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PubMed Journals Articles About "Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan" RSS

19:26 EDT 24th March 2019 | BioPortfolio

Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan PubMed articles on BioPortfolio. Our PubMed references draw on over 21 million records from the medical literature. Here you can see the latest Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan articles that have been published worldwide.

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Showing "Treating Multiple Aging Pathways Simultaneously Extends Healthy Lifespan" PubMed Articles 1–25 of 25,000+

The Insulin/IGF signaling cascade modulates SUMOylation to regulate aging and proteostasis in .

Although aging-regulating pathways were discovered a few decades ago, it is not entirely clear how their activities are orchestrated, to govern lifespan and proteostasis at the organismal level. Here we utilized the nematode to examine whether the alteration of aging, by reducing the activity of the Insulin/IGF signaling (IIS) cascade, affects protein SUMOylation. We found that IIS activity promotes the SUMOylation of the germline protein, CAR-1, thereby shortening lifespan and impairing proteostasis. In c...


Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism.

Dietary intervention constitutes a feasible approach for modulating metabolism and improving the health span and lifespan. Methionine restriction (MR) delays the appearance of age-related diseases and increases longevity in normal mice. However, the effect of MR on premature aging remains to be elucidated. Here, we describe that MR extends lifespan in two different mouse models of Hutchinson-Gilford progeria syndrome (HGPS) by reversing the transcriptome alterations in inflammation and DNA-damage response g...

Neurogenesis and brain aging.

Human aging affects the entire organism, but aging of the brain must undoubtedly be different from that of all other organs, as neurons are highly differentiated postmitotic cells, for the majority of which the lifespan in the postnatal period is equal to the lifespan of the entire organism. In this work, we examine the distinctive features of brain aging and neurogenesis during normal aging, pathological aging (Alzheimer's disease), and accelerated aging (Hutchinson-Gilford progeria syndrome and Werner syn...


Murine models of accelerated aging and musculoskeletal disease.

The primary risk factor for most musculoskeletal diseases, including osteoarthritis, osteoporosis and sarcopenia, is aging. To treat the diverse types of musculoskeletal diseases and pathologies, targeting their root cause, the aging process itself, has the potential to slow or prevent multiple age-related musculoskeletal conditions simultaneously. However, the development of approaches to delay onset of age related diseases, including musculoskeletal pathologies, has been slowed by the relatively long life...

Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA.

Downregulation of Rpd3 (histone deacetylase) or Loco (regulator of G-protein signaling protein) extends lifespan with higher stress resistance. We found -downregulated long-lived flies genetically interact with -upregulated short-lived flies in stress resistance and lifespan. Gene expression profiles between those flies revealed that they regulate common target genes in metabolic enzymes and signaling pathways, showing an opposite expression pattern in their contrasting lifespans. Functional analyses of mo...

Congeneric variability in lifespan extension and onset of senescence suggest active regulation of aging in response to low temperature.

Lifespan extension under low temperature is well conserved across both endothermic and exothermic taxa, but the mechanism underlying this change in aging is poorly understood. Low temperature is thought to decrease metabolic rate, thus slowing the accumulation of cellular damage from reactive oxygen species, although recent evidence suggests involvement of specific cold-sensing biochemical pathways. We tested the effect of low temperature on aging in 11 strains of Brachionus rotifers, with the hypothesis th...

Intestinal Snakeskin Limits Microbial Dysbiosis during Aging and Promotes Longevity.

Intestinal barrier dysfunction is an evolutionarily conserved hallmark of aging, which has been linked to microbial dysbiosis, altered expression of occluding junction proteins, and impending mortality. However, the interplay between intestinal junction proteins, age-onset dysbiosis, and lifespan determination remains unclear. Here, we show that altered expression of Snakeskin (Ssk), a septate junction-specific protein, can modulate intestinal homeostasis, microbial dynamics, immune activity, and lifespan i...

The Genetics of Aging: A Vertebrate Perspective.

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging were discovered in invertebrates. However, the genetics of aging is more complex in vertebrates because of their specialized systems. This Review discusses advances in the genetic regulation of aging in vertebrates from work in mice, humans, and organisms with exceptional lifespans. We highlight challenges for the future, including sex-dependent differences in lifespan and the interplay between genes and environment. We ...

Midlife predictors of active and healthy aging (AHA) among older businessmen.

Active and healthy aging (AHA) is an important phenomenon in aging societies.

Coupling lifespan and aging? The age at onset of body mass decline associates positively with sex-specific lifespan but negatively with environment-specific lifespan.

Whether lifespan scales to age-associated changes in health and disease is an urgent question in societies with increasing lifespan. Body mass is associated with organismal functioning in many species, and often changes with age. We here tested in zebra finches whether two factors that decreased lifespan, sex and poor environmental quality, accelerated the onset of body mass declines. We subjected 597 birds for nine years to experimentally manipulated foraging costs (harsh = H, benign = B) during de...

The Effect of Gaussian Noise on Maximum Likelihood Fitting of Gompertz and Weibull Mortality Models with Yeast Lifespan Data.

Background/study context: Empirical lifespan data sets are often studied with the best-fitted mathematical model for aging. Here, we studied how experimental noises can influence the determination of the best-fitted aging model. We investigated the influence of Gaussian white noise in lifespan data sets on the fitting outcomes of two-parameter Gompertz and Weibull mortality models, commonly adopted in aging research.

The anti-oxidation and anti-aging effects of Ganoderma lucidum in Caenorhabditis elegans.

As a traditional herbal medicine, the clinical efficacy of Ganoderma lucidum (G. lucidum, also known as Lingzhi in China) has been proved by clinical research and a large number of animal experiments. However, its pharmacological mechanism is not clear. Here, we used the Caenorhabditis elegans as an animal model to study the anti-oxidative stress and anti-aging effects of G. lucidum water extract. Our results showed that G. lucidum effectively promoted the nematodes to resist the oxidative stress of paraqua...

Protein synthesis and quality control in aging.

Aging is characterized by the accumulation of damage and other deleterious changes, leading to the loss of functionality and fitness. Age-related changes occur at most levels of organization of a living organism (molecular, organellar, cellular, tissue and organ). However, protein synthesis is a major biological process, and thus understanding how it changes with age is of paramount importance. Here, we discuss the relationships between lifespan, aging, protein synthesis and translational control, and expan...

Sesamin suppresses aging phenotypes in adult muscular and nervous systems and intestines in a Drosophila senescence-accelerated model.

Sesamin is a major lignan constituent of sesame and possesses various health-promoting effects. Previous studies have demonstrated that sesamin extends the lifespan of Drosophila and Caenorhabditis elegans and corrects oxidative damage-related tissue dysfunction in mammals. To understand its anti-aging effects, we aimed to determine whether sesamin restores tissue function hampered by oxidative damage and suppresses several aging-related phenotypes using Drosophila senescence-accelerated models.

Aerobic exercise promotes the expression of ERCC1 to prolong lifespan: A new possible mechanism.

Aerobic exercise can delay aging and extend lifespan, but its specific mechanism still remains unclear. One popular theory is that with age and the cell division times increasing, DNA damage will inevitably accumulate, leading to dysfunction and failure of various tissues and organs, which will eventually lead to aging. Thus, repairing damaged DNA is a key strategy to extend lifespan. Excision repair cross-complementary gene 1 (ERCC1) is a DNA repair enzyme that recognizes, excises and repairs damaged DNA. ...

Prospects of Pharmacological Interventions to Organismal Aging.

Intense research in the areas of cellular and organismal aging using diverse laboratory model systems has enriched our knowledge in the processes and the signalling pathways involved in normal and pathological conditions. The field finds itself in a position to take decisive steps towards clinical applications and interventions not only for targeted age-related diseases such as cardiovascular conditions and neurodegeneration but also for the modulation of health span and lifespan of a whole organism. Beyond...

Emerging Topics in C. elegans aging research: Transcriptional regulation, stress response and epigenetics.

Key discoveries in aging research have been made possible with the use of model organisms. Caenorhabditis elegans is a short-lived nematode that has become a well-established system to study aging. The practicality and powerful genetic manipulations associated with this metazoan have revolutionized our ability to understand how organisms age. 25 years after the publication of the discovery of the daf-2 gene as a genetic modifier of lifespan, C. elegans remains as relevant as ever in the quest to understand ...

Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 species with different lifespans.

N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 species with contrast longevity differences ( is longest-lived, is shortest-lived and has moderate lifespan) to test the effects of NAC at 8 different concentrations (from 10 nM to 100 mM) on the lifespan, stress-resistance and locomotor activity. Except the adverse effects of highest (10 mM and 100 mM) concentrations NAC demonstrated sexually opposite and male-bias...

Healthy aging: A bibliometric analysis of the literature.

Due to dramatic growth of the aging population worldwide, there has been an urgent call for a public health strategy to manage healthy aging, with the ultimate goal being advancement of aging research. Considerable progress has been made in uncovering the mystery of aging process using multidisciplinary methods. There is a growing consensus in the field that aging traits which were originally thought to be disparate are likely to be interconnected. Thus, emerging research is needed to incorporate current fi...

Extending the human connectome project across ages: Imaging protocols for the Lifespan development and aging projects.

The Human Connectome Projects in Development (HCP-D) and Aging (HCP-A) are two large-scale brain imaging studies that will extend the recently completed HCP Young-Adult (HCP-YA) project to nearly the full lifespan, collecting structural, resting-state fMRI, task-fMRI, diffusion, and perfusion MRI in participants from 5 to 100 + years of age. HCP-D is enrolling 1300 + healthy children, adolescents, and young adults (ages 5-21), and HCP-A is enrolling 1200 + healthy adults (ages 36-100+), with each stud...

Metabolic Stress, Autophagy, and Cardiovascular Aging: from Pathophysiology to Therapeutics.

Recent advances in health care have improved the management of cardiometabolic disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress related to obesity (insulin resistance, diabetes, hypertension, and dyslipidemia) has greatly challenged geriatric care. The ubiquitin-proteasome system and autophagy-lysosomal pathways represent two major, yet distinct cellular machineries, for degradation and removal of damaged or long-lived proteins and organelles; the function of which ...

A novel healthy metabolic phenotype developed among a cohort of families enriched for longevity.

Long-lived individuals and their offspring have healthier metabolic characteristics than expected, such as more favorable levels of fasting glucose, insulin, and lipids than controls without longevity. Dysregulation in metabolic pathways have also shown to predict accelerated aging. Using information from the Long Life Family Study (LLFS), a multi-center study of two-generation families selected for exceptional longevity, we developed an indicator of healthy metabolism to determine whether metabolic health ...

Redox parameters as markers of the rate of aging and predictors of lifespan.

Oxidative stress has been reported to increase with aging and although several age-related changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (catalase, glutathione peroxidase and reductase activities and reduced glutathione) and oxidant (oxidized glutathione, basal superoxide anion and malondialdehyde concentrations) parameters were studied in whole blood cells from humans divided into different age groups (a...

Healthy Lifestyle-Based Approaches for Successful Vascular Aging.

This review summarizes a presentation given at the 2016 Gerontological Society of America Annual Meeting as part of a Vascular Aging Workshop. The development of age-related vascular dysfunction increases the risk of cardiovascular disease as well as other chronic age-associated disorders, including chronic kidney disease and Alzheimer's disease. Healthy lifestyle behaviors, most notably regular aerobic exercise and certain dietary patterns, are considered "first-line" strategies for the prevention and/or t...

PMT1 deficiency extends the shortened replicative lifespan of TED1-deficient yeast in a Hac1p-dependent manner.

Protein O-mannosyltransferase-1 (Pmt1p) deficiency extends the replicative lifespan (RLS) of Saccharomyces cerevisiae, which is related to the activation of the unfolded protein response (UPR), an important pathway for alleviating endoplasmic reticulum (ER) stress. Trafficking of Emp24p/Erv25p-dependent cargo disrupted 1 (Ted1p) has been reported as a binding partner of yeast Pmt1p. We explored the potential relationship between Pmt1p and Ted1p in the cell lifespan and ER stress responses. The TED1-deleted ...


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