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Showing "Regulatory Cell Depleted Double Umbilical Cord Blood Transplantation" PubMed Articles 1–25 of 38,000+

Prevention of transfusion-transmitted cytomegalovirus infection using leukoreduced blood components in patients receiving seronegative umbilical cord blood transplantation.

Leukoreduced blood components have been widely implemented to prevent transfusion-transmitted cytomegalovirus (TT-CMV) in transplantation. Recent progress in leukoreduction technology has helped reduce the risk of TT-CMV in hematopoietic stem cell transplantation; however, its efficacy in umbilical cord blood transplantation (CBT) has not been systematically studied.

Identification of miRNAs from stem cell derived microparticles in umbilical cord blood.

Umbilical cord blood CD34+stem cells (UCB-CD34+) are clinically used in hematopoietic cell transplantation. However, there are limitations in the use of umbilical cord blood transplants due to the small number of cells and delayed engraftment. In order to gain a better understanding of the functional components of UCB, we have detected and characterized CD34+ microparticles (CD34+MPs) from cord blood units. Cord blood units were collected and the number of CD34+MPs was assessed before and after red blood ce...

Unlicensed umbilical cord blood units provide a safe and effective graft source for a diverse population: A study of 2456 umbilical cord blood recipients.

Umbilical Cord Blood (UCB) transplant (UCBT) is a curative procedure for patients with hematologic malignancies and genetic disorders and expands access for non-Caucasian patients unable to find a fully matched unrelated donor. In 2011, the Food and Drug Administration (FDA) required that unrelated UCBT use either licensed UCB or unlicensed UCB via an Investigational New Drug (IND). The National Marrow Donor Program® (NMDP) manages an IND under which 2456 patients (1499 adults and 957 children (564 maligna...

Reactivation of BK virus after double umbilical cord blood transplantation in adults correlates with impaired reconstitution of CD4 and CD8 T effector memory cells and increase of T regulatory cells.

BK virus (BKV), a human polyomavirus that remains latent in renal epithelial cells, can be reactivated after hematopoietic stem cell transplantation (HSCT) leading to hemorrhagic cystitis. The incidence of BK viremia is higher after Umbilical cord blood transplantation (UCBT) than HSCT from adult donors. Data regarding the role of immune recovery after UCBT in BKV reactivation is lacking. We examined the correlation between the development of BK viremia and immune reconstitution in 27 adult recipients of UC...

Obstetrical and neonatal factors associated with optimal public banking of umbilical cord blood in the context of delayed cord clamping.

To assess the association of specific newborn and maternal factors with indicators of increased blood-forming capacity in umbilical cord blood to inform strategic collection strategies that could augment the quality of units in public cord blood banks.

Role of HLA matching in single umbilical cord blood transplant outcomes.

Myeloablative unrelated cord blood transplantation in adolescents and young adults with acute leukemia.

Outcomes for adolescents and young adults (AYA) with leukemia differ from other age groups but are still underrepresented in clinical research. The aim of this study was to analyze outcomes of umbilical cord blood transplant (UCBT) in AYA with acute leukemia reported to Eurocord/EBMT. Patients (n=504) had acute lymphoblastic (59%) or myeloid leukemia (41%), were aged 15-25 years, and received UCBT after myeloablative conditioning regimens between 2004 and 2016. Primary endpoint was 3-year overall survival (...

Effects of haplotype matching on outcomes after adult single cord blood transplantation.

It remains unclear whether the HLA haplotype of unrelated cord blood (UCB) should be matched to that of the patient in single UCB transplantation. Thus, using data from a Japanese registry, we analyzed the effect of haplotype matching on outcomes.

Prospective Phase 2 Study of Umbilical Cord Blood Transplantation in Adult Acute Leukemia and Myelodysplastic Syndrome.

Almost comparable transplant outcomes were reported between HLA-matched unrelated donor transplantation (UDT) and cord blood transplantation (CBT). Herein, we conducted a prospective phase 2 study to assess efficacy and safety of single-unit myeloablative CBT in adult leukemia and myelodysplastic syndrome. Because day 180 survival of UDT was approximately 80%, we determined the alternative hypothesis of expected day 180 survival with successful engraftment rate as 80% and set the null hypothesis of thresho...

Rapid review: next generation of cord blood banks; transplantation and beyond.

Cord blood (CB) is a medicinal product of human origin with unique cellular properties such as the presence of multipotent stem cells, naive immune cells, and fetal blood components. CB transplantation provides high rate of donor chimerism, and a good balance of graft-versus-host (GVH) and graft-versus-leukemia (GVL) effects. Use of CB for transplantation has decreased in recent years as haplo-identical stem cell transplants have achieved similar short-term clinical outcomes. For most patients, however, the...

Factors Affecting Human Umbilical Cord Blood Quality Before Cryopreservation: The Importance of Birth Weight and Gestational Age.

Umbilical cord blood (UCB) is a rich source of hematopoietic stem cells and is useful for the treatment of blood diseases. The cost of UCB storage is high; thus, it is necessary to evaluate the quality of UCB before collection and cryopreservation. This study aimed to determine the maternal and neonatal factors that influence UCB before selection for cryopreservation. The analysis included 403 processed UCB units. The effects of maternal characteristics including maternal age and delivery method and neona...

Review of the Small-Molecule Nicotinamide for Ex Vivo Expansion of Umbilical Cord Blood.

Umbilical cord blood transplant (UCB) is an alternative graft source for patients lacking an HLA-matched donor; however, delayed engraftment times have historically resulted in transplant-related mortality (TRM) due to complications such as infections and ineffective hematopoiesis. Recent advances in ex vivo expansion techniques have successfully augmented the initial cell dose delivered from an UCB graft, leading to improved immune reconstitution, durable hematopoiesis, decreased TRM, and better outcomes. ...

Use of Letermovir for Salvage Therapy for Resistant Cytomegalovirus in a Pediatric Hematopoietic Stem Cell Transplant Recipient.

We present here the first published use of letermovir for the treatment of resistant cytomegalovirus (CMV) in a pediatric patient. A 14-year-old girl underwent a double unrelated umbilical cord blood transplantation to treat her sickle cell disease (hemoglobin SS) and developed ganciclovir-resistant CMV DNAemia with end-organ involvement that was treated successfully with a combination of foscarnet and letermovir. After she was transitioned to letermovir monotherapy for secondary prophylaxis, she developed ...

Allogeneic hematopoietic cell transplantation for patients with a history of multiple relapses of acute myeloid leukemia.

The prognosis of patients with acute myeloid leukemia (AML) is dismal after experiencing multiple relapses. This study retrospectively analyzed outcomes of allogeneic hematopoietic cell transplantation (HCT) for 192 adults with AML in third or subsequent complete remission (CR3+), 300 in second relapse (REL2), and 50 in third or subsequent relapse (REL3+) who were enrolled in a Japanese nationwide transplantation registry. The study population included patients undergoing umbilical cord blood transplantatio...

Liraglutide Combined with Human Umbilical Cord Mesenchymal Stem Cell Transplantation inhibits beta-cells apoptosis via mediating the ASK1/JNK/BAX pathway in rats with Type 2 Diabetes Mellitus.

Accumulating evidence suggests an association between beta-cell apoptosis and the ASK1/JNK/BAX pathway. The aim of this study was to investigate the effects of a combined therapy of liraglutide and human umbilical cord mesenchymal stem cells (hUC-MSCs) on the glucose metabolism and islet beta-cell apoptosis, and further explore its relationship to the ASK1/JNK/BAX pathway.

Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and IGF-I and IGF-II: levels in umbilical cord blood and associations with birth weight and length.

A newborn's birth weight for gestational age provides important insights into his or her fetal growth and well-being. While the underlying mechanisms regulating fetal growth remain to be fully elucidated, the IGF-axis plays an important role. Some components of this axis have been well-characterized in umbilical cord blood, but others have not yet been studied. We measured the proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and -5), and the established molecules IGF-I and -II in umbi...

Time-Varying Effects of Graft Type on Outcomes for Patients with Acute Myeloid Leukemia Undergoing Allogeneic Hematopoietic Cell Transplantation.

This study aimed to investigate time-varying effects of graft type on outcomes for patients with acute myeloid leukemia (AML) undergoing allogeneic hematopoietic cell transplantation. For this purpose, we analyzed 3952 patients comprising 720 of whom underwent matched related bone marrow transplantation (BMT), 1004 matched related peripheral blood stem cell transplantation (PBSCT), 856 matched unrelated BMT, and 1372 umbilical cord blood transplantation (UCBT). The 4-year relapse-free survival (RFS) rates w...

Umbilical artery thrombosis: Two case reports.

The umbilical cord is the way to exchange gas, supply nutrients, excrete metabolized. Thrombosis of the umbilical cord leads to fetal hypoxia, which jeopardizes fetal health and can cause fetal death. Umbilical vessel thrombosis, which is rarely reported, is difficult to detect prenatally.

Prenatal ambient air pollution exposure and SOD2 promoter methylation in maternal and cord blood.

The evidence is increasing that prenatal air pollutant exposure contributes to elevated oxidative stress in children, but the underlying mechanism is unclear. A pilot study was conducted in China to explore the associations between prenatal ambient air pollution exposure and superoxide dismutase 2 (SOD2) promoter methylation in maternal and cord blood. After detection and analyses, SOD2 promoter methylation levels in umbilical cord blood were elevated as maternal SOD2 promoter methylation levels increased. ...

Neuroapoptosis in newborns with respiratory acidosis at birth.

S100B protein is one of the most accurate biomarkers for diagnosis of neuroapoptosis and brain damage. The aim was to evaluate the lactate concentration and acid-base balance (pH, pCO, pO, HCOc and BEb) in umbilical cord blood to predict high risk of neuroapoptosis and analyze the relationship between the levels of these biomarkers and umbilical cord blood S100B protein concentration at birth.

Partial T-cell depleted peripheral blood stem cell transplantation from HLA-identical sibling donors for patients with severe aplastic anemia.

We analyzed the outcome of 26 consecutive patients with acquired severe aplastic anemia (SAA) receiving peripheral blood stem cell transplantation (PBSCT) with partial ex-vivo T-cell depletion with a targeted T-cell dose from HLA-identical sibling donors. Median age was 37 years (range, 3-63). Four patients with uncontrolled pneumonia at transplant died on days +1, +2, +21, and +26. All evaluable patients engrafted with a median time to neutrophil and platelet recovery of 11 days (range, 10 - 14) and 19 day...

Sources, Identification, and Clinical Implications of Heterogeneity in Human Umbilical Cord Stem Cells.

Heterogeneity among different subpopulations of human umbilical cord mesenchymal stem cell (hUCMSCs) lines is an ubiquitous phenomenon, with such variability being related to several factors including the identity of the individual donor, tissue source (Wharton's jelly vs. umbilical cord blood), culture conditions, as well as random variations in the cloning expansion process. In this chapter, we provide a general overview on the sources as well as available experimental techniques for proper identification...

Gestational age-related reference values for Apgar score and umbilical cord arterial and venous pH in preterm and term newborns.

Despite much literature on reference values of acid-base status in umbilical cord blood at birth, there are yet no studies performed to determine gestational age-dependent references in cord venous blood and no studies on preterm acid-base standards. Similarly, the normal reference range of Apgar score for term and preterm infants has not yet been determined.

Candida colonization is associated with severe acute GVHD in adult patients undergoing single-unit cord blood transplantation.

Candidiasis is one of the most common invasive fungal diseases (IFD) among recipients of allogeneic hematopoietic cell transplantation (HCT). Recent advancements in antifungal prophylaxis have led to more frequent non-albicans candidiasis after HCT [1-3]. Prolonged neutropenia and delayed immune reconstitution results in the higher incidence of IFD in cord blood transplantation (CBT) compared with other graft sources [4]. Although Candida colonization is one of the risk factors for development of invasive c...

Comparative analysis of graft-versus-host disease prophylaxis with tacrolimus in combination with methylprednisolone or methotrexate after umbilical cord blood transplantation.

Post-transplant early immune disorders and engraftment failure/delay are major issues in unrelated umbilical cord blood transplantation (UCBT). We evaluated graft-versus-host disease (GVHD) prophylaxis approaches after UCBT by comparing UCBT outcomes with GVHD prophylaxis using tacrolimus plus methylprednisolone (Tac/mPSL, n = 32) to that with Tac plus methotrexate (Tac/MTX, n = 31) at a single pediatric transplantation center. The 30-day cumulative incidence rates of neutrophil engraftment and medi...

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