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PubMed Journals Articles About "Thinking Zinc: A Study Of Zinc Supplements On The Navajo Nation" RSS

17:19 EDT 17th October 2019 | BioPortfolio

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Showing "Thinking Zinc Study Zinc Supplements Navajo Nation" PubMed Articles 1–25 of 60,000+

Computational study on new natural compound agonists of stimulator of interferon genes (STING).

This study aimed to screen lead compounds and medication candidates from drug library (ZINC database) which has potential agonist effect targeting STING protein.


Use of Ages & Stages Questionnaire ™ (ASQ) in a Navajo Population: Comparison With The U.S. Normative Dataset.

The Ages & Stages Questionnaires (ASQ-3) is a parent-completed screening to identify young children at-risk for developmental delays in the United States and internationally. Federal programs operating on Navajo Nation use the ASQ-3 to determine the need for early intervention services, even though the ASQ-3 national sample used to establish cut-off scores for referral included only 1% Native American children.

Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study.

The shortcomings of conventional tuberculosis treatments resulting from the development of drug resistance in Mycobacterium tuberculosis drive a need for the formulation of novel therapeutic agents. The diarylquinoline class of drugs such as bedaquiline was recently approved for the treatment of multidrug-resistant strains of tuberculosis, primarily targeting c and ε subunits of the ATP synthases. Yet resistance to bedaquiline has already been reported. Therefore, Rv1311 was used as the target for the iden...


Skin, Hair and Nail Supplements: An Evidence-Based Approach

Dermatology supplements, often marketed as “skin, hair, and nail” supplements, are becoming increasingly popular. However, many consumers lack an understanding of the science of dietary supplements or the specifics of the supplement industry. While certain supplements at the right dose in the right population may prove beneficial, the evidence is sparse for many supplements. In addition, the use of some supplements has resulted in serious adverse effects. From a regulatory standpoint, the US FDA recogni...

Fora fuelling the discovery of fortified dietary supplements - An exploratory study directed at monitoring the internet for contaminated food supplements based on the reported effects of their users.

Dietary supplements are products that are widely used for instance as energisers or to lose weight. There have been cases reported where undeclared ingredients present in such supplements have caused adverse effects on the health of the user. As there are many different products to choose from, it seems impossible to predict which might contain harmful components and to ban them from the market. Nonetheless, the use of dietary supplements and the experiences of users are shared in online discussions. We des...

Operationalizing the Concept of Critical Thinking for Student Learning Outcome Development.

Creating a curriculum that can effectively develop critical thinking skills is an elusive outcome for undergraduate nursing programs. Despite the best efforts of faculty, employers continue to note an inability of new graduates to apply critical thinking concepts that improve patient outcomes. The lack of an operational definition of critical thinking appears to be a key contributor to this issue.

Impact of Laboratory Methods, Colonization Density and Age on Detection of Streptococcus Pneumoniae in the Nasopharynx.

Culture-based methods for detecting Streptococcus pneumoniae in the nasopharynx lack sensitivity. This study aimed to compare the performance of culture and molecular methods in detecting pneumococcus in the nasopharynx of healthy individuals and to evaluate the effects of age and colonization density on detection. Nasopharyngeal specimens were collected from healthy individuals from 2010-2012 on the Navajo Nation and White Mountain Apache Tribal lands in the United States. Pneumococci were detected by brot...

Practicing prospection promotes patience: Repeated episodic future thinking cumulatively reduces delay discounting.

Delay discounting, or the preference for smaller, sooner over larger, later rewards, has been associated with alcohol use disorder and problem drinking. Episodic future thinking has been suggested as an intervention to address steep delay discounting. In the present study, we examined the effect of up to six consecutive sessions of episodic future thinking.

Improvements in episodic future thinking methodology: Establishing a standardized episodic thinking control.

Delay discounting (DD) is the choice of a smaller immediate reward over a larger delayed reward, which has been associated with a number of maladaptive behaviors. Episodic future thinking (EFT), the ability to project oneself into the future, is an intervention designed to reduce DD. EFT has reliable effects on DD, but the size of the effect varies, which could be due in part to the use of different control groups. Episodic recent thinking (ERT) serves as a common control for many EFT studies, but the tempo...

Synthesis of urea analogues bearing N-alkyl-N'-(thiophen-2-yl) scaffold and evaluation of their innate immune response to toll-like receptors.

Previous high throughput virtual screening of 10 million-compound and following cell based validation led to the discovery of a novel, nonlipopeptide-like chemotype ZINC 6662436, as toll-like receptor 2 (TLR2) agonists. In this report, compounds belonging to four areas of structural modification of ZINC6662436 were evaluated for biological activity using human HEK-Blue TLR2 reporter cells, and human THP-1 monocytic cells, yield SMU-C13 as an optimized, direct and high potent (EC = 160 nM) agonist of h...

The value of Facebook in nation-wide hospital quality assessment: a national mixed-methods study in Norway.

The objective was to assess the possibility of using a combination of official and unofficial Facebook ratings and comments as a basis for nation-wide hospital quality assessments in Norway.

Knowledge about dietary supplements and trust in advertising them: Development and validation of the questionnaires and preliminary results of the association between the constructs.

Despite offering little overall benefit and emerging concerns about their safety, dietary supplements have become increasingly popular. Trust in advertising them may contribute to high confidence in dietary supplements in public opinion.

Thinking About Thinking: Why Cognition Should Be the Sixth Vital Sign.

Psychometric Properties of the Swedish Version of the Brief Repetitive Thinking Questionnaire (RTQ-10): An Internet-Based Study on Degrees of Affective Symptoms and Levels of Distress.

Repetitive negative thinking (RNT) is reported in a wide variety of emotional disorders, although it is most often associated with either depression or anxiety disorders, assessed as symptoms of rumination and worry. Early detection of indicators for RNT across disorders is needed. To this end we explored the psychometric properties of a transdiagnostic measure, i.e., the Swedish version of the brief Repetitive Thinking Questionnaire (RTQ-10), in adults (n = 674, age: 18 years or older).

Is positive emotion an amplifier or a buffer? It depends: Dialectical thinking moderates the impact of positive emotion on intergroup conflicts.

Positive emotions have been shown to shape individuals' reactions to intergroup conflicts, but the exact mechanism remains unknown. The current research hypothesizes that the impact of positive emotions would be moderated by dialectical thinking: beliefs about accepting contradiction and change. Experiencing positive emotions in an intergroup conflict may be perceived as unacceptable and evokes discomfort among nondialectical individuals, amplifying the negative reactions toward outgroup members. In contras...

The Limits of Power: Wind Energy, Orkney, and the Post-war British State.

This article identifies the environmental components of the limits of industrial nationalization between 1945 and 1956, and with it the spatial dimensions of state power, through a case study of wind power experiments on the Orkney islands. Technocratic and socialist principles drove efforts to supply electricity to all corners of the nation, but material and environmental factors limited success, especially in remote regions. The article considers the materiality of islandness and its effects on the applic...

Patient access to oral nutritional supplements: Which policies count?

Oral nutritional supplements (ONS) represent a cost-effective method for treating malnutrition. The aim of this study was to investigate the effects of public policies on patient access to ONS, using the Italian regionalized health care system as a case study, subsequently compared with the centralized British National Health Service.

Development and validation of a novel high performance liquid chromatography-coupled with Corona charged aerosol detector method for quantification of glucosamine in dietary supplements.

Glucosamine dietary supplements are commonly used for the management of osteoarthritis (OA). However, clinical trials have reported varying outcomes with regard to joint function and disease progression. One of the possible reasons for variability in observed effects of glucosamine could be that, unlike prescription drugs, the quality of manufactured dietary supplements is not closely monitored in many countries. Therefore, there is the possibility that the actual amount of glucosamine present in a dietary ...

Acute liver failure due to food supplements.

Acute liver failure resulting from the use of food supplements is rare. However, due to the rapid rise in the use of food supplements, the incidence of liver damage is increasing.

The Dry Eye Assessment and Management (DREAM) extension study - A randomized clinical trial of withdrawal of supplementation with omega-3 fatty acid in patients with dry eye disease.

To determine effects of continued or discontinued use of omega-3 (ω3) fatty acid supplements through a randomized withdrawal trial among patients assigned to ω3 supplements in the first year of the DREAM study.

A 'Natural' thyroid storm!

Over the counter supplements are often taken for granted during medication reconciliation in the emergency department. Supplements are not regulated by FDA, and some can be potentially dangerous.

Desire thinking as a predictor of drinking status following treatment for alcohol use disorder: A prospective study.

Research has indicated that craving is one of the strongest predictors of treatment outcome and relapse in Alcohol Use Disorders (AUD) but there is little consensus on the factors that may influence its activation and escalation. Research has also shown that desire thinking is an important cognitive process which may exacerbate craving in problem drinkers. The aim of present study was to explore, for the first time, the role of desire thinking in prospectively predicting relapse, craving and binge drinking ...

From Target to Drug: Generative Modeling for Multimodal Structure-Based Ligand Design.

Chemical space is impractically large and conventional structure-based virtual screening techniques cannot be used to simply search through the entire space to discover effective bioactive molecules. To address this shortcoming we propose a generative adversarial network to generate, rather than search, diverse three-dimensional ligand shapes complementary to the pocket. Furthermore, we show that the generated molecule shapes can be decoded using a shape-captioning network into a sequence of SMILES enabling...

Young Children Are Wishful Thinkers: The Development of Wishful Thinking in 3- to 10-Year-Old Children.

Previously, research on wishful thinking has found that desires bias older children's and adults' predictions during probabilistic reasoning tasks. In this article, we explore wishful thinking in children aged 3- to 10-years-old. Do young children learn to be wishful thinkers? Or do they begin with a wishful thinking bias that is gradually overturned during development? Across five experiments, we compare low- and middle-income United States and Peruvian 3- to 10-year-old children (N = 682). Children were...

Clear skies ahead: optimizing the learning environment for critical thinking from a qualitative analysis of interviews with expert teachers.

The learning environment refers to the physical, pedagogical, and psychosocial contexts in which learning occurs and critically influences the educational experience of trainees in the health professions. However, the manner in which individual faculty explicitly organize the educational setting to facilitate learning of essential competencies such as critical thinking deserves more examination; lack of attention to this component can undermine the formal curriculum. The purpose of our study was to examine ...


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