Advertisement

Topics

PubMed Journals Articles About "Synapse Biomedical" RSS

19:31 EDT 18th March 2019 | BioPortfolio

Synapse Biomedical PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Synapse Biomedical articles that have been published worldwide.

More Information about "Synapse Biomedical" on BioPortfolio

We have published hundreds of Synapse Biomedical news stories on BioPortfolio along with dozens of Synapse Biomedical Clinical Trials and PubMed Articles about Synapse Biomedical for you to read. In addition to the medical data, news and clinical trials, BioPortfolio also has a large collection of Synapse Biomedical Companies in our database. You can also find out about relevant Synapse Biomedical Drugs and Medications on this site too.

Showing "Synapse Biomedical" PubMed Articles 1–25 of 2,800+

Astrocytes "Chordinate" Synapse Maturation and Plasticity.

A key step in excitatory synapse maturation is the switch in AMPA receptor subunit composition to GluA2-containing calcium-impermeable receptors. Now, Blanco-Suarez et al. (2018) demonstrate that astrocyte-secreted chordin-like 1 drives this process, enabling synapse maturation and limiting plasticity.


The Long and Short of It: A Dwarf Neurexin Suffices for Synapse Assembly.

Neurexins have been established as a major coordinator of synapse assembly, functioning through interactions with postsynaptic cell adhesion molecules. Kurshan et al. (2018) now show that a C. elegans "dwarf neurexin" lacking its extracellular interaction domains can conduct synapse formation independent of postsynaptic partners.

A Protocol to Study T-Cell Signaling in an Immune Synapse by Microscopy.

The immune synapse is a complex cellular structure that enables cell-cell communications between immune cells, mainly at the interface of an effector T-cell and an antigen-presenting cell (APC) that expresses the appropriate peptide-MHC complexes. With progressive technological advances, there has been increasing interest in understanding molecular events that take place in motile T-lymphocytes at the immune synapse. Here, we provide an optimized method to induce the formation of an immune synapse between a...


Immunoglobulin-Like Receptors and Their Impact on Wiring of Brain Synapses.

Synapse formation is mediated by a surprisingly large number and wide variety of genes encoding many different protein classes. One of the families increasingly implicated in synapse wiring is the immunoglobulin superfamily (IgSF). IgSF molecules are by definition any protein containing at least one Ig-like domain, making this family one of the most common protein classes encoded by the genome. Here, we review the emerging roles for IgSF molecules in synapse formation specifically in the vertebrate brain, f...

Pumping the brakes: suppression of synapse development by MDGA-neuroligin interactions.

Synapse development depends on a dynamic balance between synapse promoters and suppressors. MDGAs, immunoglobulin superfamily proteins, negatively regulate synapse development through blocking neuroligin-neurexin interactions. Recent analyses of MDGA-neuroligin complexes revealed the structural basis of this activity and indicate that MDGAs interact with all neuroligins with differential affinities. Surprisingly, analyses of mouse mutants revealed a functional divergence, with targeted mutation of Mdga1 and...

Glial regulation of synapse maturation and stabilization in the developing nervous system.

The dynamic interaction between neurons and glia is a fundamental aspect of developmental neurobiology. Astrocytic processes are extremely complex and can physically surround neuronal synapses where they are involved in regulating neuronal activity and synaptic plasticity. This review describes important roles glial cells play in synapse maturation and stabilization in the developing central nervous system. We highlight recent evidence showing that the motility of astrocytic and radial glial processes is mo...

Powerhouse of the mind: mitochondrial plasticity at the synapse.

Neurons are highly polarized cells with extraordinary energy demands, which are mainly fulfilled by mitochondria. In response to altered neuronal energy state, mitochondria adapt to enable energy homeostasis and nervous system function. This adaptation, also called mitochondrial plasticity, can be observed as alterations in the form, function and position. The primary site of energy consumption in neurons is localized at the synapse, where mitochondria are critical for both pre- and postsynaptic functions. ...

Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.

Poly(propylene imine) dendrimers have been shown to be promising 3-dimensional polymers for the use in the pharmaceutical and biomedical applications. Our aims of this study were first, to synthesize a novel type of dendrimer with poly(propylene imine) core and maltose-histidine shell (G4HisMal) assessing if maltose-histidine shell can improve the biocompatibility and the ability to cross the blood brain barrier, and second, to investigate the potential of G4HisMal to protect Alzheimer disease transgenic mi...

Synapse Formation Activates a Transcriptional Program for Persistent Enhancement in the Bi-directional Transport of Mitochondria.

Mechanisms that regulate the bi-directional transport of mitochondria in neurons for maintaining functional synaptic connections are poorly understood. Here, we show that in the pre-synaptic sensory neurons of the Aplysia gill withdrawal reflex, the formation of functional synapses leads to persistent enhancement in the flux of bi-directional mitochondrial transport. In the absence of a functional synapse, activation of cAMP signaling is sufficient to enhance bi-directional transport in sensory neurons. Fur...

Towards an Understanding of Synapse Formation.

Synapses are intercellular junctions specialized for fast, point-to-point information transfer from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal secretes neurotransmitters via a canonical release machinery, while a postsynaptic specialization senses neurotransmitters via diverse receptors. Synaptic junctions are likely organized by trans-synaptic cell-adhesion molecules (CAMs) that bidirectionally orchestrate synapse formation, restructuring, and elimination. Many candid...

Understanding of Proton Induced Synaptic Behaviors in Three-terminal Synapse Device for Neuromorphic Systems.

In this study, we investigate a proton-based three-terminal (3-T) synapse device to realize linear weight-update and I-V linearity characteristics for neuromorphic systems. The conductance states of the 3-T synapse device can be controlled by modulating the proton concentration in the WO<sub>x</sub> channel. Therefore, we estimate the dynamic change of proton concentration in the channel region, which directly affects synaptic behaviors. Our findings indicate that the supply of an excess number ...

Diversity And Specificity Of Astrocyte-Neuron Communication.

Astrocytes are emerging as important players in synaptic function, and, consequently, on brain function and animal behavior. According to the Tripartite Synapse concept, astrocytes are integral elements involved in synaptic function. They establish bidirectional communication with neurons, whereby they respond to synaptically-released neurotransmitters and, in turn, release gliotransmitters that influence neuronal and synaptic activity. Accumulating evidence is reveling that the mechanisms and functional co...

A 0.086-mm 12.7-pJ/SOP 64k-Synapse 256-Neuron Online-Learning Digital Spiking Neuromorphic Processor in 28nm CMOS.

Shifting computing architectures from von Neumann to event-based spiking neural networks (SNNs) uncovers new opportunities for low-power processing of sensory data in applications such as vision or sensorimotor control. Exploring roads toward cognitive SNNs requires the design of compact, low-power and versatile experimentation platforms with the key requirement of online learning in order to adapt and learn new features in uncontrolled environments. However, embedding online learning in SNNs is currently h...

An Oxide Schottky Junction Artificial Optoelectronic Synapse.

The rapid development of artificial intelligence techniques and future advanced robot systems sparks emergent demand on the accurate perception and understanding of the external environments via visual sensing systems that can co-locate the self-adaptive detecting, processing and memorizing of optical signals. In this contribution, a simple indium-tin oxide/Nb-doped SrTiO3 (ITO/Nb:SrTiO3) heterojunction artificial optoelectronic synapse is proposed and demonstrated. Through the light and electric field co-m...

Inhibitors of the NMDA-nitric oxides ignalling pathway protect against neuronal atrophy and synapse loss provoked by L-alpha aminoadipic acid-treated astrocytes.

The impact of treating astrocytes with the astrocytic toxin l-alpha amino adipic acid (L-AAA) on neuronal outgrowth, complexity and synapse formation was assessed, using a model of astrocyte-neuronal interaction. Treatment of rat primary cortical neurons with conditioned media (CM) derived from astrocytes treated with L-AAA reduced neuronal complexity and synapse formation. L-AAA provoked a reduction in the expression of glial fibrillary acid protein (GFAP) and a reduction in ATP linked mitochondrial respir...

Nano-scale analysis of synapse morphology in an autism mouse model with 15q11-13 copy number variation using focused ion beam milling and scanning electron microscopy.

Circuit-level alternations in patients of autism spectrum disorder (ASD) is under active investigation and detailed characterization of synapse morphology in ASD model mice should be informative. We utilized focused ion beam milling and scanning electron microscopy (FIB-SEM) to obtain three-dimensional images of synapses in the layer 2/3 of the somatosensory cortex from a mouse model for ASD with human 15q11-13 chromosomal duplication (15q dup mice). We found a trend of higher spine density and a higher fra...

Comparative Study of ROCK1 and ROCK2 in Hippocampal Spine Formation and Synaptic Function.

Rho-associated kinases (ROCKs) are serine-threonine protein kinases that act downstream of small Rho GTPases to regulate the dynamics of the actin cytoskeleton. Two ROCK isoforms (ROCK1 and ROCK2) are expressed in the mammalian central nervous system. Although ROCK activity has been implicated in synapse formation, whether the distinct ROCK isoforms have different roles in synapse formation and function in vivo is not clear. Here, we used a genetic approach to address this long-standing question. Both Rock1...

50 Anniversary Retrospective: Computers and Biomedical Research and Journal of Biomedical Informatics.

Quality Assurance of Biomedical Terminologies and Ontologies.

The Productivity and Characteristics of Iranian Biomedical Journal: A Scientometric Analysis

Scientometrics is a discipline that analyzes scientific publications to explore the structure and growth of science. In this work, the quantitative evaluation of the productivity of the Iranian Biomedical Journal (IBJ) is reviewed.

Temporal Biomedical Data Analytics.

Current Concepts in Cochlear Ribbon Synapse Formation.

In mammals, hair cells and spiral ganglion neurons (SGNs) in the cochlea together are sophisticated "sensorineural" structures that transduce auditory information from the outside world into the brain. Hair cells and SGNs are joined by glutamatergic ribbon-type synapses composed of a molecular machinery rivaling in complexity the mechanoelectric transduction components found at the apical side of the hair cell. The cochlear hair cell ribbon synapse has received much attention lately because of recent and im...

An opposing function of paralogs in balancing developmental synapse maturation.

The disc-large (DLG)-membrane-associated guanylate kinase (MAGUK) family of proteins forms a central signaling hub of the glutamate receptor complex. Among this family, some proteins regulate developmental maturation of glutamatergic synapses, a process vulnerable to aberrations, which may lead to neurodevelopmental disorders. As is typical for paralogs, the DLG-MAGUK proteins postsynaptic density (PSD)-95 and PSD-93 share similar functional domains and were previously thought to regulate glutamatergic syna...

Biomedical event extraction based on GRU integrating attention mechanism.

Biomedical event extraction is a crucial task in biomedical text mining. As the primary forum for international evaluation of different biomedical event extraction technologies, BioNLP Shared Task represents a trend in biomedical text mining toward fine-grained information extraction (IE). The fourth series of BioNLP Shared Task in 2016 (BioNLP-ST'16) proposed three tasks, in which the Bacteria Biotope event extraction (BB) task has been put forward in the earlier BioNLP-ST. Deep learning methods provide an...

Aβ oligomers: role at the synapse.


Advertisement
Quick Search
Advertisement
Advertisement