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PubMed Journals Articles About "Veeva Announces Free ERegulatory Solution Clinical Research Sites" RSS

00:15 EST 12th November 2019 | BioPortfolio

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Showing "Veeva Announces Free eRegulatory Solution Clinical Research Sites" PubMed Articles 1–25 of 61,000+

Free Ligand 1D NMR Conformational Signatures to Enhance Structure Based Drug Design of a Mcl-1 inhibitor (AZD5991) and other Synthetic Macrocycles.

The three-dimensional conformations adopted by a free ligand in solution impact bioactivity and physicochemical properties. Solution 1D NMR spectra inherently contain information on ligand conformational flexibility and three-dimensional shape, as well as on the propensity of the free ligand to fully pre-organize into the bioactive conformation. Herein we discuss some key learnings, distilled from our experience developing potent and selective synthetic macrocyclic inhibitors, including Mcl-1 clinical candi...


A Large Scale Study of Hydration Environments Through Hydration Sites.

Hydration sites are locations of interest to water and they can be used to classify the behaviour of water around chemical motifs commonly found on the surface of proteins. Inhomogeneous fluid solvation theory (IFST) is a method for calculating hydration free energy changes from molecular dynamics (MD) trajectories. In this paper hydration sites are identified from MD simulations of 380 diverse protein structures. The hydration free energies of the hydration sites are calculated using IFST and distributions...

Measurement of substance-free reinforcement in addiction: A systematic review.

A robust body of theoretical and experimental work highlights the influence of alternative, substance-free rewards on decisions to use alcohol and other drugs. However, translational applications have been limited in part by the lack of consensus on how to measure substance-free reinforcement in applied and clinical settings. The current study summarizes extant research utilizing self-report reinforcement or reward methodologies, and critically reviews the psychometric properties of the available measures. ...


Effects of hydrogen in prevention of corneal endothelial damage during phacoemulsification: a prospective randomized clinical trial.

Hydrogen (H) has been reported to scavenge free radicals, particularly the hydroxyl radical (·OH). Ultrasound oscillation in an aqueous solution produces ·OH. Our recent study demonstrated that H dissolved in an irrigation solution prevented corneal endothelial damage during phacoemulsification in an animal model. We examined the effects of H during clinical phacoemulsification.

Free energies and entropies of binding sites identified by MixMD cosolvent simulations.

In our recent efforts to map protein surfaces using mixed-solvent molecular dynamics (MixMD),1 we were able to successfully capture active sites and allosteric sites within the top-four most occupied hotspots. In this study, we describe our approach for estimating the thermodynamic profile of the binding sites identified by MixMD. First, we establish a framework for calculating free energies from MixMD simulations, and we compare our approach to alternative methods. Second, we present a means to obtain a re...

Acta Physiologica announces: publishing for nothing, open access for free for all German authors!

Readers and friends of Acta Physiologica. How much has been written about the pros and cons of open access, also with regard to Acta? Like it or not, the future may be open access in one form, or another. This article is protected by copyright. All rights reserved.

Organ preservation solution containing dissolved hydrogen gas from a hydrogen-absorbing alloy canister improves function of transplanted ischemic kidneys in miniature pigs.

Various methods have been devised to dissolve hydrogen gas in organ preservation solutions, including use of a hydrogen gas cylinder, electrolysis, or a hydrogen-generating agent. However, these methods require considerable time and effort for preparation. We investigated a practical technique for rapidly dissolving hydrogen gas in organ preservation solutions by using a canister containing hydrogen-absorbing alloy. The efficacy of hydrogen-containing organ preservation solution created by this method was t...

Methylation Landscape of RUNX3 Promoter Region as a Predictive Marker for Th1/Th2 Imbalance in Bronchiolitis.

BACKGROUND The methylation status of RUNX3 promoter region, its impact on RUNX3 gene expression, and Th1/Th2 imbalance are unknown in bronchiolitis. This study aimed to explore the predictors of bronchiolitis developing into asthma. MATERIAL AND METHODS The methylation status of RUNX3 promoter was assessed using Illumina HiSeq platform method. The relative RUNX3 mRNA levels in PBMCs were measured by qRT-PCR. Serum IL-4 and IFN-γ concentrations were measured by ELISA. RESULTS A series of sites with signific...

A multicenter randomized controlled trial using a novel collagen membrane for guided bone regeneration at dehisced single implant sites: Outcome at prosthetic delivery and at 1-year follow-up.

To compare clinical performance of a novel resorbable non-cross-linked collagen membrane, creos xenoprotect (CXP), with a reference membrane (BG) for guided bone regeneration (GBR) at dehisced single implant sites.

Validation of dabrafenib-trametinib prognostic groups in patients treated with vemurafenib and cobimetinib for advanced BRAF-mutated melanoma.

Prognostic groups defined by lactate dehydrogenase concentration and number of organ sites containing metastases have been reported for patients treated with dabrafenib and trametinib for advanced melanoma. We aimed to validate these prognostic groups for patients treated with vemurafenib and cobimetinib in the coBRIM and BRIM-3 clinical studies. Eight hundred nine patients were included, 240 treated with vemurafenib plus cobimetinib and 569 with vemurafenib. For patients treated with vemurafenib and cobime...

Ethylene-Bridged Hexadentate Bis(amidines) and Bis(amidinates) with Variable Binding Sites.

Hexadentate bis(amidines) form versatile networks of hydrogen bonds both in solid state and solution, as revealed by X-ray crystallography, IR, and NMR spectroscopy. Moreover, the corresponding bis(amidinates) produce blue and green emissions in THF solution. Tethered tetradentate bis(amidines) have emerged in coordination chemistry, enantioselective catalysis, as building blocks for polyfunctional heterocycles, and in photoluminescent materials. The next generation of flexible bis(amidine)/bis(amidinate) p...

Optimization of the removal Pb (II) and its Gibbs free energy by thiosemicarbazide modified chitosan using RSM and ANN modeling.

In this research, the removal of Pb (II) by thiosemicarbazide modified chitosan (TSFCS) using RSM and ANN modeling was studied. Also, Gibbs free energy changes of adsorption process based on changes in initial concentration and temperature of solution was investigated. Optimization of these two objectives was performed using NSGA-II and RSM. The regression coefficients of the RSM model for the removal percentage and Gibbs free energy changes were 0.9776 and 0.9864, respectively. Also, the F-values of RSM fo...

Participant Engagement in Translational Genomics Research: Respect for Persons-and Then Some.

The expansion of both formal and informal frameworks of "engaged" research in translational research settings raises emerging and substantial normative concerns. In this article, we draw on findings from a focus group study with members of a national consortium of translational genomic research sites. The goals were to catalog informal participant engagement practices, to explore the perceived roots of these practices and the motivations of research staff members for adopting them, and to reflect on their e...

A reaction density functional theory study of the solvent effect in prototype S2 reactions in aqueous solution.

The bimolecular nucleophilic substitution (SN2) reaction is a fundamental and representative reaction in organic chemistry, and the reaction rate is sensitive to the choice of underlying solvents. Herein, we investigate the solvent effect on the free energy profiles of two paradigm reactions in aqueous solution, i.e., symmetric and asymmetric SN2 reactions, by using the proposed multiscale reaction density functional theory (RxDFT) method, which employs quantum density functional theory for calculating the ...

Clinical and genetic analysis of melanomas arising in acral sites.

Melanomas arising in acral sites are associated with a poorer prognosis than other melanoma subtypes. The aim of this study was to evaluate clinical-pathological and genetic characteristics as well as therapeutic responses of a larger cohort of patients with melanomas arising in acral sites.

Ethical considerations in the design, execution, and analysis of clinical trials of chronic pain treatments.

In the field of pain research, clinical trials may randomize over 500 subjects and include more than 150 sites spanning over a dozen countries.

Mesoporous Cu-Ce-Ox Solid Solution from Spray Pyrolysis for Superior Low-Temperature CO Oxidation.

Development of Pt-group metal free catalysts for low-temperature CO oxidation remains critical. In this work, an active and stable mesoporous Cu-Ce-O x  solid solution is presented by spray pyrolysis. The specific surface areas and pore volumes reach as high as ~170 m 2 /g and 0.24 cm 3 /g, respectively. The results of CO oxidation study suggest that (1) the catalyst obtained by the spray pyrolysis possess much higher activity than co-precipitation, sol-gel and hydrothermal methods; (2) the optimal Cu...

Multi-site performance evaluation and Sigma metrics of 20 assays on the Atellica chemistry and immunoassay analyzers.

Background The Atellica Solution comprises chemistry (CH) and immunoassay (IM) analyzers. Recently, six early adopter clinical laboratories across Europe evaluated the analytical performance of 20 CH and IM assays. To measure analytical performance quality, Sigma metrics were calculated for individual-site and pooled-site results. Methods Precision, detection capability, linearity, and method comparison studies were performed according to Clinical Laboratory Standards Institute protocols. Global Sigma metri...

Albumin-Based Hydrogels for Regenerative Engineering and Cell Transplantation.

Albumin, the most abundant plasma protein in mammals, is a versatile and easily obtainable biomaterial. It is pH and temperature responsive, dissolvable in high concentrations and gels readily in defined conditions. This versatility, together with its inexpensiveness and biocompatibility, makes albumin an attractive biomaterial for biomedical research and therapeutics. So far, clinical research in albumin has centred mainly on its use as a carrier molecule or nanoparticle to improve drug pharmacokinetics an...

Identification of hydroxyl and sulfate free radicals involved the reaction of 1,4-dioxane with peroxone activated persulfate oxidant.

This research investigates the formation of free radical intermediates in an advanced oxidation processes (AOP) capable of destroying recalcitrant contaminants. The AOP studied is marketed as OxyZone® and relies on the premise of successful persulfate activation by peroxone (hydrogen peroxide plus ozone) and the formation of free radicals. The goal of this research was to determine which radicals are involved in the treatment of the model contaminant, 1,4-dioxane, which is a ubiquitous, recalcitrant organi...

Interfacing the basic sciences and clinical orthodontics.

Translational research aims to move knowledge generated from basic science and apply it to the clinical setting. As orthodontists, we continually strive for faster, safer and alternative clinical therapies in our goal to improve our patient outcomes and experiences. Our clinical questions may be answered by benchtop research and the ensuing translational research involving relevant animal models and robust clinical trials.

A Generic Method and Implementation to Evaluate and Improve Data Quality in Distributed Research Networks.

 With the increasing personalization of clinical therapies, translational research is evermore dependent on multisite research cooperations to obtain sufficient data and biomaterial. Distributed research networks rely on the availability of high-quality data stored in local databases operated by their member institutions. However, reusing data documented by independent health providers for the purpose of care, rather than research ("secondary use"), reveal a high variability in terms of data formats, as w...

Ridge preservation in molar extraction sites with an open healing approach: a randomized controlled clinical trial.

To determine the effect of alveolar ridge preservation (ARP) in molar sites without primary flap closure.

Relocation of study participants for rare and ultra-rare disease trials: Ethics and operations.

Clinical trials for investigational new products to treat rare and ultra-rare diseases typically involve a limited number of research sites recruiting from a small pool of patients dispersed over a large geographical area. When remote access is not possible and participants must be present at a trial site, participation in research may require individuals and their families/caregivers to travel great distances, often at significant cost personally and financially and, frequently, for the duration of the tri...

Coordination of platinum to α-synuclein inhibits filamentous aggregation in solution.

Accumulation of filamentous aggregates of α-synuclein (AS) in Lewy bodies and neurites characterizes neurodegenerative diseases such as Parkinson's disease. Inhibition of AS fibrillation is helpful for understanding of AS aggregate structure and for developing chemical therapies. Herein we report that the Pt(II)-containing antitumor drug cisplatin suppresses filamentous aggregation of AS in solution. Pt(II) contrasts strongly with reported transition-metal ions such as Mn(II), Fe(III), and Cu(II), which ac...


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