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21:24 EST 17th November 2018 | BioPortfolio

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Showing "Updating Thoughts Celgene" PubMed Articles 1–25 of 334

Letter--Incorporating Real-World Evidence and Patient Value Criteria into Value-Based Frameworks for Relapsed/Refractory Multiple Myeloma.

Orlowski has received research funding from Amgen, BioTheryX, Bristol-Myers Squibb, Celgene Corporation, and Takeda Pharmaceuticals; honoraria from Amgen, Bristol-Myers Squibb, Celgene Corporation, Janssen, Millennium Pharmaceuticals, and Onyx Pharmaceuticals; and is a member of advisory boards for Amgen, Bristol-Myers Squibb, Celgene Corporation, Incyte, Kite, Legend Biotech, Sanofi-Aventis, and Takeda Pharmaceuticals.

Artificial Intelligence and the Future of the Drug Safety Professional.

The healthcare industry, and specifically the pharmacovigilance industry, recognizes the need to support the increasing amount of data received from individual case safety reports (ICSRs). To cope with this increase, more healthcare and qualified professionals are required to capture and evaluate the data. To address the evolving landscape, it will be necessary to embrace assistive technologies such as artificial intelligence (AI) at scale. AI in the field of pharmacovigilance will possibly result in the tr...

Absence of age effects on spontaneous past and future thinking in daily life.

Previous research on voluntary mental time travel (i.e., deliberately thinking about the past or future) has resulted in negative age effects. In contrast, studies on spontaneous past thoughts (i.e., involuntary autobiographical memories) have reported small or no age effects. The aim of the present research was to investigate the effects of age on the nature and frequency of spontaneous future thoughts in everyday life. In two studies, we examined whether older adults reported spontaneous future thoughts a...

God, I Can't Stop Thinking About Sex! The Rebound Effect in Unsuccessful Suppression of Sexual Thoughts Among Religious Adolescents.

The rebound effect of thought suppression refers to attempts to suppress thoughts that result in an increase of those thoughts. The aim of this three-study research was to investigate the suppression of thoughts and its possible importance in the cognitive model of predicted compulsive sexual behavior (CSB) among Israeli Jewish religious and secular adolescents. Study 1 (N = 661): Do religious and secular adolescents differ in CSB and related psychopathology? Study 2 (N = 522): Does CSB mediate the link...

Digital phenotyping of suicidal thoughts.

To examine whether there are subtypes of suicidal thinking using real-time digital monitoring, which allows for the measurement of such thoughts with greater temporal granularity than ever before possible.

Indirect effects of parental and peer attachment on bullying and victimization among adolescents: The role of negative automatic thoughts.

The association between parental and peer attachment and youths' bullying involvement is well documented. However, there is little research examining mechanisms linking the quality of relationships with parents and peers to bullying perpetration and victimization. The present study investigated the indirect effects of attachment to the mother, the father, and peers on bullying and victimization through children's negative automatic thoughts in a sample of 476 adolescents (10-17 years). Path analysis indicat...

Momentary experiential avoidance: Within-person correlates, antecedents, and consequences and between-person moderators.

We used ecological momentary assessment to investigate momentary correlates, antecedents, and consequences of experiential avoidance (EA), and to explore whether depression and anxiety moderate these within-person relationships. Participants recorded their mood, thoughts, stress, and EA four times daily for one week. Baseline depression and anxiety were associated with EA. EA was lower when participants reported more positive mood and thoughts, and higher when participants reported more negative mood, negat...

Oscillatory Correlates of Control over Working Memory Gating and Updating: An EEG Study Using the Reference-back Paradigm.

Optimal working memory (WM) functioning depends on a control mechanism that balances between maintenance and updating by closing or opening the gate to WM, respectively. Here, we examined the neural oscillation correlates of WM updating and of the control processes involved in gating. The reference-back paradigm was employed to manipulate gate opening, gate closing, and updating independently and examine how the control functions involved in these processes are mapped to oscillatory EEG activity. The result...

Action goal changes caused by agents and patients both induce global updating of event models.

Observers represent everyday actions in event models along multiple dimensions such as space, time, or goals. Whenever new information along those dimensions is perceived, the event model is updated accordingly. In 3 experiments, we investigated event model updating associated with goal changes during ongoing actions that involved both an agent performing the action and a patient receiving the action. We presented short action clips showing goal-directed actions-such as handing over a book-as self-paced sli...

Unity and diversity in working memory load: Evidence for the separability of the executive functions updating and inhibition using machine learning.

According to current theoretical models of working memory (WM), executive functions (EFs) like updating, inhibition and shifting play an important role in WM functioning. The models state that EFs highly correlate with each other but also have some individual variance which makes them separable processes. Since this theory has mostly been substantiated with behavioral data like reaction time and the ability to execute a task correctly, the aim of this paper is to find evidence for diversity (unique properti...

Do thoughts about dieting matter? Testing the relationship between thoughts about dieting, body shape concerns, and state self-esteem.

Dieters are likely primed to think about their diet throughout the day (e.g., as they feel hungry). However, prior research has not tested whether and how thinking about dieting might have negative effects, like poor self-esteem and body shape concerns.

Economic stress in childhood and suicide thoughts and suicide attempts: a population-based study among adults.

To investigate associations between economic stress in childhood and suicide thoughts and attempts.

Impact of putamen stroke on task context updating: Evidence from P300 brain waves.

According to the context updating theory, the oddball P300 component indexes brain activities underlying revision of the mental representation induced by incoming stimuli. It involves an attention-driven comparison process that evaluates the representation of the previous event in working memory. Delayed latencies have been reported for various types of stroke such as unilateral thalamic stroke. We investigated memory updating effects in patients with putamen stroke. Two groups of patients with putamen and ...

Anxiety sensitivity and post-traumatic stress reactions: Effects of time-varying intrusive thoughts and associated distress.

The present study examines the extent to which intrusive thoughts and associated distress explains the association between anxiety sensitivity (AS) and post-traumatic stress (PTS) using the "trauma film paradigm".

Negative affect is more strongly associated with suicidal thinking among suicidal patients with borderline personality disorder than those without.

Patients suffering from borderline personality disorder (BPD) are at elevated risk for suicidal thoughts and behaviors (STBs), but this well-described and clinically important association is not well-understood. Prior research suggests that STBs often function as an attempt to escape aversive affect, and that people with BPD experience stronger emotion reactivity and greater discomfort with emotion than those without BPD. Here, we tested whether negative affective states are more likely to predict suicidal ...

's academic thoughts on the treatment of stroke.

, known as gold-needle master has its own unique academic system in the treatment of stroke. In view of principle, rule, recipe, acupoint and technique, 's academic thoughts were reviewed in the treatment of stroke. In terms of theoretic foundation, treating principles, formula application, rules of acupoint selection and manipulation techniques, the characteristics on the academic thoughts on the treatment of stroke were explained. Professor believes that stroke is caused by deficiency, fire, wind, phlegm...

Anhedonia and suicidal thoughts and behaviors in psychiatric outpatients: The role of acuity.

Anhedonia-impairment related to the experience of pleasure-has been identified as a potential risk factor for suicide, with some mixed findings. The current study sought to clarify the role of acuity of anhedonia in the relationship between anhedonia and suicidal thoughts and behaviors by comparing acutely and chronically anhedonic subjects on severity of suicidal ideation (SI) and suicide attempt (SA) history.

The neural architecture of executive functions is established by middle childhood.

Executive functions (EFs) are regulatory cognitive processes that support goal-directed thoughts and behaviors and that involve two primary networks of functional brain activity in adulthood: the fronto-parietal and cingulo-opercular networks. The current study assessed whether the same networks identified in adulthood underlie child EFs. Using task-based fMRI data from a diverse sample of N = 117 children and early adolescents (M age = 10.17 years), we assessed the extent to which neural activity w...

Modes of Resting Functional Brain Organization Differentiate Suicidal Thoughts and Actions: A Preliminary Study.

A major target in suicide prevention is interrupting the progression from suicidal thoughts to action. Use of complex algorithms in large samples has identified individuals at very high risk for suicide. We tested the ability of data-driven pattern classification analysis of brain functional connectivity to differentiate recent suicide attempters from patients with suicidal ideation.

White Bear Suppression Inventory: translation and cross-cultural adaptation to Brazilian Portuguese.

Introduction Intrusive thoughts may cause a significant level of distress, since some individuals evaluate the content of those thoughts as aversive. Suppression of intrusive thoughts is one of the strategies adopted by these individuals, which increases the level of distress. Suppression of thoughts may be present as one of the factors that maintain different psychological disorders. Objective To describe the translation and adaptation into Brazilian Portuguese of the White Bear Suppression Inventory (WBSI...

Disentangling cognitive from motor control: Influence of response modality on updating, inhibiting, and shifting.

It is unclear whether cognitive and motor control are parallel and interactive or serial and independent processes. According to one view, cognitive control refers to a set of modality-nonspecific processes that act on supramodal representations and precede response modality-specific motor processes. An alternative view is that cognitive control represents a set of modality-specific operations that act directly on motor-related representations, implying dependence of cognitive control on motor control. Here...

Association between operative technique and intrusive thoughts on health-related Quality of Life 3 years after APE/ELAPE for rectal cancer: results from a national Swedish cohort with comparison with normative Swedish data.

The aim of this prospective registry-based population study was to investigate the association between QoL 3 years after surgery for rectal cancer and intrusive thoughts and to assess the association with the type of surgery (i.e., APE or ELAPE) in a population-based national cohort. ELAPE has been proposed as a superior surgical technique for distal rectal cancer, but long-term effects on QoL are not known. There are also no studies on the association of negative intrusive thoughts on patients' self-repor...

Effects of Task Complexity and Age-Differences on Task-Related Functional Connectivity of Attentional Networks.

Studies investigating the strength and membership of regions within multiple functional networks primarily focus on either resting state or single cognitive tasks. The goals of the current study were to investigate whether task-related functional connectivity changes with task complexity, and whether this connectivity-complexity relationship is age-sensitive. We assessed seed-to-voxel functional connectivity for the default mode network (DMN) and two attentional networks [cingulo-opercular (CO), fronto-pari...

The association between motives, perceived problems and current thoughts of self-harm following an episode of self-harm. A network analysis.

A history of self-harm is a major risk factor for suicide. Some patients are more likely than others to repeat suicidal behaviour after an episode of self-harm. Insight in the relation between current thoughts of self-harm, motives for the self-harm episode and perceived problems may improve prevention strategies. Network analysis allows to investigate the co-occurence of these factors and their association with each other.

Work-life balance : Thoughts of the Young Surgeon representatives of the German Surgical Society.

Work-life balance is a commonly used term that appears in different contexts and has a different meaning for many colleagues. Unfortunately, however, it is often used as a negative, simplified term to describe the assumed attitude of young surgeons towards work and a medical career, even though this is not universally applicable. As the representatives for Young Surgeons of the German Society of Surgery the aim of this article is to present our thoughts on the issue and associated problems and provide a...

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