topics, including vaccinations and climate change, science skepticism in the United States is of growing concern. Some skepticism of science may stem from the perceived association between science and atheism, as well as stereotypes of religious individuals as prosocial. Three studies examine how scientists' religious affiliation (or lack thereof) influences perceptions of their warmth and trustworthiness among Christian participants. (Study 1 also includes at...

Transcriptomic analysis on the promoter regions discover gene networks involving mastitis in cattle.

Mastitis is one of the costliest diseases in dairy farms caused by infection of different microorganisms such as Escherichia coli, Streptococcus uberis and Staphylococcus aureus. Promoters are significantly involved in regulating gene expression and shedding light on the mechanisms of transcriptional regulation in physiological and immunological processes of the infections. Exploiting regulatory elements such as transcription factor binding sites (TFBSs modules) on the promoter region could reveal co-regula...

Genes dysregulated in the blood of people with Williams syndrome are enriched in protein-coding genes positively selected in humans.

Williams syndrome is a complex condition resulting from the heterozygous deletion of nearly 30 genes in chromosome 7. However, precise genotype-to-phenotype mappings are not available for most of its distinctive features. Because WS entails changes in the expression patterns of multiple genes outside the WS region, it can be expected that many other genes besides the deleted genes contribute to this condition. In this paper, we hypothesise that genes that have changed recently in our history could account f...

NIH Knockout Mouse Phenotyping Program (KOMP2) and IMPC: Database to Discover New Roles of Genes in Cardiovascular Physiology and Disease.

The collaborative goal of NIH Knockout Mouse Phenotyping Program (KOMP2) and International Knockout Mouse Phenotyping Consortium (IMPC) is to discover functional insight for every gene in the mouse genome by 2021, by generating and systematically phenotyping approximately 20,000 unique knockout (KO) mouse strains. The purpose of the present study is to introduce the KOMP2/IMPC program and its publicly-accessible gene-phenotype database to the research community and to specifically illustrate its utility for...

Drosophila Neuroblast Selection Is Gated by Notch, Snail, SoxB, and EMT Gene Interplay.

In the developing Drosophila central nervous system (CNS), neural progenitor (neuroblast [NB]) selection is gated by lateral inhibition, controlled by Notch signaling and proneural genes. However, proneural mutants still generate many NBs, indicating the existence of additional proneural genes. Moreover, recent studies reveal involvement of key epithelial-mesenchymal transition (EMT) genes in NB selection, but the regulatory interplay between Notch signaling and the EMT machinery is unclear. We find that So...

Does increased interdisciplinary contact among hard and social scientists help or hinder interdisciplinary research?

Scientists across disciplines must often work together to address pressing global issues facing our societies. For interdisciplinary projects to flourish, scientists must recognise the potential contribution of other disciplines in answering key research questions. Recent research suggested that social sciences may be appreciated less than hard sciences overall. Building on the extensive evidence of ingroup bias and ethnocentrism in intergroup relations, however, one could also expect scientists, especially...

MoS decorated nanocomposite: FeO@MoS inhibits the conjugative transfer of antibiotic resistance genes.

Nanomaterials of AlO and TiO have been proved to promote the spread of antibiotic resistance genes (ARGs) by horizontal gene transfer. In this work, we found that FeO@MoS nanocomposite inhibited the horizontal gene transfer (HGT) by inhibiting the conjugative transfer mediated by RP4-7 plasmid. To discover the mechanism of FeO@MoS inhibiting HGT, the bacterial cells were collected under the optimal mating conditions. The collected bacterial cells were used for analyzing the expression levels of genes unique...

Genetic polymorphisms and transcription profiles associated with intracranial aneurysm: a key role for NOTCH3.

Intracranial aneurysm (IA) incidence is about 1~2%. However, the specific mechanisms of IA onset and development need further study. Our objective was to discover novel IA-related genes to determine possible etiologies further. We performed next-generation sequencing on nineteen Chinese patients with familial IA and one patient with sporadic IA. We obtained mRNA expression data of 129 samples from Gene Expression Omnibus (GEO) and made statistical computing to discover differentially expressed genes (DEGs)....

Next generation diabetes scientists shape global research culture.

The annual Winter School of the Danish Diabetes Academy (DDA) in November 2019 challenged postdoctoral researchers with tough questions regarding research culture that scientists around the world are discussing. The complexity and competitiveness of modern research makes it increasingly difficult for junior researchers to navigate in the science community. This editorial reflects the voices of nearly 200 international researchers ranging from early-career scientists to professors and medical doctors discuss...

Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm.

Oil palm (Elaeis guineensis Jacq.) is a representative tropical oil crop that is sensitive to low temperature. Oil palm can experience cold damage when exposed to low temperatures for a long period. During these unfavorable conditions, a series of gene induction/repression and physico-chemical changes occur in oil palm. To better understand the link between these events, we investigated the expression levels of various genes (including COR410, COR413, CBF1, CBF2, CBF3, ICE1-1, ICE1-2, ICE1-4, SIZ1-1, SIZ1-2...

Physiology without Borders: US and Cuban Scientists Meet in Space.

Over 400 delegates from 28 countries gathered recently in Havana for the 2nd Pan-American Congress of Physiological Sciences (May, 2019). It was quite an event, the level of science attesting to the quality of participants from the world over. The conference attracted more US scientists to Cuba than any other in the field of medicine over the last several years: 228. I find this number particularly noteworthy amidst the pressures they faced to keep them from coming.

Colon cancer data analysis by chameleon algorithm.

Detecting the key differential genes of colon cancers is very important to tell colon cancer patients from normal people. A gene selection algorithm for colon cancers is proposed by using the dynamic modeling properties of chameleon algorithm and its capability to discover any arbitrary shape clusters. This chameleon algorithm based gene selection algorithm comprises three steps. The first step is to select those genes with higher Fisher function values as candidate genes. The second step is to detect gene ...

Bioinformatic profiling of prognosis-related genes in the breast cancer immune microenvironment.

In the microenvironment of breast cancer, immune cell infiltration is associated with an improved prognosis. To identify immune-related prognostic markers and therapeutic targets, we determined the lymphocyte-specific kinase (LCK) metagene scores of samples from breast cancer patients in The Cancer Genome Atlas. The LCK metagene score correlated highly with other immune-related scores, as well as with the clinical stage, prognosis and tumor suppressor gene mutation status (, , ) of patients in the four brea...

An Initial Comparative Genomic Autopsy of Wasting Disease in Sea Stars.

Beginning in 2013, sea stars throughout the Eastern North Pacific were decimated by wasting disease, also known as 'asteroid idiopathic wasting syndrome' (AIWS) due to its elusive etiology. The geographic extent and taxonomic scale of AIWS meant events leading up to the outbreak were heterogeneous, multifaceted, and oftentimes unobserved; progression from morbidity to death was rapid, leaving few tell-tale symptoms. Here we take a forensic genomic approach to discover candidate genes that may help explain s...

When Genetics Meets Religion: What Scientists and Religious Leaders Can Learn from Each Other.

To date scientists and religious leaders have not yet engaged in sustained face-to-face conversation concerning precision public health-related genetic technologies.

Author Correction: MicroRNA-125b-5p regulates IL-1β induced inflammatory genes via targeting TRAF6-mediated MAPKs and NF-κB signaling in human osteoarthritic chondrocytes.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Can scientists fill the science journalism void? Online public engagement with science stories authored by scientists.

In many countries the public's main source of information about science and technology is the mass media. Unfortunately, in recent years traditional journalism has experienced a collapse, and science journalism has been a major casualty. One potential remedy is to encourage scientists to write for news media about science. On these general news platforms, scientists' stories would have to compete for attention with other news stories on hard (e.g. politics) and entertaining (e.g. celebrity news) topics writ...

Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis.

Sexual dimorphism requires regulation of gene expression in developing organisms. These developmental differences are caused by differential expression of genes and isoforms. The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). However, few studies have described how these processes change across development. We compare the dynamics of differential expression, isoform switching and functional interactions in the sexual development of...

Strategic science communication as planned behavior: Understanding scientists' willingness to choose specific tactics.

Strategic science communicators need to select tactics that can help them achieve both their short-term communication objectives and long-term behavioral goals. However, little previous research has sought to develop theory aimed at understanding what makes it more likely that a communicator will prioritize specific communication tactics. The current study aims to advance the development of a theory of strategic science communication as planned behavior based on the Integrated Behavioral Model. It does so i...

Revealing Functional Crosstalk between Distinct Bioprocesses through Reciprocal Functional Tests of Genetically Interacting Genes.

To systematically explore the genes mediating functional crosstalk between metazoan biological processes, we apply comparative genetic interaction (GI) mapping in Saccharomyces cerevisiae and Caenorhabditis elegans to generate an inter-bioprocess network consisting of 178 C. elegans GIs. The GI network spans six annotated biological processes including aging, intracellular transport, microtubule-based processes, cytokinesis, lipid metabolic processes, and anatomical structure development. By proposing a st...

bHLH121 Functions as A Direct Link that Facilitates the Activation of FIT by bHLH IVc Transcription Factors for Maintaining Fe Homeostasis in Arabidopsis.

Iron (Fe) deficiency is prevalent in plants grown in neutral or alkaline soil. Plants have evolved sophisticated mechanisms that regulate Fe homeostasis, ensuring survival. In Arabidopsis FER-LIKE IRON DEFICIENCY-INDUCED TRANSCRIPTION FACTOR (FIT) is a crucial regulator of Fe deficiency response. FIT is activated indirectly by bHLH IVc transcription factors (TFs) under Fe deficiency; however, it remains unclear which protein(s) act as a linker to mediate the activation of FIT by bHLH IVc TFs. In this study,...


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