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PubMed Journals Articles About "Varian Medical Systems Signs Brachytherapy Applicator Distribution Agreement" RSS

14:18 EST 22nd February 2018 | BioPortfolio

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Showing "Varian Medical Systems Signs Brachytherapy Applicator Distribution Agreement" PubMed Articles 1–25 of 25,000+

A generic TG-186 shielded applicator for commissioning model-based dose calculation algorithms for high-dose-rate (192) Ir brachytherapy.

A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform model-based dose calculation algorithms (MBDCA) dose calculations and comparisons. Its main goal is to facilitate a smooth transition from the AAPM Task Group No. 43 (TG-43) dose calculation formalism, widely being us...


Direction Modulated Brachytherapy (DMBT) for Treatment of Cervical Cancer: A Planning Study with 192Ir, 60Co, and 169Yb HDR Sources.

To evaluate plan quality of a novel MRI-compatible direction modulated brachytherapy (DMBT) tandem applicator using 192Ir, 60Co, and 169Yb HDR brachytherapy sources, for various cervical cancer high-risk clinical target volumes (CTVHR ).

A novel system for commissioning brachytherapy applicators: example of a ring applicator.

A novel system was developed to improve commissioning and quality assurance of brachytherapy applicators used in High Dose Rate (HDR). It employs an imaging panel to create reference images and to measure dwell times and dwell positions. As an example: two ring applicators of the same model were evaluated. An applicator was placed on the surface of an imaging panel and a HDR 192Ir source was positioned in an imaging channel above the panel to generate an image of the applicator, using the gamma photons of t...


Image-guided navigation systems for interstitial brachytherapy.

Interstitial brachytherapy has shown quite promising therapeutic effects in the treatment of tumors in various body regions. Prior to the navigation techniques with quantitative imaging feedback during the procedure, the safety and accuracy of interstitial brachytherapy mainly depended upon the operator's experience, spatial skills and mind reconstruction of the anatomical structures. Different navigation systems have been reported to be experimented on various phantoms and clinically applied in the brachyt...

Performance evaluation of a collapsed cone dose calculation algorithm for HDR Ir-192 of APBI treatments.

Most dose calculations for HDR brachytherapy treatments are based on the AAPM-TG43 formalism. Because patient's anatomy, heterogeneities and applicator shielding are not considered, the dose calculation based on this formalism is inaccurate in some cases. Alternatively, Collapsed Cone (CC) methods as well as Monte Carlo (MC) algorithms belong to the model based dose calculation algorithms, which are expected to improve the accuracy of calculated dose distributions. In this work, the performance of a CC algo...

Semiconductor real-time quality assurance dosimetry in brachytherapy.

With the increase in complexity of brachytherapy treatments, there has been a demand for the development of sophisticated devices for delivery verification. The Centre for Medical Radiation Physics (CMRP), University of Wollongong, has demonstrated the applicability of semiconductor devices to provide cost-effective real-time quality assurance for a wide range of brachytherapy treatment modalities. Semiconductor devices have shown great promise to the future of pretreatment and in vivo quality assurance in...

Challenges in MR-only seed localization for postimplant dosimetry in permanent prostate brachytherapy.

An MR-only postimplant dosimetry workflow for low dose rate (LDR) brachytherapy could reduce patient burden, improve accuracy, and improve cost efficiency. However, localization of brachytherapy seeds on MRI scans remains a major challenge for this type of workflow. In this study, we propose and validate an MR-only seed localization method, and identify remaining challenges.

Outcomes and Toxicities in Intermediate-Risk Prostate Cancer Patients Treated with Brachytherapy Alone or Brachytherapy and Supplemental External Beam Radiation Therapy.

To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and EBRT in patients with intermediate-risk prostate cancer.

A Medicare cost analysis of MRI- versus CT-based high-dose-rate brachytherapy of the cervix: Can MRI-based planning be less costly?

While some institutions deliver multiple fractions per implant for MRI-based planning, it is common for only one fraction to be delivered per implant with CT-based cervical brachytherapy. The purpose of this study was to compare physician costs, hospital costs, and overall costs for cervical cancer patients treated with either CT-based or MRI-based high-dose-rate (HDR) cervical brachytherapy to determine if MRI-based brachytherapy as described can be financially feasible.

Can reference images improve interobserver agreement in reporting liver fibrosis?

Staging of fibrosis in medical liver biopsies has inherent interobserver variability. There are a number of disease-specific scoring systems available. While recognising the importance of these scoring systems, there is scope to consider how concordance amongst histopathologists could be improved using a generic fibrosis staging system.Using virtual slides, we approached both specialist liver histopathologists and general histopathologists from the UK to assess the degree of fibrosis against a proposed four...

Validation of MRI to TRUS registration for high-dose-rate prostate brachytherapy.

The objective of this study was to develop and validate an open-source module for MRI to transrectal ultrasound (TRUS) registration to support tumor-targeted prostate brachytherapy.

Identification of the suitable leaf margin for liver stereotactic body radiotherapy with flattening filter-free beams.

The purpose of this study is to identify the suitable leaf margin for liver stereotactic body radiotherapy (SBRT) with flattening filter-free (FFF) beams, as compared with that with flattening filter (FF) beams. SBRT treatment planning for 10 patients with liver cancer was performed using 10-MV FFF and FF beams obtained from a Varian TrueBeam (Varian Medical Systems, Palo Alto, CA) linear accelerator. Each plan was generated with the leaf margin to the planning target volume (PTV) ranging from -3 to 5 mm....

Preliminary Determination of Activation Products for a Varian Truebeam Linear Accelerator.

Medical linear accelerators used to treat various forms of cancers are operated at a number of different energies. A by-product of the high-energy photons produced by accelerators is activation of components within the machine itself and its surrounding bunker. The activation products pose radiological and regulatory challenges during the operation of the accelerator as well as when it is time for final decommissioning. The Varian TrueBeam is a new state-of-the-art linear accelerator now operating in the Ca...

Clinical outcomes with MRI-guided image-based brachytherapy in cervical cancer: An institutional experience.

To evaluate the long-term disease control and toxicity to the organs at risk after dose-escalated image-based adaptive brachytherapy (BT) in cervical cancer.

Multisource Rotating Shield Brachytherapy Apparatus for Prostate Cancer.

Our purpose is to present a novel multisource rotating shield brachytherapy (RSBT) apparatus for the simultaneous precise angular and linear positioning of partially shielded (153)Gd brachytherapy sources in interstitial needles for the treatment of locally advanced prostate cancer. It is designed to lower the dose to nearby healthy tissues, the urethra in particular, relative to conventional high-dose-rate brachytherapy techniques.

The role of (125)I interstitial brachytherapy for inoperable parotid gland carcinoma.

The treatment of inoperable parotid gland carcinoma is challenging and controversial. The purpose of this paper was to present our experience in treating this malignancy using (125)I interstitial brachytherapy.

Porosity of flowable resin composites is not influenced by applicator tip diameter.

To assess the influence of applicator tip diameter on the inclusion of porosities in three different flowable resin composites.

Comments on "Low-dose-rate prostate brachytherapy: 4-8 week postimplant prostate-specific antigen a novel predictor of biochemical failure-free survival".

Manual vs. automated implantation of seeds in prostate brachytherapy: Oncologic results from a single-center study.

The objective of this study was to study survival and tolerance of prostate cancer patients treated with (125)I permanent interstitial brachytherapy by automated vs. manual implantation of seeds.

Microdosimetric Evaluation of Current and Alternative Brachytherapy Sources-A Geant4-DNA Simulation Study.

Radioisotopes such as (75)Se, (169)Yb, and (153)Gd have photon energy spectra and half-lives that make them excellent candidates as alternatives to (192)Ir for high-dose-rate brachytherapy. The aim of the present study was to evaluate the relative biological effectiveness (RBE) of current ((192)Ir, (125)I, (103)Pd) and alternative ((75)Se, (169)Yb, (153)Gd) brachytherapy radionuclides using Monte Carlo simulations of lineal energy distributions.

Assessment of a source position checking tool for the quality assurance of transfer tubes used in HDR 192Ir brachytherapy treatments.

The determination of source positions before treatment is an essential part of the quality assurance (QA) associated with high dose rate brachytherapy treatments. The purpose of this study was to design and commission a tool to allow the quantification of source positions across multiple transfer tube types.

Automatic Torso Detection in Images of Preterm Infants.

Imaging systems have applications in patient respiratory monitoring but with limited application in neonatal intensive care units (NICU). In this paper we propose an algorithm to automatically detect the torso in an image of a preterm infant during non-invasive respiratory monitoring. The algorithm uses normalised cut to segment each image into clusters, followed by two fuzzy inference systems to detect the nappy and torso. Our dataset comprised overhead images of 16 preterm infants in a NICU, with uncontro...

A novel approach to an automated needle insertion in brachytherapy procedures.

One of the most challenging phases in interstitial brachytherapy is the placement of the needles. In these medical procedures, the needles are inserted inside the tissue to guide the positioning of the radioactive sources. The low-dose-rate radioactive sources are placed inside the tissue permanently, whereas a radioactive source in the high-dose-rate brachytherapy is temporarily placed in the desired positions so that the delivery of the prescription dose to the clinical targets can be achieved. Consequent...

Parent and clinician agreement regarding early behavioral signs in 12- and 18-month-old infants at-risk of autism spectrum disorder.

Parent and clinician agreement regarding early behavioral signs of Autism Spectrum Disorder (ASD) in children from a high-risk cohort (siblings of children diagnosed with ASD, n = 188) was examined. Infants were assessed prospectively at 12 and 18 months of age using the clinician administered Autism Observational Scale for Infants (AOSI) and the Autism Parent Screen for Infants (APSI) and underwent a blind independent diagnostic assessment for ASD at 36 months of age. Direct comparison of parent and cl...

A novel urethral sparing technique for high-dose-rate prostate brachytherapy after transurethral resection of the prostate.

The purpose of this study was to assess retrospectively the variability of the urethral dose optimized using a Foley catheter versus urethral contrast injected using a new modified triple-lumen catheter, in CT-based high-dose-rate (HDR) prostate brachytherapy of posttransurethral resection of prostate (TURP) patients.


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