PubMed Journals Articles About "Tumors Wounds That Heal Historical Perspective With Focus" RSS

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Showing "Tumors Wounds That Heal Historical Perspective with Focus" PubMed Articles 1–25 of 10,000+

Tumors: Wounds That Do Not Heal-A Historical Perspective with a Focus on the Fundamental Roles of Increased Vascular Permeability and Clotting.

Similarities between solid tumor stroma generation, wound healing, chronic inflammation, and associated inflammatory diseases have prompted interest from the time of Virchow. However, it was not until the 1970s that these entities were shown to share important molecular mechanisms. Foundational to all of them is the initiating role of vascular endothelial growth factor (VEGF-A) in increasing vascular permeability to plasma and plasma proteins. Extravasated plasma activates the tissue factor clotting pathway...

Cost-effectiveness of soluble beta-glucan gel in hard-to-heal wounds: an evaluation.

To evaluate the cost-effectiveness of a soluble beta-glucan-containing gel as short-term adjunct therapy in the treatment of hard-to-heal wounds in a UK community health-care setting.

Depression risk among patients with chronic wounds.

A wound is defined as chronic when it requires more than 6 weeks to heal. The link between chronic wounds and depression was first pointed out by House and Hughes in 1996 and later evaluated by other numerous studies. Several studies demonstrate that among chronic skin wounds causing chronical physical disease, the leg ulcers are the most frequently associated with depression. The aim of our study is to evaluate the prevalence of depression in patients with different types of chronic wounds.

Home care nurses' experience of providing health-care to patients with hard-to-heal wounds.

To investigate and describe the experience of nurses working in home care, with responsibility for providing health-care to patients with hard-to-heal wounds.

Use of a transforming powder dressing in the lower leg wounds of two older patients: case studies.

This report describes the use of a transforming powder dressing to treat lower leg surgical wounds occurring in two older patients. Wounds in this location are difficult and slow to heal. Both of these wounds exhibited complete granulation within two weeks of powder application and total healing in under four weeks, all while requiring no patient or nursing wound care.

Hard-to-heal wounds: TIMERS for action.

Implementing TIMERS: the race against hard-to-heal wounds.

Stratification of chronic and complex wounds according to healing characteristics: a retrospective study.

Wound risk-stratified analyses are clinically relevant as they can assist in identifying hard-to-heal wounds. The aim of the study is to develop risk categories for wound healing based on a limited number of reliably recordable clinical data.

Poor survival of dialysis patients with unhealed wounds because of critical limb ischemia: Limb salvage and survival requires wound healing.

Maintenance of blood flow in the wound area is required to heal wounds of critical limb ischemia (CLI) in dialysis patients. However, many dialysis patients have both a stenotic lesion in below-knee blood vessels and a cardiovascular event as complications, and thus, it may be difficult to ensure sufficient blood flow. Therefore, many deaths occur because of problems with wound healing. The aim of this study is to identify the optimal treatment, including revascularisation and amputation, from the perspecti...

Transformational Change as a Function of Scale and Diversity: A Historical Perspective on Academic Leadership as Dynamic Process.

This article proposes that while it is widely understood that large-scale institutions require leadership, there is little consensus as to its definition or how to judge its degree of success or failure. A distinction is drawn between leadership and management. Historical background is provided to indicate change in the scale of academic and professional institutions. Attention is drawn to the impact of demographic changes and the expansion of academic opportunities to formerly underrepresented groups. The ...

The Natural History of Wilms Tumor - A Case Comparison of Two Different Tumors.

Due to the rarity of Wilms tumor and the relative urgency that pediatric renal tumors are treated, there is little reported data on the natural history and growth of Wilms tumors. Historical reports of estimated doubling times of Wilms tumors were based on time to disease recurrence after initial diagnosis and treatment, and were published before the current advancements in molecular biomarker testing. We compare two cases of Wilms tumor with sequential imaging, and postulate how the growth parameters of th...

Clinical experience using a dehydrated amnion/chorion membrane construct for the management of wounds.

Over time, acute and chronic, nonhealing wounds impose heavy financial and quality-of-life burdens on patients. The introduction of new therapies for wounds is essential in benefiting the patient, and in this report, the clinical experience of various wound care providers treating wounds with dehydrated amnion/chorion membrane (dACM) is presented.

The Nucleus Basalis of Meynert and Its Role in Deep Brain Stimulation for Cognitive Disorders: A Historical Perspective.

The nucleus basalis of Meynert (nbM) was first described at the end of the 19th century and named after its discoverer, Theodor Meynert. The nbM contains a large population of cholinergic neurons that project their axons to the entire cortical mantle, the olfactory tubercle, and the amygdala. It has been functionally associated with the control of attention and maintenance of arousal, both key functions for appropriate learning and memory formation. This structure is well-conserved across vertebrates, altho...

Swift Downregulation of Gelatinases (MMP-2, MMP-9) in Neuropathic Diabetic Foot Ulcers Treated With Total Contact Cast.

The aim of this study is to evaluate how treatment with total contact cast (TCC) affects the balance of proteases in diabetic foot ulcers (DFUs) as they heal.

Cost-effectiveness analysis of an innovative model of care for chronic wounds patients.

Current provision of services for the care of chronic wounds in Australia is disjointed and costly. There is large variability in the way that services are provided, and little evidence regarding the cost-effectiveness of a specialist model of care for treatment and management. A decision-analytic model to evaluate the cost-effectiveness of a specialist wound care clinic as compared to usual care for chronic wounds is presented. We use retrospective and prospective data from a cohort of patients as well as ...

Current concepts in curative surgery for diabetic forefoot ulcers.

Forefoot ulcerations in patients with diabetes are quite common. Underlying mechanical deformities of the foot in combination with neuropathy are the most important risk factors for ulcer development and adequate offloading is the mainstay of management. Most ulcers heal with local wound care, adequate blood supply, and pressure relief. If a foot deformity cannot be accommodated, ulcers will not heal or may recur. In this case, surgical correction of deformity is necessary. This paper reviews the most commo...

Revisiting Bruner's Legacy from the Perspective of Historical Materialism.

The book Jerome S. Bruner beyond 100: cultivating possibilities (2015) is a celebration and a continuing development of Jerome S. Bruner's contribution in psychology. As a review of this book, this article aims to commemorate Bruner's legacy by developing it further. The main content of the book is summarized into four issues: culture and language, narrative and folk psychology, dilemmas and shared dilemmas, subjectivity and intersubjectivity. Hegel's contribution to 'social reality' and Karl Marx's histori...

Effects of Dressing Materials on Donor Site Morbidity: A Comparative Study at a Tertiary Hospital in Kenya.

Skin graft donor wounds should heal with rapid epithelialization resulting in good aesthetic and minimal donor site morbidity. Several dressing materials are now available for the dressing of the donor sites. Few studies have, however, been done to compare the efficacy of these dressing materials.This study compared the effectiveness of paraffin gauze, hydrocolloid, antimicrobial biguanide foam, and silver hydrofiber dressings on donor site wounds at a tertiary hospital in Kenya.Patients who underwent split...

Health-related Quality of Life and Wound Care Practices Among Patients With Chronic Wounds in a Southwestern Nigerian Community.

Chronic wounds (CWs) are a common problem around the world. Although known to affect quality of life, patients' perception may vary among cultures.

The bioinformatics of the yeast genome - a historical perspective.

From 1989 to 1997 the Yeast Genome was sequenced by a worldwide international consortium initiated and conducted by André Goffeau (1935-2018). The article describes the pioneering collaboration of yeast scientists from a bioinformatics perspective. Indeed, the yeast genome has turned bioinformatics from an exotic hobby of few nerds into a discipline indispensable for answering biological questions using computational methods.

Unique Origins of Modern Opioid Marketing and the Link to the Opioid Epidemic: A Historical Perspective.

The current status and future directions of CRS Focus Groups.

In 2018, the Controlled Release Society introduced a new, member-led organizational structure (called "CRS Focus Groups") that provided new opportunities for members at any stage of professional development to be elected to leadership positions, be recognized for their work, and to become a part of close-knit communities in a variety of sub-fields of Controlled Release. This article provides a perspective that spans the origins of this initiative and motivation for building the Focus Groups, to the progress...

Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine.

Molecules isolated from natural sources including bacteria, fungi, and plants are a long-standing source of therapeutics that continue to add to our medicinal arsenal today. Despite their potency and prominence in the clinic, complex natural products often exhibit a number of liabilities that hinder their development as therapeutics, which may be partially responsible for the current trend away from natural product discovery, research, and development. However, advances in synthetic biology and organic synt...

Regional Gene Therapy with 3D Printed Scaffolds to Heal Critical Sized Bone Defects in a Rat Model.

The objective of the present study was to assess the ability of transduced rat bone-marrow cells (RBMCs) that overexpress BMP-2 loaded on a three-dimensionally (3D) printed scaffold to heal a critical sized rat femoral defect.

Early-stage Management of Complex Wounds Using Negative Pressure Wound Therapy With Instillation and a Dressing With Through Holes.

An early-stage decision clinicians often make in the management of complex wounds is which method of wound preparation will be appropriate for the patient. This decision can be affected by numerous wound and patient risk factors that present challenges and may make surgical debridement difficult in patients with complex wounds. Recently, negative pressure wound therapy with instillation and dwell time (NPWTi-d) using a novel reticulated open-cell foam dressing with through holes (ROCF-CC) was shown to aid i...

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