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PubMed Journals Articles About "Vaxil Licenses Synthetic Esbp Polymer From Technologies" RSS

06:45 EDT 1st April 2020 | BioPortfolio

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Showing "Vaxil licenses synthetic Esbp polymer from Technologies" PubMed Articles 1–25 of 5,900+

Attenuation of neutrophil-mediated liver injury in mice by drug-free E-Selectin binding polymer.

Inflammation with neutrophils infiltration is a prominent feature of alcohol-related liver disease (ARLD) and contributes to the severity of the disease. Although an array of potential treatments has been studied, the standard treatment regimen is controversial and can induce severe side effects and infection-related complications. E-selectin, a cytokine inducible cell adhesion molecule, mediates the initial interaction of leucocytes with endothelial cells, and facilitates their further adhesion and extrava...


Molecular docking and dynamic approach to virtual screen inhibitors against Esbp of Candidatus Liberibacter asiaticus.

Citrus greening (huanglongbing) is the most destructive disease of citrus worldwide caused by Candidatus Liberibacter asiaticus (CLA). Currently, no strategies have been developed to manage the Huanglongbing (HLB) disease and to stop the spreading of this disease to new citrus areas. Esbp is an extracellular solute-binding protein, involved in the uptake of iron in CLA. Thus, inhibiting this process may be a promising approach to design a drug against CLA. Thus, the present study focused on the identificati...

Current Advances in Biodegradable Synthetic Polymer based Cardiac Patches.

The number of people affected by heart disease such as coronary artery disease (CAD) and myocardial infarction (MI) increases at an alarming rate each year. Currently, the methods to treat these diseases are restricted to lifestyle change, pharmaceuticals, and eventually heart transplant if the condition is severe enough. While these treatment options are the standard for caring for patients who suffer from heart disease, limited regenerative ability of the heart restricts the effectiveness of treatment and...


MSPolyCalc: a web-based App for polymer mass spectrometry data interpretation. The case study of a pharmaceutical excipient.

In contrast to biological polymers, synthetic macromolecules consist of distributions of size, chemical composition, functionality and eventually architecture. The mass spectrum of a synthetic polymer may exhibit a tremendous amount of signals. The availability of suitable IT tools to support interpretation is key.

The application of a novel cyclic ion mobility-mass spectrometer to the analysis of synthetic polymers: A preliminary evaluation.

Mass spectrometry (MS) is often employed in the characterisation of synthetic polymers. As polymer architecture becomes more complex, ion mobility (IM) is increasingly being coupled with MS to provide an additional dimension of separation, along with structural information. Here we explore the use of a novel cyclic ion mobility (cIM) mass spectrometer for the analysis of a co-polymer sample.

Synthetic Photoelectrochemistry.

Photoredox Catalysis (PRC) and Synthetic Organic Electrochemistry (SOE) are often considered competing technologies in organic synthesis and their fusion has been largely overlooked. We review state-of-the-art synthetic organic photoelectrochemistry, grouping examples into three categories: 1) electrochemically-mediated PhotoRedox Catalysis (e-PRC), 2) decoupled PhotoElectrochemistry (dPEC) and 3) interfacial PhotoElectrochemistry (iPEC). Such synergies prove beneficial not only for synthetic 'greenness' an...

A Wish List for Synthetic Biology in Photosynthesis Research.

The perspective summarizes the presentations and discussions at the International Symposium on Synthetic Biology in Photosynthesis Research, which was held in Shanghai in 2018. Leveraging the current advanced understanding of photosynthetic systems, the symposium brain stormed about the redesign and engineering photosynthetic systems for translational goals and evaluated available new technologies/tools for synthetic biology as well as technological obstacles and new tools that would be needed to overcome t...

A review of polymer nanohybrids for oil recovery.

As oil fields go into their final stage of production, new technologies are necessary to sustain production and increase the recovery of the hydrocarbon. Chemical injection is an enhanced recovery technique, which focuses on increasing the effectiveness of waterfloods. However, the use of chemical flooding has been hampered by its relatively high cost and the adsorption of the injected chemicals onto the reservoir rocks. In recent years, nanofluids have been launched as an overall less expensive and more ef...

Controlling the Packing of Metal-Organic Layers by Inclusion of Polymer Guests.

The preparation of metal-organic structures with a controlled degree of disorder is currently one of the most promising fields of materials science. Here, we describe the effect of guest polymer chains on the transformation of a MOF. Heating a pillared-layer type MOF at a controlled temperature resulted in the exclusive removal of the pillar ligands, while the connectivity of the metal-organic square grid layers was maintained. In absence of polymer, the structure of MOF rearranged to form a new crystalline...

Bioinert and Lubricious Surfaces by Macromolecular Design.

The modification of a variety of biomaterials and medical devices often encompasses the generation of biopassive and lubricious layers on their exposed surfaces. This is valid when the synthetic supports are required to integrate within physiological media without altering their interfacial composition, and when minimization of shear stress prevents or reduce damage on the surrounding environment. In many of these cases, hydrophilic polymer brushes assembled from surface-interacting polymer adsorbates, or d...

Light-driven ATP regeneration in diblock/grafted hybrid vesicles.

Light-driven ATP regeneration systems combining ATP synthase and bacteriorhodopsin have been proposed as an energy supply in the field of synthetic biology. Energy is required to power biochemical reactions within artificially created reaction compartments like protocells, which are typically based on either lipid or polymer membranes. The insertion of membrane proteins in different hybrid membranes is delicate and studies comparing these systems with liposomes are needed. Here we present a detailed study o...

Ion Mobility Spectrometry - Mass Spectrometry Coupling for Synthetic Polymers.

This review covers applications of ion mobility spectrometry (IMS) hyphenated to mass spectrometry (MS) in the field of synthetic polymers. MS has become an essential technique in polymer science, but increasingly complex samples produced to provide desirable macroscopic properties of high performance materials often require separation of species prior to their mass analysis. Similar to liquid chromatography, the IMS dimension introduces shape selectivity but enables separation at a much faster rate (millis...

Clay-polymer nanocomposites: Progress and challenges for use in sustainable water treatment.

Contaminant removal from water involves various technologies among which adsorption is considered to be simple, effective, economical, and sustainable. In recent years, nanocomposites prepared by combining clay minerals and polymers have emerged as a novel technology for cleaning contaminated water. Here, we provide an overview of various types of clay-polymer nanocomposites focusing on their synthesis processes, characteristics, and possible applications in water treatment. By evaluating various mechanisms...

All-Solid-State Lithium Organic Batteries Comprising Single-Ion Polymer Nanoparticle Electrolytes.

Advances in lithium battery technologies necessitate improved energy densities, long cycle lives, fast charging, safe operation, and environment-friendly components. In this study, we investigated lithium organic batteries comprising bioinspired polyvinyl catechol (P4VC) cathode materials and single-ion conducting polymer nanoparticle electrolytes. The controlled synthesis of P4VC resulted in a two-step redox reaction with voltage plateaus at ~3.1 and ~3.5 V as well as a high initial specific capacity of 35...

Biobased technologies for the efficient extraction of biopolymers from waste biomass.

Regardless of considerable progress in synthetic plastic or polymer-based industry, its low biodegradability is a critical issue. Nevertheless, natural "biopolymers" are gradually replacing them for being inherently biodegradable, eco-friendly with other unique properties. This article aims to present a review regarding different extraction techniques of biopolymers [natural (cellulose, chitin, lignin, pectin, starch, xylan), synthetic (polyglycolic acid (PGA), polylactic acid (PLA), polycaprolactone (PCL),...

In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays.

"Nonfouling" polymer brush surfaces can greatly improve the performance of in vitro diagnostic (IVD) assays due to the reduction of nonspecific protein adsorption and consequent improvement of signal-to-noise ratios. The development of synthetic polymer brush architectures that suppress adventitious protein adsorption is reviewed, and their integration into surface plasmon resonance and fluorescent sandwich immunoassay formats is discussed. Also, highlighted is a novel, self-contained immunoassay platform (...

Interaction between microalgae, marine snow and anionic polyacrylamide APAM at marine conditions.

When an oil field ages and the pressure in the reservoir decreases, or for oil fields with heavy oil, there may be a need for enhanced oil recovery (EOR) technologies. Polymer injection is a water-based EOR method where the viscosity of the water injected for pressure support is increased by mixing with a high concentration polymer solution. In this project, the potential fate of a synthetic anionic polyacrylamide (APAM) in seawater was investigated, since these EOR polymers may enter the marine environment...

Additive manufacturing technologies for processing zirconia in dental applications.

The objective of this narrative review was to summarize the current status and future perspectives of additive manufacturing (AM) technologies with a particular emphasis on manufacturing zirconia-based materials. AM technologies include vat photopolymerization, material jetting, material extrusion, selective laser sintering (SLS), and selective laser melting (SLM) technologies based on either powder bed fusion (PBF) technologies or direct energy deposition, or sheet lamination based on binder jetting techno...

MOF-Polymer Hybrid Materials: From Simple Composites to Tailored Architectures.

Metal-organic frameworks (MOFs) are inherently crystalline, brittle porous solids. Conversely, polymers are flexible, malleable, and processable solids that are used for a broad range of commonly used technologies. The stark differences between the nature of MOFs and polymers has motivated efforts to hybridize crystalline MOFs and flexible polymers to produce composites that retain the desired properties of these disparate materials. Importantly, studies have shown that MOFs can be used to influence polymer...

Polymer grafting on graphene layers by controlled radical polymerization.

In situ controlled radical polymerization (CRP) is considered as an important approach to graft polymer brushes with controlled grafting density, functionality, and thickness on graphene layers. Polymers are tethered with chain end or through its backbone to the surface or edge of graphene layers with two in situ polymerization methods of "grafting from" and "grafting through" and also a method based on coupling reactions known as "grafting to". The "grafting from" method relies on the propagation of polyme...

Yeast bioprospecting versus synthetic biology-which is better for innovative beverage fermentation?

Producers often utilise some of the many available yeast species and strains in the making of fermented alcoholic beverages in order to augment flavours, aromas, acids and textural properties. But still, the demand remains for more yeasts with novel phenotypes that not only impact sensory characteristics but also offer process and engineering advantages. Two strategies for finding such yeasts are (i) bioprospecting for novel strains and species and (ii) genetic modification of known yeasts. The latter enjoy...

Redox-Mediated, Transient Supramolecular Charge-Transfer Gel and Ink.

Unprecedented spatiotemporal control exhibited by natural systems has aroused interest in the construction of its synthetic mimics. Cytoskeleton proteins utilize fuel-driven dissipative self-assembly to temporally regulate cell shape and motility. Until now, synthetic efforts have majorly contributed to fundamental strategies; however, temporally programmed functions are rarely explored. Herein, we work toward alleviating this scenario by using a charge-transfer (CT) based supramolecular polymer that underg...

Engineering the binding kinetics of synthetic polymer nanoparticles for siRNA delivery.

The affinity of a synthetic polymer nanoparticle (NP) to a target biomacromolecule is determined by the association and dissociation rate constants (kon, koff) of the interaction. The individual rates and their sensitivity to local environmental influences are important factors for the on demand capture and release a target biomacromolecule. Positively charged NPs for siRNA delivery is a case in point. The knockdown efficacy of siRNA can be strongly influenced by the binding kinetics to the NP. Here, we sho...

The Price of Substitute Technologies.

Only a small share of new drugs is truly innovative; 85% to 90% of all new health technologies have little or no advantage over existing therapeutic alternatives. Health economic evaluations can be used to induce acceptable prices for new technologies through threshold pricing.

Preconcentration of digoxin using a synthetic imprinted polymer deposited upon the surface of double-layered hydroxides on porous anodised aluminium wire a triple solid-phase microextraction fibre.

A new solid-phase microextraction fibre is fabricated through polymerisation of molecularly imprinted polymer on the surface of a layered double hydroxide framework that has been fabricated via the in situ synthesis on a non-porous anodic aluminium oxide/aluminium wire as both the substrate and the aluminium source.


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