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05:19 EST 16th December 2018 | BioPortfolio

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Showing "With Commissioner Scott Gottlieb" PubMed Articles 1–25 of 28

Editorial Board Member's Commentary: Commissioner Scott Gottlieb's Predictable Imaginarium.

Eugene L. Gottlieb, 1919-2018.

An appreciation of the science and philanthropy of sir Oliver Scott, founder of the Gray Cancer Institute.

This Commentary focuses on the landmark paper about hypoxia in radiotherapy by Gray, Scott et al published in 1953. By then, it was known that hypoxic regions in tumours could make them resistant to radiation treatment and that this was a possible cause of failure. The paper proposed that oxygen breathing could substantially decrease this resistance without incurring significant additional damage to normal tissues, thus reducing the likelihood of recurrence. Although the paper's supporting data were in some...

Cancer immunology and radiobiology: Oliver Scott's struggle for the perfect tumour model in translational research.

Oliver Scott is best known for his research into the role of tumour hypoxia in radiation oncology. Yet no less important were Oliver's activities in the development of concepts and methods for performing translational research on the effect of ionizing radiation on tumour in experimental animals, stressing the importance of using strictly inbred animals for transplantation of tumours which had arisen in exactly the identical mouse strain. Otherwise residual immunity would lead to uncontrollable bias in the ...

Gene expression responses of Listeria monocytogenes Scott A exposed to sub-lethal concentrations of natural antimicrobials.

One of the emerging strategies proposed to prevent the presence and the growth of Listeria monocytogenes in food products is the use of natural antimicrobial compounds like essential oils (EOs) or their components alone or in combination with other mild hurdles. The aim of this study was to explore the gene expression mechanisms of L. monocytogenes Scott A exposed for 1 h to different sub-lethal antimicrobial concentrations of (E)-2-hexenal, citral, carvarcol and thyme EO in order to understand the impact...

An analysis of retractions of papers authored by Scott Reuben, Joachim Boldt and Yoshitaka Fujii.

We analysed how long it has taken for papers authored by Scott Reuben, Joachim Boldt and Yoshitaka Fujii to be retracted: investigations into these three anaesthetists have shown much of their research to be unethical or fraudulent. To date, 94% of their combined papers requiring retraction have been retracted; however, only 85% of the retraction notices were compliant with guidelines produced by the Committee on Publication Ethics. We contacted the Editors-in-Chief and/or publishers of all the journals con...

A new coefficient of interrater agreement: The challenge of highly unequal category proportions.

We derive a general structure that encompasses important coefficients of interrater agreement such as the S-coefficient, Cohen's kappa, Scott's pi, Fleiss' kappa, Krippendorff's alpha, and Gwet's AC1. We show that these coefficients share the same set of assumptions about rater behavior; they only differ in how the unobserved category proportions are estimated. We incorporate Bayesian estimates of the category proportions and propose a new agreement coefficient with uniform prior beliefs. To correct for gue...

2018 HONOR ROLL AWARD: Presented to RANDALL E. SCOTT at the 63rd Annual Meeting of the Health Physics Society Cleveland, Ohio 15-19 July 2018.

Vitreoretinal disease diagnosis, management, and clinical pearls by Ingrid U. Scott, Carl D. Regillo, Harry W. Flynn, Jr., Gary C. Brown (2017) pp. 640, Hardback ISBN: 9781626231337 Thieme Publishers.

Vitreoretinal disease diagnosis, management, and clinical pearls by Ingrid U. Scott, Carl D. Regillo, Harry W. Flynn, Jr., Gary C. Brown (2017) pp. 640, Hardback ISBN: 9781626231337 Thieme Publishers.

Vitreoretinal disease diagnosis, management, and clinical pearls by Ingrid U. Scott, Carl D. Regillo, Harry W. Flynn, Jr., Gary C. Brown (2017) pp. 640, Hardback ISBN: 9781626231337 Thieme Publishers.

Self-plagiarism and conference papers: editorial.

Editor-in-Chief P. Scott Carney and Topical Editor Samuel T. Thurman discuss self-plagiarism and conference papers.


The purpose of these acoustical patent reviews is to provide enough information for a Journal reader to decide whether to seek more information from the patent itself. Any opinions expressed here are those of the reviewers as individuals and are not legal opinions. Printed copies of United States Patents may be ordered at $3.00 each from the Commissioner of Patents and Trademarks, Washington, DC 20231. Patents are available via the Internet at

How will alcohol research be impacted by future reduction in nicotine content in cigarettes?

The United States (US) Food and Drug Administration (FDA) is taking unprecedented steps to regulate tobacco products in order to improve public health. The FDA recently announced its intention to set product standards to reduce the nicotine content in cigarettes available in the US to a minimally- or non-addictive level through an advance notice of proposed rulemaking (ANPRM) (Gottlieb and Zeller, 2017). Because of the strong connection of cigarette smoking to alcohol drinking, there is compelling reason fo...

Pathways to use of communication campaigns' evaluation findings within international organizations.

This article presents a study on the pathways and processes regarding the use of evaluation findings of communication campaigns from two international organizations, the Office of the High Commissioner for Human Rights (OHCHR) and the International Committee of the Red Cross (ICRC). Several years after the completion of the campaigns and their evaluations, our research identified 28 instances of use and six instances of non-use of the evaluation results, of which the large majority being surprising in natur...

Reply to Ashwin Shinde, Richard Li, Arya Amini, and Scott Glaser's Letter to the Editor re: Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomis

Psychiatric Jim Crow: Desegregation at the Crownsville State Hospital, 1948-1970.

The Crownsville State Hospital, located in Maryland just outside of Annapolis, provides a thought-provoking example of the impact of desegregation in the space of the mental hospital. Using institutional reports, patient records, and oral histories, this article reconstructs the three phases of desegregation at Crownsville. First, as a result of its poor conditions, lack of qualified staff, and its egregious mistreatment of patients, African American community leaders and organizations such as the NAACP cal...

Cholera Outbreak in Dadaab Refugee Camp, Kenya - November 2015-June 2016.

Dadaab Refugee camp in Garissa County, Kenya, hosts nearly 340,000 refugees in five subcamps (Dagahaley, Hagadera, Ifo, Ifo2, and Kambioos) (1). On November 18 and 19, 2015, during an ongoing national cholera outbreak (2), two camp residents were evaluated for acute watery diarrhea (three or more stools in ≤24 hours); Vibrio cholerae serogroup O1 serotype Ogawa was isolated from stool specimens collected from both patients. Within 1 week of the report of index cases, an additional 45 cases of acute watery...

Reply to Comment on 'Origins of the changing detector response in small megavotage photon radiation fields'.

Andreo and Benmakhlouf (A-B 2017) have disputed a finding of Scott et al (2012) that the variation with field-size of the response of small ion chambers and solid-state dosimeters in small megavoltage photon radiation fields can largely be attributed to density. Further evidence for this finding was provided by Fenwick et al (2018), but A-B (2018) have now challenged the methodology used in that study. Specifically, A-B suggest that mass stopping-powers of fictitious materials used in Monte Carlo radiation ...

Tackling poor specificity of cocaine color tests by electrochemical strategies.

This paper presents electrochemical strategies for the fast screening of cocaine and most common cutting agents found in seized drug samples. First, a study on the performance of Scott color tests on cocaine and a wide range of cutting agents is described. The cutting agents causing false positive or false negative results when in mixture with cocaine are identified. To overcome the lack of specificity of color tests, we further propose a fast screening strategy by means of square wave voltammetry on dispos...

Structure and Function of the Fgd Family of Divergent FYVE Domain Proteins.

FYVE domains are highly conserved protein modules that typically bind phosphatidylinositol 3-phosphate (PI3P) on the surface of early endosomes. Along with pleckstrin homology (PH) and phox homology (PX) domains, FYVE domains are the principal readers of the phosphoinositide (PI) code that mediate specific recognition of eukaryotic organelles. Of all the human FYVE domain-containing proteins, those within the Faciogenital dysplasia (Fgd) subfamily are particularly divergent, and couple with GTPases to exert...

"Other minds than ours": a controversial discussion on the limits and possibilities of comparative psychology in the light of C. Lloyd Morgan's work.

C. Lloyd Morgan is mostly known for Morgan's canon (An introduction to comparative psychology, Walter Scott, Limited, London, 1894), still a popular and frequently quoted principle in comparative psychology and ethology. There has been a fair amount of debate on the canon's interpretation, function, and value regarding the research on animal minds, usually referring to it as an isolated principle. In this paper we rather shed light on Morgan's overall scientific program and his vision for comparative psycho...

"Implicit alcohol associations, especially drinking identity, predict drinking over time": Correction to Lindgren et al. (2016).

Reports an error in "Implicit alcohol associations, especially drinking identity, predict drinking over time" by Kristen P. Lindgren, Clayton Neighbors, Bethany A. Teachman, Scott A. Baldwin, Jeanette Norris, Debra Kaysen, Melissa L. Gasser and Reinout W. Wiers (, 2016[Aug], Vol 35[8], 908-918). This erratum reports that two responses for item 9 of the Alcohol Use Disorders Identification Test (AUDIT; Babor et al., 2001) were coded incorrectly. Specifically, the response options "Yes, but not in the last ye...

New insights on Listeria monocytogenes growth in pressurised cooked ham: A piezo-stimulation effect enhanced by organic acids during storage.

The aim of the present study was to understand growth and survival responses of Listeria monocytogenes during the storage of high pressure processed (HPP) cooked ham formulated with organic acids to inhibit growth of the pathogen. Cooked ham batches were manufactured without organic acids (control), with potassium lactate (2.8% or 4%) or with potassium lactate and sodium diacetate (2.0% + 0.11% or 2.0% + 0.45%). Products were aseptically sliced and inoculated with 10 cfu/g or 10 cfu/g of either ...

Rethinking the doctor-patient relationship: toward a hermeneutically-informed epistemology of medical practice.

Although typically implicit, clinicians face an inherent conflict between their roles as medical healers and as providers of technical biomedicine (Scott et al. in Philos Ethics Humanit Med 4:11, 2009). This conflict arises from the tension between the physicalist model which still predominates in medical training and practice and the extra-physicalist dimensions of medical practice as epitomised in the concept of patient-centred care. More specifically, the problem is that, as grounded in a "borrowed" phys...

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