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Showing "What like rejected from clinical trial feeling like" PubMed Articles 1–25 of 33,000+

Authenticity made visible in medical students' experiences of feeling like a doctor.

To interpret the phenomenon of authenticity made visible in medical students' experiences of feeling like a doctor, i.e., how authenticity took shape in narratives about feeling like a doctor in clinical situations where students were challenged to be independent and to a high degree make choices and clinical decisions.

Conceptual Framework to Support Clinical Trial Optimization and End-to-End Enrollment Workflow.

In this work, we present a conceptual framework to support clinical trial optimization and enrollment workflows and review the current state, limitations, and future trends in this space. This framework includes knowledge representation of clinical trials, clinical trial optimization, clinical trial design, enrollment workflows for prospective clinical trial matching, waitlist management, and, finally, evaluation strategies for assessing improvement.

Artificial Intelligence for Clinical Trial Design.

Clinical trials consume the latter half of the 10 to 15 year, 1.5-2.0 billion USD, development cycle for bringing a single new drug to market. Hence, a failed trial sinks not only the investment into the trial itself but also the preclinical development costs, rendering the loss per failed clinical trial at 800 million to 1.4 billion USD. Suboptimal patient cohort selection and recruiting techniques, paired with the inability to monitor patients effectively during trials, are two of the main causes for high...

OCTANE: Oncology Clinical Trial Annotation Engine.

Many targeted therapies are currently available only via clinical trials. Therefore, routine precision oncology using biomarker-based assignment to drug depends on matching patients to clinical trials. A comprehensive and up-to-date trial database is necessary for optimal patient-trial matching.

A pragmatic, adaptive clinical trial design for a rare disease: The FOcal Cerebral Arteriopathy Steroid (FOCAS) trial.

Pediatric stroke investigators identified as their top research priority a clinical trial of corticosteroids for focal cerebral arteriopathy (FCA). However, FCA is both rare and an acute condition making it infeasible to enroll the large sample sizes needed for standard, confirmatory clinical trials. We present a pragmatic approach to clinical trial design that may inform the approach to other rare disorders.

Soothe ourselves in times of need: A qualitative exploration of how the feeling of 'soothe' is understood and experienced in everyday life.

Evidence suggests that self-compassion is linked to psychological benefits. Compassion-focused therapy emphasizes the importance of developing abilities to self-soothe in alleviating psychological distress. However, little is known about how the feeling of soothe is understood, experienced, and achieved in everyday life. This study addressed two research questions: (1) How is the feeling of soothe understood? (2) How is the feeling of soothe experienced in everyday life?

Applying Data Warehousing to a Phase III Clinical Trial From the Fondazione Italiana Linfomi Ensures Superior Data Quality and Improved Assessment of Clinical Outcomes.

Data collection in clinical trials is becoming complex, with a huge number of variables that need to be recorded, verified, and analyzed to effectively measure clinical outcomes. In this study, we used data warehouse (DW) concepts to achieve this goal. A DW was developed to accommodate data from a large clinical trial, including all the characteristics collected. We present the results related to baseline variables with the following objectives: developing a data quality (DQ) control strategy and improving ...

Mobility and outcomes for validated evidence - Incentive trial (MOVE IT): Randomized clinical trial study protocol.

The Clinical trial transparency in oncology significantly increased over the recent years.

Persistent efforts have been made to promote clinical trial transparency, which included encouraging trial registration and prospective registration, as well as protocol disclosure. This study aims to analyze the extent of registration, prospective registration and protocol disclosure in oncology clinical trials and their changing trends.

Suppressor of cytokine signaling genes in renal transplant receivers: Association with transplant fate.

Suppressor of cytokine signaling (SOCS) proteins have acknowledged roles in regulation of immune responses. Moreover, their role in the evolution of allograft rejection is being elucidated. In the current investigation, we measured transcript levels of SOCS1-4 in the peripheral blood of a group of renal transplant recipients including both rejected and non-rejected allografts. Expression analyses showed that relative expression of SOCS2 was significantly higher in transplant-rejected male patients compared ...

Varieties of recollective experience.

Four variants on Tulving's "Remember/Know" paradigm supported a tripartite classification of recollective experience in recognition memory into Remembering (as in conscious recollection of a past episode), Knowing (similar to retrieval from semantic memory), and Feeling (a priming-based judgment of familiarity). Recognition-by-knowing and recognition-by-feeling are differentiated by level of processing at the time of encoding (Experiments 1-3), shifts in the criterion for item recognition (Experiment 2), re...

Extractive summarization of clinical trial descriptions.

Text summarization of clinical trial descriptions has the potential to reduce the time required to familiarize oneself with the subject of studies by condensing long-form detailed descriptions to concise, meaning-preserving synopses. This work describes the process and quality of automatically generated summaries of clinical trial descriptions using extractive text summarization methods.

Infrequent use of clinical trials registries in published systematic reviews in urology.

Validity of systematic reviews may be affected by non-publication of statistically non-significant or unfavorable clinical trial results. One function of clinical trial registries is to make these non-published studies available and thereby reduce potential publication bias. We aim to assess the use of clinical trial registries in published systematic reviews in urology.

Automatic trial eligibility surveillance based on unstructured clinical data.

Insufficient patient enrollment in clinical trials remains a serious and costly problem and is often considered the most critical issue to solve for the clinical trials community. In this project, we assessed the feasibility of automatically detecting a patient's eligibility for a sample of breast cancer clinical trials by mapping coded clinical trial eligibility criteria to the corresponding clinical information automatically extracted from text in the EHR.

Hippocampal neuroimaging-informed clinical trial enrichment tool for amnestic mild cognitive impairment using open data.

Our goal was to assess the enrichment utility of hippocampal volume (HV) as an enrichment biomarker in amnestic mild cognitive impairment (aMCI) clinical trials, and, hence, develop a HV neuroimaging-informed clinical trial enrichment tool. Modeling of integrated longitudinal patient-level data came from open-access natural history studies in patients diagnosed with aMCI - the Alzheimer's disease Neuroimaging Initiative (ADNI)-1 and ADNI-2 - and indicated that a decrease of 1cm with respect to the analysis ...

The dynamic nature of the sense of ownership after brain injury. Clues from asomatognosia and somatoparaphrenia.

The sense of ownership is the feeling that a body part belongs to ourselves. Brain damage may disrupt this feeling, leading to somatoparaphrenia (SP), i.e., the delusion that one's limbs belong to someone else. This delusional feeling is typically associated with profound motor and somatosensory deficits. We reviewed the cases of SP reported so far in the literature outlining the clinical and neuroanatomical profile of SP. We then investigated and reported three new peculiar cases of SP that allow new insig...

A randomized pragmatic clinical trial of gestational diabetes screening (ScreenR2GDM): Study design, baseline characteristics, and protocol adherence.

ScreenR2GDM is a pragmatic randomized clinical trial designed to investigate if one of two gestational diabetes (GDM) screening and treatment protocols results in improved outcomes in the context of standard clinical care.

Technical Note - In silico imaging tools from the VICTRE clinical trial.

In silico imaging clinical trials are emerging alternative sources of evidence for regulatory evaluation and are typically cheaper and faster than human trials. In this note, we describe the set of in silico imaging software tools used in the VICTRE (Virtual Clinical Trial for Regulatory Evaluation) which replicated a traditional trial using a computational pipeline.

An Evaluation of Clinical Trial Multimedia to Support Hispanic Cancer Patients' Informational and Decision-Making Needs.

The inclusion of diverse populations in clinical trial research is a social justice imperative. Creating the communicative tools that can support cancer patients across varied cultural backgrounds in processing complex clinical trial information, to achieve informed consent, has been a challenge. This study sought to evaluate specific clinical trial multimedia-a website, four animations, and a decision aid-to meet the decision-making and informational needs of Hispanic patients. The multimedia content was p...

The Future of Clinical Trial Design: The Transition from Hard Endpoints to Value-Based Endpoints.

Clinical trials have been conducted since 500 BC. Currently, the methodological gold standard is the randomized controlled clinical trial, introduced by Austin Bradford Hill. This standard has produced enormous amounts of high-quality evidence, resulting in evidence-based clinical guidelines for physicians. However, the current trial paradigm needs to evolve because of the ongoing decrease of the incidence of hard endpoints and spiraling trial costs. While new trial designs, such as adaptive clinical trial...

Effectiveness of Cervical Spine High Velocity Low Amplitude Thrust Added to Behavioral Education, Soft Tissue Mobilization, and Exercise in Individuals With Temporomandibular Disorder (TMD) With Myalgia: A Randomized Clinical Trial.

Randomized clinical trial.

Guidance Means Accuracy: A Randomized Clinical Trial on Freehand vs. Guided Dental Implantation.

A randomized clinical trial was conducted to compare all three known static guided surgery protocols (pilot, partial, full) with each other and with freehand surgery in terms of accuracy, under the same conditions.

New Graduate Registered Nurses and the Spectrum of Comfort in Clinical Practice.

The comfort zone is where a person consistently performs his or her role in an affective state devoid of anxiety and without a feeling of risk. This study challenges the notion of a singular comfort zone and suggests that a spectrum of comfort is a more accurate reflection of the new graduate experience. A grounded theory methodology was used to identify and explain the spectrum of comfort considerations helpful to nine new graduates amid their transition to professional practice. Emerging from the data wer...

Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C).

In Japan, the first domestic clinical trial of proton beam therapy for the liver was initiated as the Japan Clinical Oncology Group trial (JCOG1315C: Non-randomized controlled study comparing proton beam therapy and hepatectomy for resectable hepatocellular carcinoma). Purposes of this study were to develop a new dosimetric verification system and to carry out a credentialing for the JCOG1315C clinical trial.

Association of National Cancer Institute-Sponsored Clinical Trial Network Group Studies With Guideline Care and New Drug Indications.

National Cancer Institute Clinical Trial Network (NCTN) groups serve a vital role in identifying effective new antineoplastic regimens. However, the downstream clinical effect of their trials has not been systematically examined.

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