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PubMed Journals Articles About "Scientists Take First Step Towards Digital Channels Brain" RSS

06:16 EDT 16th September 2019 | BioPortfolio

Scientists Take First Step Towards Digital Channels Brain PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Scientists Take First Step Towards Digital Channels Brain articles that have been published worldwide.

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Showing "Scientists take first step towards digital channels brain" PubMed Articles 1–25 of 14,000+

Loose Coupling Between SK and P/Q-type Ca Channels in Cartwheel Cells of the Dorsal Cochlear Nucleus.

Small-conductance Ca-activated K (SK) and large conductance, voltage- and Ca-activated K (BK) channels are Ca-activated K channels that control action potential firing diverse neurons in the brain. In cartwheel cells of the dorsal cochlear nucleus, blockade of either channel type leads to excessive production of spike bursts. In the same cells, P/Q-type Ca channels in plasma membrane and ryanodine receptors in endoplasmic reticulum supply Ca to BK channels through Ca nanodomain signaling. In this study, vol...


Head-to-head comparison of image quality between brain F-FDG images recorded with a fully digital versus a last-generation analog PET camera.

The quality of phantom images was previously shown to be higher on digital (Vereos Philips®) compared to analog PET (Ingenuity Philips®) cameras. This study aimed to determine the extent to which this difference still remains significant on normal brain F-FDG PET images.

Design and Development of the Brain Training System for the Digital "Maintain Your Brain" Dementia Prevention Trial.

Dementia is the leading cause of disability worldwide, and interventions aimed at reducing the prevalence and burden of the disease are urgently needed. Maintain Your Brain (MYB) is a randomized controlled trial of a multimodal digital health intervention targeting modifiable dementia risk factors to combat cognitive decline and potentially prevent dementia. In addition to behavioral modules targeting mood, nutrition, and physical exercise, a new Brain Training System (BTS) will deliver computerized cogniti...


Fully Open-Access Passive Dry Electrodes BIOADC: Open-Electroencephalography (EEG) Re-Invented.

The Open-electroencephalography (EEG) framework is a popular platform to enable EEG measurements and general purposes Brain Computer Interface experimentations. However, the current platform is limited by the number of available channels and electrode compatibility. In this paper we present a fully configurable platform with up to 32 EEG channels and compatibility with virtually any kind of passive electrodes including textile, rubber and contactless electrodes. Together with the full hardware details, resu...

Facile synthesis of Ag-CuO/SBA-15 for aerobic epoxidation of olefins with high activity.

An efficient "structure-property" catalyst Ag-CuO/SBA-15 for aerobic epoxidation of olefins was designed and prepared via simple grinding method, which provides a dynamic assembly driving force to push the precursors into the channels step by step. Partial melting on the precursor particles surface is necessary for synthesizing the Ag-CuO/SBA-15 catalysts. During the thermal grinding process, the melting Cu(NO3)2 first adhered on AgNO3 particles surface which were also in partial melting state, and then the...

LightProbe: A Digital Ultrasound Probe for Software-Defined Ultrafast Imaging.

Digital ultrasound probes integrate the analog front-end in the housing of the probe handle and provide a digital interface instead of requiring an expensive coaxial cable harness to connect. Current digital probes target the portable market and perform the bulk of the processing (beamforming) on the probe, which enables the probe to be connected to commodity devices such as tablets or smartphones running an ultrasound app to display the image and control the probe. Thermal constraints limit the number of f...

Use of the Principles of Design Thinking to Address Limitations of Digital Mental Health Interventions for Youth: Viewpoint.

Numerous reviews and meta-analyses have indicated the enormous potential of technology to improve the appeal, effectiveness, cost, and reach of mental health interventions. However, the promise of digital mental health interventions for youth has not yet been realized. Significant challenges have been repeatedly identified, including engagement, fidelity, and the lack of personalization. We introduce the main tenets of design thinking and explain how they can specifically address these challenges, with an e...

Hyperpolarization-activated and cyclic nucleotide-gated channel proteins as emerging new targets in neuropathic pain.

Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels are activated during hyperpolarization, and there is an inward flow of current, which is termed as hyperpolarization-activated current, Ih. Initially, these channels were identified on the pacemaker cells of the heart. Nowadays, these are identified on different regions of the nervous system, including peripheral nerves, dorsal root ganglia, dorsal horns, and different parts of the brain. There are four different types of HCN channels (H...

Quantitative assessment of phased array coils with different numbers of receiving channels in terms of signal-to-noise ratio and spatial noise variation in magnetic resonance imaging.

The neuroimaging of humans using 7T magnetic resonance imaging (MRI) has been conducted using phased array (PA) coils with different numbers of receiving channels. PA coils with a high number of channels may offer parallel imaging (PI) with a high reduction (R)-factor, which is enabled via under-sampling and coil geometry (g) factor, increasing the radiofrequency signal sensitivity provided by a small coil. The goals of this study were to assess and validate the coil performance of PA coils with different n...

Digital Health Innovation in Gastroenterology.

While digital health is changing the way we perform medicine, implementation of novel diagnostic or therapeutic approaches into clinical practice remains challenging. In this paper we discuss strategies and problems that need to be addressed to enable the translation of new technologies. With its broad spectrum of diseases and procedures the field of gastroenterology offers a perfect test bed for digital innovation. Two clusters of excellence funded by the German Research Foundation focus on data driven per...

TRP channels in gastric cancer: New hopes and clinical perspectives.

Gastric cancer is a multifactorial disease associated with a combination of and environmental factors. Each year, one million new gastric cancer cases are diagnosed worldwide and two-thirds end up losing the battle with this devastating disease. Currently, surgery represents the only effective treatment option for patients with early stage tumors. However, the asymptomatic phenotype of this disease during the early stages poses as a significant limiting factor to diagnosis and often renders treatments ineff...

Usefulness of the "two-step method" of digital follow-up in early stage melanoma detection in at high risk French patients - A retrospective 4-year study.

Dermoscopy was proven more accurate than naked-eye examination and sequential digital dermoscopy imaging (SDDI) superior to dermoscopy alone for melanoma detection . SDDI combined with total-body photography (TBP) namely the "two-step method" of digital follow-up (DFU), seems at present the best surveillance strategy for high risk patients. With the aim to endorse its usefulness, we retrospectively studied 148 at high risk patients included in DFU at the Dermato-oncology Unit of Hôpital Saint-Louis between...

Ion channel engineering for modulation and de novo generation of electrical excitability.

Ion channels play essential roles in regulating electrical properties of excitable tissues. By leveraging various ion channel gating mechanisms, scientists have developed a versatile set of genetically encoded tools to modulate intrinsic tissue excitability under different experimental settings. In this article, we will review how ion channels activated by voltage, light, small chemicals, stretch, and temperature have been customized to enable control of tissue excitability both in vitro and in vivo. Advant...

Two-view digital breast tomosynthesis versus digital mammography in a population-based breast cancer screening programme (To-Be): a randomised, controlled trial.

Digital breast tomosynthesis is an advancement of mammography, and has the potential to overcome limitations of standard digital mammography. This study aimed to compare first-generation digital breast tomo-synthesis including two-dimensional (2D) synthetic mammograms versus digital mammography in a population-based screening programme.

Using selfies to challenge public stereotypes of scientists.

In an online Qualtrics panel survey experiment (N = 1620), we found that scientists posting self-portraits ("selfies") to Instagram from the science lab/field were perceived as significantly warmer and more trustworthy, and no less competent, than scientists posting photos of only their work. Participants who viewed scientist selfies, especially posts containing the face of a female scientist, perceived scientists as significantly warmer than did participants who saw science-only images or control images. P...

Beyond the Isolated Brain: The Promise and Challenge of Interacting Minds.

As scientists, we brainstorm and develop experimental designs with our colleagues and students. Paradoxically, this teamwork has produced a field focused nearly exclusively on mapping the brain as if it evolved in isolation. Here, we discuss promises and challenges in advancing our understanding of how human minds connect during social interaction.

A review of transient receptor potential channel (TRPC) modulators and diseases.

Transient receptor potential canonical (TRPC) channels are highly homologous, non-selective cation channels that form many homo- and heterotetrameric channels. These channels are highly abundant in the brain and kidney and have been implicated in numerous diseases, such as depression, addiction, and chronic kidney disease, among others. Historically, there have been very few selective modulators of the TRPC family in order to fully understand their role in disease despite their physiological significance. H...

Recent progress in structural studies on canonical TRP ion channels.

Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and th...

Scientific Community Image Forum: A discussion forum for scientific image software.

Forums and email lists play a major role in assisting scientists in using software. Previously, each open-source bioimaging software package had its own distinct forum or email list. Although each provided access to experts from various software teams, this fragmentation resulted in many scientists not knowing where to begin with their projects. Thus, the scientific imaging community lacked a central platform where solutions could be discussed in an open, software-independent manner. In response, we introdu...

TRP Channel Reconstitution in Lipid Bilayers.

The family of the transient receptor potential (TRP) proteins presents a diverse group of polymodal ion channels intertwined in the regulation of various physiological processes. Currently, TRP channels are well established in temperature-sensation, thermoregulation, pain sensation, and mineral homeostasis. Furthermore, new evidence suggests that TRP channels are also implicated in hormonal signaling, where the channels are responsible for propagating hormone-induced signals along the neural circuitry and a...

Cell-Specific Neuropharmacology.

Neuronal communication involves a multitude of neurotransmitters and an outstanding diversity of receptors and ion channels. Linking the activity of cell surface receptors and ion channels in defined neural circuits to brain states and behaviors has been a key challenge in neuroscience, since cell targeting is not possible with traditional neuropharmacology. We review here recent technologies that enable the effect of drugs to be restricted to specific cell types, thereby allowing acute manipulation of the ...

Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics.

Alzheimer's disease (AD) is a complex neurodegenerative disorder causing progressive cognitive decline, memory loss, and death of neural tissue. Current research suggests a connection between bulk flow of interstitial fluid and cerebrospinal fluid across the blood-brain barrier and the recently confirmed meningeal lymphatic channels of the brain. The main symptom of interest in AD is the spontaneous aggregation of amyloid beta (Aβ) proteins resulting from increased production or lack of clearance from brai...

Monosynaptic tracing: a step-by-step protocol.

Monosynaptic tracing using deletion-mutant rabies virus allows whole-brain mapping of neurons that are directly presynaptic to a targeted population of neurons. The most common and robust way of implementing it is to use Cre mouse lines in combination with Cre-dependent adeno-associated viral vectors for expression of the required genes in the targeted neurons before subsequent injection of the rabies virus. Here we present a step-by-step protocol for performing such experiments using first-generation (ΔG)...

Validity of Using Accreditation Phantom in Quality Control of Digital Tomosynthesis.

This study was undertaken to compare the two image-quality phantoms commonly used in full-field digital mammography (FFDM) and digital breast tomosynthesis (DBT) imaging.

Diurnal properties of voltage-gated Ca currents in SCN and roles in action potential firing.

Circadian oscillations in spontaneous action potential firing in the suprachiasmatic nucleus (SCN) translates time-of-day throughout the mammalian brain. The ion channels that regulate the circadian pattern of SCN firing have not been comprehensively identified. Ca channels regulate action potential activity across many types of excitable cells, and the activity of L-, N-, P/Q-, R-type channels are required for normal daytime firing frequency in SCN neurons and circuit rhythms. Only the L-type Ca current ex...


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