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04:44 EST 24th January 2019 | BioPortfolio

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Showing "West Nile Virus Infections Pipeline Review 2018 Report" PubMed Articles 1–25 of 36,000+

Emergence of human West Nile Virus infection among paediatric population in Madhya Pradesh, India.

Human infections caused by West Nile Virus (WNV) mostly remain subclinical and self limited. However, nearly 20% infected people suffer from febrile illness and very few of them (

Prevalence of chronic comorbidities in dengue fever and West Nile virus: A systematic review and meta-analysis.

Flavivirus diseases such as dengue fever (DENV), West Nile virus (WNV), Zika and yellow fever represent a substantial global public health concern. Preexisting chronic conditions such as cardiovascular diseases, diabetes, obesity, and asthma were thought to predict risk of progression to severe infections.

West Nile virus lineage 2 in Romania, 2015-2016: co-circulation and strain replacement.

West Nile virus (WNV) is endemic in southeastern Romania and, after the unprecedented urban epidemic in Bucharest in 1996 caused by lineage 1 WNV, cases of West Nile fever have been recorded every year. Furthermore, a new outbreak occurred in 2010, this time produced by a lineage 2 WNV belonging to the Eastern European clade (Volgograd 2007-like strain), which was detected in humans and mosquitoes in the following years.

Pediatric West Nile Virus-Associated Neuroinvasive Disease: A Review of the Literature.

Over the past two decades, West Nile virus has become the most common arbovirus in North America, leading to several outbreaks and infecting thousands of people. Mosquitos help transmit the virus in the majority of cases, but transmission occurs via blood transfusions, organ transplantation, and possibly pregnancy and breastfeeding. While most infected patients experience mild to no symptoms, thousands of West Nile virus-associated neuroinvasive cases have been reported in the United States, with over 700 c...

West Nile virus epizootic in Germany, 2018.

The summer of 2018 in Germany was the second hottest and driest on record. These generally extremely favorable climatic conditions most likely triggered the further expansion and the efficient propagation of the zoonotic arthropod-borne West Nile virus in many Southern/Southeastern and even Central European countries. WNV infections were detected for the first time in resident wild and aviary birds, such as common blackbirds, northern goshawks and great grey owls in Eastern and Southeastern Germany. The cau...

West Nile Virus infection in Northern Italy: Case-crossover study on the short-term effect of climatic parameters.

Changes in climatic conditions are hypothesized to play a role in the increasing number of West Nile Virus (WNV) outbreaks observed in Europe in recent years.

Forecasting the West-Nile virus in the USA: a Google Trends-based time series analysis.

West-Nile virus (WNV) is an arbovirus responsible of an infection, which tends to peak during the late summer and early fall period. Recently, tools monitoring web searches are emerging as powerful sources of data concerning especially infectious diseases.

Short Communication: West Nile Fever imported from Austria to Germany.

This is the first report of West Nile virus infection imported by a traveler returning from a neighboring country to Germany (Austria). Physicians should be aware of the expansion of WNV endemic areas in Europe. This article is protected by copyright. All rights reserved.

Outbreak of West Nile Virus disease in Israel (2015): A retrospective analysis of notified cases.

West Nile Virus (WNV) is mosquito-borne virus that is endemic in Israel. In 2015, national disease surveillance demonstrated a sharp increase in disease cases, with 149 cases diagnosed.

Mortality of Goshawks (Accipiter gentilis) Due to West Nile Virus Lineage 2.

In 2017, we isolated and identified West Nile virus (WNV) lineage 2 from two dead captive goshawks (Accipiter gentilis), for the first time in the Czech Republic. Goshawk might serve as an early indicator species for the ongoing WNV emergence in several European countries.

Seroprevalence of West Nile and Dengue virus in the human population of the Bolivian Chaco.

To determine the seroprevalence of antibodies against Dengue virus (DENV) and West Nile Virus (WNV) in the human population of the Bolivian Chaco, we tested 256 inhabitants of 2 rural communities. The seroprevalence, confirmed by Plaque Reduction Neutralization Test, was 7.8%, and 2.7% for DENV and WNV, respectively. This article is protected by copyright. All rights reserved.

West Nile Neuroinvasive Disease Presenting as Elsberg Syndrome.

Elsberg syndrome (ES) is a rarely recognized cause of cauda equina syndrome and lower thoracic myelitis, mainly linked to reactivation, or occasionally primary, infection with herpes simplex virus type 2. West Nile virus neuroinvasive disease is rarely considered in the differential diagnosis of patients with ES.

Detection of West Nile virus lineage 1 sequences in blood donors, Punjab province, Pakistan.

This study was performed to determine the presence of West Nile virus (WNV) in mosquito specimens and human blood donors from Pakistan.

Use of Next-Generation Sequencing for Diagnosis of West Nile Virus Infection in Patient Returning to Belgium from Hungary.

An elderly patient in Belgium who became critically ill after returning from Hungary was tested for pathogens using routine diagnostic tests. All results were negative. However, using next-generation sequencing on a cultured respiratory sample, laboratorians detected a complete West Nile virus genome, similar to strains isolated in southeastern Europe.

Evaluation of a new West Nile virus nucleic acid test for screening of blood donations.

West Nile virus (WNV) is transmitted to humans through mosquito bites and can be further transmitted to humans through transfusion or transplantation. Because most infected individuals are asymptomatic, blood donor screening is important in areas where WNV is endemic. These studies evaluated the performance of a new test for detection of WNV RNA in blood donations.

West Nile virus and other mosquito-borne viruses present in Eastern Europe.

Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with the combination of introduction of different WNV strains from lineages 1 and 2, and the establishment of endemic cycles. We found a positive correlation between the risk of WNV re-emergence in...

Immunology of West Nile Virus Infection and the Role of Alpha-Synuclein as a Viral Restriction Factor.

West Nile virus (WNV) is a single-stranded RNA flavivirus and is a major cause of viral encephalitis worldwide. Experimental models of WNV infection in mice are commonly used to define acute neuroinflammatory responses in the brain. Alpha-synuclein (Asyn) is a protein of primarily neuronal origin and is a major cause of Parkinson's disease (PD), a disorder characterized by loss of dopaminergic neurons. Both WNV and PD pathologies are largely mediated by inflammation of the central nervous system (neuroinfla...

West Nile virus season in Europe.

Mosquito excreta: A sample type with many potential applications for the investigation of Ross River virus and West Nile virus ecology.

Emerging and re-emerging arthropod-borne viruses (arboviruses) cause human and animal disease globally. Field and laboratory investigation of mosquito-borne arboviruses requires analysis of mosquito samples, either individually, in pools, or a body component, or secretion such as saliva. We assessed the applicability of mosquito excreta as a sample type that could be utilized during studies of Ross River and West Nile viruses, which could be applied to the study of other arboviruses.

Zika Virus and Other Emerging Arboviral Central Nervous System Infections.

In recent years, we have observed the emergence and reemergence of a number of arthropod-borne viruses (arboviruses). Zika virus is the most recent addition to this group, first causing sporadic cases of uncomplicated febrile illness followed by sizeable outbreaks in the Pacific. However, the epidemiology and clinical features of Zika virus infection have changed rapidly and dramatically; it is now recognized as causing Guillain-Barré syndrome (GBS) in children and adults and congenital abnormalities in in...

A Discrete Time West Nile Virus Transmission Model with Optimal Bird- and Vector-Specific Controls.

A discrete-time model describing the west nile virus transmission among the mosquito, wild bird, and domestic bird populations is constructed. The expressions for the basic reproduction number R and the disease-free fixed point of the model are computed. The local stability of the disease-free fixed point is established based on R. Optimal control theory is used to devise the most effective administration profile of mosquito larvicide, mosquito adulticide and domestic bird-protection in controlling the viru...

Breathing new life into West Nile virus therapeutics; discovery and study of zafirlukast as an NS2B-NS3 protease inhibitor.

The West Nile virus (WNV) has spread throughout the world causing neuroinvasive diseases with no treatments available. The viral NS2B-NS3 protease is essential for WNV survival and replication in host cells and is a promising drug target. Through an enzymatic screen of the National Institute of Health clinical compound library, we report the discovery of zafirlukast, an FDA approved treatment for asthma, as an inhibitor for the WNV NS2B-NS3 protease. Zafirlukast was determined to inhibit the protease throug...

Coexistence of a cross-diffusive West Nile virus model in a heterogenous environment.

This paper is concerned with a strongly-coupled elliptic system, which describes a West Nile virus (WNv) model with cross-diffusion in a heterogeneous environment. The basic reproduction number is introduced through the next generation infection operator and some related eigenvalue problems. The existence of coexistence states is presented by using a method of upper and lower solutions. The true positive solutions are obtained by monotone iterative schemes. Our results show that a cross-diffusive WNv model ...

Terrestrial Bird Migration and West Nile Virus Circulation, United States.

Host migration and emerging pathogens are strongly associated, especially with regard to zoonotic diseases. West Nile virus (WNV), a mosquitoborne pathogen capable of causing severe, sometimes fatal, neuroinvasive disease in humans, is maintained in highly mobile avian hosts. Using phylogeographic approaches, we investigated the relationship between WNV circulation in the United States and the flight paths of terrestrial birds. We demonstrated southward migration of WNV in the eastern flyway and northward m...

Analysis of acute respiratory infections due to influenza virus A, B and RSV during an influenza epidemic 2018.

We studied the incidence, morbidity and mortality of all patients presenting in our teaching hospital with proven influenza virus and/or respiratory syncytial virus (RSV) infection during the influenza epidemic season 2018 which was characterized by a predominant incidence of influenza virus B type B of the Yamagata line.

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