PubMed Journals Articles About "Winners NACDS Product Showcase Announced" RSS

20:29 EDT 20th September 2018 | BioPortfolio

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Showing "Winners NACDS Product Showcase announced" PubMed Articles 1–25 of 2,700+

Congress2017 poster winners.

The following articles represent the first-place and runner-up winners from the NMCongress2017 poster contest. Both posters were presented and recognized at last year's conference. Congratulations to our winners!

Product Showcase - multi advertisers.

Dying to win? Olympic Gold medals and longevity.

This paper compares mortality between Gold and Silver medalists in Olympic Track and Field to study how achievement influences health. Contrary to conventional wisdom, winners die over one year earlier than losers. I find strong evidence of differences in earnings and occupational choices as a mechanism. Losers pursued higher-paying occupations than winners according to individual Census records. I find no evidence consistent with selection or risk-taking. How people respond to success or failure in pivotal...

Medical negligence: there are no winners.

Congratulations to APIC award winners.

Rotating Catalysts Are Superior - Suppressing Product Inhibition by Anchimeric Assistance in Four-Component Catalytic Machinery.

Three distinct four-component supramolecular nanorotors, prepared by varying the rotator's structure and keeping all other components constant, exhibit rotational frequencies that differ by almost two orders of magnitude. When the rotors were used as catalyst for two click reactions, the product yield correlated with the speed of the machine, e.g. 20% at 0.50 kHz, 44% at 20 kHz and 62% at 42 kHz. The kinetic effect on the product yield is attributed to the ability of the rotating catalysts to displace the p...

JNPT Congratulates APTA Award Winners.

How will alcohol research be impacted by future reduction in nicotine content in cigarettes?

The United States (US) Food and Drug Administration (FDA) is taking unprecedented steps to regulate tobacco products in order to improve public health. The FDA recently announced its intention to set product standards to reduce the nicotine content in cigarettes available in the US to a minimally- or non-addictive level through an advance notice of proposed rulemaking (ANPRM) (Gottlieb and Zeller, 2017). Because of the strong connection of cigarette smoking to alcohol drinking, there is compelling reason fo...

Nobel Prize Winners Who Contributed To Transplantation.

The effect of cigarillo packaging elements on young adult perceptions of product flavor, taste, smell, and appeal.

Product packaging has long been used by the tobacco industry to target consumers and manipulate product perceptions. This study examines the extent to which cigarillo packaging influences perceptions of product flavor, taste, smell, and appeal.

Can estrogens be considered as key elements of the challenge hypothesis? The case of intrasexual aggression in a cichlid fish.

Territorial aggression has been widely studied in males and it has been historically suggested that androgens are key mediators of this behavior. However, more recent evidence suggests that it is the aromatization to estrogens, rather than androgens themselves, that is key to regulating this behavior. Females also display aggressive behaviors, but the physiological regulation of female aggression is still understudied when compared to males. In this context, the challenge hypothesis postulates that male-mal...

Winners of the Emanuel Merck Lectureship and the Heinrich Emanuel Merck Award.

Award winners 2018.

Sources of Safety Data and Statistical Strategies for Design and Analysis: Postmarket Surveillance.

Safety data are continuously evaluated throughout the life cycle of a medical product to accurately assess and characterize the risks associated with the product. The knowledge about a medical product's safety profile continually evolves as safety data accumulate.

Tobacco product initiation is correlated with cross-product changes in tobacco harm perception and susceptibility: Longitudinal analysis of the Population Assessment of Tobacco and Health youth cohort.

Youth initiation with one tobacco product is associated with risk of using additional tobacco types. How use of one product potentially encourages use of others could result from changing tobacco-related perceptions. This study aimed to evaluate how tobacco product initiation correlates with changes in susceptibility (curiosity and willingness) and perceived harm of other tobacco products. For each of cigarettes, e-cigarettes, hookah, and smokeless tobacco, youth (ages 12-16; N = 8005) rated perceived h...

SELEX and SHAPE reveal that sequence motifs and an extended hairpin in the 5' portion of Turnip crinkle virus satellite RNA C mediate fitness in plants.

Noncoding RNAs use their sequence and/or structure to mediate function(s). The 5' portion (166 nt) of the 356-nt noncoding satellite RNA C (satC) of Turnip crinkle virus (TCV) was previously modeled to contain a central region with two stem-loops (H6 and H7) and a large connecting hairpin (H2). We now report that in vivo functional selection (SELEX) experiments assessing sequence/structure requirements in H2, H6, and H7 reveal that H6 loop sequence motifs were recovered at nonrandom rates and only some resi...

Design of a K-Winners-Take-All Model With a Binary Spike Train.

A continuous-time K-winners-take-all (KWTA) neural model that can identify the largest K of N inputs, where command signal 1 łe K < N is described. The model is given by a differential equation where the spike train is a sum of delta functions. A functional block-diagram of the model includes N feed-forward hard-limiting neurons and one feedback neuron, used to handle input dynamics. The existence and uniqueness of the model steady states are analyzed, the convergence analysis of the state variable traject...

A pharmacology guided approach for setting limits on product-related impurities for bispecific antibody manufacturing.

bFKB1 is a humanized bispecific IgG1 antibody, created by conjoining an anti-Fibroblast Growth Factor Receptor 1 (FGFR1) half-antibody to an anti-Klothoβ (KLB) half-antibody, using the knobs-into-holes strategy. bFKB1 acts as a highly selective agonist for the FGFR1/KLB receptor complex and is intended to ameliorate obesity-associated metabolic defects by mimicking the activity of the hormone FGF21. An important aspect of the biologics product manufacturing process is to establish meaningful product specif...

Mechanism of Mg-Accompanied Product Release in Sugar Nucleotidyltransferases.

The nucleotidyl transfer reaction, catalyzed by sugar nucleotidyltransferases (SNTs), is assisted by two active site Mgions. While studying this reaction using X-ray crystallography, we captured snapshots of the pyrophosphate (product) as it exits along a pocket. Surprisingly, one of the active site Mgions remains coordinated to the exiting pyrophosphate. This hints at the participation of Mgin the process of product release, besides its role in catalyzing nucleotidyl transfer. These observations are furthe...

New product identification in the sterol metabolism by an industrial strain Mycobacterium neoaurum NRRL B-3805.

Mycobacterium neoaurum NRRL B-3805 metabolizes sterols to produce androst-4-en-3,17-dione (AD) as the main product, and androsta-1,4-dien-3,17-dione, 9α-hydroxyandrost-4-en-3,17-dione and 22-hydroxy-23,24-bisnorchol-4-en-3-one have been identified as by-products. In this study, a new by-product was isolated from the metabolites of sterols and identified as methyl 3-oxo-23,24-bisnorchol-4-en-22-oate (BNC methyl ester), which was proposed to be produced via the esterification of BNC catalyzed by an O-methylt...

Evaluation of Natural Language Processing (NLP) Systems to Annotate Drug Product Labeling with MedDRA Terminology.

The FDA Adverse Event Reporting System (FAERS) is a primary data source for identifying unlabeled adverse events (AEs) in a drug or biologic drug product's postmarketing phase. Many AE reports must be reviewed by drug safety experts to identify unlabeled AEs, even if the reported AEs are previously identified, labeled AEs. Integrating the labeling status of drug product AEs into FAERS could increase report triage and review efficiency. Medical Dictionary for Regulatory Activities (MedDRA) is the standard fo...

Determination of the dried product resistance variability and its influence on the product temperature in pharmaceutical freeze-drying.

During the primary drying step of the freeze-drying process, mass transfer resistance strongly affects the product temperature, and consequently the final product quality. The main objective of this study was to evaluate the variability of the mass transfer resistance resulting from the dried product layer (R) in a manufacturing batch of vials, and its potential effect on the product temperature, from data obtained in a pilot scale freeze-dryer. Sublimation experiments were run at -25 °C and 10 Pa using tw...

On the use of IR thermography for monitoring a vial freeze-drying process.

Monitoring a vial freeze-drying process without interfering with product dynamics is a challenging issue. This paper presents a novel device constituted by an IR camera designed to be placed inside the drying chamber, able to monitor the temperature of the vials, very close to that of the product inside. By this way it is possible to estimate the ending point of the primary drying, the heat transfer coefficient to the product (K) and the resistance of the dried product to vapour flux (R). Experiments were c...

Enantioselective analysis for L-pidolic acid in ertugliflozin drug substance and drug product by chiral gas chromatography with derivatization.

L-pidolic acid is being used as a coformer for ertugliflozin, a sodium-glucose cotransport 2 inhibitor. A sensitive and rapid two-step achiral derivatization combined with gas chromatography with flame ionization detection or gas chromatography with mass spectroscopic detection was developed and validated for the enantiomeric purity determination of L-pidolic acid in the drug substance and drug product, respectively. The method was used to analyze ertugliflozin drug substance forced degradation samples and ...

Identification of 2, 3-dihydrodipicolinate as the product of the dihydrodipicolinate synthase reaction from Escherichia coli.

Dihydrodipicolinate synthase (DHDPS) catalyzes the first step in the pathway for the biosynthesis of L-lysine in most bacteria and plants. The substrates for the enzyme are pyruvate and L-aspartate-β-semialdehyde (ASA). The product of the reaction was originally proposed to be 2, 3-dihydrodipicolinate (DHDP), but has now generally been assumed to be (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate (HTPA). ASA is unstable at high pH and it is proposed that ASA reacts with itself. At high pH ASA also reac...

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