PubMed Journals Articles About "Stream Extends Launch Novel Bioimaging Probes European Markets" RSS

15:46 EDT 18th March 2019 | BioPortfolio

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Showing "Stream extends launch novel bioimaging probes European markets" PubMed Articles 1–25 of 8,900+

Material failure in dynamic spine implants: are the standardized implant tests before market launch sufficient?

International Standards Organization (ISO) 12189 and American Society for Testing and Materials F2624 are two standard material specification and test methods for spinal implant devices. The aim of this study was to assess whether the existing and required tests before market launch are sufficient.

Marketplaces, Markets, and Market Design.

Marketplaces are often small parts of large markets, and both markets and marketplaces come in many varieties. Market design seeks to understand what marketplaces must accomplish to enable different kinds of markets. Marketplaces can have varying degrees of success, and there can be marketplace failures. I’ll discuss labor markets like the market for new economists, and also markets for new lawyers and doctors that have suffered from the unraveling of appointment dates to well before employment begins. Ma...

Pharmaceutical markets regulation overview of the selected European Union countries.

Introduction: Pharmacy markets, operating in the European Union are regulated by national laws. In many of them, the main restrictions concern the process of creating a new pharmacy - institutions. They are basic criteria for entities that can carry out this form of business, as well as demographic and geographic factors regulating the possible location of a new pharmacy. In Poland, the Act of from the 7th of April 2017 has changed the pharmaceutical law and introduced new legal restrictions so far unknown ...

Synthesis and in vitro evaluation of ADAM10 and ADAM17 highly selective bioimaging probes.

A Disintegrin And Metalloproteinase (ADAMs) are membrane-bound metalloproteases responsible for the ectodomain shedding of various transmembrane proteins and play an important role in multiple relevant biological processes. Their altered expression is involved in several pathological conditions, and in particular ADAM10 or ADAM17 overexpression is found in different forms of cancer. To better understand how they are regulated in the cellular context, it is useful to visualize the specific ADAMs pathway by m...

A novel water-soluble fluorescence probe based on ICT lighten for detecting hydrogen sulfide and its application in bioimaging.

Endogenous HS, considered to be involved in many physiological processes, has attracted more attention in fluorescence detection and bioimaging. Therefore, it is necessary to design probes with good biocompatibility and high bioavailability. In this study, a novel fluorescent probe, QN-1, based on azide group and quinoline derivatives was developed for detecting HS. QN-1 can detect HS specifically in aqueous phase, which indicated QN-1 has excellent water solubility. Besides, QN-1 shows excellent properties...

Zn Complexes for Bioimaging and Correlated Applications.

Zinc is a biocompatible element that exists as the second most abundant transition metal ion and an indispensable trace element in the human body. Compared to traditional metal-organic complexes systems, d metal Zn complexes not only exhibit a large Stokes shift and good photon stability but also possess strong emission and low cytotoxicity with a relatively small molecular weight. The use of Zn complexes has emerged in the last decade as a versatile and convenient tool for numerous biological applications,...

FRET probes for measuring sphingolipid metabolizing enzyme activity.

Förster resonance energy transfer (FRET) probes are unique tools in biology, as they allow for a non-destructive monitoring of a certain state of a biomolecule or of an artificial substrate within living cells in real time. FRET substrates indicate their relative cleavage rate and thus the in situ activity of a given enzyme. In contrast to quenched probes or turn-on probes, one of the two separate signals of the FRET probes can be used as internal reference, which makes ratio-imaging and quantitation of cl...

'Pre-launch' finite element analysis of a short-stem total hip arthroplasty system consisting of two implant types.

We applied a previously established and validated numerical model to a novel short-stemmed implant for a 'pre-launch' investigation.

In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections.

Photodynamic therapy is one of the most promising non-invasive strategies employed for the treatment of several kinds of bacterial infections. Though the vast majority of clinically approved photosensitisers are administered intravenously, most of the in vitro experiments are performed under static conditions which do not represent the physiological environment of the venous bloodstream. To address this issue, a dynamic circulation model was developed to facilitate in situ antibacterial photodynamic therapy...

Near-infrared excited cooperative upconversion in luminescent Ytterbium(ΙΙΙ) bioprobes as light-responsive theranostic agents.

Near-infrared (NIR) Ytterbium(ΙΙΙ) complexes namely [Yb(dpq)(DMF)Cl] (1), [Yb(dppz)(DMF)Cl] (2), [Yb(dpq)(ttfa)] (3) and [Yb(dppz)(ttfa)] (4) based on photosensitizing antenna: dipyrido-[3,2-d:2',3'-f]-quinoxaline (dpq), dipyrido-[3,2-a:2',3'-c]-phenazine (dppz) and 4,4,4-trifluoro-1-(2-thienyl)-1,3-butanedione (Httfa), were designed as NIR bioimaging agents utilizing cooperative upconversion luminescence (CUCL) of Yb(III). Their structures, detailed photophysical properties, biological interactions, pho...

Cell-compatible Nanoprobes for Imaging Intracellular Phosphatase Activities.

Phosphatases play an important role in cell biology, but there are few suitable probes for selectively imaging phosphatase activity of live cells because the current probes require cell fixation or exhibit considerable cytotoxicity. Here we show that conjugating a D-peptide to a quinazolinone derivative generates cell-compatible, biostable probes for imaging phosphatase activities inside live cells. Moreover, our results show that inhibiting ectophosphatases is a critical factor for imaging intracellular ph...

Comparing Agent Based Delivery of DNA and PNA FIT-Probes for Multicolor mRNA Imaging.

Fluorogenic oligonucleotide probes allow mRNA imaging in living cells. A key challenge is the cellular delivery of probes. Most delivery agents such as cell penetrating peptides (CPPs) and pore-forming proteins require interactions with the membrane. Charges play an important role. To explore the influence of charge on fluorogenic properties and delivery efficiency, we compared PNA- with DNA-based FIT probes. Perhaps counterintuitively, fluorescence signalling by charged DNA FIT-probes proved tolerant to CP...

Evolution of Average European Medicine Prices: Implications for the Methodology of External Price Referencing.

There are indications of staggered market entry of medicines in the national markets, with medicines being marketed first in countries with high prices. This study aimed to analyse the availability and evolution of medicine prices in the European Union (EU).

New coumarin- and phenoxazine-based fluorescent probes for live-cell STED nanoscopy.

The potential of live-cell stimulated emission depletion (STED) nanoscopy has not yet been fully exploited. Currently, the main limitation is the small number of fluorophores and probes that can sustain high light intensity/high dose employed in STED. Namely, fluorophores suitable for STED nanoscopy must be bright and highly photostable and exhibit a large Stokes shift. To expand the list of available probes, we synthesized and evaluated several new membrane probes for live-cell STED nanoscopy. Of the teste...

A large Stokes shift fluorescent protein constructed from the fusion of the red fluorescent mCherry and far-red fluorescent BDFP1.6.

While phycobiliproteins are organized as the phycobilisomes, they can harvest orange, red and/or far-red lights for photosynthesis in cyanobacteria and red algae, phycobiliproteins in the phycobilisome cores such as allophycocyanins absorb far-red light for funneling the energy to the reaction centers. The allophycocyanin subunits have been engineered as far-red fluorescent proteins such as BDFP1.6. However, most current fluorescent probes have small Stokes shifts, which limits their applications in multico...

Theoretical study of lanthanide-based in vivo luminescent probes for detecting hydrogen peroxide.

The 4f-4f emissions from lanthanide trication (Ln ) complexes are widely used in bioimaging probes. The emission intensity from Ln depends on the surroundings, and thus, the design of appropriate photo-antenna ligands is indispensable. In this study, we focus on two probes for detecting hydrogen peroxide, for which emission intensities from Tb are enhanced chemo-selectively by the H O -mediated oxidation of ligands. To understand the mechanism, the Gibbs free energy profiles of the ground and excited states...

Leveraging EUnetHTA's conceptual framework to compare HTA decision drivers in France, Italy, and Germany from a manufacturer's point of view.

Health Technology Assessments (HTA) procedures differ substantially across the various European countries. We reviewed recent appraisals of a pharmaceutical manufacturer in three major European markets (France; Italy; Germany) and identified and categorized related decision drivers.

Recent progress and developments of iridium-based compounds as probes for environmental analytes.

Metal complexes based on iridium metal centers have attracted attention as probes due to their tunable biological and chemical characteristics. This review highlights recent examples of iridium-based compounds that have been developed as probes for various environmental analytes. We also discuss the further challenges to be overcome for this class of probes in the future.

Lessons learned from a hospital-wide review of blood stream infections for paediatric central line-associated blood stream infection prevention.

Bacteraemia episodes were assessed to calculate a hospital-wide central line-associated blood stream infection (CLABSI) rate per 1000 catheter-days. Secondary objectives were to describe risk factors, microbiology and outcomes of children with CLABSI.

A high-resolution streamflow and hydrological metrics dataset for ecological modeling using a regression model.

Hydrological variables are among the most influential when analyzing or modeling stream ecosystems. However, available hydrological data are often limited in their spatiotemporal scale and resolution for use in ecological applications such as predictive modeling of species distributions. To overcome this limitation, a regression model was applied to a 1 km gridded stream network of Germany to obtain estimated daily stream flow data (m s) spanning 64 years (1950-2013). The data are used as input to calcula...

Crime displacement in digital drug markets.

Background Crackdowns on urban sites with concentrated criminal activity are sometimes followed by geographical relocation of crime. Is this also the case in cyberspace, where illegal websites and online networks can be wiped clean, but also quickly rebuilt and replaced on new servers and URLs? Methods I address this question in three steps. First, I measure MDMA trade in a large digital market for drugs, before and after the arrest of a leading MDMA seller in the same market. Second, I count the number of ...

From aggregation-induced to solution emission: a new strategy for designing ratiometric fluorescent probes and its application for in vivo HClO detection.

In this paper, we introduced a new strategy for converting aggregation-induced emission (AIE) to fluorescence emission in solution into the rational design of new fluorescent probes. Two fluorescent probes based on this strategy, namely, PDAM-Lyso and PDAM-Me, have been synthesized and tested both in vitro and in vivo. The fluorophores of the two probes are both phenothiazine molecules, which link to the diaminomaleonitrile (DAMN) moiety through imine bonds. In the presence of imine bonds, the probes emit r...

Highly sensitive glutathione assay and intracellular imaging with functionalized semiconductor quantum dots.

Glutathione (GSH) plays a vital role in biological systems and is associated with human pathology. The engineering of semiconductor quantum dots (QDs) as fluorescent probes for GSH sensing and bioimaging is a potential yet rarely reported approach. Herein, we report the in situ growth of manganese dioxide nanosheets (MnO2) on silica-coated semiconductor quantum dots (QD@SiO2), to prepare a stable and biocompatible fluorescent nanoprobe (QD@SiO2-MnO2) for the selective and sensitive detection of GSH. The mod...

Photoluminescent arginine-functionalized polycitrate with enhanced cell activity and hemocompatibility for live cell bioimaging.

Development of biodegradable and highly biocompatible polymer with intrinsical photoluminescence and high photostability for real-time live cell bioimaging has attracted much attention recently. Here, a biodegradable and amphiphilic poly (citrate)-co-poly (ethylene glycol) (PEG) grafted with arginine (PCGA) polymer with intrinsical fluorescence was synthesized for targeted live cell bioimaging. The physicochemical structure, photoluminescent properties, hemocompatibility, cytotoxicity, and fluorescent bioim...

Cohort study of electronic cigarette use: safety and effectiveness after 4 years of follow-up.

More than a decade after e-cigarette (e-cig) market launch, limited information are available on their safety after 24 months of use. In 2013, we started the first observational study assessing e-cig long-term effectiveness and safety, directly comparing tobacco smokers and e-cig users. Here we report the results after four years of follow-up.

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