PubMed Journals Articles About "THOREN CAGING SYSTEMS, INC" RSS

02:51 EST 16th December 2018 | BioPortfolio

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Showing "THOREN CAGING SYSTEMS" PubMed Articles 1–25 of 8,400+

7-Hydroxy- N-Methylquinolinium Chromophore: A Photolabile Protecting Group for Blue-Light Uncaging.

The development of the N-methyl-7-hydroxymethylquinolinium ( N-Me-7-HQm) caging chromophore as a novel visible-light-sensitive photolabile protecting group is described. N-Me-7-HQm-caged compounds can be photoactivated by blue-light-emitting diode (LED) light (458 nm) with high photolytic efficiency, supporting applications to caging chemistry, and they also have sufficient water solubility and high resistance to spontaneous hydrolysis.

Recommended housing densities for research mice: filling the gap in data-driven alternatives.

Space recommendations for mice made in the Guide for Care and Use of Laboratory Animals have not changed since 1972, despite important improvements in husbandry and caging practices. The 1996 version of the Guide put forth a challenge to investigators to produce new data evaluating the effects of space allocation on the well-being of mice. In this review, we summarize many studies published in response to this challenge. We distinguish between studies using ventilated or nonventilated caging systems and tho...

Improved Synthesis of Caged Glutamate and Caging Each Functional Group.

Glutamate is an excitatory neurotransmitter that controls numerous pathways in the brain. Neuroscientists make use of photoremovable protecting groups, also known as cages, to release glutamate with precise spatial and temporal control. Various cage designs have been developed and amongst the most effective has been the nitroindolinyl caging of glutamate. We, hereby, report an improved synthesis of one of the current leading molecules of caged glutamate, 4-carboxymethoxy-5,7-dinitroindolinyl glutamate (CDNI...

Optimal destabilization of DNA double strands by single-nucleobase caging.

Photolabile protecting groups are widely used to trigger oligonucleotide activity. The ON/OFF-amplitude is a critical parameter. We have developed an experimental setup to identify protecting group derivatives with superior caging properties. Bulky rests are attached to the cage moiety via Cu-catalyzed azide-alkyne cycloaddition post-synthetically on DNA. Interestingly, we found that the decrease in melting temperature upon introducing o-nitrobenzyl-caged (NPBY-) and diethylaminocoumarin-cages (DEACM-) in D...

On String Languages Generated by Spiking Neural P Systems with Structural Plasticity.

Spiking neural P systems (in short, SNP systems) are parallel and non-deterministic models of computation, inspired by the neural system of the brain. A variant of SNP systems known as SNP systems with structural plasticity (in short, SNPSP systems) includes the feature of adding or removing synapses among neurons. This feature is inspired by plasticity from neuroscience during cognition, learning etc. Despite the reductionist framework of SNP and SNPSP systems, such brain-like systems are capable of comput...

Bioinspired Infrared Sensing Materials and Systems.

Bioinspired engineering offers a promising alternative approach in accelerating the development of many man-made systems. Next-generation infrared (IR) sensing systems can also benefit from such nature-inspired approach. The inherent compact and uncooled operation of biological IR sensing systems provides ample inspiration for the engineering of portable and high-performance artificial IR sensing systems. This review overviews the current understanding of the biological IR sensing systems, most of which are...

Systems vaccinology and big data in the vaccine development chain.

Systems vaccinology has proven a fascinating development in the last decade. Where traditionally vaccine development has been dominated by trial and error, systems vaccinology is a tool that provides novel and comprehensive understanding if properly used. Datasets retrieved from systems-based studies endorses rational design and effective development of safe and efficacious vaccines. In this review we first describe different omics-techniques that form the pillars of systems vaccinology. In the second part,...

Understanding Classification Systems in Spine Deformity.

Classification systems provide organization for pathologic conditions and guide treatment for similar disease states. Spine deformity is a growing field with newer classification systems being developed as our surgical techniques and clinical understanding advances. The evolution of these classification systems reflects our current knowledge and are used to better understand the evolving field of spine surgery. Currently, classification systems in spine surgery range from describing deformity in different a...

Anglicization of hospital information systems: Managing diversity alongside particularity.

Despite widespread efforts to improve the quality and safety of healthcare through use of hospital information systems (HIS), many healthcare organizations face challenges in implementation and effective use of these applications, in particular when systems have been developed internationally (mainly in the US). Suppliers of these technologies also find it challenging to produce systems that work effectively across a range of geographical, cultural and institutional boundaries. In this paper, we seek to und...

A Parallel Workflow Pattern Modelling Using Spiking Neural P Systems with Colored Spikes.

Spiking neural P systems, otherwise known as named SN P systems, are bio-inspired parallel and distributed neural-like computing models. Due to the spiking behavior, SN P systems fall into the category of spiking neural networks, and are considered to be an auspicious candidate of the third generation of neural networks. It has been reported that SN P systems with colored spikes are computationally capable, and perform well in describing behaviors of complex systems. Nonetheless, some practical issue is ope...

Enhancing Systems Thinking for Undergraduate Nursing Students Using Friday Night at the ER.

The complexity of health care systems requires cooperation between system stakeholders, structures, and functions. Nurses need an understanding of systems thinking to work effectively in this complex environment.

Commentary: Lectins and Nanostructured Drug Delivery Systems.

The advances and the impact of nanostructured systems on therapeutics constitute a constantly evolving reality. New strategies have been developed for drug delivery control and for directing these systems to the targeted site improving the therapy. In this commentary, the lectins are briefly reviewed; their fundamentals and the proposed applications as ligands in nanostructured drug delivery systems are discussed.

Systems thinking and ethics in public health: a necessary and mutually beneficial partnership.

Systems thinking has emerged as a means of conceptualizing and addressing complex public health problems, thereby challenging more commonplace understanding of problems and corresponding solutions as straightforward explanations of cause and effect. Systems thinking tries to address the complexity of problems through qualitative and quantitative modeling based on a variety of systems theories, each with their own assumptions and, more importantly, implicit and unexamined values. To date, however, there has ...

Rapid Response Systems.

Rapid response systems are commonly employed by hospitals to identify and respond to deteriorating patients outside of the intensive care unit. Controversy exists about the benefits of rapid response systems.

Bioinspired and biomimetic systems for advanced drug and gene delivery.

Natural nanocarriers found in biological frameworks have motivated the scientists to fabricate new structures that help to build characteristic systems mimicking the natural processes. Furthermore, these bioinspired and biomimetic systems improve biocompatibility during drug and gene delivery applications. The success of such a drug delivery system depends on parameters like shape, surface, texture, movement, and preparation methods. To date, various bioinspired and biomimetic drug delivery systems are avai...

Opportunities and Challenges of Behavior Change Support Systems for Enhancing Habit Formation: A Qualitative Study.

The formation of healthy habits is considered to play a fundamental role in health behavior change. A variety of studies on Health Behavior Change Support Systems (HBCSS) have been conducted recently, in which individuals use such systems to influence their own attitudes or behaviors to achieve their personal goals. However, comparatively much less research has been devoted to studying how the users of these systems form habits with the help of HBCSS, or to understanding how to design these systems to suppo...

Engineering virus resistance via CRISPR-Cas systems.

In prokaryotes, CRISPR/Cas adaptive immunity systems target and destroy nucleic acids derived from invading bacteriophages and other foreign genetic elements. In eukaryotes, the native function of these systems has been exploited to combat viruses in mammals and plants. Rewired CRISPR/Cas9 and CRISPR/Cas13 systems have been used to confer resistance against DNA and RNA viruses, respectively. Here, we discuss recent approaches employing CRISPR/Cas systems to combat viruses in eukaryotes, highlight key challe...

Using systems evaluation theory to improve points of dispensing planning, training, and evaluation.

Recurring throughput problems served as a catalyst to search for a better approach to planning, training, and evaluating points of dispensing (POD) exercises. The paper begins with a discussion of the potential of systems thinking and systems theory to improve exercise planning, training, and evaluation. The paper then illustrates how systems concepts guided a POD design team in improving their planning, training, and evaluation strategy. The paper concludes by suggesting the application of systems thinking...

The Effect of Dyes with Different π-Linkers on Overall Performance of P-DSSCs: Lessons from Theory.

A series of Keggin-type polyoxometalates (POMs)-based organic-inorganic complexes (systems 2-8) were designed with different π-linkers based on the molybdate-pyrene hybrid (system 1). UV-vis spectra and charge transfer (CT) parameters of designed systems were systematically analyzed by density functional theory (DFT) and time-dependent DFT (TD-DFT). The results indicate that the absorption spectra are red-shifted and the absorption intensities are enhanced with increasing the number of phenylacetylene π-o...

Interplay between spontaneous decay rates and Lamb shifts in open photonic systems.

In this Letter, we describe the modified decay rate and photonic Lamb (frequency) shift of quantum emitters in terms of the resonant states of a neighboring photonic resonator. This description illustrates a fundamental distinction in the behaviors of closed (conservative) and open (dissipative) systems: the Lamb shift is bounded by the emission linewidth in closed systems while it overcomes this limit in open systems.

Recent Advancement of Clinical Information Systems: Opportunities and Challenges.

 Clinical information systems (CISs) have generated opportunities for meaningful improvements both in patient care and workflow but there is still a long way to perfection. Healthcare providers are still facing challenges of data exchange, management, and integration due to lack of functionality among these systems. Our objective here is to systematically review, synthesize, and summarize the literature that describes the current stage of clinical information systems, so as to assess the current state of ...

Molecular networks in dynamic multilevel systems.

Dynamic multilevel systems can be assembled from molecular building blocks through two or more reversible reactions that form covalent bonds. Molecular networks of dynamic multilevel systems can exhibit different connectivities between nodes. The design and creation of molecular networks in multilevel systems require to control the crossed reactivity of the functional groups (how to connect nodes) and the conditions of the reactions (when to connect nodes). In the recent years, the combination of orthogonal...

Correction to "Statistically Reconstructed Multiplexing for Very Dense, High-Channel-Count Acquisition Systems".

3 D laparoscopy versus 2 D laparoscopy : An up to date evaluation.

The 3D laparoscopy is currently under intensive discussion. At the moment the majority of newly acquired laparoscopy systems include the 3D technique. New 4K systems, which will be offered in combination with 3D, are complicating the decision-making when buying new laparoscopic systems. The aim of the article is to show the advantages and possible limitations of 3D laparoscopy. Furthermore, the position of 3D laparoscopy in the current video market is evaluated.

Verbal autopsy in health policy and systems: a literature review.

Estimates suggest that one in two deaths go unrecorded globally every year in terms of medical causes, with the majority occurring in low and middle-income countries (LMICs). This can be related to low investment in civil registration and vital statistics (CRVS) systems. Verbal autopsy (VA) is a method that enables identification of cause of death where no other routine systems are in place and where many people die at home. Considering the utility of VA as a pragmatic, interim solution to the lack of funct...

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